Abstract

We present a proof of concept prototype of a time-domain diffuse optics probe exploiting a fast Silicon PhotoMultiplier (SiPM), featuring a timing resolution better than 80 ps, a fast tail with just 90 ps decay time-constant and a wide active area of 1 mm2. The detector is hosted into the probe and used in direct contact with the sample under investigation, thus providing high harvesting efficiency by exploiting the whole SiPM numerical aperture and also reducing complexity by avoiding the use of cumbersome fiber bundles. Our tests also demonstrate high accuracy and linearity in retrieving the optical properties and suitable contrast and depth sensitivity for detecting localized inhomogeneities. In addition to a strong improvement in both instrumentation cost and size with respect to legacy solutions, the setup performances are comparable to those of state-of-the-art time-domain instrumentation, thus opening a new way to compact, low-cost and high-performance time-resolved devices for diffuse optical imaging and spectroscopy.

© 2015 Optical Society of America

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2015 (2)

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

2014 (10)

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
[Crossref]

M. Buttafava, G. Boso, A. Ruggeri, A. Dalla Mora, and A. Tosi, “Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate,” Rev. Sci. Instrum. 85(8), 083114 (2014).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

F. Scholkmann, S. Kleiser, A. J. Metz, R. Zimmermann, J. Mata Pavia, U. Wolf, and M. Wolf, “A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology,” Neuroimage 85(Pt 1), 6–27 (2014).
[Crossref] [PubMed]

A. T. Eggebrecht, S. L. Ferradal, A. Robichaux-Viehoever, M. S. Hassanpour, H. Dehghani, A. Z. Snyder, T. Hershey, and J. P. Culver, “Mapping distributed brain function and networks with diffuse optical tomography,” Nat. Photonics 8(6), 448–454 (2014).
[Crossref] [PubMed]

T. Svensson, K. Vynck, E. Adolfsson, A. Farina, A. Pifferi, and D. S. Wiersma, “Light diffusion in quenched disorder: role of step correlations,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 89(2), 022141 (2014).
[Crossref] [PubMed]

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

2013 (7)

I. Bargigia, A. Nevin, A. Farina, A. Pifferi, C. D’Andrea, M. Karlsson, P. Lundin, G. Somesfalean, and S. Svanberg, “Diffuse optical techniques applied to wood characterisation,” J. Near Infrared Spectrosc. 21(4), 259–268 (2013).
[Crossref]

G. Boso, A. Dalla Mora, A. Della Frera, and A. Tosi, “Fast-gating of single-photon avalanche diodes with 200 ps transitions and 30 ps timing jitter,” Sens. Actuators A Phys. 191, 61–67 (2013).
[Crossref]

F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts,” J. Biomed. Opt. 18(6), 066014 (2013).
[Crossref] [PubMed]

C. Zhang, L. Zhang, R. Yang, K. Liang, and D. Han, “Time-correlated Raman and fluorescence spectroscopy based on a silicon photomultiplier and time-correlated single photon counting technique,” Appl. Spectrosc. 67(2), 136–140 (2013).
[Crossref] [PubMed]

R. Zimmermann, F. Braun, T. Achtnich, O. Lambercy, R. Gassert, and M. Wolf, “Silicon photomultipliers for improved detection of low light levels in miniature near-infrared spectroscopy instruments,” Biomed. Opt. Express 4(5), 659–666 (2013).
[Crossref] [PubMed]

D. Khoptyar, A. A. Subash, S. Johansson, M. Saleem, A. Sparén, J. Johansson, and S. Andersson-Engels, “Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges,” Opt. Express 21(18), 20941–20953 (2013).
[Crossref] [PubMed]

R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, and A. Torricelli, “Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing,” Biomed. Opt. Express 4(10), 2231–2246 (2013).
[Crossref] [PubMed]

2012 (5)

E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
[Crossref] [PubMed]

K. Johnson, M. Hibbs-Brenner, W. Hogan, and M. Dummer, “Advances in red VCSEL technology,” Adv. Opt. Technol. 2012, 1–13 (2012).
[Crossref]

A. Ghosh, C. Elwell, and M. Smith, “Review article: cerebral near-infrared spectroscopy in adults: a work in progress,” Anesth. Analg. 115(6), 1373–1383 (2012).
[Crossref] [PubMed]

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
[Crossref]

2011 (2)

2010 (3)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. I. R. Maas and G. Citerio, “Noninvasive monitoring of cerebral oxygenation in traumatic brain injury: a mix of doubts and hope,” Intensive Care Med. 36(8), 1283–1285 (2010).
[Crossref] [PubMed]

2008 (3)

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

A. Torricelli, L. Spinelli, D. Contini, M. Vanoli, A. Rizzolo, and P. Eccher Zerbini, “Time-resolved reflectance spectroscopy for non-destructive assessment of food quality,” Sens. Instrumen. Food Qual. 2(2), 82–89 (2008).
[Crossref]

