Abstract

High-resolution full-field optical coherence microscopy (FF-OCM) is demonstrated using a single broadband light-emitting diode (LED). The characteristics of the LED-illumination FF-OCM system are measured and compared to those obtained using a halogen lamp, the light source of reference in FF-OCM. Both light sources yield identical performance in terms of spatial resolution and detection sensitivity, using the same setup and camera. In particular, an axial resolution of 0.7 μm (in water) is reached. A Xenopus laevis tadpole and ex-vivo human skin have been imaged using both sources, resulting in similar images, showing for the first time that LEDs could favorably replace halogen lamps in high-resolution FF-OCM for biomedical imaging.

© 2016 Optical Society of America

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References

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2015 (2)

2014 (4)

C. Li, J. A. Zeitler, Y. Dong, and Y. C. Shen, “Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography,” J. Pharm. Sci. 103(1), 161–166 (2014).
[Crossref] [PubMed]

R. Kimura, T. Iwai, and T. Tsugita, “Optical characterization of facial foundation applied to skin replicas by using visible FF OCT,” Proc. SPIE 9232, 92320X (2014).

A. Grebenyuk, A. Federici, V. Ryabukho, and A. Dubois, “Numerically focused full-field swept-source optical coherence microscopy with low spatial coherence illumination,” Appl. Opt. 53(8), 1697–1708 (2014).
[Crossref] [PubMed]

B.-W. Yang, Y.-Y. Wang, Y.-M. Lin, Y.-S. Juan, H.-T. Chen, and S.-P. Ying, “Applying RGB LED in full-field optical coherence tomography for real-time full-color tissue imaging,” Appl. Opt. 53(22), E56–E60 (2014).
[Crossref] [PubMed]

2012 (1)

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

2010 (2)

2009 (1)

D. Sacchet, J. Moreau, P. Georges, and A. Dubois, “Multi-band ultrahigh resolution full-field optical coherence tomography,” Proc. SPIE 7372, 73721F (2009).
[Crossref]

2007 (2)

H. C. Cheng and C. K. Sun, “WLED-Based Low Coherence Interferometry in the Visible Wavelength Range,” J. Med. Biol. Eng. 27, 173–176 (2007).

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

2006 (2)

2005 (5)

2004 (4)

2002 (3)

2001 (1)

1999 (1)

1998 (2)

1997 (1)

J. M. Schmitt, S. L. Lee, and K. M. Yung, “An optical coherence microscope with enhanced resolving power in thick tissue,” Opt. Commun. 142(4-6), 203–207 (1997).
[Crossref]

1994 (1)

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Arthaber, H.

Auksorius, E.

Beaurepaire, E.

Benattar, L.

Blanchot, L.

Boccara, A. C.

E. Auksorius and A. C. Boccara, “Dark-field full-field optical coherence tomography,” Opt. Lett. 40(14), 3272–3275 (2015).
[Crossref] [PubMed]

K. Grieve, G. Moneron, A. Dubois, J.-F. Le Gargasson, and A. C. Boccara, “Ultrahigh-resolution ex-vivo ocular imaging using ultrashort acquisition time en-face optical coherence tomography,” J. Opt. A, Pure Appl. Opt. 7(8), 368–373 (2005).
[Crossref]

G. Moneron, A. C. Boccara, and A. Dubois, “Stroboscopic ultrahigh-resolution full-field optical coherence tomography,” Opt. Lett. 30(11), 1351–1353 (2005).
[Crossref] [PubMed]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol. 49(7), 1227–1234 (2004).
[Crossref] [PubMed]

L. Vabre, A. Dubois, and A. C. Boccara, “Thermal-light full-field optical coherence tomography,” Opt. Lett. 27(7), 530–532 (2002).
[Crossref] [PubMed]

A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, “High-resolution full-field optical coherence tomography with a Linnik microscope,” Appl. Opt. 41(4), 805–812 (2002).
[Crossref] [PubMed]

E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, “Full-field optical coherence microscopy,” Opt. Lett. 23(4), 244–246 (1998).
[Crossref] [PubMed]

E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, “Full-field optical coherence microscopy,” Opt. Lett. 23(4), 244–246 (1998).
[Crossref] [PubMed]

Boccara, C.

