Abstract

Two-dimensional (2D) light scattering patterns of single microspheres, normal granulocytes and leukemic cells are obtained by label-free static cytometry. Statistical results of experimental 2D light scattering patterns obtained from standard microspheres with a mean diameter of 4.19 μm agree well with theoretical simulations. High accuracy rates (greater than 92%) for label-free differentiation of normal granulocytes and leukemic cells, both the acute and chronic leukemic cells, are achieved by analyzing the 2D light scattering patterns. Our label-free static cytometry is promising for leukemia screening in clinics.

© 2016 Optical Society of America

Full Article  |  PDF Article
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References

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  1. S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
    [Crossref] [PubMed]
  2. T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
    [Crossref]
  3. S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
    [Crossref] [PubMed]
  4. R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
    [Crossref] [PubMed]
  5. K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
    [Crossref] [PubMed]
  6. M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
    [Crossref] [PubMed]
  7. J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
    [Crossref] [PubMed]
  8. S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
    [Crossref] [PubMed]
  9. R. A. Harouaka, M. Nisic, and S. Y. Zheng, “Circulating tumor cell enrichment based on physical properties,” J. Lab. Autom. 18(6), 455–468 (2013).
    [Crossref] [PubMed]
  10. A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
    [Crossref] [PubMed]
  11. T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
    [Crossref] [PubMed]
  12. M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry,” Lab Chip 8(7), 1062–1070 (2008).
    [Crossref] [PubMed]
  13. A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
    [Crossref] [PubMed]
  14. S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
    [Crossref] [PubMed]
  15. G. Perozziello, P. Candeloro, A. De Grazia, F. Esposito, M. Allione, M. L. Coluccio, R. Tallerico, I. Valpapuram, L. Tirinato, G. Das, A. Giugni, B. Torre, P. Veltri, U. Kruhne, G. Della Valle, and E. Di Fabrizio, “Microfluidic device for continuous single cells analysis via Raman spectroscopy enhanced by integrated plasmonic nanodimers,” Opt. Express 24(2), A180–A190 (2016).
    [Crossref] [PubMed]
  16. G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
    [PubMed]
  17. J. R. Mourant, J. P. Freyer, A. H. Hielscher, A. A. Eick, D. Shen, and T. M. Johnson, “Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics,” Appl. Opt. 37(16), 3586–3593 (1998).
    [Crossref] [PubMed]
  18. V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
    [Crossref]
  19. R. Drezek, A. Dunn, and R. Richards-Kortum, “Light scattering from cells: finite-difference time-domain simulations and goniometric measurements,” Appl. Opt. 38(16), 3651–3661 (1999).
    [Crossref] [PubMed]
  20. X. Li, A. Taflove, and V. Backman, “Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures,” IEEE J. Sel. Top. Quantum Electron. 11(4), 759–765 (2005).
    [Crossref]
  21. A. J. Gomes, H. C. Wolfsen, M. B. Wallace, F. K. Cayer, and V. Backman, “Monte Carlo model of the depolarization of backscattered linearly polarized light in the sub-diffusion regime,” Opt. Express 22(5), 5325–5340 (2014).
    [Crossref] [PubMed]
  22. D. Ho, T. K. Drake, R. C. Bentley, F. A. Valea, and A. Wax, “Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium,” Biomed. Opt. Express 6(8), 2755–2765 (2015).
    [Crossref] [PubMed]
  23. X. T. Su, C. Capjack, W. Rozmus, and C. Backhouse, “2D light scattering patterns of mitochondria in single cells,” Opt. Express 15(17), 10562–10575 (2007).
    [Crossref] [PubMed]
  24. X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
    [Crossref] [PubMed]
  25. Y. Zhu, M. G. Giacomelli, and A. Wax, “Fiber-optic interferometric two-dimensional scattering-measurement system,” Opt. Lett. 35(10), 1641–1643 (2010).
    [Crossref] [PubMed]
  26. X. Su, S. E. Kirkwood, M. Gupta, L. Marquez-Curtis, Y. Qiu, A. Janowska-Wieczorek, W. Rozmus, and Y. Y. Tsui, “Microscope-based label-free microfluidic cytometry,” Opt. Express 19(1), 387–398 (2011).
    [Crossref] [PubMed]
  27. J. Zhang, Y. Feng, M. S. Moran, J. Q. Lu, L. V. Yang, Y. Sa, N. Zhang, L. Dong, and X. H. Hu, “Analysis of cellular objects through diffraction images acquired by flow cytometry,” Opt. Express 21(21), 24819–24828 (2013).
    [Crossref] [PubMed]
  28. D. Arifler, C. Macaulay, M. Follen, and M. Guillaud, “Numerical investigation of two-dimensional light scattering patterns of cervical cell nuclei to map dysplastic changes at different epithelial depths,” Biomed. Opt. Express 5(2), 485–498 (2014).
    [Crossref] [PubMed]
  29. X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
    [Crossref] [PubMed]
  30. E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
    [Crossref] [PubMed]
  31. N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
    [Crossref] [PubMed]
  32. L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
    [Crossref] [PubMed]
  33. P. M. Pilarski, X. T. Su, D. M. Glerum, and C. J. Backhouse, “Rapid simulation of wide-angle scattering from mitochondria in single cells,” Opt. Express 16(17), 12819–12834 (2008).
    [Crossref] [PubMed]

