Abstract

A method is proposed to measure sample stiffness using terahertz wave and acoustic stimulation. The stiffness-dependent vibration is measured using terahertz wave (T-ray) during an acoustic stimulation. To quantify the vibration, time of the peak amplitude of the reflected T-ray is measured. In our experiment, the T-ray is asynchronously applied during the period of the acoustic stimulation, and multiple measurements are taken to use the standard deviation and the maximum difference in the peak times to estimate the amplitude of the vibration. Some preliminary results are shown using biological samples.

© 2015 Optical Society of America

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References

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  1. J. L. Katz, “Anisotropy of Young’s modulus of bone,” Nature 283(5742), 106–107 (1980).
    [Crossref] [PubMed]
  2. J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
    [Crossref] [PubMed]
  3. J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
    [Crossref] [PubMed]
  4. R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
    [Crossref] [PubMed]
  5. Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
    [Crossref] [PubMed]
  6. A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
    [Crossref] [PubMed]
  7. H. J. Ko, W. Tan, R. Stack, and S. A. Boppart, “Optical coherence elastography of engineered and developing tissue,” Tissue Eng. 12(1), 63–73 (2006).
    [Crossref] [PubMed]
  8. B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express 19(7), 6623–6634 (2011).
    [Crossref] [PubMed]
  9. A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
    [Crossref] [PubMed]
  10. L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
    [Crossref] [PubMed]
  11. M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
    [Crossref] [PubMed]
  12. D. L. Cochlin, R. H. Ganatra, and D. F. R. Griffiths, “Elastography in the detection of prostatic cancer,” Clin. Radiol. 57(11), 1014–1020 (2002).
    [Crossref] [PubMed]
  13. J. J. Wortman and R. A. Evans, “Young’s modulus, shear modulus, and Poisson’s ratio in silicon and germanium,” J. Appl. Phys. 36(1), 153–156 (1965).
    [Crossref]
  14. K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
    [Crossref] [PubMed]
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  16. H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
    [Crossref] [PubMed]
  17. J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
    [Crossref] [PubMed]
  18. P. N. Wells and H. D. Liang, “Medical ultrasound: Imaging of soft tissue strain and elasticity,” J. R. Soc. Interface 8(64), 1521–1549 (2011).
    [PubMed]
  19. S. H. Cho, S. H. Lee, C. Nam-Gung, S. J. Oh, J. H. Son, H. Park, and C. B. Ahn, “Fast terahertz reflection tomography using block-based compressed sensing,” Opt. Express 19(17), 16401–16409 (2011).
    [Crossref] [PubMed]
  20. K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
    [Crossref] [PubMed]

2015 (1)

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

2013 (2)

J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
[Crossref] [PubMed]

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

2011 (3)

2010 (2)

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

2008 (1)

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

2007 (1)

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

2006 (2)

H. J. Ko, W. Tan, R. Stack, and S. A. Boppart, “Optical coherence elastography of engineered and developing tissue,” Tissue Eng. 12(1), 63–73 (2006).
[Crossref] [PubMed]

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

2003 (2)

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
[Crossref] [PubMed]

2002 (1)

D. L. Cochlin, R. H. Ganatra, and D. F. R. Griffiths, “Elastography in the detection of prostatic cancer,” Clin. Radiol. 57(11), 1014–1020 (2002).
[Crossref] [PubMed]

1995 (1)

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

1991 (1)

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

1980 (1)

J. L. Katz, “Anisotropy of Young’s modulus of bone,” Nature 283(5742), 106–107 (1980).
[Crossref] [PubMed]

1965 (1)

J. J. Wortman and R. A. Evans, “Young’s modulus, shear modulus, and Poisson’s ratio in silicon and germanium,” J. Appl. Phys. 36(1), 153–156 (1965).
[Crossref]

Adie, S. G.

Ahn, C. B.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

S. H. Cho, S. H. Lee, C. Nam-Gung, S. J. Oh, J. H. Son, H. Park, and C. B. Ahn, “Fast terahertz reflection tomography using block-based compressed sensing,” Opt. Express 19(17), 16401–16409 (2011).
[Crossref] [PubMed]

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Beaugrand, M.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Bishop, J.

A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
[Crossref] [PubMed]

Boppart, S. A.

Burbar, Z.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Céspedes, I.

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

Chin, L.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

Cho, S. H.

Christidis, C.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Claussen, C. D.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Cochlin, D. L.

