Abstract

Magnetomotive optical coherence tomography (MM-OCT) is a functional extension of OCT which utilizes magnetically responsive materials that are modulated by an external magnetic field for contrast enhancement and for elastography to assess the structural and viscoelastic properties of the surrounding tissues. Traditionally, magnetomotive contrast relies on the interaction between the displacement of magnetic particles induced by an external magnetic field and the micro-environmental restoring (elastic) force acting on the particles. When the restoring force from a sample containing magnetic particles is weak or non-existent, the MM-OCT signal-to-noise ratio (SNR) can degrade significantly. We have developed a novel solenoid configuration to enable MM-OCT imaging in samples that do not have an elastic restoring force, such as liquids. This coil configuration may potentially enable real-time MM-OCT imaging.

© 2013 OSA

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  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
    [CrossRef] [PubMed]
  2. E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, “High-speed optical coherence domain reflectometry,” Opt. Lett.17(2), 151–153 (1992).
    [CrossRef] [PubMed]
  3. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,” Opt. Lett.21(7), 543–545 (1996).
    [CrossRef] [PubMed]
  4. A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express13(17), 6597–6614 (2005).
    [CrossRef] [PubMed]
  5. A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, “Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues,” Opt. Express16(15), 11525–11539 (2008).
    [PubMed]
  6. S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt.10(4), 041208 (2005).
    [CrossRef] [PubMed]
  7. R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
    [CrossRef] [PubMed]
  8. A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, “Imaging magnetically labeled cells with magnetomotive optical coherence tomography,” Opt. Lett.30(7), 747–749 (2005).
    [CrossRef] [PubMed]
  9. J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Hemoglobin contrast in magnetomotive optical Doppler tomography,” Opt. Lett.31(6), 778–780 (2006).
    [CrossRef] [PubMed]
  10. J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
    [CrossRef] [PubMed]
  11. R. John, E. J. Chaney, and S. A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron.16(3), 691–697 (2010).
    [CrossRef]
  12. V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express17(25), 23114–23122 (2009).
    [CrossRef] [PubMed]
  13. A. L. Oldenburg and S. A. Boppart, “Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography,” Phys. Med. Biol.55(4), 1189–1201 (2010).
    [CrossRef] [PubMed]
  14. G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
    [CrossRef] [PubMed]
  15. M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
    [CrossRef] [PubMed]
  16. F. J. Toublan, S. A. Boppart, and K. S. Suslick, “Tumor targeting by surface-modified protein microspheres,” J. Am. Chem. Soc.128(11), 3472–3473 (2006).
    [CrossRef] [PubMed]
  17. R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
    [CrossRef] [PubMed]
  18. T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. Toublan, K. S. Suslick, and S. A. Boppart, “Engineered microsphere contrast agents for optical coherence tomography,” Opt. Lett.28(17), 1546–1548 (2003).
    [CrossRef] [PubMed]
  19. M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
    [CrossRef] [PubMed]
  20. J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
    [CrossRef] [PubMed]

2012

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

2011

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

2010

R. John, E. J. Chaney, and S. A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron.16(3), 691–697 (2010).
[CrossRef]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

A. L. Oldenburg and S. A. Boppart, “Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography,” Phys. Med. Biol.55(4), 1189–1201 (2010).
[CrossRef] [PubMed]

2009

2008

A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, “Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues,” Opt. Express16(15), 11525–11539 (2008).
[PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

2007

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
[CrossRef] [PubMed]

2006

F. J. Toublan, S. A. Boppart, and K. S. Suslick, “Tumor targeting by surface-modified protein microspheres,” J. Am. Chem. Soc.128(11), 3472–3473 (2006).
[CrossRef] [PubMed]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Hemoglobin contrast in magnetomotive optical Doppler tomography,” Opt. Lett.31(6), 778–780 (2006).
[CrossRef] [PubMed]

2005

2003

1996

1992

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Adie, S. G.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

Bartlett, L. A.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Boppart, S. A.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

A. L. Oldenburg and S. A. Boppart, “Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography,” Phys. Med. Biol.55(4), 1189–1201 (2010).
[CrossRef] [PubMed]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

R. John, E. J. Chaney, and S. A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron.16(3), 691–697 (2010).
[CrossRef]

V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express17(25), 23114–23122 (2009).
[CrossRef] [PubMed]

A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, “Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues,” Opt. Express16(15), 11525–11539 (2008).
[PubMed]

F. J. Toublan, S. A. Boppart, and K. S. Suslick, “Tumor targeting by surface-modified protein microspheres,” J. Am. Chem. Soc.128(11), 3472–3473 (2006).
[CrossRef] [PubMed]

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt.10(4), 041208 (2005).
[CrossRef] [PubMed]

A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, “Imaging magnetically labeled cells with magnetomotive optical coherence tomography,” Opt. Lett.30(7), 747–749 (2005).
[CrossRef] [PubMed]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express13(17), 6597–6614 (2005).
[CrossRef] [PubMed]

T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. Toublan, K. S. Suslick, and S. A. Boppart, “Engineered microsphere contrast agents for optical coherence tomography,” Opt. Lett.28(17), 1546–1548 (2003).
[CrossRef] [PubMed]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,” Opt. Lett.21(7), 543–545 (1996).
[CrossRef] [PubMed]

Bouma, B. E.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,” Opt. Lett.21(7), 543–545 (1996).
[CrossRef] [PubMed]

Brezinski, M. E.

