Abstract

The recent development of THz sources in a wide range of THz frequencies and power levels has led to greatly increased interest in potential biomedical applications such as cancer and burn wound diagnosis. However, despite its importance in realizing THz wave based applications, our knowledge of how THz wave irradiation can affect a live tissue at the cellular level is very limited. In this study, an acute inflammatory response caused by pulsed THz wave irradiation on the skin of a live mouse was analyzed at the cellular level using intravital laser-scanning confocal microscopy. Pulsed THz wave (2.7 THz, 4 μs pulsewidth, 61.4 μJ per pulse, 3Hz repetition), generated using compact FEL, was used to irradiate an anesthetized mouse’s ear skin with an average power of 260 mW/cm2 for 30 minutes using a high-precision focused THz wave irradiation setup. In contrast to in vitro analysis using cultured cells at similar power levels of CW THz wave irradiation, no temperature change at the surface of the ear skin was observed when skin was examined with an IR camera. To monitor any potential inflammatory response, resident neutrophils in the same area of ear skin were repeatedly visualized before and after THz wave irradiation using a custom-built laser-scanning confocal microscopy system optimized for in vivo visualization. While non-irradiated control skin area showed no changes in the number of resident neutrophils, a massive recruitment of newly infiltrated neutrophils was observed in the THz wave irradiated skin area after 6 hours, which suggests an induction of acute inflammatory response by the pulsed THz wave irradiation on the skin via a non-thermal process.

© 2014 Optical Society of America

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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]
  38. Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
    [CrossRef]
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    [CrossRef] [PubMed]
  41. T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
    [CrossRef] [PubMed]
  42. S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
    [CrossRef] [PubMed]

2013 (6)

P. Doradla, K. Alavi, C. Joseph, R. Giles, “Detection of colon cancer by continuous-wave terahertz polarization imaging technique,” J. Biomed. Opt. 18(9), 090504 (2013).
[CrossRef]

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

K. Choe, Y. Hwang, H. Seo, P. Kim, “In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes,” J. Biomed. Opt. 18(3), 036005 (2013).
[CrossRef] [PubMed]

2012 (4)

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

K. W. Kim, K. S. Kim, H. Kim, S. H. Lee, J. H. Park, J. H. Han, S. H. Seok, J. Park, Y. Choi, Y. I. Kim, J. K. Han, J. H. Son, “Terahertz dynamic imaging of skin drug absorption,” Opt. Express 20(9), 9476–9484 (2012).
[PubMed]

2011 (7)

H. Chen, W. J. Lee, H. Y. Huang, C. M. Chiu, Y. F. Tsai, T. F. Tseng, J. T. Lu, W. L. Lai, C. K. Sun, “Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors,” Opt. Express 19(20), 19523–19531 (2011).
[CrossRef] [PubMed]

H. Chen, T. H. Chen, T. F. Tseng, J. T. Lu, C. C. Kuo, S. C. Fu, W. J. Lee, Y. F. Tsai, Y. Y. Huang, E. Y. Chuang, Y. J. Hwang, C. K. Sun, “High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model,” Opt. Express 19(22), 21552–21562 (2011).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

P. Shumyatsky, R. R. Alfano, “Terahertz sources,” J. Biomed. Opt. 16(3), 033001 (2011).
[CrossRef] [PubMed]

G. J. Wilmink, J. E. Grundt, “Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation,” J. Infrared Millim. Terahertz Waves 32(10), 1074–1122 (2011).
[CrossRef]

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

2010 (4)

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

V. F. Kirichuk, A. A. Tsymbal, “Use of Terahertz Electromagnetic Waves for Correcting the Hemostasis Functions,” Med. Tekh. 44(1), 12–16 (2010).
[PubMed]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

2009 (3)

V. F. Kirichuk, N. V. Efimova, E. V. Andronov, “Effect of high power terahertz irradiation on platelet aggregation and behavioral reactions of albino rats,” Bull. Exp. Biol. Med. 148(5), 746–749 (2009).
[CrossRef] [PubMed]

A. R. Orlando, G. P. Gallerano, “Terahertz Radiation Effects and Biological Applications,” J. Infrared Millim. Terahertz Waves 30, 1308–1318 (2009).