R. Michels, F. Foschum, and A. Kienle, “Optical properties of fat emulsions,” Opt. Express 16(8), 5907–5925 (2008).
[Crossref] [PubMed]

2007 (5)

F. Martelli and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. CW method,” Opt. Express 15(2), 486–500 (2007).
[Crossref] [PubMed]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

M. Wolf, M. Ferrari, and V. Quaresima, “Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications,” J. Biomed. Opt. 12(6), 062104 (2007).
[Crossref] [PubMed]

D. Renker, “New trends on photodetectors,” Nucl. Instrum. Methods Phys. Res. A 571(1-2), 1–6 (2007).
[Crossref]

A. Dalla Mora, A. Tosi, S. Tisa, and F. Zappa, “Single-photon avalanche diode model for circuit simulations,” IEEE Photon. Technol. Lett. 19(23), 1922–1924 (2007).
[Crossref]

2006 (1)

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

2005 (4)

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, “Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation,” J. Biomed. Opt. 10(1), 011013 (2005).
[Crossref] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
[Crossref] [PubMed]

2003 (1)

P. Buzhan, B. Dolgoshein, L. Filatov, A. Ilyin, V. Kantzerov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, E. Popova, and S. Smirnov, “Silicon photomultiplier and its possible applications,” Nucl. Instrum. Methods Phys. Res. A 504(1-3), 48–52 (2003).
[Crossref]

2001 (1)

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

1997 (1)

1989 (1)

Acerbi, F.

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
[Crossref]

A. Tosi, A. Dalla Mora, A. Della Frera, F. Acerbi, A. Bahgat Shehata, and F. Zappa, “Advanced single photon counting instrumentation for SPADs,” Proc. SPIE 7945, 79452O (2011).
[Crossref]

Achtnich, T.

Adamo, G.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Adolfsson, E.

T. Svensson, K. Vynck, E. Adolfsson, A. Farina, A. Pifferi, and D. S. Wiersma, “Light diffusion in quenched disorder: role of step correlations,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 89(2), 022141 (2014).
[Crossref] [PubMed]

Agrò, D.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Alerstam, E.

Andersson-Engels, S.

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

D. Khoptyar, A. A. Subash, S. Johansson, M. Saleem, A. Sparén, J. Johansson, and S. Andersson-Engels, “Broadband photon time-of-flight spectroscopy of pharmaceuticals and highly scattering plastics in the VIS and close NIR spectral ranges,” Opt. Express 21(18), 20941–20953 (2013).
[Crossref] [PubMed]

E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

Arridge, S.

Arridge, S. R.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Avrillier, S.

Bahgat Shehata, A.

A. Tosi, A. Dalla Mora, A. Della Frera, F. Acerbi, A. Bahgat Shehata, and F. Zappa, “Advanced single photon counting instrumentation for SPADs,” Proc. SPIE 7945, 79452O (2011).
[Crossref]

Baker, W. B.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref]

Balagura, V.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Ballizany, R.

T. Frach, G. Prescher, C. Degenhardt, R. de Gruyter, A. Schmitz, and R. Ballizany, “The digital silicon photomultiplier - Principle of operation and intrinsic detector performance,” 2009 IEEE Nuclear Science Symposium Conference Record, 1959–1965 (2009).
[Crossref]

Bargigia, I.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

I. Bargigia, A. Nevin, A. Farina, A. Pifferi, C. D’Andrea, M. Karlsson, P. Lundin, G. Somesfalean, and S. Svanberg, “Diffuse optical techniques applied to wood characterisation,” J. Near Infrared Spectrosc. 21(4), 259–268 (2013).
[Crossref]

Baribeau, F.

Bassi, A.

Bellisai, S.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

Bénazech-Lavoué, M.

Bérubé-Lauzière, Y.

Boas, D. A.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, “Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation,” J. Biomed. Opt. 10(1), 011013 (2005).
[Crossref] [PubMed]

Bodnar, O.

Boso, G.

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

M. Buttafava, G. Boso, A. Ruggeri, A. Dalla Mora, and A. Tosi, “Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate,” Rev. Sci. Instrum. 85(8), 083114 (2014).
[Crossref] [PubMed]

G. Boso, A. Dalla Mora, A. Della Frera, and A. Tosi, “Fast-gating of single-photon avalanche diodes with 200 ps transitions and 30 ps timing jitter,” Sens. Actuators A Phys. 191, 61–67 (2013).
[Crossref]

Botwicz, M.

Bouchard, J.-P.

Braun, F.

Brockherde, W.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

Bronzi, D.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

F. Villa, D. Bronzi, M. Vergani, Y. Zou, A. Ruggeri, F. Zappa, and A. Dalla Mora, “Analog SiPM in planar CMOS technology,” Proceedings of ESSDERC, 294–297 (2014).

