Abstract

Stability is of utmost importance to a wide range of phase-sensitive processing techniques. In Doppler optical coherence tomography and optical coherence elastography, in addition to defocus and aberration correction techniques such as interferometric synthetic aperture microscopy and computational/digital adaptive optics, a precise understanding of the system and sample stability helps to guide the system design and choice of imaging parameters. This article focuses on methods to accurately and quantitatively measure the stability of an imaging configuration in vivo. These methods are capable of partially decoupling axial from transverse motion and are compared against the stability requirements for computed optical interferometric tomography laid out in the first part of this article.

© 2014 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. V. X. D. Yang, M. L. Gordon, B. Qi, J. Pekar, S. Lo, E. Seng-Yue, A. Mok, B. C. Wilson, and I. A. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance,” Opt. Express 11(7), 794–809 (2003).
    [CrossRef] [PubMed]
  2. V. X. D. Yang, M. L. Gordon, E. Seng-Yue, S. Lo, B. Qi, J. Pekar, A. Mok, B. C. Wilson, and I. A. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamics of Xenopus laevis,” Opt. Express 11(14), 1650–1658 (2003).
    [CrossRef] [PubMed]
  3. R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express 15(7), 4083–4097 (2007).
    [CrossRef] [PubMed]
  4. J. Fingler, R. J. Zawadzki, J. S. Werner, D. Schwartz, and S. E. Fraser, “Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique,” Opt. Express 17(24), 22190–22200 (2009).
    [CrossRef] [PubMed]
  5. A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express 13(17), 6597–6614 (2005).
    [CrossRef] [PubMed]
  6. C. Joo, T. Akkin, B. Cense, B. H. Park, and J. F. de Boer, “Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging,” Opt. Lett. 30(16), 2131–2133 (2005).
    [CrossRef] [PubMed]
  7. W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
    [CrossRef] [PubMed]
  8. V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express 17(25), 23114–23122 (2009).
    [CrossRef] [PubMed]
  9. V. Crecea, A. Ahmad, and S. A. Boppart, “Magnetomotive optical coherence elastography for microrheology of biological tissues,” J. Biomed. Opt. 18(12), 121504 (2013).
    [CrossRef] [PubMed]
  10. C. Dorronsoro, D. Pascual, P. Pérez-Merino, S. Kling, and S. Marcos, “Dynamic OCT measurement of corneal deformation by an air puff in normal and cross-linked corneas,” Biomed. Opt. Express 3(3), 473–487 (2012).
    [CrossRef] [PubMed]
  11. T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys. 3(2), 129–134 (2007).
    [CrossRef]
  12. B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Non-paraxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy,” J. Opt. Soc. Am. A 24(9), 2527–2542 (2007).
    [CrossRef]
  13. B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
    [CrossRef] [PubMed]
  14. S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
    [CrossRef] [PubMed]
  15. S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
    [CrossRef] [PubMed]
  16. A. Kumar, W. Drexler, and R. A. Leitgeb, “Subaperture correlation based digital adaptive optics for full field optical coherence tomography,” Opt. Express 21(9), 10850–10866 (2013).
    [CrossRef] [PubMed]
  17. D. Hillmann, C. Lührs, T. Bonin, P. Koch, and G. Hüttmann, “Holoscopy--holographic optical coherence tomography,” Opt. Lett. 36(13), 2390–2392 (2011).
    [CrossRef] [PubMed]
  18. D. Hillmann, G. Franke, C. Lührs, P. Koch, and G. Hüttmann, “Efficient holoscopy image reconstruction,” Opt. Express 20(19), 21247–21263 (2012).
    [CrossRef] [PubMed]