Y. B. Ji, E. S. Lee, S. H. Kim, J. H. Son, T. I. Jeon, “A miniaturized fiber-coupled terahertz endoscope system,” Opt. Express 17(19), 17082–17087 (2009).
[CrossRef] [PubMed]

2008 (3)

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

N. Bourne, R. H. Clothier, M. D’Arienzo, P. Harrison, “The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures,” Altern. Lab. Anim. 36(6), 667–684 (2008).
[PubMed]

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

2007 (3)

E. Y. Chiang, A. Hidalgo, J. S. Chang, P. S. Frenette, “Imaging receptor microdomains on leukocyte subsets in live mice,” Nat. Methods 4(3), 219–222 (2007).
[CrossRef] [PubMed]

V. I. Fedorov, A. G. Khamoyan, E. Y. Shevela, E. R. Chernykh, “Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine,” Proc. SPIE 6734, 673404 (2007).
[CrossRef]

M. Tonouchi, “Cutting-edge terahertz technology,” Nat. Photonics 1(2), 97–105 (2007).
[CrossRef]

2006 (1)

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

2004 (2)

P. H. Siegel, “Terahertz technology in biology and medicine,” IEEE Trans. Microw. Theory Tech. 52(10), 2438–2447 (2004).
[CrossRef]

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

2003 (4)

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

2002 (1)

P. H. Siegel, “Terahertz technology,” IEEE Trans. Microw. Theory Tech. 50(3), 910–928 (2002).
[CrossRef]

2001 (1)

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

2000 (1)

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Alavi, K.

P. Doradla, K. Alavi, C. Joseph, R. Giles, “Detection of colon cancer by continuous-wave terahertz polarization imaging technique,” J. Biomed. Opt. 18(9), 090504 (2013).
[CrossRef]

Alfano, R. R.

P. Shumyatsky, R. R. Alfano, “Terahertz sources,” J. Biomed. Opt. 16(3), 033001 (2011).
[CrossRef] [PubMed]

Andronov, E. V.

V. F. Kirichuk, N. V. Efimova, E. V. Andronov, “Effect of high power terahertz irradiation on platelet aggregation and behavioral reactions of albino rats,” Bull. Exp. Biol. Med. 148(5), 746–749 (2009).
[CrossRef] [PubMed]

Arbab, M. H.

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

Arnone, D.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

Arnone, D. D.

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

Ashworth, P. C.

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

Avgustinovich, D. F.

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

Bajwa, N.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

Barnett, K. S.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

Bennett, D.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Bennett, D. B.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Bernhard, J.

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

Blu, T.

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

Bobrow, L.

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

Bondar, N. P.

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

Borjesson, D. L.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Bourne, N.

N. Bourne, R. H. Clothier, M. D’Arienzo, P. Harrison, “The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures,” Altern. Lab. Anim. 36(6), 667–684 (2008).
[PubMed]

Brown, E.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Brown, E. R.

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Campurra, G.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Cha, B. H.

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Chang, J. S.

E. Y. Chiang, A. Hidalgo, J. S. Chang, P. S. Frenette, “Imaging receptor microdomains on leukocyte subsets in live mice,” Nat. Methods 4(3), 219–222 (2007).
[CrossRef] [PubMed]

Chau, T. C.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Chen, A. T.

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

Chen, H.

Chen, T. H.

Chernykh, E. R.

V. I. Fedorov, A. G. Khamoyan, E. Y. Shevela, E. R. Chernykh, “Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine,” Proc. SPIE 6734, 673404 (2007).
[CrossRef]

Cheung, A. L.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Chiang, E. Y.