Busacca, A. C.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Buttafava, M.

M. Buttafava, G. Boso, A. Ruggeri, A. Dalla Mora, and A. Tosi, “Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate,” Rev. Sci. Instrum. 85(8), 083114 (2014).
[Crossref] [PubMed]

Buzhan, P.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

P. Buzhan, B. Dolgoshein, L. Filatov, A. Ilyin, V. Kantzerov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, E. Popova, and S. Smirnov, “Silicon photomultiplier and its possible applications,” Nucl. Instrum. Methods Phys. Res. A 504(1-3), 48–52 (2003).
[Crossref]

Caffini, M.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, and A. Torricelli, “Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing,” Biomed. Opt. Express 4(10), 2231–2246 (2013).
[Crossref] [PubMed]

Canicattì, R.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Carbone, B.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Cazzanelli, M.

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
[Crossref]

Chance, B.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

M. S. Patterson, B. Chance, and B. C. Wilson, “Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties,” Appl. Opt. 28(12), 2331–2336 (1989).
[Crossref] [PubMed]

Charbon, E.

S. Mandai and E. Charbon, “Multi-channel digital SiPMs: concept, analysis and implementation,” Proc. of IEEE Nuclear Science Symposium and Medical Imaging Conference, 1840–1844 (2012).
[Crossref]

Choe, R.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Citerio, G.

A. I. R. Maas and G. Citerio, “Noninvasive monitoring of cerebral oxygenation in traumatic brain injury: a mix of doubts and hope,” Intensive Care Med. 36(8), 1283–1285 (2010).
[Crossref] [PubMed]

Contini, D.

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, and A. Torricelli, “Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing,” Biomed. Opt. Express 4(10), 2231–2246 (2013).
[Crossref] [PubMed]

F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts,” J. Biomed. Opt. 18(6), 066014 (2013).
[Crossref] [PubMed]

E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
[Crossref] [PubMed]

A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
[Crossref] [PubMed]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
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A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
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A. Torricelli, L. Spinelli, D. Contini, M. Vanoli, A. Rizzolo, and P. Eccher Zerbini, “Time-resolved reflectance spectroscopy for non-destructive assessment of food quality,” Sens. Instrumen. Food Qual. 2(2), 82–89 (2008).
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D. Contini, F. Martelli, and G. Zaccanti, “Photon migration through a turbid slab described by a model based on diffusion approximation. I. Theory,” Appl. Opt. 36(19), 4587–4599 (1997).
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Cooper, R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
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Corlu, A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
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Cova, S.

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
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A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
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Cubeddu, R.

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
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H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
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H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
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L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
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R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, and A. Torricelli, “Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing,” Biomed. Opt. Express 4(10), 2231–2246 (2013).
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A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
[Crossref]

A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
[Crossref] [PubMed]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
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A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
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Culver, J. P.

A. T. Eggebrecht, S. L. Ferradal, A. Robichaux-Viehoever, M. S. Hassanpour, H. Dehghani, A. Z. Snyder, T. Hershey, and J. P. Culver, “Mapping distributed brain function and networks with diffuse optical tomography,” Nat. Photonics 8(6), 448–454 (2014).
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D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
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Czerniecki, B. J.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
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D’Andrea, C.

I. Bargigia, A. Nevin, A. Farina, A. Pifferi, C. D’Andrea, M. Karlsson, P. Lundin, G. Somesfalean, and S. Svanberg, “Diffuse optical techniques applied to wood characterisation,” J. Near Infrared Spectrosc. 21(4), 259–268 (2013).
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Dalla Mora, A.

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
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A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
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M. Buttafava, G. Boso, A. Ruggeri, A. Dalla Mora, and A. Tosi, “Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate,” Rev. Sci. Instrum. 85(8), 083114 (2014).
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G. Boso, A. Dalla Mora, A. Della Frera, and A. Tosi, “Fast-gating of single-photon avalanche diodes with 200 ps transitions and 30 ps timing jitter,” Sens. Actuators A Phys. 191, 61–67 (2013).
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E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
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A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
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A. Tosi, A. Dalla Mora, A. Della Frera, F. Acerbi, A. Bahgat Shehata, and F. Zappa, “Advanced single photon counting instrumentation for SPADs,” Proc. SPIE 7945, 79452O (2011).
[Crossref]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
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A. Dalla Mora, A. Tosi, S. Tisa, and F. Zappa, “Single-photon avalanche diode model for circuit simulations,” IEEE Photon. Technol. Lett. 19(23), 1922–1924 (2007).
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F. Villa, D. Bronzi, M. Vergani, Y. Zou, A. Ruggeri, F. Zappa, and A. Dalla Mora, “Analog SiPM in planar CMOS technology,” Proceedings of ESSDERC, 294–297 (2014).