2016 (1)

2015 (5)

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

D. Ho, T. K. Drake, R. C. Bentley, F. A. Valea, and A. Wax, “Evaluation of hybrid algorithm for analysis of scattered light using ex vivo nuclear morphology measurements of cervical epithelium,” Biomed. Opt. Express 6(8), 2755–2765 (2015).
[Crossref] [PubMed]

X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
[Crossref] [PubMed]

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

2014 (3)

2013 (4)

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

R. A. Harouaka, M. Nisic, and S. Y. Zheng, “Circulating tumor cell enrichment based on physical properties,” J. Lab. Autom. 18(6), 455–468 (2013).
[Crossref] [PubMed]

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

J. Zhang, Y. Feng, M. S. Moran, J. Q. Lu, L. V. Yang, Y. Sa, N. Zhang, L. Dong, and X. H. Hu, “Analysis of cellular objects through diffraction images acquired by flow cytometry,” Opt. Express 21(21), 24819–24828 (2013).
[Crossref] [PubMed]

2012 (2)

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

2011 (1)

2010 (3)

Y. Zhu, M. G. Giacomelli, and A. Wax, “Fiber-optic interferometric two-dimensional scattering-measurement system,” Opt. Lett. 35(10), 1641–1643 (2010).
[Crossref] [PubMed]

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

2008 (3)

M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry,” Lab Chip 8(7), 1062–1070 (2008).
[Crossref] [PubMed]

X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
[Crossref] [PubMed]

P. M. Pilarski, X. T. Su, D. M. Glerum, and C. J. Backhouse, “Rapid simulation of wide-angle scattering from mitochondria in single cells,” Opt. Express 16(17), 12819–12834 (2008).
[Crossref] [PubMed]

2007 (2)

X. T. Su, C. Capjack, W. Rozmus, and C. Backhouse, “2D light scattering patterns of mitochondria in single cells,” Opt. Express 15(17), 10562–10575 (2007).
[Crossref] [PubMed]

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

2005 (1)

X. Li, A. Taflove, and V. Backman, “Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures,” IEEE J. Sel. Top. Quantum Electron. 11(4), 759–765 (2005).
[Crossref]

2002 (1)

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

2001 (1)

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

2000 (2)

S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
[Crossref] [PubMed]

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

1999 (2)

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

R. Drezek, A. Dunn, and R. Richards-Kortum, “Light scattering from cells: finite-difference time-domain simulations and goniometric measurements,” Appl. Opt. 38(16), 3651–3661 (1999).
[Crossref] [PubMed]

1998 (1)

1975 (1)

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Albert, J.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Allione, M.

Andersen, M. K.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Arifler, D.

Atta, J.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Backhouse, C.

X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
[Crossref] [PubMed]

X. T. Su, C. Capjack, W. Rozmus, and C. Backhouse, “2D light scattering patterns of mitochondria in single cells,” Opt. Express 15(17), 10562–10575 (2007).
[Crossref] [PubMed]

Backhouse, C. J.

Backman, V.

A. J. Gomes, H. C. Wolfsen, M. B. Wallace, F. K. Cayer, and V. Backman, “Monte Carlo model of the depolarization of backscattered linearly polarized light in the sub-diffusion regime,” Opt. Express 22(5), 5325–5340 (2014).
[Crossref] [PubMed]

X. Li, A. Taflove, and V. Backman, “Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures,” IEEE J. Sel. Top. Quantum Electron. 11(4), 759–765 (2005).
[Crossref]

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

Badizadegan, K.