E. Y. Chiang, A. Hidalgo, J. S. Chang, P. S. Frenette, “Imaging receptor microdomains on leukocyte subsets in live mice,” Nat. Methods 4(3), 219–222 (2007).
[CrossRef] [PubMed]

Chiu, C. M.

Cho, S. O.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Choe, K.

K. Choe, Y. Hwang, H. Seo, P. Kim, “In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes,” J. Biomed. Opt. 18(3), 036005 (2013).
[CrossRef] [PubMed]

Choi, Y.

Chuang, E. Y.

Chung, E.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Clothier, R. H.

N. Bourne, R. H. Clothier, M. D’Arienzo, P. Harrison, “The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures,” Altern. Lab. Anim. 36(6), 667–684 (2008).
[PubMed]

Cole, B.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

Coniglio, D.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Crawley, D.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

Culjat, M.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Culjat, M. O.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Cundin, L. X.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Curry, F. R.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

D’Arienzo, M.

N. Bourne, R. H. Clothier, M. D’Arienzo, P. Harrison, “The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures,” Altern. Lab. Anim. 36(6), 667–684 (2008).
[PubMed]

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Di Pietro, R.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Dickey, T. C.

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

Doradla, P.

P. Doradla, K. Alavi, C. Joseph, R. Giles, “Detection of colon cancer by continuous-wave terahertz polarization imaging technique,” J. Biomed. Opt. 18(9), 090504 (2013).
[CrossRef]

Doria, A.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Echchgadda, I.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

Efimova, N. V.

V. F. Kirichuk, N. V. Efimova, E. V. Andronov, “Effect of high power terahertz irradiation on platelet aggregation and behavioral reactions of albino rats,” Bull. Exp. Biol. Med. 148(5), 746–749 (2009).
[CrossRef] [PubMed]

Fedorov, V. I.

V. I. Fedorov, A. G. Khamoyan, E. Y. Shevela, E. R. Chernykh, “Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine,” Proc. SPIE 6734, 673404 (2007).
[CrossRef]

Fitzgerald, A. J.

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

Frenette, P. S.

E. Y. Chiang, A. Hidalgo, J. S. Chang, P. S. Frenette, “Imaging receptor microdomains on leukocyte subsets in live mice,” Nat. Methods 4(3), 219–222 (2007).
[CrossRef] [PubMed]

Fu, S. C.

Fukumura, D.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Gallerano, G. P.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

A. R. Orlando, G. P. Gallerano, “Terahertz Radiation Effects and Biological Applications,” J. Infrared Millim. Terahertz Waves 30, 1308–1318 (2009).

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Gavrilov, N. G.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Giles, R.

P. Doradla, K. Alavi, C. Joseph, R. Giles, “Detection of colon cancer by continuous-wave terahertz polarization imaging technique,” J. Biomed. Opt. 18(9), 090504 (2013).
[CrossRef]

Giovenale, E.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Grundfest, W.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Grundfest, W. S.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Grundt, J. A.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

Grundt, J. E.

G. J. Wilmink, J. E. Grundt, “Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation,” J. Infrared Millim. Terahertz Waves 32(10), 1074–1122 (2011).
[CrossRef]

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Han, J. H.

Han, J. K.

Harrison, P.

N. Bourne, R. H. Clothier, M. D’Arienzo, P. Harrison, “The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures,” Altern. Lab. Anim. 36(6), 667–684 (2008).
[PubMed]

Hidalgo, A.

E. Y. Chiang, A. Hidalgo, J. S. Chang, P. S. Frenette, “Imaging receptor microdomains on leukocyte subsets in live mice,” Nat. Methods 4(3), 219–222 (2007).
[CrossRef] [PubMed]

Holzmann, S.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Horn, C. B.

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Huang, H. Y.

Huang, Y. Y.

Hubschman, J. P.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Huh, Y. M.

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

Hung, K. E.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Hwang, Y.