  19. N. D. Shemonski, S. G. Adie, Y.-Z. L. F. A. South, P. S. Carney, and S. A. Boppart, “Stability in computed optical interferometric tomography (Part I): Stability requirements,” (to be published).
  20. W. Choi, B. Potsaid, V. Jayaraman, B. Baumann, I. Grulkowski, J. J. Liu, C. D. Lu, A. E. Cable, D. Huang, J. S. Duker, and J. G. Fujimoto, “Phase-sensitive swept-source optical coherence tomography imaging of the human retina with a vertical cavity surface-emitting laser light source,” Opt. Lett. 38(3), 338–340 (2013).
    [CrossRef] [PubMed]
  21. T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” in Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro (2006), pp. 578–581.
    [CrossRef]
  22. C. Sun, F. Nolte, K. H. Y. Cheng, B. Vuong, K. K. C. Lee, B. A. Standish, B. Courtney, T. R. Marotta, A. Mariampillai, and V. X. D. Yang, “In vivo feasibility of endovascular Doppler optical coherence tomography,” Biomed. Opt. Express 3(10), 2600–2610 (2012).
    [CrossRef] [PubMed]
  23. M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
    [CrossRef]
  24. M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Phase contrast coherence microscopy based on transverse scanning,” Opt. Lett. 34(12), 1750–1752 (2009).
    [CrossRef] [PubMed]
  25. M. A. Choma, A. K. Ellerbee, C. Yang, T. L. Creazzo, and J. A. Izatt, “Spectral-domain phase microscopy,” Opt. Lett. 30(10), 1162–1164 (2005).
    [CrossRef] [PubMed]
  26. M. V. Sarunic, S. Weinberg, and J. A. Izatt, “Full-field swept-source phase microscopy,” Opt. Lett. 31(10), 1462–1464 (2006).
    [CrossRef] [PubMed]
  27. T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Inverse scattering for optical coherence tomography,” J. Opt. Soc. Am. A 23(5), 1027–1037 (2006).
    [CrossRef] [PubMed]
  28. V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express 18(3), 2477–2494 (2010).
    [CrossRef] [PubMed]
  29. B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 28(6), 814–821 (2009).
    [CrossRef] [PubMed]
  30. B. H. Park, M. C. Pierce, B. Cense, S.-H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13(11), 3931–3944 (2005).
    [CrossRef] [PubMed]
  31. B. Braaf, K. A. Vermeer, K. V. Vienola, and J. F. de Boer, “Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans,” Opt. Express 20(18), 20516–20534 (2012).
    [CrossRef] [PubMed]
  32. J. Lee, V. Srinivasan, H. Radhakrishnan, and D. A. Boas, “Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex,” Opt. Express 19(22), 21258–21270 (2011).
    [CrossRef] [PubMed]
  33. B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. H. Park, G. J. Tearney, B. E. Bouma, T. C. Chen, and J. F. de Boer, “In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography,” Opt. Express 11(25), 3490–3497 (2003).
    [CrossRef] [PubMed]
  34. X. Liu, Y. Huang, and J. U. Kang, “Distortion-free freehand-scanning OCT implemented with real-time scanning speed variance correction,” Opt. Express 20(15), 16567–16583 (2012).
    [CrossRef]
  35. A. Ahmad, S. G. Adie, E. J. Chaney, U. Sharma, and S. A. Boppart, “Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography,” Opt. Express 17(10), 8125–8136 (2009).
    [CrossRef] [PubMed]
  36. X. Liu, J. C. Ramella-Roman, Y. Huang, Y. Guo, and J. U. Kang, “Robust spectral-domain optical coherence tomography speckle model and its cross-correlation coefficient analysis,” J. Opt. Soc. Am. A 30(1), 51–59 (2013).
    [CrossRef] [PubMed]
  37. B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett. 35(18), 3120–3122 (2010).
    [CrossRef] [PubMed]
  38. A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
    [CrossRef] [PubMed]
  39. B. Považay, B. Hofer, C. Torti, B. Hermann, A. R. Tumlinson, M. Esmaeelpour, C. A. Egan, A. C. Bird, and W. Drexler, “Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography,” Opt. Express 17(5), 4134–4150 (2009).
    [CrossRef] [PubMed]