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

Behm, F. G.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Beleites, C.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Béné, M. C.

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Bentley, R. C.

Bidard, F. C.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Bloomfield, C. D.

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

Bryan, A. K.

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

Burbano-Ceron, L.

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Camacho-Del Monte, O.

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Camitta, B. M.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Campana, D.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Candeloro, P.

Capjack, C.

X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
[Crossref] [PubMed]

X. T. Su, C. Capjack, W. Rozmus, and C. Backhouse, “2D light scattering patterns of mitochondria in single cells,” Opt. Express 15(17), 10562–10575 (2007).
[Crossref] [PubMed]

Carroll, W. L.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Cayer, F. K.

Chen, P.

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Clement, J.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Coluccio, M. L.

Coustan-Smith, E.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Crowell, J. M.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Das, G.

Dasari, R. R.

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

De Grazia, A.

Del Giovane, C.

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

Della Valle, G.

Devidas, M.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Di Fabrizio, E.

Dochow, S.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Dong, L.

Drake, T. K.

Drezek, R.

Dunn, A.

Eick, A. A.

Esposito, F.

European, L.

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Farace, F.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Fauth, F.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Feld, M. S.

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

Feng, Y.

Filippini, T.

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

Fletcher, D. A.

M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry,” Lab Chip 8(7), 1062–1070 (2008).
[Crossref] [PubMed]

Follen, M.

Fraisier, V.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Freyer, J. P.

Gaynon, P. S.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Giacomelli, M. G.

Giugni, A.

Glerum, D. M.

Goad, C. A.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Gomes, A. J.

Greschniok, A.

S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
[Crossref] [PubMed]

Grimwade, D.

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Grover, W. H.

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

Guillaud, M.

Gupta, M.

Gurjar, R.

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

Haferlach, C.

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Haferlach, T.

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Hancock, M. L.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Hansen, K. M.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Harouaka, R. A.

R. A. Harouaka, M. Nisic, and S. Y. Zheng, “Circulating tumor cell enrichment based on physical properties,” J. Lab. Autom. 18(6), 455–468 (2013).
[Crossref] [PubMed]

Hasle, H.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Hecht, V. C.

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

Heck, J. E.

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

Henkel, T.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Hiebert, R. D.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Hielscher, A. H.

Ho, D.

Hoelzer, D.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Horny, H. P.

S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
[Crossref] [PubMed]

Hu, X. H.

Hunger, S. P.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Ingram, M. L.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Itzkan, L.

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

Janowska-Wieczorek, A.

Johnson, T. M.

Kaiserling, E.

S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
[Crossref] [PubMed]

Keyser, M.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Kirkwood, S. E.

Kong, B.

X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
[Crossref] [PubMed]

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

Krafft, C.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Kröber, S. M.

S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
[Crossref] [PubMed]

Kruhne, U.

LaBauve, P. M.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Lakshmi, R. L.

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Lam, W. A.

M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry,” Lab Chip 8(7), 1062–1070 (2008).
[Crossref] [PubMed]

Lausen, B.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Li, C. W.

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

Li, X.

X. Li, A. Taflove, and V. Backman, “Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures,” IEEE J. Sel. Top. Quantum Electron. 11(4), 759–765 (2005).
[Crossref]

Lim, C. T.

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Lim, W. T.

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Lippok, G.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Liu, Q.

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

Liu, S.

Lopez-Santiago, N.

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Lu, J. Q.

Lu, X.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Macaulay, C.

Madsen, H. O.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Malagoli, C.

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

Malaquin, L.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Manalis, S. R.

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

Marcucci, G.

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

Marquart, H. V.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Marquez-Curtis, L.

Martin, H.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Martin, J. C.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Mathiot, C.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Mayer, G.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Minc, N.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Moran, M. S.

Mourant, J. R.

Mrózek, K.

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

Mullaney, P. F.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Nieto-Martinez, S.

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Nisic, M.

R. A. Harouaka, M. Nisic, and S. Y. Zheng, “Circulating tumor cell enrichment based on physical properties,” J. Lab. Autom. 18(6), 455–468 (2013).
[Crossref] [PubMed]

Øbro, N. F.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Paredes-Aguilera, R.

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Paschka, P.

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

Payer, K.

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

Perelman, L. T.

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

Perozziello, G.

Petershofen, E.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Petrácek, J.