K. Choe, Y. Hwang, H. Seo, P. Kim, “In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes,” J. Biomed. Opt. 18(3), 036005 (2013).
[CrossRef] [PubMed]

Hwang, Y. J.

Ibey, B. L.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Isseroff, R. R.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Jain, R. K.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Janke, K.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Jeon, T. I.

Jeong, K.

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

Jeong, Y. U.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Ji, Y. B.

Jimenez-Linan, M.

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

Jo, S. J.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Johnson, R. D.

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Joseph, C.

P. Doradla, K. Alavi, C. Joseph, R. Giles, “Detection of colon cancer by continuous-wave terahertz polarization imaging technique,” J. Biomed. Opt. 18(9), 090504 (2013).
[CrossRef]

Jung, S.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Kawate, T.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Kazakevitch, G. M.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Kealey, C. P.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

Khamoyan, A. G.

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

V. I. Fedorov, A. G. Khamoyan, E. Y. Shevela, E. R. Chernykh, “Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine,” Proc. SPIE 6734, 673404 (2007).
[CrossRef]

Kim, H.

Kim, K. S.

Kim, K. T.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Kim, K. W.

Kim, M. H.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Kim, P.

K. Choe, Y. Hwang, H. Seo, P. Kim, “In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes,” J. Biomed. Opt. 18(3), 036005 (2013).
[CrossRef] [PubMed]

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Kim, S. H.

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

Y. B. Ji, E. S. Lee, S. H. Kim, J. H. Son, T. I. Jeon, “A miniaturized fiber-coupled terahertz endoscope system,” Opt. Express 17(19), 17082–17087 (2009).
[CrossRef] [PubMed]

Kim, S. K.

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Kim, Y. I.

Kirichuk, V. F.

V. F. Kirichuk, A. A. Tsymbal, “Use of Terahertz Electromagnetic Waves for Correcting the Hemostasis Functions,” Med. Tekh. 44(1), 12–16 (2010).
[PubMed]

V. F. Kirichuk, N. V. Efimova, E. V. Andronov, “Effect of high power terahertz irradiation on platelet aggregation and behavioral reactions of albino rats,” Bull. Exp. Biol. Med. 148(5), 746–749 (2009).
[CrossRef] [PubMed]

Klein, M. B.

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

Koch, F.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Kovalenko, I. L.

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

Kubarev, V. V.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Kucherlapati, R.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Kudryavtseva, N. N.

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

Kulipanov, G. N.

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Kuno, J.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Kuo, C. C.

Kwon, O. S.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Lai, A.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Lai, W. L.

Lee, B. C.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Lee, E. S.

Lee, J.

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Lee, S. H.

Lee, W. J.

Liang, M.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

Liao, W.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Linfield, E. H.

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

Liu, F. T.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Liu, W.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Longbottom, C.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

Loughna, S.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Lu, J. T.

Maccabi, A.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Messina, G.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Miller, L. S.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Mixon, D. G.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Mizoguchi, A.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Motoike, T.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Mourad, P. D.

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

O’Kelly, P.

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

Oh, S. J.

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

Orlando, A. R.

A. R. Orlando, G. P. Gallerano, “Terahertz Radiation Effects and Biological Applications,” J. Infrared Millim. Terahertz Waves 30, 1308–1318 (2009).

Park, G. S.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Park, J.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

K. W. Kim, K. S. Kim, H. Kim, S. H. Lee, J. H. Park, J. H. Han, S. H. Seok, J. Park, Y. Choi, Y. I. Kim, J. K. Han, J. H. Son, “Terahertz dynamic imaging of skin drug absorption,” Opt. Express 20(9), 9476–9484 (2012).
[PubMed]

Park, J. H.

Park, W. Y.

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Park, Y.

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

Parrott, E. P.

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

Payne, J. A.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Pepper, M.

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

Peralta, X.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Perens, E.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Pickwell-Macpherson, E.

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

Pinder, S.

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

Purushotham, A. D.

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

Pye, R. J.

