Abstract

White light diffraction microscopy (wDPM) is a quantitative phase imaging method that benefits from both temporal and spatial phase sensitivity, granted, respectively, by the common-path geometry and white light illumination. However, like all off-axis quantitative phase imaging methods, wDPM is characterized by a reduced space-bandwidth product compared to phase shifting approaches. This happens essentially because the ultimate resolution of the image is governed by the period of the interferogram and not just the diffraction limit. As a result, off-axis techniques generates single-shot, i.e., high time-bandwidth, phase measurements, at the expense of either spatial resolution or field of view. Here, we show that combining phase-shifting and off-axis, the original space-bandwidth is preserved. Specifically, we developed phase-shifting diffraction phase microscopy with white light, in which we measure and combine two phase shifted interferograms. Due to the white light illumination, the phase images are characterized by low spatial noise, i.e., <1nm pathlength. We illustrate the operation of the instrument with test samples, blood cells, and unlabeled prostate tissue biopsy.

© 2016 Optical Society of America

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]
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    [Crossref]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]

2016 (1)

2015 (4)

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

2014 (4)

M. Mir, A. Bergamaschi, B. S. Katzenellenbogen, and G. Popescu, “Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response,” PLoS One 9(2), e89000 (2014).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

P. Bon, S. Aknoun, S. Monneret, and B. Wattellier, “Enhanced 3D spatial resolution in quantitative phase microscopy using spatially incoherent illumination,” Opt. Express 22(7), 8654–8671 (2014).
[Crossref] [PubMed]

C. Edwards, B. Bhaduri, B. G. Griffin, L. L. Goddard, and G. Popescu, “Epi-illumination diffraction phase microscopy with white light,” Opt. Lett. 39(21), 6162–6165 (2014).
[Crossref] [PubMed]

2013 (1)

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

2012 (2)

2011 (4)

L. Miccio, A. Finizio, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Dynamic DIC by digital holography microscopy for enhancing phase-contrast visualization,” Biomed. Opt. Express 2(2), 331–344 (2011).
[Crossref] [PubMed]

R. Wang, Z. Wang, L. Millet, M. U. Gillette, A. J. Levine, and G. Popescu, “Dispersion-relation phase spectroscopy of intracellular transport,” Opt. Express 19(21), 20571–20579 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[Crossref] [PubMed]

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

2010 (4)

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

N. T. Shaked, T. M. Newpher, M. D. Ehlers, and A. Wax, “Parallel on-axis holographic phase microscopy of biological cells and unicellular microorganism dynamics,” Appl. Opt. 49(15), 2872–2878 (2010).
[Crossref] [PubMed]

P. Kolman and R. Chmelík, “Coherence-controlled holographic microscope,” Opt. Express 18(21), 21990–22003 (2010).
[Crossref] [PubMed]

2009 (2)

2008 (2)

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

2007 (1)

2006 (1)

2005 (1)

1998 (1)

D. Paganin and K. A. Nugent, “Noninterferometric phase imaging with partially coherent light,” Phys. Rev. Lett. 80(12), 2586–2589 (1998).
[Crossref]

Aknoun, S.

Badizadegan, K.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Balduzzi, D.

Balla, A.

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

Bauwens, A.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Bergamaschi, A.

M. Mir, A. Bergamaschi, B. S. Katzenellenbogen, and G. Popescu, “Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response,” PLoS One 9(2), e89000 (2014).
[Crossref] [PubMed]

Best, C. A.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Best-Popescu, C.

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Best-Popescu, C. A.

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[Crossref] [PubMed]

Bhaduri, B.

C. Edwards, B. Bhaduri, B. G. Griffin, L. L. Goddard, and G. Popescu, “Epi-illumination diffraction phase microscopy with white light,” Opt. Lett. 39(21), 6162–6165 (2014).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

H. Pham, B. Bhaduri, H. Ding, and G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[Crossref] [PubMed]

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

Bon, P.

Brand, R. E.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Ceballos, S.

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

Chmelík, R.

Choi, W.

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

Cuche, E.

Dasari, R. R.

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

Deflores, L.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Depeursinge, C.

Diez-Silva, M.

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

Ding, H.

Edwards, C.

C. Edwards, B. Bhaduri, B. G. Griffin, L. L. Goddard, and G. Popescu, “Epi-illumination diffraction phase microscopy with white light,” Opt. Lett. 39(21), 6162–6165 (2014).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Ehlers, M. D.

Emery, Y.