Danilov, M.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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de Gruyter, R.

T. Frach, G. Prescher, C. Degenhardt, R. de Gruyter, A. Schmitz, and R. Ballizany, “The digital silicon photomultiplier - Principle of operation and intrinsic detector performance,” 2009 IEEE Nuclear Science Symposium Conference Record, 1959–1965 (2009).
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Degenhardt, C.

T. Frach, G. Prescher, C. Degenhardt, R. de Gruyter, A. Schmitz, and R. Ballizany, “The digital silicon photomultiplier - Principle of operation and intrinsic detector performance,” 2009 IEEE Nuclear Science Symposium Conference Record, 1959–1965 (2009).
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Dehghani, H.

A. T. Eggebrecht, S. L. Ferradal, A. Robichaux-Viehoever, M. S. Hassanpour, H. Dehghani, A. Z. Snyder, T. Hershey, and J. P. Culver, “Mapping distributed brain function and networks with diffuse optical tomography,” Nat. Photonics 8(6), 448–454 (2014).
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Del Bianco, S.

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
[Crossref] [PubMed]

Della Frera, A.

G. Boso, A. Dalla Mora, A. Della Frera, and A. Tosi, “Fast-gating of single-photon avalanche diodes with 200 ps transitions and 30 ps timing jitter,” Sens. Actuators A Phys. 191, 61–67 (2013).
[Crossref]

A. Tosi, A. Dalla Mora, A. Della Frera, F. Acerbi, A. Bahgat Shehata, and F. Zappa, “Advanced single photon counting instrumentation for SPADs,” Proc. SPIE 7945, 79452O (2011).
[Crossref]

DeMichele, A.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Di Ninni, P.

Dolgoshein, B.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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P. Buzhan, B. Dolgoshein, L. Filatov, A. Ilyin, V. Kantzerov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, E. Popova, and S. Smirnov, “Silicon photomultiplier and its possible applications,” Nucl. Instrum. Methods Phys. Res. A 504(1-3), 48–52 (2003).
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Dummer, M.

K. Johnson, M. Hibbs-Brenner, W. Hogan, and M. Dummer, “Advances in red VCSEL technology,” Adv. Opt. Technol. 2012, 1–13 (2012).
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Durduran, T.

Durini, D.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
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Eccher Zerbini, P.

A. Torricelli, L. Spinelli, D. Contini, M. Vanoli, A. Rizzolo, and P. Eccher Zerbini, “Time-resolved reflectance spectroscopy for non-destructive assessment of food quality,” Sens. Instrumen. Food Qual. 2(2), 82–89 (2008).
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Eggebrecht, A. T.

A. T. Eggebrecht, S. L. Ferradal, A. Robichaux-Viehoever, M. S. Hassanpour, H. Dehghani, A. Z. Snyder, T. Hershey, and J. P. Culver, “Mapping distributed brain function and networks with diffuse optical tomography,” Nat. Photonics 8(6), 448–454 (2014).
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Elster, C.

Elwell, C.

A. Ghosh, C. Elwell, and M. Smith, “Review article: cerebral near-infrared spectroscopy in adults: a work in progress,” Anesth. Analg. 115(6), 1373–1383 (2012).
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Fallica, P. G.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
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Farina, A.

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
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T. Svensson, K. Vynck, E. Adolfsson, A. Farina, A. Pifferi, and D. S. Wiersma, “Light diffusion in quenched disorder: role of step correlations,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 89(2), 022141 (2014).
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H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

I. Bargigia, A. Nevin, A. Farina, A. Pifferi, C. D’Andrea, M. Karlsson, P. Lundin, G. Somesfalean, and S. Svanberg, “Diffuse optical techniques applied to wood characterisation,” J. Near Infrared Spectrosc. 21(4), 259–268 (2013).
[Crossref]

A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
[Crossref]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

Ferradal, S. L.

A. T. Eggebrecht, S. L. Ferradal, A. Robichaux-Viehoever, M. S. Hassanpour, H. Dehghani, A. Z. Snyder, T. Hershey, and J. P. Culver, “Mapping distributed brain function and networks with diffuse optical tomography,” Nat. Photonics 8(6), 448–454 (2014).
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Ferrari, M.

M. Wolf, M. Ferrari, and V. Quaresima, “Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications,” J. Biomed. Opt. 12(6), 062104 (2007).
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Ferri, A.

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
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Filatov, L.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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P. Buzhan, B. Dolgoshein, L. Filatov, A. Ilyin, V. Kantzerov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, E. Popova, and S. Smirnov, “Silicon photomultiplier and its possible applications,” Nucl. Instrum. Methods Phys. Res. A 504(1-3), 48–52 (2003).
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Foschum, F.

Frach, T.