D. L. Cochlin, R. H. Ganatra, and D. F. R. Griffiths, “Elastography in the detection of prostatic cancer,” Clin. Radiol. 57(11), 1014–1020 (2002).
[Crossref] [PubMed]

Deffieux, T.

J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
[Crossref] [PubMed]

Ehman, R. L.

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Enholm, J. K.

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Evans, R. A.

J. J. Wortman and R. A. Evans, “Young’s modulus, shear modulus, and Poisson’s ratio in silicon and germanium,” J. Appl. Phys. 36(1), 153–156 (1965).
[Crossref]

Fidler, J. L.

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

Fink, M.

J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
[Crossref] [PubMed]

Fournier, C.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Fourquet, B.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Ganatra, R. H.

D. L. Cochlin, R. H. Ganatra, and D. F. R. Griffiths, “Elastography in the detection of prostatic cancer,” Clin. Radiol. 57(11), 1014–1020 (2002).
[Crossref] [PubMed]

Gennisson, J. L.

J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
[Crossref] [PubMed]

Gerstmann, D. K.

Glaser, K. J.

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

Greenleaf, J. F.

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Griffiths, D. F. R.

D. L. Cochlin, R. H. Ganatra, and D. F. R. Griffiths, “Elastography in the detection of prostatic cancer,” Clin. Radiol. 57(11), 1014–1020 (2002).
[Crossref] [PubMed]

Grimm, R. C.

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

Ham, W. G.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

Hasquenoph, J.-M.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Heiss, W. D.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Itoh, A.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Jacob, P. K.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Jang, J.

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Jattke, K.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Kamma, H.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Katz, J. L.

J. L. Katz, “Anisotropy of Young’s modulus of bone,” Nature 283(5742), 106–107 (1980).
[Crossref] [PubMed]

Kazemi, F.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Kennedy, B. F.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express 19(7), 6623–6634 (2011).
[Crossref] [PubMed]

Kennedy, K. M.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

Kim, K.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

Ko, H. J.

H. J. Ko, W. Tan, R. Stack, and S. A. Boppart, “Optical coherence elastography of engineered and developing tissue,” Tissue Eng. 12(1), 63–73 (2006).
[Crossref] [PubMed]

Köhler, M. O.

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Ku, J.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

Ladebeck, R.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Latham, B.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

Lee, D. G.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

Lee, S. H.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

S. H. Cho, S. H. Lee, C. Nam-Gung, S. J. Oh, J. H. Son, H. Park, and C. B. Ahn, “Fast terahertz reflection tomography using block-based compressed sensing,” Opt. Express 19(17), 16401–16409 (2011).
[Crossref] [PubMed]

Li, X.

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

Liang, H. D.

P. N. Wells and H. D. Liang, “Medical ultrasound: Imaging of soft tissue strain and elasticity,” J. R. Soc. Interface 8(64), 1521–1549 (2011).
[PubMed]

Liang, X.

Lomas, D. J.

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Luginbuhl, C.

A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
[Crossref] [PubMed]

Mal, F.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Manduca, A.

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Mariappan, Y. K.

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

Matsumura, T.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

McLaughlin, R. A.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

Michel, C.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Moonen, C. T. W.

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Mougenot, C.

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Muthupillai, R.

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Nahmias, C.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Nam-Gung, C.

Oh, S. J.

Ophir, J.

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

Palau, R.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Park, G. S.

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Park, H.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

S. H. Cho, S. H. Lee, C. Nam-Gung, S. J. Oh, J. H. Son, H. Park, and C. B. Ahn, “Fast terahertz reflection tomography using block-based compressed sensing,” Opt. Express 19(17), 16401–16409 (2011).
[Crossref] [PubMed]

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Park, J.

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Pichler, B. J.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Plewes, D. B.

A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
[Crossref] [PubMed]

Ponnekanti, H.

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

Poulet, B.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Quesson, B.

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Quirk, B. C.

Rossman, P. J.

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Samani, A.

A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
[Crossref] [PubMed]

Sampson, D. D.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express 19(7), 6623–6634 (2011).
[Crossref] [PubMed]

Sandrin, L.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Saunders, C. M.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

Schlemmer, H. P.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Schmand, M.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Shiina, T.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Sokka, S. D.

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

Son, J. H.