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

Richardson, C. D.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Rivest, B. D.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Roach, W. P.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

Roberson, D.

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Roman, B. L.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Romani, N.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Romanò, M.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Roth, C. C.

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Roth, C. L.

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Saeland, S.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Sassoon, D. J.

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Sato, T. N.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Scarfì, M. R.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Schmuth, M.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Seo, H.

K. Choe, Y. Hwang, H. Seo, P. Kim, “In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes,” J. Biomed. Opt. 18(3), 036005 (2013).
[CrossRef] [PubMed]

Seok, S. H.

Shevela, E. Y.

V. I. Fedorov, A. G. Khamoyan, E. Y. Shevela, E. R. Chernykh, “Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine,” Proc. SPIE 6734, 673404 (2007).
[CrossRef]

Shumyatsky, P.

P. Shumyatsky, R. R. Alfano, “Terahertz sources,” J. Biomed. Opt. 16(3), 033001 (2011).
[CrossRef] [PubMed]

Siegel, P. H.

P. H. Siegel, “Terahertz technology in biology and medicine,” IEEE Trans. Microw. Theory Tech. 52(10), 2438–2447 (2004).
[CrossRef]

P. H. Siegel, “Terahertz technology,” IEEE Trans. Microw. Theory Tech. 50(3), 910–928 (2002).
[CrossRef]

Simon, S. I.

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

Singh, R.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Singh, R. S.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Son, J. H.

Stainier, D. Y. R.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Stoitzner, P.

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Stojadinovic, A.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

Suh, J. S.

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

Sun, C. K.

Sung, S.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Sy, S. M.

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

Tarango, M.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

Taylor, Z.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

Taylor, Z. D.

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Tewari, P.

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

Tongue, T.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
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M. Tonouchi, “Cutting-edge terahertz technology,” Nat. Photonics 1(2), 97–105 (2007).
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S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Tsai, Y. F.

Tseng, T. F.

Tsymbal, A. A.

V. F. Kirichuk, A. A. Tsymbal, “Use of Terahertz Electromagnetic Waves for Correcting the Hemostasis Functions,” Med. Tekh. 44(1), 12–16 (2010).
[PubMed]

Vincelette, R. L.

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Vobly, P. D.

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
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Wallace, V. P.

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

Weinstein, B. M.

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

Wilmink, G. J.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

G. J. Wilmink, J. E. Grundt, “Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation,” J. Infrared Millim. Terahertz Waves 32(10), 1074–1122 (2011).
[CrossRef]

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Winebrenner, D. P.

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

Woodward, R. M.

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

Xin, H.

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

Yamashita, H.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
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Yoo, J.

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Yun, S. H.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

Zeni, O.

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

Altern. Lab. Anim. (1)

N. Bourne, R. H. Clothier, M. D’Arienzo, P. Harrison, “The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures,” Altern. Lab. Anim. 36(6), 667–684 (2008).
[PubMed]

Bull. Exp. Biol. Med. (2)

V. F. Kirichuk, N. V. Efimova, E. V. Andronov, “Effect of high power terahertz irradiation on platelet aggregation and behavioral reactions of albino rats,” Bull. Exp. Biol. Med. 148(5), 746–749 (2009).
[CrossRef] [PubMed]

N. P. Bondar, I. L. Kovalenko, D. F. Avgustinovich, A. G. Khamoyan, N. N. Kudryavtseva, “Behavioral effect of terahertz waves in male mice,” Bull. Exp. Biol. Med. 145(4), 401–405 (2008).
[CrossRef] [PubMed]

Genesis (1)

T. Motoike, S. Loughna, E. Perens, B. L. Roman, W. Liao, T. C. Chau, C. D. Richardson, T. Kawate, J. Kuno, B. M. Weinstein, D. Y. R. Stainier, T. N. Sato, “Universal GFP reporter for the study of vascular development,” Genesis 28(2), 75–81 (2000).
[CrossRef] [PubMed]