Feld, M. S.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

Ferraro, P.

Finizio, A.

Galli, A.

Gillette, M. U.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

R. Wang, Z. Wang, L. Millet, M. U. Gillette, A. J. Levine, and G. Popescu, “Dispersion-relation phase spectroscopy of intracellular transport,” Opt. Express 19(21), 20571–20579 (2011).
[Crossref] [PubMed]

Goddard, L. L.

C. Edwards, B. Bhaduri, B. G. Griffin, L. L. Goddard, and G. Popescu, “Epi-illumination diffraction phase microscopy with white light,” Opt. Lett. 39(21), 6162–6165 (2014).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Griffin, B. G.

Hartman, D. J.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Henle, M. L.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Ikeda, T.

John, R.

Kajdacsy-Balla, A.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

Kandel, M.

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

Karch, H.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Katzenellenbogen, B. S.

M. Mir, A. Bergamaschi, B. S. Katzenellenbogen, and G. Popescu, “Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response,” PLoS One 9(2), e89000 (2014).
[Crossref] [PubMed]

Kemper, B.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Ketelhut, S.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Kim, M. K.

Kim, T.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

Kolman, P.

Kuriabova, T.

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

LaFace, J.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Langehanenberg, P.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Leibowitz, B.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Levine, A. J.

R. Wang, Z. Wang, L. Millet, M. U. Gillette, A. J. Levine, and G. Popescu, “Dispersion-relation phase spectroscopy of intracellular transport,” Opt. Express 19(21), 20571–20579 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Liu, S. C.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

Liu, Y.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Lue, N.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Lykotrafitis, G.

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

Macias, V.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

Magistretti, P.

Majeed, H.

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

Majumder, A.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

Marquet, P.

Miccio, L.

Millet, L.

Mir, M.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

M. Mir, A. Bergamaschi, B. S. Katzenellenbogen, and G. Popescu, “Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response,” PLoS One 9(2), e89000 (2014).
[Crossref] [PubMed]

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

M. Mir, Z. Wang, K. Tangella, and G. Popescu, “Diffraction Phase Cytometry: blood on a CD-ROM,” Opt. Express 17(4), 2579–2585 (2009).
[Crossref] [PubMed]

Monneret, S.

Monroy, F.

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

Müthing, J.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Newpher, T. M.

Nguyen, T. H.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Nugent, K. A.

D. Paganin and K. A. Nugent, “Noninterferometric phase imaging with partially coherent light,” Phys. Rev. Lett. 80(12), 2586–2589 (1998).
[Crossref]

Paganin, D.

D. Paganin and K. A. Nugent, “Noninterferometric phase imaging with partially coherent light,” Phys. Rev. Lett. 80(12), 2586–2589 (1998).
[Crossref]

Pandiyan, V. P.

Park, Y.

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Pham, H.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

H. Pham, B. Bhaduri, H. Ding, and G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[Crossref] [PubMed]

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

Pham, H. V.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

Popescu, G.

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

M. Mir, A. Bergamaschi, B. S. Katzenellenbogen, and G. Popescu, “Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response,” PLoS One 9(2), e89000 (2014).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

C. Edwards, B. Bhaduri, B. G. Griffin, L. L. Goddard, and G. Popescu, “Epi-illumination diffraction phase microscopy with white light,” Opt. Lett. 39(21), 6162–6165 (2014).
[Crossref] [PubMed]

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

H. Pham, B. Bhaduri, H. Ding, and G. Popescu, “Spectroscopic diffraction phase microscopy,” Opt. Lett. 37(16), 3438–3440 (2012).
[Crossref] [PubMed]

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

R. Wang, Z. Wang, L. Millet, M. U. Gillette, A. J. Levine, and G. Popescu, “Dispersion-relation phase spectroscopy of intracellular transport,” Opt. Express 19(21), 20571–20579 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[Crossref] [PubMed]

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

M. Mir, Z. Wang, K. Tangella, and G. Popescu, “Diffraction Phase Cytometry: blood on a CD-ROM,” Opt. Express 17(4), 2579–2585 (2009).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

Puglisi, R.

Rappaz, B.

Rinehart, M. T.

Shaked, N. T.

Sridharan, S.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

Stice, S.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

Suresh, S.