Boppart, S. A.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In-vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 24(17), 1221–1223 (1999).
[Crossref] [PubMed]

Bouma, B. E.

Bourquin, S.

Brzezinski, M.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chen, H.-T.

Cheng, H. C.

H. C. Cheng and C. K. Sun, “WLED-Based Low Coherence Interferometry in the Visible Wavelength Range,” J. Med. Biol. Eng. 27, 173–176 (2007).

De Martino, A.

Dhalla, A.-H.

Dong, Y.

C. Li, J. A. Zeitler, Y. Dong, and Y. C. Shen, “Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography,” J. Pharm. Sci. 103(1), 161–166 (2014).
[Crossref] [PubMed]

Drévillon, B.

Drexler, W.

Dubois, A.

A. Federici and A. Dubois, “Full-field optical coherence microscopy with optimized ultrahigh spatial resolution,” Opt. Lett. 40(22), 5347–5350 (2015).
[Crossref] [PubMed]

A. Grebenyuk, A. Federici, V. Ryabukho, and A. Dubois, “Numerically focused full-field swept-source optical coherence microscopy with low spatial coherence illumination,” Appl. Opt. 53(8), 1697–1708 (2014).
[Crossref] [PubMed]

D. Sacchet, M. Brzezinski, J. Moreau, P. Georges, and A. Dubois, “Motion artifact suppression in full-field optical coherence tomography,” Appl. Opt. 49(9), 1480–1488 (2010).
[Crossref] [PubMed]

D. Sacchet, J. Moreau, P. Georges, and A. Dubois, “Multi-band ultrahigh resolution full-field optical coherence tomography,” Proc. SPIE 7372, 73721F (2009).
[Crossref]

K. Grieve, G. Moneron, A. Dubois, J.-F. Le Gargasson, and A. C. Boccara, “Ultrahigh-resolution ex-vivo ocular imaging using ultrashort acquisition time en-face optical coherence tomography,” J. Opt. A, Pure Appl. Opt. 7(8), 368–373 (2005).
[Crossref]

K. Grieve, A. Dubois, M. Simonutti, M. Paques, J. Sahel, J. F. Le Gargasson, and C. Boccara, “In-vivo anterior segment imaging in the rat eye with high speed white light full-field optical coherence tomography,” Opt. Express 13(16), 6286–6295 (2005).
[Crossref] [PubMed]

G. Moneron, A. C. Boccara, and A. Dubois, “Stroboscopic ultrahigh-resolution full-field optical coherence tomography,” Opt. Lett. 30(11), 1351–1353 (2005).
[Crossref] [PubMed]

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt. 43(14), 2874–2883 (2004).
[Crossref] [PubMed]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol. 49(7), 1227–1234 (2004).
[Crossref] [PubMed]

L. Vabre, A. Dubois, and A. C. Boccara, “Thermal-light full-field optical coherence tomography,” Opt. Lett. 27(7), 530–532 (2002).
[Crossref] [PubMed]

A. Dubois, L. Vabre, A. C. Boccara, and E. Beaurepaire, “High-resolution full-field optical coherence tomography with a Linnik microscope,” Appl. Opt. 41(4), 805–812 (2002).
[Crossref] [PubMed]

Eckhaus, M. A.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[Crossref] [PubMed]

Federici, A.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fujimoto, J. G.

W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In-vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 24(17), 1221–1223 (1999).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Georges, P.

D. Sacchet, M. Brzezinski, J. Moreau, P. Georges, and A. Dubois, “Motion artifact suppression in full-field optical coherence tomography,” Appl. Opt. 49(9), 1480–1488 (2010).
[Crossref] [PubMed]

D. Sacchet, J. Moreau, P. Georges, and A. Dubois, “Multi-band ultrahigh resolution full-field optical coherence tomography,” Proc. SPIE 7372, 73721F (2009).
[Crossref]

Grebenyuk, A.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Grieve, K.