IEEE Trans. Microw. Theory Tech. (2)

P. H. Siegel, “Terahertz technology,” IEEE Trans. Microw. Theory Tech. 50(3), 910–928 (2002).
[CrossRef]

P. H. Siegel, “Terahertz technology in biology and medicine,” IEEE Trans. Microw. Theory Tech. 52(10), 2438–2447 (2004).
[CrossRef]

J. Biol. Phys. (2)

R. M. Woodward, V. P. Wallace, D. D. Arnone, E. H. Linfield, M. Pepper, “Terahertz pulsed imaging of skin cancer in the time and frequency domain,” J. Biol. Phys. 29(2/3), 257–259 (2003).
[CrossRef] [PubMed]

M. R. Scarfì, M. Romanò, R. Di Pietro, O. Zeni, A. Doria, G. P. Gallerano, E. Giovenale, G. Messina, A. Lai, G. Campurra, D. Coniglio, M. D’Arienzo, “THz exposure of whole blood for the study of biological effects on human lymphocytes,” J. Biol. Phys. 29(2/3), 171–176 (2003).
[CrossRef] [PubMed]

J. Biomed. Opt. (12)

I. Echchgadda, J. A. Grundt, M. Tarango, B. L. Ibey, T. Tongue, M. Liang, H. Xin, G. J. Wilmink, “Using a portable terahertz spectrometer to measure the optical properties of in vivo human skin,” J. Biomed. Opt. 18(12), 120503 (2013).
[CrossRef] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[CrossRef] [PubMed]

P. Shumyatsky, R. R. Alfano, “Terahertz sources,” J. Biomed. Opt. 16(3), 033001 (2011).
[CrossRef] [PubMed]

E. P. Parrott, S. M. Sy, T. Blu, V. P. Wallace, E. Pickwell-Macpherson, “Terahertz pulsed imaging in vivo: measurements and processing methods,” J. Biomed. Opt. 16(10), 106010 (2011).
[CrossRef] [PubMed]

A. J. Fitzgerald, S. Pinder, A. D. Purushotham, P. O’Kelly, P. C. Ashworth, V. P. Wallace, “Classification of terahertz-pulsed imaging data from excised breast tissue,” J. Biomed. Opt. 17(1), 016005 (2012).
[CrossRef] [PubMed]

P. Doradla, K. Alavi, C. Joseph, R. Giles, “Detection of colon cancer by continuous-wave terahertz polarization imaging technique,” J. Biomed. Opt. 18(9), 090504 (2013).
[CrossRef]

P. Tewari, C. P. Kealey, D. B. Bennett, N. Bajwa, K. S. Barnett, R. S. Singh, M. O. Culjat, A. Stojadinovic, W. S. Grundfest, Z. D. Taylor, “In vivo terahertz imaging of rat skin burns,” J. Biomed. Opt. 17(4), 040503 (2012).
[CrossRef] [PubMed]

M. H. Arbab, D. P. Winebrenner, T. C. Dickey, A. T. Chen, M. B. Klein, P. D. Mourad, “Terahertz spectroscopy for the assessment of burn injuries in vivo,” J. Biomed. Opt. 18(7), 077004 (2013).
[CrossRef] [PubMed]

D. B. Bennett, Z. D. Taylor, P. Tewari, R. S. Singh, M. O. Culjat, W. S. Grundfest, D. J. Sassoon, R. D. Johnson, J. P. Hubschman, E. R. Brown, “Terahertz sensing in corneal tissues,” J. Biomed. Opt. 16(5), 057003 (2011).
[CrossRef] [PubMed]

D. Bennett, Z. Taylor, P. Tewari, S. Sung, A. Maccabi, R. Singh, M. Culjat, W. Grundfest, J. P. Hubschman, E. Brown, “Assessment of corneal hydration sensing in the terahertz band: in vivo results at 100 GHz,” J. Biomed. Opt. 17(9), 097008 (2012).
[CrossRef] [PubMed]