2013 (5)

2012 (8)

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

C. Dorronsoro, D. Pascual, P. Pérez-Merino, S. Kling, and S. Marcos, “Dynamic OCT measurement of corneal deformation by an air puff in normal and cross-linked corneas,” Biomed. Opt. Express 3(3), 473–487 (2012).
[CrossRef] [PubMed]

X. Liu, Y. Huang, and J. U. Kang, “Distortion-free freehand-scanning OCT implemented with real-time scanning speed variance correction,” Opt. Express 20(15), 16567–16583 (2012).
[CrossRef]

B. Braaf, K. A. Vermeer, K. V. Vienola, and J. F. de Boer, “Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans,” Opt. Express 20(18), 20516–20534 (2012).
[CrossRef] [PubMed]

D. Hillmann, G. Franke, C. Lührs, P. Koch, and G. Hüttmann, “Efficient holoscopy image reconstruction,” Opt. Express 20(19), 21247–21263 (2012).
[CrossRef] [PubMed]

C. Sun, F. Nolte, K. H. Y. Cheng, B. Vuong, K. K. C. Lee, B. A. Standish, B. Courtney, T. R. Marotta, A. Mariampillai, and V. X. D. Yang, “In vivo feasibility of endovascular Doppler optical coherence tomography,” Biomed. Opt. Express 3(10), 2600–2610 (2012).
[CrossRef] [PubMed]

2011 (3)

2010 (2)

2009 (6)

2008 (1)

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

2007 (3)

2006 (2)

2005 (4)

2003 (3)

Adie, S. G.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett. 35(18), 3120–3122 (2010).
[CrossRef] [PubMed]

A. Ahmad, S. G. Adie, E. J. Chaney, U. Sharma, and S. A. Boppart, “Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography,” Opt. Express 17(10), 8125–8136 (2009).
[CrossRef] [PubMed]

Ahmad, A.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

V. Crecea, A. Ahmad, and S. A. Boppart, “Magnetomotive optical coherence elastography for microrheology of biological tissues,” J. Biomed. Opt. 18(12), 121504 (2013).
[CrossRef] [PubMed]

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

A. Ahmad, S. G. Adie, E. J. Chaney, U. Sharma, and S. A. Boppart, “Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography,” Opt. Express 17(10), 8125–8136 (2009).
[CrossRef] [PubMed]

Akkin, T.

Baumann, B.

Bird, A. C.

Boas, D. A.

Bonin, T.

Boppart, S. A.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

V. Crecea, A. Ahmad, and S. A. Boppart, “Magnetomotive optical coherence elastography for microrheology of biological tissues,” J. Biomed. Opt. 18(12), 121504 (2013).
[CrossRef] [PubMed]

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett. 35(18), 3120–3122 (2010).
[CrossRef] [PubMed]

A. Ahmad, S. G. Adie, E. J. Chaney, U. Sharma, and S. A. Boppart, “Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography,” Opt. Express 17(10), 8125–8136 (2009).
[CrossRef] [PubMed]

V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express 17(25), 23114–23122 (2009).
[CrossRef] [PubMed]

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys. 3(2), 129–134 (2007).
[CrossRef]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Non-paraxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy,” J. Opt. Soc. Am. A 24(9), 2527–2542 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Inverse scattering for optical coherence tomography,” J. Opt. Soc. Am. A 23(5), 1027–1037 (2006).
[CrossRef] [PubMed]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express 13(17), 6597–6614 (2005).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” in Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro (2006), pp. 578–581.
[CrossRef]

Bouma, B. E.

Braaf, B.

Cable, A. E.

Carney, P. S.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys. 3(2), 129–134 (2007).
[CrossRef]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Non-paraxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy,” J. Opt. Soc. Am. A 24(9), 2527–2542 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Inverse scattering for optical coherence tomography,” J. Opt. Soc. Am. A 23(5), 1027–1037 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” in Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro (2006), pp. 578–581.
[CrossRef]

Cense, B.

Chaney, E. J.

Chang, F.-Y.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Chen, R.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Chen, T. C.

Chen, Z.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Cheng, K. H. Y.

Chi, T.-T.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Choi, W.

Choma, M. A.

Chou, L.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Courtney, B.

Creazzo, T. L.

Crecea, V.

V. Crecea, A. Ahmad, and S. A. Boppart, “Magnetomotive optical coherence elastography for microrheology of biological tissues,” J. Biomed. Opt. 18(12), 121504 (2013).
[CrossRef] [PubMed]

V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express 17(25), 23114–23122 (2009).
[CrossRef] [PubMed]

Davis, B. J.

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Non-paraxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy,” J. Opt. Soc. Am. A 24(9), 2527–2542 (2007).
[CrossRef]

de Boer, J. F.

Dorronsoro, C.

Drexler, W.

Duker, J. S.

Egan, C. A.

Ellerbee, A. K.

Esmaeelpour, M.

Fingler, J.

Franke, G.

Fraser, S. E.

Fujimoto, J. G.

Gorczynska, I.

Gordon, M. L.

Götzinger, E.

Graf, B. W.