K. Grieve, G. Moneron, A. Dubois, J.-F. Le Gargasson, and A. C. Boccara, “Ultrahigh-resolution ex-vivo ocular imaging using ultrashort acquisition time en-face optical coherence tomography,” J. Opt. A, Pure Appl. Opt. 7(8), 368–373 (2005).
[Crossref]

K. Grieve, A. Dubois, M. Simonutti, M. Paques, J. Sahel, J. F. Le Gargasson, and C. Boccara, “In-vivo anterior segment imaging in the rat eye with high speed white light full-field optical coherence tomography,” Opt. Express 13(16), 6286–6295 (2005).
[Crossref] [PubMed]

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt. 43(14), 2874–2883 (2004).
[Crossref] [PubMed]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol. 49(7), 1227–1234 (2004).
[Crossref] [PubMed]

Häuser, S.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Heise, B.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Hermann, B.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Iftimia, N.

Ippen, E. P.

Iwai, T.

R. Kimura, T. Iwai, and T. Tsugita, “Optical characterization of facial foundation applied to skin replicas by using visible FF OCT,” Proc. SPIE 9232, 92320X (2014).

Izatt, J. A.

Juan, Y.-S.

Karamata, B.

Kärtner, F. X.

Kim, M.

Kimura, R.

R. Kimura, T. Iwai, and T. Tsugita, “Optical characterization of facial foundation applied to skin replicas by using visible FF OCT,” Proc. SPIE 9232, 92320X (2014).

Knüttel, A.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[Crossref] [PubMed]

Lambelet, P.

Lasser, T.

Laubscher, M.

Laude, B.

Le Gargasson, J. F.

Le Gargasson, J.-F.

K. Grieve, G. Moneron, A. Dubois, J.-F. Le Gargasson, and A. C. Boccara, “Ultrahigh-resolution ex-vivo ocular imaging using ultrashort acquisition time en-face optical coherence tomography,” J. Opt. A, Pure Appl. Opt. 7(8), 368–373 (2005).
[Crossref]

Lebec, M.

Lecaque, R.

Lee, S. L.

J. M. Schmitt, S. L. Lee, and K. M. Yung, “An optical coherence microscope with enhanced resolving power in thick tissue,” Opt. Commun. 142(4-6), 203–207 (1997).
[Crossref]

Leiss-Holzinger, E.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Leutenegger, M.

Li, C.

C. Li, J. A. Zeitler, Y. Dong, and Y. C. Shen, “Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography,” J. Pharm. Sci. 103(1), 161–166 (2014).
[Crossref] [PubMed]

Li, X. D.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lin, Y.-M.

Marks, D. L.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

Migacz, J. V.

Moneron, G.

G. Moneron, A. C. Boccara, and A. Dubois, “Stroboscopic ultrahigh-resolution full-field optical coherence tomography,” Opt. Lett. 30(11), 1351–1353 (2005).
[Crossref] [PubMed]

K. Grieve, G. Moneron, A. Dubois, J.-F. Le Gargasson, and A. C. Boccara, “Ultrahigh-resolution ex-vivo ocular imaging using ultrashort acquisition time en-face optical coherence tomography,” J. Opt. A, Pure Appl. Opt. 7(8), 368–373 (2005).
[Crossref]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol. 49(7), 1227–1234 (2004).
[Crossref] [PubMed]

A. Dubois, K. Grieve, G. Moneron, R. Lecaque, L. Vabre, and C. Boccara, “Ultrahigh-resolution full-field optical coherence tomography,” Appl. Opt. 43(14), 2874–2883 (2004).
[Crossref] [PubMed]

Moreau, J.

D. Sacchet, M. Brzezinski, J. Moreau, P. Georges, and A. Dubois, “Motion artifact suppression in full-field optical coherence tomography,” Appl. Opt. 49(9), 1480–1488 (2010).
[Crossref] [PubMed]

D. Sacchet, J. Moreau, P. Georges, and A. Dubois, “Multi-band ultrahigh resolution full-field optical coherence tomography,” Proc. SPIE 7372, 73721F (2009).
[Crossref]

Morgner, U.

Nguyen, F. T.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

Oh, W. Y.

Oldenburg, A. L.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

Paques, M.

Pitris, C.

Plank, B.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Považay, B.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ryabukho, V.

Sacchet, D.