T. Frach, G. Prescher, C. Degenhardt, R. de Gruyter, A. Schmitz, and R. Ballizany, “The digital silicon photomultiplier - Principle of operation and intrinsic detector performance,” 2009 IEEE Nuclear Science Symposium Conference Record, 1959–1965 (2009).
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Fraker, D. L.

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
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J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, “Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation,” J. Biomed. Opt. 10(1), 011013 (2005).
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A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts,” J. Biomed. Opt. 18(6), 066014 (2013).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

F. Martelli and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. CW method,” Opt. Express 15(2), 486–500 (2007).
[Crossref] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
[Crossref] [PubMed]

D. Contini, F. Martelli, and G. Zaccanti, “Photon migration through a turbid slab described by a model based on diffusion approximation. I. Theory,” Appl. Opt. 36(19), 4587–4599 (1997).
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Martinenghi, E.

Mata Pavia, J.

F. Scholkmann, S. Kleiser, A. J. Metz, R. Zimmermann, J. Mata Pavia, U. Wolf, and M. Wolf, “A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology,” Neuroimage 85(Pt 1), 6–27 (2014).
[Crossref] [PubMed]

Mazurenka, M.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

Mazzillo, M.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Mermut, O.

Metz, A. J.

F. Scholkmann, S. Kleiser, A. J. Metz, R. Zimmermann, J. Mata Pavia, U. Wolf, and M. Wolf, “A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology,” Neuroimage 85(Pt 1), 6–27 (2014).
[Crossref] [PubMed]

Meyer, H.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Michels, R.

Milej, D.

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

Mizuk, R.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Möller, M.

Morgunov, V.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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Morsellino, G.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Nevin, A.

I. Bargigia, A. Nevin, A. Farina, A. Pifferi, C. D’Andrea, M. Karlsson, P. Lundin, G. Somesfalean, and S. Svanberg, “Diffuse optical techniques applied to wood characterisation,” J. Near Infrared Spectrosc. 21(4), 259–268 (2013).
[Crossref]

Nghiem, H. L.

Noiseux, I.

Novikov, E.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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Obrig, H.

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
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Pagano, R.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
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Pakhlov, P.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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Parisi, A.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
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Paschen, U.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
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Patterson, M. S.

Pavesi, L.

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
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Piana, A.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
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Piemonte, C.

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
[Crossref]

Pifferi, A.

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
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T. Svensson, K. Vynck, E. Adolfsson, A. Farina, A. Pifferi, and D. S. Wiersma, “Light diffusion in quenched disorder: role of step correlations,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 89(2), 022141 (2014).
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L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts,” J. Biomed. Opt. 18(6), 066014 (2013).
[Crossref] [PubMed]

I. Bargigia, A. Nevin, A. Farina, A. Pifferi, C. D’Andrea, M. Karlsson, P. Lundin, G. Somesfalean, and S. Svanberg, “Diffuse optical techniques applied to wood characterisation,” J. Near Infrared Spectrosc. 21(4), 259–268 (2013).
[Crossref]

A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
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E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
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A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
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A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
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Pinto, M.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

Popova, E.

B. Dolgoshein, V. Balagura, P. Buzhan, M. Danilov, L. Filatov, E. Garutti, M. Groll, A. Ilyin, V. Kantserov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, V. Korbel, H. Meyer, R. Mizuk, V. Morgunov, E. Novikov, P. Pakhlov, E. Popova, V. Rusinov, F. Sefkow, E. Tarkovsky, and I. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
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P. Buzhan, B. Dolgoshein, L. Filatov, A. Ilyin, V. Kantzerov, V. Kaplin, A. Karakash, F. Kayumov, S. Klemin, E. Popova, and S. Smirnov, “Silicon photomultiplier and its possible applications,” Nucl. Instrum. Methods Phys. Res. A 504(1-3), 48–52 (2003).
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Prescher, G.

T. Frach, G. Prescher, C. Degenhardt, R. de Gruyter, A. Schmitz, and R. Ballizany, “The digital silicon photomultiplier - Principle of operation and intrinsic detector performance,” 2009 IEEE Nuclear Science Symposium Conference Record, 1959–1965 (2009).
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Quaresima, V.

M. Wolf, M. Ferrari, and V. Quaresima, “Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications,” J. Biomed. Opt. 12(6), 062104 (2007).
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Quarto, G.

A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
[Crossref]

Re, R.

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A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
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A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
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A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
[Crossref] [PubMed]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

A. Torricelli, L. Spinelli, D. Contini, M. Vanoli, A. Rizzolo, and P. Eccher Zerbini, “Time-resolved reflectance spectroscopy for non-destructive assessment of food quality,” Sens. Instrumen. Food Qual. 2(2), 82–89 (2008).
[Crossref]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

Tosi, A.