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

B. W. Graf, S. G. Adie, and S. A. Boppart, “Correction of coherence gate curvature in high numerical aperture optical coherence imaging,” Opt. Lett. 35(18), 3120–3122 (2010).
[CrossRef] [PubMed]

Gruber, A.

Grulkowski, I.

Guo, Y.

Hanson, S. R.

Hermann, B.

Hillmann, D.

Hitzenberger, C. K.

Hofer, B.

Huang, D.

Huang, Y.

Hurst, S.

Hüttmann, G.

Hwu, W.-M. W.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

Izatt, J. A.

Jacques, S. L.

Jayaraman, V.

Joo, C.

Kang, J. U.

Kim, H.-S.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

Kling, S.

Koch, P.

Kumar, A.

Lee, C.-K.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Lee, J.

Lee, K. K. C.

Leitgeb, R. A.

Liang, X.

Liu, G.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Liu, H.-L.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Liu, J. J.

Liu, X.

Lo, S.

Lu, C. D.

Lührs, C.

Ma, Z.

Marcos, S.

Mariampillai, A.

Marks, D. L.

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys. 3(2), 129–134 (2007).
[CrossRef]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Non-paraxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy,” J. Opt. Soc. Am. A 24(9), 2527–2542 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Inverse scattering for optical coherence tomography,” J. Opt. Soc. Am. A 23(5), 1027–1037 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” in Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro (2006), pp. 578–581.
[CrossRef]

Marotta, T. R.

Mok, A.

Mujat, M.

Nassif, N.

Nolte, F.

Oldenburg, A. L.

Park, B. H.

Pascual, D.

Pekar, J.

Pérez-Merino, P.

Pierce, M. C.

Pircher, M.

Potsaid, B.

Považay, B.

Qi, B.

Qi, W.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Radhakrishnan, H.

Ralston, T. S.

V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express 17(25), 23114–23122 (2009).
[CrossRef] [PubMed]

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys. 3(2), 129–134 (2007).
[CrossRef]

B. J. Davis, S. C. Schlachter, D. L. Marks, T. S. Ralston, S. A. Boppart, and P. S. Carney, “Non-paraxial vector-field modeling of optical coherence tomography and interferometric synthetic aperture microscopy,” J. Opt. Soc. Am. A 24(9), 2527–2542 (2007).
[CrossRef]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Inverse scattering for optical coherence tomography,” J. Opt. Soc. Am. A 23(5), 1027–1037 (2006).
[CrossRef] [PubMed]

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” in Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro (2006), pp. 578–581.
[CrossRef]

Ramella-Roman, J. C.

Ruvinskaya, S.

Sakadzic, S.

Sarunic, M. V.

Sattmann, H.

Schlachter, S. C.

Schwartz, D.

Scott Carney, P.

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

Seng-Yue, E.

Sharma, U.

Shemonski, N. D.

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

Srinivasan, V.

Srinivasan, V. J.

Standish, B. A.

Sun, C.

Suslick, K. S.

Tearney, G. J.

Torti, C.

Toublan, F. J. J.

Tsai, M.-T.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Tumlinson, A. R.

Vakoc, B. J.

B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 28(6), 814–821 (2009).
[CrossRef] [PubMed]

Vermeer, K. A.

Vienola, K. V.

Vitkin, I. A.

Vuong, B.

Wang, R. K.

Wei, A.

Weinberg, S.

Werner, J. S.

White, B. R.

Wilson, B. C.

Wu, W.

Yang, C.

Yang, C.-C.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Yang, C.-H.

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Yang, V. X. D.

Yun, S.-H.

Zawadzki, R. J.

Zhang, J.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Zhou, Q.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

Appl. Phys. Express (1)

M.-T. Tsai, T.-T. Chi, H.-L. Liu, F.-Y. Chang, C.-H. Yang, C.-K. Lee, and C.-C. Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express 4(9), 097001 (2011).
[CrossRef]

Appl. Phys. Lett. (1)

S. G. Adie, N. D. Shemonski, B. W. Graf, A. Ahmad, P. Scott Carney, and S. A. Boppart, “Guide-star-based computational adaptive optics for broadband interferometric tomography,” Appl. Phys. Lett. 101(22), 221117 (2012).
[CrossRef] [PubMed]

Biomed. Opt. Express (2)

IEEE Trans. Med. Imaging (1)

B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 28(6), 814–821 (2009).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[CrossRef] [PubMed]