K. Jeong, Y. M. Huh, S. H. Kim, Y. Park, J. H. Son, S. J. Oh, J. S. Suh, “Characterization of blood using terahertz waves,” J. Biomed. Opt. 18(10), 107008 (2013).
[CrossRef] [PubMed]

K. Choe, Y. Hwang, H. Seo, P. Kim, “In vivo high spatiotemporal resolution visualization of circulating T lymphocytes in high endothelial venules of lymph nodes,” J. Biomed. Opt. 18(3), 036005 (2013).
[CrossRef] [PubMed]

J. Infrared Millim. Terahertz Waves (2)

A. R. Orlando, G. P. Gallerano, “Terahertz Radiation Effects and Biological Applications,” J. Infrared Millim. Terahertz Waves 30, 1308–1318 (2009).

G. J. Wilmink, J. E. Grundt, “Invited Review Article: Current State of Research on Biological Effects of Terahertz Radiation,” J. Infrared Millim. Terahertz Waves 32(10), 1074–1122 (2011).
[CrossRef]

J. Invest. Dermatol. (2)

M. H. Kim, W. Liu, D. L. Borjesson, F. R. Curry, L. S. Miller, A. L. Cheung, F. T. Liu, R. R. Isseroff, S. I. Simon, “Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging,” J. Invest. Dermatol. 128(7), 1812–1820 (2008).
[CrossRef] [PubMed]

S. Holzmann, C. H. Tripp, M. Schmuth, K. Janke, F. Koch, S. Saeland, P. Stoitzner, N. Romani, “A model system using tape stripping for characterization of langerhans cell-precursors in vivo,” J. Invest. Dermatol. 122(5), 1165–1174 (2004).
[CrossRef] [PubMed]

Lasers Surg. Med. (1)

G. J. Wilmink, B. D. Rivest, C. C. Roth, B. L. Ibey, J. A. Payne, L. X. Cundin, J. E. Grundt, X. Peralta, D. G. Mixon, W. P. Roach, “In Vitro Investigation of the Biological Effects Associated With Human Dermal Fibroblasts Exposed to 2.52 THz Radiation,” Lasers Surg. Med. 43(2), 152–163 (2011).
[PubMed]

Med. Tekh. (1)

V. F. Kirichuk, A. A. Tsymbal, “Use of Terahertz Electromagnetic Waves for Correcting the Hemostasis Functions,” Med. Tekh. 44(1), 12–16 (2010).
[PubMed]

Nat. Methods (2)

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods 7(4), 303–305 (2010).
[CrossRef] [PubMed]

E. Y. Chiang, A. Hidalgo, J. S. Chang, P. S. Frenette, “Imaging receptor microdomains on leukocyte subsets in live mice,” Nat. Methods 4(3), 219–222 (2007).
[CrossRef] [PubMed]

Nat. Photonics (1)

M. Tonouchi, “Cutting-edge terahertz technology,” Nat. Photonics 1(2), 97–105 (2007).
[CrossRef]

Nucl. Instrum. Meth. A (2)

Y. U. Jeong, B. C. Lee, S. K. Kim, S. O. Cho, B. H. Cha, J. Lee, G. M. Kazakevitch, P. D. Vobly, N. G. Gavrilov, V. V. Kubarev, G. N. Kulipanov, “First lasing of the KAERI compact far-infrared free-electron laser driven by a magnetron-based microtron,” Nucl. Instrum. Meth. A 475(1-3), 47–50 (2001).
[CrossRef]

Y. U. Jeong, G. M. Kazakevitch, B. C. Lee, S. O. Cho, J. Yoo, N. G. Gavrilov, V. V. Kubarev, “Upgrade of a compact FIR FEL driven by a magnetron-based microtron for the wavelength range of 100-300 mu m,” Nucl. Instrum. Meth. A 507(1-2), 125–128 (2003).
[CrossRef]

Opt. Express (4)