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

M. Buttafava, G. Boso, A. Ruggeri, A. Dalla Mora, and A. Tosi, “Time-gated single-photon detection module with 110 ps transition time and up to 80 MHz repetition rate,” Rev. Sci. Instrum. 85(8), 083114 (2014).
[Crossref] [PubMed]

G. Boso, A. Dalla Mora, A. Della Frera, and A. Tosi, “Fast-gating of single-photon avalanche diodes with 200 ps transitions and 30 ps timing jitter,” Sens. Actuators A Phys. 191, 61–67 (2013).
[Crossref]

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
[Crossref] [PubMed]

A. Tosi, A. Dalla Mora, A. Della Frera, F. Acerbi, A. Bahgat Shehata, and F. Zappa, “Advanced single photon counting instrumentation for SPADs,” Proc. SPIE 7945, 79452O (2011).
[Crossref]

A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
[Crossref] [PubMed]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

A. Dalla Mora, A. Tosi, S. Tisa, and F. Zappa, “Single-photon avalanche diode model for circuit simulations,” IEEE Photon. Technol. Lett. 19(23), 1922–1924 (2007).
[Crossref]

Tualle, J.-M.

Turola, M.

Valvo, G.

D. Sanfilippo, G. Valvo, M. Mazzillo, A. Piana, B. Carbone, L. Renna, P. G. Fallica, D. Agrò, G. Morsellino, M. Pinto, R. Canicattì, N. Galioto, A. Tomasino, G. Adamo, S. Stivala, A. Parisi, L. Curcio, C. Giaconia, A. C. Busacca, R. Pagano, S. Libertino, and S. Lombardo, “Design and development of a fNIRS system prototype based on SiPM detectors,” Proc. SPIE 8990, 899016 (2014).
[Crossref]

van Veen, R. L. P.

Vanoli, M.

A. Torricelli, L. Spinelli, D. Contini, M. Vanoli, A. Rizzolo, and P. Eccher Zerbini, “Time-resolved reflectance spectroscopy for non-destructive assessment of food quality,” Sens. Instrumen. Food Qual. 2(2), 82–89 (2008).
[Crossref]

Vergani, M.

F. Villa, D. Bronzi, M. Vergani, Y. Zou, A. Ruggeri, F. Zappa, and A. Dalla Mora, “Analog SiPM in planar CMOS technology,” Proceedings of ESSDERC, 294–297 (2014).

Villa, F.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

F. Villa, D. Bronzi, M. Vergani, Y. Zou, A. Ruggeri, F. Zappa, and A. Dalla Mora, “Analog SiPM in planar CMOS technology,” Proceedings of ESSDERC, 294–297 (2014).

Villringer, A.

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

Vynck, K.

T. Svensson, K. Vynck, E. Adolfsson, A. Farina, A. Pifferi, and D. S. Wiersma, “Light diffusion in quenched disorder: role of step correlations,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 89(2), 022141 (2014).
[Crossref] [PubMed]

Wabnitz, H.

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts,” J. Biomed. Opt. 18(6), 066014 (2013).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer, and H. Rinneberg, “Determining changes in NIR absorption using a layered model of the human head,” Phys. Med. Biol. 46(3), 879–896 (2001).
[Crossref] [PubMed]

Weigel, U.

Weyers, S.

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

Whelan, M.

Wiersma, D. S.

T. Svensson, K. Vynck, E. Adolfsson, A. Farina, A. Pifferi, and D. S. Wiersma, “Light diffusion in quenched disorder: role of step correlations,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 89(2), 022141 (2014).
[Crossref] [PubMed]

Wilson, B. C.

Wolf, M.

F. Scholkmann, S. Kleiser, A. J. Metz, R. Zimmermann, J. Mata Pavia, U. Wolf, and M. Wolf, “A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology,” Neuroimage 85(Pt 1), 6–27 (2014).
[Crossref] [PubMed]

R. Zimmermann, F. Braun, T. Achtnich, O. Lambercy, R. Gassert, and M. Wolf, “Silicon photomultipliers for improved detection of low light levels in miniature near-infrared spectroscopy instruments,” Biomed. Opt. Express 4(5), 659–666 (2013).
[Crossref] [PubMed]

M. Wolf, M. Ferrari, and V. Quaresima, “Progress of near-infrared spectroscopy and topography for brain and muscle clinical applications,” J. Biomed. Opt. 12(6), 062104 (2007).
[Crossref] [PubMed]

Wolf, U.

F. Scholkmann, S. Kleiser, A. J. Metz, R. Zimmermann, J. Mata Pavia, U. Wolf, and M. Wolf, “A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology,” Neuroimage 85(Pt 1), 6–27 (2014).
[Crossref] [PubMed]

Yang, R.

Yodh, A. G.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref]

R. Choe, A. Corlu, K. Lee, T. Durduran, S. D. Konecky, M. Grosicka-Koptyra, S. R. Arridge, B. J. Czerniecki, D. L. Fraker, A. DeMichele, B. Chance, M. A. Rosen, and A. G. Yodh, “Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: A case study with comparison to MRI,” Med. Phys. 32(4), 1128–1139 (2005).
[Crossref] [PubMed]

Zaccanti, G.