X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
[Crossref] [PubMed]

Pierga, J. Y.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Pilarski, P. M.

Popp, J.

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Psychari, E.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Pui, C. H.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Qiao, X.

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
[Crossref] [PubMed]

Qiu, Y.

Razzouk, B. I.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Reaman, G. H.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Ribeiro, R. C.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Richards-Kortum, R.

Rivera, G. K.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Romero-Guzman, L.

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Rosenbluth, M. J.

M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry,” Lab Chip 8(7), 1062–1070 (2008).
[Crossref] [PubMed]

Rozmus, W.

Rubnitz, J. E.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Ryder, L. P.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Sa, Y.

Saada, V.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Saias, L.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Salamero, J.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Saliba, A. E.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Salzman, G. C.

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Sancho, J.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Sandlund, J. T.

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Schmiegelow, K.

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

Shen, D.

Shen, W.

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

Simon, D.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Singh, K.

X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
[Crossref] [PubMed]

Song, K.

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
[Crossref] [PubMed]

Su, X.

Su, X. T.

Sun, X.

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

Taflove, A.

X. Li, A. Taflove, and V. Backman, “Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures,” IEEE J. Sel. Top. Quantum Electron. 11(4), 759–765 (2005).
[Crossref]

Tallerico, R.

Tan, S. J.

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Tirinato, L.

Torre, B.

Tsui, Y. Y.

Valea, F. A.

Valpapuram, I.

Veltri, P.

Vielh, P.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Vinceti, M.

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

Viovy, J. L.

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

Wallace, M. B.

Wax, A.

Weber, C.

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Whitman, S. P.

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

Winick, N. J.

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

Wolfsen, H. C.

Xie, L.

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

Xu, T.

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

Yang, L. V.

Yang, M.

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

Yang, Y.

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
[Crossref] [PubMed]

Yao, X.

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

Yobas, L.

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Yue, W.

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

Zhang, J.

Zhang, N.

Zheng, S. Y.

R. A. Harouaka, M. Nisic, and S. Y. Zheng, “Circulating tumor cell enrichment based on physical properties,” J. Lab. Autom. 18(6), 455–468 (2013).
[Crossref] [PubMed]

Zhu, Y.

Zini, G.

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Am. J. Hematol. (1)

R. Paredes-Aguilera, L. Romero-Guzman, N. Lopez-Santiago, L. Burbano-Ceron, O. Camacho-Del Monte, and S. Nieto-Martinez, “Flow cytometric analysis of cell-surface and intracellular antigens in the diagnosis of acute leukemia,” Am. J. Hematol. 68(2), 69–74 (2001).
[Crossref] [PubMed]

Anal. Bioanal. Chem. (1)

S. Dochow, C. Beleites, T. Henkel, G. Mayer, J. Albert, J. Clement, C. Krafft, and J. Popp, “Quartz microfluidic chip for tumour cell identification by Raman spectroscopy in combination with optical traps,” Anal. Bioanal. Chem. 405(8), 2743–2746 (2013).
[Crossref] [PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (2)

Biosens. Bioelectron. (1)

S. J. Tan, R. L. Lakshmi, P. Chen, W. T. Lim, L. Yobas, and C. T. Lim, “Versatile label free biochip for the detection of circulating tumor cells from peripheral blood in cancer patients,” Biosens. Bioelectron. 26(4), 1701–1705 (2010).
[Crossref] [PubMed]

Blood (2)

K. Mrózek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield, “Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?” Blood 109(2), 431–448 (2007).
[Crossref] [PubMed]

E. Coustan-Smith, J. Sancho, F. G. Behm, M. L. Hancock, B. I. Razzouk, R. C. Ribeiro, G. K. Rivera, J. E. Rubnitz, J. T. Sandlund, C. H. Pui, and D. Campana, “Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia,” Blood 100(1), 52–58 (2002).
[Crossref] [PubMed]

Bone Marrow Transplant. (1)

J. Atta, F. Fauth, M. Keyser, E. Petershofen, C. Weber, G. Lippok, D. Hoelzer, and H. Martin, “Purging in BCR-ABL-positive acute lymphoblastic leukemia using immunomagnetic beads: comparison of residual leukemia and purging efficiency in bone marrow vs peripheral blood stem cells by semiquantitative polymerase chain reaction,” Bone Marrow Transplant. 25(1), 97–104 (2000).
[Crossref] [PubMed]

Clin. Chem. (1)