D. Sacchet, M. Brzezinski, J. Moreau, P. Georges, and A. Dubois, “Motion artifact suppression in full-field optical coherence tomography,” Appl. Opt. 49(9), 1480–1488 (2010).
[Crossref] [PubMed]

D. Sacchet, J. Moreau, P. Georges, and A. Dubois, “Multi-band ultrahigh resolution full-field optical coherence tomography,” Proc. SPIE 7372, 73721F (2009).
[Crossref]

Sahel, J.

Saint-Jalmes, H.

Salaberger, D.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Salathé, R. P.

Sato, M.

Sattmann, H.

Schausberger, S. E.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Schmitt, J. M.

J. M. Schmitt, S. L. Lee, and K. M. Yung, “An optical coherence microscope with enhanced resolving power in thick tissue,” Opt. Commun. 142(4-6), 203–207 (1997).
[Crossref]

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[Crossref] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Schwartz, L.

Shen, Y. C.

C. Li, J. A. Zeitler, Y. Dong, and Y. C. Shen, “Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography,” J. Pharm. Sci. 103(1), 161–166 (2014).
[Crossref] [PubMed]

Simonutti, M.

Stifter, D.

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Sun, C. K.

H. C. Cheng and C. K. Sun, “WLED-Based Low Coherence Interferometry in the Visible Wavelength Range,” J. Med. Biol. Eng. 27, 173–176 (2007).

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Tanno, N.

Tearney, G. J.

Tsugita, T.

R. Kimura, T. Iwai, and T. Tsugita, “Optical characterization of facial foundation applied to skin replicas by using visible FF OCT,” Proc. SPIE 9232, 92320X (2014).

Unterhuber, A.

Vabre, L.

Wang, Y.-Y.

Yadlowsky, M.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[Crossref] [PubMed]

Yang, B.-W.

Yelin, R.

Ying, S.-P.

Yu, L.

Yun, S. H.

Yung, K. M.

J. M. Schmitt, S. L. Lee, and K. M. Yung, “An optical coherence microscope with enhanced resolving power in thick tissue,” Opt. Commun. 142(4-6), 203–207 (1997).
[Crossref]

Zeitler, J. A.

C. Li, J. A. Zeitler, Y. Dong, and Y. C. Shen, “Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography,” J. Pharm. Sci. 103(1), 161–166 (2014).
[Crossref] [PubMed]

Zhang, Y.

Zysk, A. M.

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

Appl. Opt. (6)

J. Biomed. Opt. (1)

A. M. Zysk, F. T. Nguyen, A. L. Oldenburg, D. L. Marks, and S. A. Boppart, “Optical coherence tomography: a review of clinical development from bench to bedside,” J. Biomed. Opt. 12(5), 051403 (2007).
[Crossref] [PubMed]

J. Med. Biol. Eng. (1)

H. C. Cheng and C. K. Sun, “WLED-Based Low Coherence Interferometry in the Visible Wavelength Range,” J. Med. Biol. Eng. 27, 173–176 (2007).

J. Opt. A, Pure Appl. Opt. (1)

K. Grieve, G. Moneron, A. Dubois, J.-F. Le Gargasson, and A. C. Boccara, “Ultrahigh-resolution ex-vivo ocular imaging using ultrashort acquisition time en-face optical coherence tomography,” J. Opt. A, Pure Appl. Opt. 7(8), 368–373 (2005).
[Crossref]

J. Opt. Soc. Am. A (2)

J. Pharm. Sci. (1)

C. Li, J. A. Zeitler, Y. Dong, and Y. C. Shen, “Non-destructive evaluation of polymer coating structures on pharmaceutical pellets using full-field optical coherence tomography,” J. Pharm. Sci. 103(1), 161–166 (2014).
[Crossref] [PubMed]

Opt. Commun. (1)

J. M. Schmitt, S. L. Lee, and K. M. Yung, “An optical coherence microscope with enhanced resolving power in thick tissue,” Opt. Commun. 142(4-6), 203–207 (1997).
[Crossref]

Opt. Express (4)

Opt. Fiber Technol. (1)

B. Heise, S. E. Schausberger, S. Häuser, B. Plank, D. Salaberger, E. Leiss-Holzinger, and D. Stifter, “Full-field optical coherence microscopy with a sub-nanosecond supercontinuum light source for material research,” Opt. Fiber Technol. 18(5), 403–410 (2012).
[Crossref]