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

F. Martelli, A. Pifferi, D. Contini, L. Spinelli, A. Torricelli, H. Wabnitz, R. Macdonald, A. Sassaroli, and G. Zaccanti, “Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: Basic concepts,” J. Biomed. Opt. 18(6), 066014 (2013).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

L. Spinelli, F. Martelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. Time-resolved method,” Opt. Express 15(11), 6589–6604 (2007).
[Crossref] [PubMed]

F. Martelli and G. Zaccanti, “Calibration of scattering and absorption properties of a liquid diffusive medium at NIR wavelengths. CW method,” Opt. Express 15(2), 486–500 (2007).
[Crossref] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco, and G. Zaccanti, “Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging,” Phys. Rev. Lett. 95(7), 078101 (2005).
[Crossref] [PubMed]

D. Contini, F. Martelli, and G. Zaccanti, “Photon migration through a turbid slab described by a model based on diffusion approximation. I. Theory,” Appl. Opt. 36(19), 4587–4599 (1997).
[Crossref] [PubMed]

Zappa, F.

D. Contini, A. Dalla Mora, L. Spinelli, A. Farina, A. Torricelli, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, G. Boso, F. Zappa, and A. Pifferi, “Effects of time-gated detection in diffuse optical imaging at short source-detector separation,” J. Phys. D Appl. Phys. 48(4), 045401 (2015).
[Crossref]

F. Villa, B. Markovic, S. Bellisai, D. Bronzi, A. Tosi, F. Zappa, S. Tisa, D. Durini, S. Weyers, U. Paschen, and W. Brockherde, “SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements,” IEEE Photonics J. 4(3), 795–804 (2012).
[Crossref]

E. Alerstam, T. Svensson, S. Andersson-Engels, L. Spinelli, D. Contini, A. Dalla Mora, A. Tosi, F. Zappa, and A. Pifferi, “Single-fiber diffuse optical time-of-flight spectroscopy,” Opt. Lett. 37(14), 2877–2879 (2012).
[Crossref] [PubMed]

A. Tosi, A. Dalla Mora, F. Zappa, A. Gulinatti, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon counting technique widens dynamic range and speeds up acquisition time in time-resolved measurements,” Opt. Express 19(11), 10735–10746 (2011).
[Crossref] [PubMed]

A. Tosi, A. Dalla Mora, A. Della Frera, F. Acerbi, A. Bahgat Shehata, and F. Zappa, “Advanced single photon counting instrumentation for SPADs,” Proc. SPIE 7945, 79452O (2011).
[Crossref]

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
[Crossref]

A. Pifferi, A. Torricelli, L. Spinelli, D. Contini, R. Cubeddu, F. Martelli, G. Zaccanti, A. Tosi, A. Dalla Mora, F. Zappa, and S. Cova, “Time-resolved diffuse reflectance using small source-detector separation and fast single-photon gating,” Phys. Rev. Lett. 100(13), 138101 (2008).
[Crossref] [PubMed]

A. Dalla Mora, A. Tosi, S. Tisa, and F. Zappa, “Single-photon avalanche diode model for circuit simulations,” IEEE Photon. Technol. Lett. 19(23), 1922–1924 (2007).
[Crossref]

F. Villa, D. Bronzi, M. Vergani, Y. Zou, A. Ruggeri, F. Zappa, and A. Dalla Mora, “Analog SiPM in planar CMOS technology,” Proceedings of ESSDERC, 294–297 (2014).

Zhang, C.

Zhang, L.

Zimmermann, R.

F. Scholkmann, S. Kleiser, A. J. Metz, R. Zimmermann, J. Mata Pavia, U. Wolf, and M. Wolf, “A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology,” Neuroimage 85(Pt 1), 6–27 (2014).
[Crossref] [PubMed]

R. Zimmermann, F. Braun, T. Achtnich, O. Lambercy, R. Gassert, and M. Wolf, “Silicon photomultipliers for improved detection of low light levels in miniature near-infrared spectroscopy instruments,” Biomed. Opt. Express 4(5), 659–666 (2013).
[Crossref] [PubMed]

Zolek, N.

Zorzi, N.

F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
[Crossref]

Zou, Y.

F. Villa, D. Bronzi, M. Vergani, Y. Zou, A. Ruggeri, F. Zappa, and A. Dalla Mora, “Analog SiPM in planar CMOS technology,” Proceedings of ESSDERC, 294–297 (2014).