G. C. Salzman, J. M. Crowell, C. A. Goad, K. M. Hansen, R. D. Hiebert, P. M. LaBauve, J. C. Martin, M. L. Ingram, and P. F. Mullaney, “A flow-system multiangle light-scattering instrument for cell characterization,” Clin. Chem. 21(9), 1297–1304 (1975).
[PubMed]

Cytometry A (1)

L. Xie, Y. Yang, X. Sun, X. Qiao, Q. Liu, K. Song, B. Kong, and X. Su, “2D light scattering static cytometry for label-free single cell analysis with submicron resolution,” Cytometry A 87(11), 1029–1037 (2015).
[Crossref] [PubMed]

Eur. J. Haematol. (1)

M. C. Béné, D. Grimwade, C. Haferlach, T. Haferlach, G. Zini, and L. European, “Leukemia diagnosis: today and tomorrow,” Eur. J. Haematol. 95(4), 365–373 (2015).
[Crossref] [PubMed]

Haematologica (1)

N. F. Øbro, L. P. Ryder, H. O. Madsen, M. K. Andersen, B. Lausen, H. Hasle, K. Schmiegelow, and H. V. Marquart, “Identification of residual leukemic cells by flow cytometry in childhood B-cell precursor acute lymphoblastic leukemia: verification of leukemic state by flow-sorting and molecular/cytogenetic methods,” Haematologica 97(1), 137–141 (2012).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (2)

X. Li, A. Taflove, and V. Backman, “Recent progress in exact and reduced-order modeling of light-scattering properties of complex structures,” IEEE J. Sel. Top. Quantum Electron. 11(4), 759–765 (2005).
[Crossref]

V. Backman, R. Gurjar, K. Badizadegan, L. Itzkan, R. R. Dasari, L. T. Perelman, and M. S. Feld, “Polarized light scattering spectroscopy for quantitative measurement of epithelial cellular structures in situ,” IEEE J. Sel. Top. Quantum Electron. 5(4), 1019–1026 (1999).
[Crossref]

J. Biomed. Opt. (1)

X. T. Su, K. Singh, C. Capjack, J. Petrácek, C. Backhouse, and W. Rozmus, “Measurements of light scattering in an integrated microfluidic waveguide cytometer,” J. Biomed. Opt. 13(2), 024024 (2008).
[Crossref] [PubMed]

J. Clin. Oncol. (1)

S. P. Hunger, X. Lu, M. Devidas, B. M. Camitta, P. S. Gaynon, N. J. Winick, G. H. Reaman, and W. L. Carroll, “Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group,” J. Clin. Oncol. 30(14), 1663–1669 (2012).
[Crossref] [PubMed]

J. Environ. Sci. (1)

T. Filippini, J. E. Heck, C. Malagoli, C. Del Giovane, and M. Vinceti, “A review and meta-analysis of outdoor air pollution and risk of childhood leukemia,” J. Environ. Sci. 33(1), 36–66 (2015).
[Crossref]

J. Lab. Autom. (1)

R. A. Harouaka, M. Nisic, and S. Y. Zheng, “Circulating tumor cell enrichment based on physical properties,” J. Lab. Autom. 18(6), 455–468 (2013).
[Crossref] [PubMed]

Lab Chip (3)

A. K. Bryan, V. C. Hecht, W. Shen, K. Payer, W. H. Grover, and S. R. Manalis, “Measuring single cell mass, volume, and density with dual suspended microchannel resonators,” Lab Chip 14(3), 569–576 (2014).
[Crossref] [PubMed]

T. Xu, W. Yue, C. W. Li, X. Yao, and M. Yang, “Microfluidics study of intracellular calcium response to mechanical stimulation on single suspension cells,” Lab Chip 13(6), 1060–1069 (2013).
[Crossref] [PubMed]

M. J. Rosenbluth, W. A. Lam, and D. A. Fletcher, “Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry,” Lab Chip 8(7), 1062–1070 (2008).
[Crossref] [PubMed]

MP, Mol. Pathol. (1)

S. M. Kröber, A. Greschniok, E. Kaiserling, and H. P. Horny, “Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens,” MP, Mol. Pathol. 53(2), 83–87 (2000).
[Crossref] [PubMed]

Opt. Express (7)

A. J. Gomes, H. C. Wolfsen, M. B. Wallace, F. K. Cayer, and V. Backman, “Monte Carlo model of the depolarization of backscattered linearly polarized light in the sub-diffusion regime,” Opt. Express 22(5), 5325–5340 (2014).
[Crossref] [PubMed]