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

S. H. Cho, S. H. Lee, C. Nam-Gung, S. J. Oh, J. H. Son, H. Park, and C. B. Ahn, “Fast terahertz reflection tomography using block-based compressed sensing,” Opt. Express 19(17), 16401–16409 (2011).
[Crossref] [PubMed]

Stack, R.

H. J. Ko, W. Tan, R. Stack, and S. A. Boppart, “Optical coherence elastography of engineered and developing tissue,” Tissue Eng. 12(1), 63–73 (2006).
[Crossref] [PubMed]

Takahashi, H.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Talwalkar, J. A.

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

Tan, W.

H. J. Ko, W. Tan, R. Stack, and S. A. Boppart, “Optical coherence elastography of engineered and developing tissue,” Tissue Eng. 12(1), 63–73 (2006).
[Crossref] [PubMed]

Tanter, M.

J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
[Crossref] [PubMed]

Tohno, E.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Townsend, D.

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Ueno, E.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Wells, P. N.

P. N. Wells and H. D. Liang, “Medical ultrasound: Imaging of soft tissue strain and elasticity,” J. R. Soc. Interface 8(64), 1521–1549 (2011).
[PubMed]

Wortman, J. J.

J. J. Wortman and R. A. Evans, “Young’s modulus, shear modulus, and Poisson’s ratio in silicon and germanium,” J. Appl. Phys. 36(1), 153–156 (1965).
[Crossref]

Yamakawa, M.

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

Yang, Y. J.

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Yazdi, Y.

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

Yin, M.

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

Yon, S.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Yoon, J. H.

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

Ziol, M.

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Clin. Anat. (1)

Y. K. Mariappan, K. J. Glaser, and R. L. Ehman, “Magnetic resonance elastography: a review,” Clin. Anat. 23(5), 497–511 (2010).
[Crossref] [PubMed]

Clin. Gastroenterol. Hepatol. (1)

M. Yin, J. A. Talwalkar, K. J. Glaser, A. Manduca, R. C. Grimm, P. J. Rossman, J. L. Fidler, and R. L. Ehman, “Assessment of hepatic fibrosis with magnetic resonance elastography,” Clin. Gastroenterol. Hepatol. 5(10), 1207 (2007).
[Crossref] [PubMed]

Clin. Radiol. (1)

D. L. Cochlin, R. H. Ganatra, and D. F. R. Griffiths, “Elastography in the detection of prostatic cancer,” Clin. Radiol. 57(11), 1014–1020 (2002).
[Crossref] [PubMed]

Diagn. Interv. Imaging (1)

J. L. Gennisson, T. Deffieux, M. Fink, and M. Tanter, “Ultrasound elastography: principles and techniques,” Diagn. Interv. Imaging 94(5), 487–495 (2013).
[Crossref] [PubMed]

IEEE J. Biomed. Health Inform. (1)

K. Kim, D. G. Lee, W. G. Ham, J. Ku, S. H. Lee, C. B. Ahn, J. H. Son, and H. Park, “Adaptive compressed sensing for the fast terahertz reflection tomography,” IEEE J. Biomed. Health Inform. 17(4), 806–812 (2013).
[Crossref] [PubMed]

IEEE Trans. Biomed. Eng. (1)

J. K. Enholm, M. O. Köhler, B. Quesson, C. Mougenot, C. T. W. Moonen, and S. D. Sokka, “Improved volumetric MR-HIFU ablation by robust binary feedback control,” IEEE Trans. Biomed. Eng. 57(1), 103–113 (2010).
[Crossref] [PubMed]

J. Appl. Phys. (1)

J. J. Wortman and R. A. Evans, “Young’s modulus, shear modulus, and Poisson’s ratio in silicon and germanium,” J. Appl. Phys. 36(1), 153–156 (1965).
[Crossref]

J. R. Soc. Interface (1)

P. N. Wells and H. D. Liang, “Medical ultrasound: Imaging of soft tissue strain and elasticity,” J. R. Soc. Interface 8(64), 1521–1549 (2011).
[PubMed]

Nature (1)

J. L. Katz, “Anisotropy of Young’s modulus of bone,” Nature 283(5742), 106–107 (1980).
[Crossref] [PubMed]

Opt. Express (2)

Phys. Med. Biol. (1)

A. Samani, J. Bishop, C. Luginbuhl, and D. B. Plewes, “Measuring the elastic modulus of ex vivo small tissue samples,” Phys. Med. Biol. 48(14), 2183–2198 (2003).
[Crossref] [PubMed]