Zucchelli, L.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85(Pt 1), 28–50 (2014).
[Crossref] [PubMed]

H. Wabnitz, A. Jelzow, M. Mazurenka, O. Steinkellner, R. Macdonald, D. Milej, N. Żołek, M. Kacprzak, P. Sawosz, R. Maniewski, A. Liebert, S. Magazov, J. Hebden, F. Martelli, P. Di Ninni, G. Zaccanti, A. Torricelli, D. Contini, R. Re, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Pifferi, “Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol,” J. Biomed. Opt. 19(8), 086012 (2014).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, and A. Torricelli, “Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing,” Biomed. Opt. Express 4(10), 2231–2246 (2013).
[Crossref] [PubMed]

Adv. Opt. Technol. (1)

K. Johnson, M. Hibbs-Brenner, W. Hogan, and M. Dummer, “Advances in red VCSEL technology,” Adv. Opt. Technol. 2012, 1–13 (2012).
[Crossref]

Anesth. Analg. (1)

A. Ghosh, C. Elwell, and M. Smith, “Review article: cerebral near-infrared spectroscopy in adults: a work in progress,” Anesth. Analg. 115(6), 1373–1383 (2012).
[Crossref] [PubMed]

Appl. Opt. (3)

Appl. Spectrosc. (1)

Biomed. Opt. Express (4)

R. Zimmermann, F. Braun, T. Achtnich, O. Lambercy, R. Gassert, and M. Wolf, “Silicon photomultipliers for improved detection of low light levels in miniature near-infrared spectroscopy instruments,” Biomed. Opt. Express 4(5), 659–666 (2013).
[Crossref] [PubMed]

R. Re, D. Contini, M. Turola, L. Spinelli, L. Zucchelli, M. Caffini, R. Cubeddu, and A. Torricelli, “Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing,” Biomed. Opt. Express 4(10), 2231–2246 (2013).
[Crossref] [PubMed]

L. Spinelli, M. Botwicz, N. Zolek, M. Kacprzak, D. Milej, P. Sawosz, A. Liebert, U. Weigel, T. Durduran, F. Foschum, A. Kienle, F. Baribeau, S. Leclair, J.-P. Bouchard, I. Noiseux, P. Gallant, O. Mermut, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, H.-C. Ho, M. Mazurenka, H. Wabnitz, K. Klauenberg, O. Bodnar, C. Elster, M. Bénazech-Lavoué, Y. Bérubé-Lauzière, F. Lesage, D. Khoptyar, A. A. Subash, S. Andersson-Engels, P. Di Ninni, F. Martelli, and G. Zaccanti, “Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink,” Biomed. Opt. Express 5(7), 2037–2053 (2014).
[Crossref] [PubMed]

A. Dalla Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref]

IEEE J. Sel. Top. Quantum Electron. (1)

A. Dalla Mora, A. Tosi, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, and R. Cubeddu, “Fast-gated single-photon avalanche diode for wide dynamic range near infrared spectroscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 1023–1030 (2010).
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IEEE Photon. Technol. Lett. (1)

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F. Acerbi, A. Ferri, A. Gola, M. Cazzanelli, L. Pavesi, N. Zorzi, and C. Piemonte, “Characterization of single-photon time resolution: from single SPAD to silicon photomultiplier,” IEEE Trans. Nucl. Sci. 61(5), 2678–2686 (2014).
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A. Pifferi, A. Farina, A. Torricelli, G. Quarto, R. Cubeddu, and P. Taroni, “Review: Time-domain broadband near infrared spectroscopy of the female breast: a focused review from basic principles to future perspectives,” J. Near Infrared Spectrosc. 20(1), 223–235 (2012).
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Figures (5)

Fig. 1
Fig. 1

Photograph of the developed compact optode based on a silicon photomultiplier.

Fig. 2
Fig. 2

Scheme of the experimental setup employed: a pulse generator provides voltage pulses to a VCSEL and a synchronization signal for the system; a signal amplifier increases the amplitude of the SiPM avalanche transient; a PC-hosted TCSPC board builds the histogram of the photon time-of-flights.

Fig. 3
Fig. 3

Single-photon timing response at 690 nm of the SiPM-based detection system when stimulated by a picosecond laser pulse (solid line). Global instrument response function using pulsed VCSEL at 690 nm (dotted line).

Fig. 4
Fig. 4

Measured absorption coefficient (squares) and reduced scattering coefficient (triangles) as a function of the reference absorption coefficient for phantoms with nominal reduced scattering coefficient of 5.5 cm−1 (a); 10 cm−1 (b), 14.5 cm−1 (c), 20 cm−1 (d). Reference values have been obtained using time-resolved broadband diffuse optics spectrometers with top-class performances [21]. In each panel, the oblique and horizontal lines represent the reference values for the absorption and reduced scattering coefficients, respectively.

Fig. 5
Fig. 5

Average and standard deviation over 10 repetitions of the relative contrast produced by the cylinder as a function of depth from the surface, calculated within a time window of 500 ps starting at different delays with respect to the peak of the IRF.

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