G. Perozziello, P. Candeloro, A. De Grazia, F. Esposito, M. Allione, M. L. Coluccio, R. Tallerico, I. Valpapuram, L. Tirinato, G. Das, A. Giugni, B. Torre, P. Veltri, U. Kruhne, G. Della Valle, and E. Di Fabrizio, “Microfluidic device for continuous single cells analysis via Raman spectroscopy enhanced by integrated plasmonic nanodimers,” Opt. Express 24(2), A180–A190 (2016).
[Crossref] [PubMed]

X. T. Su, C. Capjack, W. Rozmus, and C. Backhouse, “2D light scattering patterns of mitochondria in single cells,” Opt. Express 15(17), 10562–10575 (2007).
[Crossref] [PubMed]

X. Su, S. Liu, X. Qiao, Y. Yang, K. Song, and B. Kong, “Pattern recognition cytometry for label-free cell classification by 2D light scattering measurements,” Opt. Express 23(21), 27558–27565 (2015).
[Crossref] [PubMed]

X. Su, S. E. Kirkwood, M. Gupta, L. Marquez-Curtis, Y. Qiu, A. Janowska-Wieczorek, W. Rozmus, and Y. Y. Tsui, “Microscope-based label-free microfluidic cytometry,” Opt. Express 19(1), 387–398 (2011).
[Crossref] [PubMed]

J. Zhang, Y. Feng, M. S. Moran, J. Q. Lu, L. V. Yang, Y. Sa, N. Zhang, L. Dong, and X. H. Hu, “Analysis of cellular objects through diffraction images acquired by flow cytometry,” Opt. Express 21(21), 24819–24828 (2013).
[Crossref] [PubMed]

P. M. Pilarski, X. T. Su, D. M. Glerum, and C. J. Backhouse, “Rapid simulation of wide-angle scattering from mitochondria in single cells,” Opt. Express 16(17), 12819–12834 (2008).
[Crossref] [PubMed]

Opt. Lett. (1)

Proc. Natl. Acad. Sci. U.S.A. (1)

A. E. Saliba, L. Saias, E. Psychari, N. Minc, D. Simon, F. C. Bidard, C. Mathiot, J. Y. Pierga, V. Fraisier, J. Salamero, V. Saada, F. Farace, P. Vielh, L. Malaquin, and J. L. Viovy, “Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays,” Proc. Natl. Acad. Sci. U.S.A. 107(33), 14524–14529 (2010).
[Crossref] [PubMed]

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Figures (4)

Fig. 1
Fig. 1 A schematic diagram of the experimental setup and the determination of the scattered light angular range in the 2D label-free static cytometer. In Fig. (a), the incident beam is coupled into an optical fiber via a microscope objective to illuminate the single static microspheres or cells, and the scattered light is collected by a CMOS sensor. Figure (b) demonstrates the propagation of the scattered light from a scatterer on chip to the microscope objective (as shown by the red circle in Fig. (a)). Figure (c) shows the intersections between the CMOS sensor plane and the cones of the scattered light at fixed polar angles.
Fig. 2
Fig. 2 Representative 2D light scattering patterns with 4 and 5 fringes from 4.19 μm (mean diameter) microspheres. Figures (a) and (b) are microscopic images of two different microspheres, and their corresponding 2D patterns with 4 and 5 fringes are shown in Figs. (c) and (d), respectively. Differences in the number of fringes are primarily due to size variations of the microspheres. Numbers of 2D patterns with 4 or 5 fringes of experimental and simulation results are shown in Fig. (e).
Fig. 3
Fig. 3 Two dimensional light scattering patterns obtained from normal granulocytes and leukemia cells. Figures (a)-(c) show the microscopic images from a normal granulocyte, an HL-60 cell and a K562 cell, and their corresponding 2D light scattering patterns are shown in Figs. (d)-(f), respectively.
Fig. 4
Fig. 4 Classification of normal and leukemic cells using 2D light scattering label-free cytometry. Two parameters (the total number of speckles and the average area of these speckles in each 2D light scattering pattern) are extracted from 53 normal granulocytes, 53 HL-60 cells, and 53 K562 cells. Figures (a) and (b) show the classification of HL-60 cells and K562 cells from normal granulocytes, respectively.

Equations (2)

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y=24.25x+62
y=26x90

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