Opt. Lett. (10)

G. Moneron, A. C. Boccara, and A. Dubois, “Stroboscopic ultrahigh-resolution full-field optical coherence tomography,” Opt. Lett. 30(11), 1351–1353 (2005).
[Crossref] [PubMed]

E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, “Full-field optical coherence microscopy,” Opt. Lett. 23(4), 244–246 (1998).
[Crossref] [PubMed]

E. Auksorius and A. C. Boccara, “Dark-field full-field optical coherence tomography,” Opt. Lett. 40(14), 3272–3275 (2015).
[Crossref] [PubMed]

Y. Zhang, M. Sato, and N. Tanno, “Resolution improvement in optical coherence tomography by optimal synthesis of light-emitting diodes,” Opt. Lett. 26(4), 205–207 (2001).
[Crossref] [PubMed]

W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In-vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 24(17), 1221–1223 (1999).
[Crossref] [PubMed]

B. Karamata, P. Lambelet, M. Laubscher, R. P. Salathé, and T. Lasser, “Spatially incoherent illumination as a mechanism for cross-talk suppression in wide-field optical coherence tomography,” Opt. Lett. 29(7), 736–738 (2004).
[Crossref] [PubMed]

A. Federici and A. Dubois, “Full-field optical coherence microscopy with optimized ultrahigh spatial resolution,” Opt. Lett. 40(22), 5347–5350 (2015).
[Crossref] [PubMed]

A.-H. Dhalla, J. V. Migacz, and J. A. Izatt, “Crosstalk rejection in parallel optical coherence tomography using spatially incoherent illumination with partially coherent sources,” Opt. Lett. 35(13), 2305–2307 (2010).
[Crossref] [PubMed]

E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, “Full-field optical coherence microscopy,” Opt. Lett. 23(4), 244–246 (1998).
[Crossref] [PubMed]

L. Vabre, A. Dubois, and A. C. Boccara, “Thermal-light full-field optical coherence tomography,” Opt. Lett. 27(7), 530–532 (2002).
[Crossref] [PubMed]

Phys. Med. Biol. (2)

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, “Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering,” Phys. Med. Biol. 39(10), 1705–1720 (1994).
[Crossref] [PubMed]

A. Dubois, G. Moneron, K. Grieve, and A. C. Boccara, “Three-dimensional cellular-level imaging using full-field optical coherence tomography,” Phys. Med. Biol. 49(7), 1227–1234 (2004).
[Crossref] [PubMed]

Proc. SPIE (2)

D. Sacchet, J. Moreau, P. Georges, and A. Dubois, “Multi-band ultrahigh resolution full-field optical coherence tomography,” Proc. SPIE 7372, 73721F (2009).
[Crossref]

R. Kimura, T. Iwai, and T. Tsugita, “Optical characterization of facial foundation applied to skin replicas by using visible FF OCT,” Proc. SPIE 9232, 92320X (2014).

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

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Figures (7)

Fig. 1
Fig. 1 Spectral power distribution (SPD) of the LED and the halogen lamp, modulated by the spectral response of the camera. LED: λ0 = 630 nm, Δλ = 225 nm. Halogen lamp: λ0 = 700 nm, Δλ = 330 nm.
Fig. 2
Fig. 2 Experimental interferograms obtained with the broadband LED and the halogen lamp.
Fig. 3
Fig. 3 Comparison of the measured axial responses of the system with LED and halogen illumination, on linear scale (left) and logarithmic scale (right).
Fig. 4
Fig. 4 En-face FF-OCM images of a Xenopus laevis tadpole (ex-vivo) obtained with broadband LED illumination (left) and halogen illumination (right).
Fig. 5
Fig. 5 Cross-sectional FF-OCM images of a Xenopus laevis tadpole (ex-vivo) obtained with broadband LED illumination (top) and halogen illumination (bottom).
Fig. 6
Fig. 6 En-face FF-OCM image of human skin (ex-vivo) obtained with broadband LED illumination (left) and halogen illumination (right).
Fig. 7
Fig. 7 Cross-sectional FF-OCM images of human skin (ex-vivo) obtained with broadband LED illumination (top) and halogen illumination (bottom).

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