Proc. SPIE (3)

V. I. Fedorov, A. G. Khamoyan, E. Y. Shevela, E. R. Chernykh, “Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine,” Proc. SPIE 6734, 673404 (2007).
[CrossRef]

G. J. Wilmink, B. D. Rivest, B. L. Ibey, C. L. Roth, J. Bernhard, W. P. Roach, “Quantitative investigation of the bioeffects associated with terahertz radiation,” Proc. SPIE 7562, 75620L (2010).
[CrossRef]

G. J. Wilmink, B. L. Ibey, C. L. Roth, R. L. Vincelette, B. D. Rivest, C. B. Horn, J. Bernhard, D. Roberson, W. P. Roach, “Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures,” Proc. SPIE 7562, 75620K (2010).
[CrossRef]

Radiology (1)

A. J. Fitzgerald, V. P. Wallace, M. Jimenez-Linan, L. Bobrow, R. J. Pye, A. D. Purushotham, D. D. Arnone, “Terahertz pulsed imaging of human breast tumors,” Radiology 239(2), 533–540 (2006).
[CrossRef] [PubMed]

Sci. Rep. (1)

K. T. Kim, J. Park, S. J. Jo, S. Jung, O. S. Kwon, G. P. Gallerano, W. Y. Park, G. S. Park, “High-power femtosecond-terahertz pulse induces a wound response in mouse skin,” Sci. Rep. 3, 2296 (2013).
[PubMed]

Other (2)

Y.-S. Lee, Principles of Terahertz Science and Technology, (Springer, 2008), Chap. 3.

C. S. Joseph, R. Patel, V. A. Neel, R. H. Giles, and A. N. Yaroslavsky, “Imaging of ex vivo nonmelanoma skin cancers in the optical and terahertz spectral regions Optical and Terahertz skin cancers imaging,” J. Biophotonics (2012).

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Figures (5)

Fig. 1
Fig. 1

THz wave generation and irradiation setup, (a) Schematics, (b) Photograph of the THz irradiation setup. A live anesthetized mouse was placed on the animal holder fixed to a motorized 3D stage.

Fig. 2
Fig. 2

High precision THz wave irradiation setup for mouse model, (a) Photograph of the setup, (b) Photographs of the focus mask holder (top), the focus mask holder inserted with the focus mask (middle), and the animal holder placed against the focus mask holder (bottom), (c) Microscopic picture of mouse ear skin showing distinctive blood vessel pattern identified for repetitive imaging analysis. (d) Microscopic picture of mouse ear skin attached against the vertical plate of the animal holder. Distinctive blood vessel pattern identical to the area in (c) marked by dotted circle was clearly visible through 2 mm diameter hole of the vertical plate of the animal holder.

Fig. 3
Fig. 3

Schematic of custom-built intravital laser-scanning confocal Microscopy: DBS, dichroic beam splitter; BPF, band pass filter; M, mirror; PMT, photomultiplier tube. Photograph shows the preparation of an anesthetized live mouse for ear skin imaging, in vivo.

Fig. 4
Fig. 4

(a) Distribution of neutrophils in the ear skin of a live mouse before and after THz wave irradiation, Gr-1 + neutrophil (red), Tie2 + blood vessel (green) and autofluorescent hair follicle (magenta). (b) Magnified images of the skin area marked by dotted line in (a). (c) Gr-1 + neutrophil density in the THz wave irradiated and non-irradiated skin. Scale bars are (a) 250 μm and (b) 50 μm, respectively.

Fig. 5
Fig. 5

Hematoxylin and Eosin (H&E)-stained microscope images from THz wave non-irradiated (left) and irradiated (right) ear skin harvested at 6 hours after THz wave irradiation. In the dermis, the increased number of inflammatory cells, neutrophils, was observed (arrowhead). In the epidermis, no definitely damaged cells or atypical keratinocytes were found. Also, no differences in the sebaceous gland or in the auricular cartilage were observed.

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