V. Crecea, A. Ahmad, and S. A. Boppart, “Magnetomotive optical coherence elastography for microrheology of biological tissues,” J. Biomed. Opt. 18(12), 121504 (2013).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (3)

Nat. Photonics (1)

A. Ahmad, N. D. Shemonski, S. G. Adie, H.-S. Kim, W.-M. W. Hwu, P. S. Carney, and S. A. Boppart, “Real-time in vivo computed optical interferometric tomography,” Nat. Photonics 7(6), 444–448 (2013).
[CrossRef] [PubMed]

Nat. Phys. (1)

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy,” Nat. Phys. 3(2), 129–134 (2007).
[CrossRef]

Opt. Express (16)

V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express 17(25), 23114–23122 (2009).
[CrossRef] [PubMed]

V. X. D. Yang, M. L. Gordon, B. Qi, J. Pekar, S. Lo, E. Seng-Yue, A. Mok, B. C. Wilson, and I. A. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part I): System design, signal processing, and performance,” Opt. Express 11(7), 794–809 (2003).
[CrossRef] [PubMed]

V. X. D. Yang, M. L. Gordon, E. Seng-Yue, S. Lo, B. Qi, J. Pekar, A. Mok, B. C. Wilson, and I. A. Vitkin, “High speed, wide velocity dynamic range Doppler optical coherence tomography (Part II): Imaging in vivo cardiac dynamics of Xenopus laevis,” Opt. Express 11(14), 1650–1658 (2003).
[CrossRef] [PubMed]

R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express 15(7), 4083–4097 (2007).
[CrossRef] [PubMed]

J. Fingler, R. J. Zawadzki, J. S. Werner, D. Schwartz, and S. E. Fraser, “Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique,” Opt. Express 17(24), 22190–22200 (2009).
[CrossRef] [PubMed]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express 13(17), 6597–6614 (2005).
[CrossRef] [PubMed]

A. Kumar, W. Drexler, and R. A. Leitgeb, “Subaperture correlation based digital adaptive optics for full field optical coherence tomography,” Opt. Express 21(9), 10850–10866 (2013).
[CrossRef] [PubMed]

D. Hillmann, G. Franke, C. Lührs, P. Koch, and G. Hüttmann, “Efficient holoscopy image reconstruction,” Opt. Express 20(19), 21247–21263 (2012).
[CrossRef] [PubMed]

B. Považay, B. Hofer, C. Torti, B. Hermann, A. R. Tumlinson, M. Esmaeelpour, C. A. Egan, A. C. Bird, and W. Drexler, “Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography,” Opt. Express 17(5), 4134–4150 (2009).
[CrossRef] [PubMed]

B. H. Park, M. C. Pierce, B. Cense, S.-H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13(11), 3931–3944 (2005).
[CrossRef] [PubMed]

B. Braaf, K. A. Vermeer, K. V. Vienola, and J. F. de Boer, “Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans,” Opt. Express 20(18), 20516–20534 (2012).
[CrossRef] [PubMed]

J. Lee, V. Srinivasan, H. Radhakrishnan, and D. A. Boas, “Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex,” Opt. Express 19(22), 21258–21270 (2011).
[CrossRef] [PubMed]

B. R. White, M. C. Pierce, N. Nassif, B. Cense, B. H. Park, G. J. Tearney, B. E. Bouma, T. C. Chen, and J. F. de Boer, “In vivo dynamic human retinal blood flow imaging using ultra-high-speed spectral domain optical coherence tomography,” Opt. Express 11(25), 3490–3497 (2003).
[CrossRef] [PubMed]

X. Liu, Y. Huang, and J. U. Kang, “Distortion-free freehand-scanning OCT implemented with real-time scanning speed variance correction,” Opt. Express 20(15), 16567–16583 (2012).
[CrossRef]

A. Ahmad, S. G. Adie, E. J. Chaney, U. Sharma, and S. A. Boppart, “Cross-correlation-based image acquisition technique for manually-scanned optical coherence tomography,” Opt. Express 17(10), 8125–8136 (2009).
[CrossRef] [PubMed]

V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express 18(3), 2477–2494 (2010).
[CrossRef] [PubMed]

Opt. Lett. (7)

Proc. Natl. Acad. Sci. U.S.A. (1)