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

Tangella, K.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

M. Mir, Z. Wang, K. Tangella, and G. Popescu, “Diffraction Phase Cytometry: blood on a CD-ROM,” Opt. Express 17(4), 2579–2585 (2009).
[Crossref] [PubMed]

Uttam, S.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Vollmer, A.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

von Bally, G.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Wang, R.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

R. Wang, Z. Wang, L. Millet, M. U. Gillette, A. J. Levine, and G. Popescu, “Dispersion-relation phase spectroscopy of intracellular transport,” Opt. Express 19(21), 20571–20579 (2011).
[Crossref] [PubMed]

Wang, Z.

Warnasooriya, N.

Wattellier, B.

Wax, A.

Xiang, M.

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

Yu, J.

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

Zhou, R.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Zhu, Y.

Adv. Opt. Photonics (1)

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Am. J. Physiol. Cell Physiol. (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (1)

Cancer Res. (1)

S. Uttam, H. V. Pham, J. LaFace, B. Leibowitz, J. Yu, R. E. Brand, D. J. Hartman, and Y. Liu, “Early prediction of cancer progression by depth-resolved nanoscale mapping of nuclear architecture from unstained tissue specimens,” Cancer Res. 75(22), 4718–4727 (2015).
[Crossref] [PubMed]

J. Biomed. Opt. (4)

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

S. Ceballos, M. Kandel, S. Sridharan, H. Majeed, F. Monroy, and G. Popescu, “Active intracellular transport in metastatic cells studied by spatial light interference microscopy,” J. Biomed. Opt. 20(11), 111209 (2015).
[Crossref] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[Crossref] [PubMed]

Opt. Express (7)

Opt. Lett. (4)

Phys. Rev. Lett. (1)

D. Paganin and K. A. Nugent, “Noninterferometric phase imaging with partially coherent light,” Phys. Rev. Lett. 80(12), 2586–2589 (1998).
[Crossref]

PLoS One (2)

M. Mir, A. Bergamaschi, B. S. Katzenellenbogen, and G. Popescu, “Highly sensitive quantitative imaging for monitoring single cancer cell growth kinetics and drug response,” PLoS One 9(2), e89000 (2014).
[Crossref] [PubMed]

H. V. Pham, B. Bhaduri, K. Tangella, C. Best-Popescu, and G. Popescu, “Real time blood testing using quantitative phase imaging,” PLoS One 8(2), e55676 (2013).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (2)

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Y. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[Crossref] [PubMed]

Sci. Rep. (2)

M. Mir, T. Kim, A. Majumder, M. Xiang, R. Wang, S. C. Liu, M. U. Gillette, S. Stice, and G. Popescu, “Corrigendum: Label-Free Characterization of Emerging Human Neuronal Networks,” Sci. Rep. 5, 11311 (2015).
[Crossref] [PubMed]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci. Rep. 5, 9976 (2015).
[Crossref] [PubMed]

Other (1)

G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw-Hill, 2011).

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Figures (4)

Fig. 1
Fig. 1 PSwDPM setup. Abbreviations: HAL, Halogen Lamp; CL, Collector Lens; AP, Aperture; CO, Condenser; S, Sample; MO, Microscope Objective; TL, Tube Lens; G, Grating; L1/L2, Lens; PH, Pinhole; FP, Fourier Plane.
Fig. 2
Fig. 2 wDPM vs. PSwDPM applied to image a blood smear. (a) Interferogram I(0); (b) Interferogram I(π); (c) Power spectrum of I(0); (d) Power spectrum of I(0)-I(π); Reconstructed phase obtained by wDPM (e) and PSwDPM(f). Colorbars in c-d indicate intensity in log scale and arbitrary units and in e-f show phase in rad, as indicated.
Fig. 3
Fig. 3 (a-h) Height maps of USAF resolution target with different BPF size, with the color bar indicates height in nm. (i) Angular spectrum
Fig. 4
Fig. 4 Phase maps of an unlabeled prostate biopsy obtained by wDPM and PSwDPM, with the color bar indicating phase in radians.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

I( x,y )= I 0 + I 1 +2 I 0 I 1 cos[ ϕ( x,y )+αx ]
I ˜ ( k x , k y )= [ U 0 U 0 + U 1 ( x,y ) U 1 ( x,y )+ U 0 U 1 ( x,y ) e iαx + U 0 U 1 ( x,y ) e iαx ]
I ˜ ( k x , k y )= | U 0 | 2 δ( k x , k y )+ U 1 ˜ ( k x , k y ) U 1 ˜ ( k x , k y ) U 0 U 1 ˜ ( k x α, k y )+ U 0 U 1 ˜ ( k x +α, k y )

Metrics