Radiology (2)

A. Itoh, E. Ueno, E. Tohno, H. Kamma, H. Takahashi, T. Shiina, M. Yamakawa, and T. Matsumura, “Breast disease: clinical application of US elastography for diagnosis,” Radiology 239(2), 341–350 (2006).
[Crossref] [PubMed]

H. P. Schlemmer, B. J. Pichler, M. Schmand, Z. Burbar, C. Michel, R. Ladebeck, K. Jattke, D. Townsend, C. Nahmias, P. K. Jacob, W. D. Heiss, and C. D. Claussen, “Simultaneous MR/PET imaging of the human brain: feasibility study,” Radiology 248(3), 1028–1035 (2008).
[Crossref] [PubMed]

Sci. Rep. (1)

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(4), 15538 (2015).
[Crossref] [PubMed]

Science (1)

R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca, and R. L. Ehman, “Magnetic resonance elastography by direct visualization of propagating acoustic strain waves,” Science 269(5232), 1854–1857 (1995).
[Crossref] [PubMed]

Tissue Eng. (1)

H. J. Ko, W. Tan, R. Stack, and S. A. Boppart, “Optical coherence elastography of engineered and developing tissue,” Tissue Eng. 12(1), 63–73 (2006).
[Crossref] [PubMed]

Ultrason. Imaging (1)

J. Ophir, I. Céspedes, H. Ponnekanti, Y. Yazdi, and X. Li, “Elastography: A quantitative method for imaging the elasticity of biological tissues,” Ultrason. Imaging 13(2), 111–134 (1991).
[Crossref] [PubMed]

Ultrasound Med. Biol. (1)

L. Sandrin, B. Fourquet, J.-M. Hasquenoph, S. Yon, C. Fournier, F. Mal, C. Christidis, M. Ziol, B. Poulet, F. Kazemi, M. Beaugrand, and R. Palau, “Transient elastography: a new noninvasive method for assessment of hepatic fibrosis,” Ultrasound Med. Biol. 29(12), 1705–1713 (2003).
[Crossref] [PubMed]

Other (1)

J. H. Yoon, Y. J. Yang, J. Park, J. Jang, H. Park, G. S. Park, and C. B. Ahn, “Stiffness measurement using terahertz and acoustic waves,” in Proc. 6th International THz-Bio Workshop, (2015), paper P-12.

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Figures (5)

Fig. 1
Fig. 1 Schematic diagram of system to measure the stiffness of the sample using T-rays and an acoustic stimulation. (a) Schematic system setup, (b) schematic diagram to show the variation in the peak time due to the vibration.
Fig. 2
Fig. 2 Experimental setup for the stiffness measurements.
Fig. 3
Fig. 3 Estimation of the amplitude of the vibration as a function of the number of measurements (N) using the standard deviation (SD) and the maximum difference (MD) from the computer simulation. (a) Normalized SD and MD, and (b) relative errors in the estimation. The blue circle represents MD and the asterisk denotes SD.
Fig. 4
Fig. 4 Samples for which stiffness is measured. For each sample, two spots of different stiffness were chosen for comparison. (a) Aluminum foil: (1) regular foil and (2) foil coated with correction fluid; (b) bacon: (3) fat and (4) lean meat; and (c) plant leaf: (5) mesophyll and (6) vein.
Fig. 5
Fig. 5 The peak times of the T-ray without (left) and with (right) the acoustic stimulation for three samples (a, b, and c). The unit of the vertical axis is femtoseconds. Two spots were chosen in each sample. Measurements were made for 100 times as denoted in the horizontal axis. The peak times are shown for (1) plain aluminum foil and (2) foil coated with the correction fluid; (3) fat and (4) lean meat in bacon; and (5) mesophyll and (6) vein in the plant leaf. For a better comparison, the mean value of the peak times was subtracted in each graph.

Tables (1)

Tables Icon

Table 1 The SD and MD for the Peak Times without (Off) and with (On) the Acoustic Stimulation. The Vibration Amplitudes in boldface, the On and Off Ratios (B/A), and the Stiffness Ratios (SR) are also shown.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

d(t)=Asin(2π f 0 t+ϕ)
A= d 2 ( t 1 )+ d 2 ( t 2 )
SD{ d i ,i=1,2,N}=A/ 2 MD{ d i ,i=1,2,N}=2A

Metrics