S. G. Adie, B. W. Graf, A. Ahmad, P. S. Carney, and S. A. Boppart, “Computational adaptive optics for broadband optical interferometric tomography of biological tissue,” Proc. Natl. Acad. Sci. U.S.A. 109(19), 7175–7180 (2012).
[CrossRef] [PubMed]

Sensors (Basel) (1)

B. J. Davis, D. L. Marks, T. S. Ralston, P. S. Carney, and S. A. Boppart, “Interferometric synthetic aperture microscopy: computed imaging for scanned coherent microscopy,” Sensors (Basel) 8(6), 3903–3931 (2008).
[CrossRef] [PubMed]

Other (2)

N. D. Shemonski, S. G. Adie, Y.-Z. L. F. A. South, P. S. Carney, and S. A. Boppart, “Stability in computed optical interferometric tomography (Part I): Stability requirements,” (to be published).

T. S. Ralston, D. L. Marks, P. S. Carney, and S. A. Boppart, “Phase stability technique for inverse scattering in optical coherence tomography,” in Proceedings of 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro (2006), pp. 578–581.
[CrossRef]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1

Flow chart providing details for stability analysis. A single M-mode scan is used for two sets of analyses. The top path utilizes phase differences between adjacent A-scans to measure axial phase fluctuations. The bottom path utilizes the amplitude-based XCC between adjacent A-scans to measure motion on a larger scale.

Fig. 2
Fig. 2

Validating phase and XCC measurements. The left column shows the phase analysis which measures pure axial motion and the right column shows the XCC analysis which measured motion in all three dimensions. (a) Baseline stability measurements are made to provide a reference scale for the other figures. (b) Axial motion was induced by changing the OPL in the reference arm. With knowledge of the induced motion, both the measured and expected values are plotted for the phase and XCC analysis. This shows that for sufficiently large axial motion, the motion is also measured with the XCC analysis. (c) Transverse motion was induced by jittering the scanning galvanometer mirrors. As this represents almost purely transverse motion, the phase analysis should measure displacements close to the baseline measured in (a). (d) Motion is induced by both the reference arm and scanning mirrors. Since the axial motion is much smaller than the transverse, the XCC analysis measures mostly transverse motion while the phase analysis still only measures the axial motion.

Fig. 3
Fig. 3

Stability analysis for ex vivo tissues. The analysis procedure detailed in Fig. 1 is utilized to measure the stability of static samples. A tape phantom was used as the speckle-generating sample for stability measurement at three speeds: 21, 8, and 2.6 FPS. The plots on the right show colored/dashed lines which correspond to the resulting stability assessment. The colors and dash-type match the en face planes on the left with the same color/dash outline. The plots show that 21 and 8 FPS satisfy the stability requirements from [19], but at 2.6 FPS, motion is too great and predicts that reconstructions will no longer work. The vertical black line in the plots on the right indicates approximately the interrogation length for the phantom images. On the left, OCT and ISAM en face planes from both ex vivo breast tissue and a tissue phantom are shown. The reconstructions are seen to properly correct defocus at 21 and 8 FPS, but deteriorate at the slow, 2.6 FPS imaging speed. Scale bars in the phantom represent 10 µm and in the breast tissue represent 85 µm.

Fig. 4
Fig. 4

Photographs of two in vivo tissue mounting systems. Pictured on the left is a cantilever mount (note 3-axis stage on table) where the sample and mount are separate from the rest of the sample arm optics (as indicated by the air gap). On the right is a monolithic, objective-mounted design where the sample mount is attached to objective lens tube. In the objective-mounted configuration, the optics and sample will move together providing a more stable configuration.

Fig. 5
Fig. 5

Stability analysis for in vivo tissues. (a-d) Images and stability analysis from a cantilever-mounted finger. The OCT and ISAM reconstructions show en face planes through a single sweat duct. The reconstruction in (b) shows motion artifacts due to the large amount of motion, which is also seen in the stability analysis in (c,d). (e-h) Images and stability analysis from an objective-mounted finger. The ISAM reconstruction in (f) is free of motion artifacts due to a much more stable imaging configuration. The smaller motion is also reflected in the stability analysis in (g,h). Scale bars represent 100 µm.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

Δϕ=2 n sample k 0 Δz
||Δr||= w 1/e ln( 1/ρ )
P { | r n r 0 | } = N f ( 0 , n σ 2 )

Metrics