Chaney, E. J.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

R. John, E. J. Chaney, and S. A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron.16(3), 691–697 (2010).
[CrossRef]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Condit, C.

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

Crecea, V.

Desjardins, A. E.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Emelianov, S.

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

Emelianov, S. Y.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Feldman, M. D.

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Freilich, M. I.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Fujimoto, J. G.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Gunther, J. R.

Haldar, J. P.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

Hee, M. R.

E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, “High-speed optical coherence domain reflectometry,” Opt. Lett.17(2), 151–153 (1992).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Huang, D.

E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, “High-speed optical coherence domain reflectometry,” Opt. Lett.17(2), 151–153 (1992).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Jaffer, F. A.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

John, R.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

R. John, E. J. Chaney, and S. A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron.16(3), 691–697 (2010).
[CrossRef]

Johnston, K. P.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Kim, J.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
[CrossRef] [PubMed]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Hemoglobin contrast in magnetomotive optical Doppler tomography,” Opt. Lett.31(6), 778–780 (2006).
[CrossRef] [PubMed]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

Kolbeck, K. J.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

Lee, T. M.

Liang, X.

Lin, C. P.

E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, “High-speed optical coherence domain reflectometry,” Opt. Lett.17(2), 151–153 (1992).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Luo, W.

Ma, L. L.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Marjanovic, M.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

Marks, D. L.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt.10(4), 041208 (2005).
[CrossRef] [PubMed]

T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. Toublan, K. S. Suslick, and S. A. Boppart, “Engineered microsphere contrast agents for optical coherence tomography,” Opt. Lett.28(17), 1546–1548 (2003).
[CrossRef] [PubMed]

Mehrmohammadi, M.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Milner, T. E.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
[CrossRef] [PubMed]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Hemoglobin contrast in magnetomotive optical Doppler tomography,” Opt. Lett.31(6), 778–780 (2006).
[CrossRef] [PubMed]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

Nadkarni, S. K.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

Nelson, J. S.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
[CrossRef] [PubMed]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Hemoglobin contrast in magnetomotive optical Doppler tomography,” Opt. Lett.31(6), 778–780 (2006).
[CrossRef] [PubMed]

Nguyen, F. T.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

Oh, J.

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
[CrossRef] [PubMed]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Hemoglobin contrast in magnetomotive optical Doppler tomography,” Opt. Lett.31(6), 778–780 (2006).
[CrossRef] [PubMed]

Oh, W. Y.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Oldenburg, A. L.

A. L. Oldenburg and S. A. Boppart, “Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography,” Phys. Med. Biol.55(4), 1189–1201 (2010).
[CrossRef] [PubMed]

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

V. Crecea, A. L. Oldenburg, X. Liang, T. S. Ralston, and S. A. Boppart, “Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials,” Opt. Express17(25), 23114–23122 (2009).
[CrossRef] [PubMed]

A. L. Oldenburg, V. Crecea, S. A. Rinne, and S. A. Boppart, “Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues,” Opt. Express16(15), 11525–11539 (2008).
[PubMed]

A. L. Oldenburg, J. R. Gunther, and S. A. Boppart, “Imaging magnetically labeled cells with magnetomotive optical coherence tomography,” Opt. Lett.30(7), 747–749 (2005).
[CrossRef] [PubMed]

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt.10(4), 041208 (2005).
[CrossRef] [PubMed]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express13(17), 6597–6614 (2005).
[CrossRef] [PubMed]

T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. Toublan, K. S. Suslick, and S. A. Boppart, “Engineered microsphere contrast agents for optical coherence tomography,” Opt. Lett.28(17), 1546–1548 (2003).
[CrossRef] [PubMed]

Puliafito, C. A.

E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, “High-speed optical coherence domain reflectometry,” Opt. Lett.17(2), 151–153 (1992).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Qu, M.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Ralston, T. S.

Rezaeipoor, R.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

Rinne, S. A.

Romanovicz, D. K.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Rosenberg, M.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Shishkov, M.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Sitafalwalla, S.

Sokolov, K. V.

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

Southern, J. F.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Suslick, K. S.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

F. J. Toublan, S. A. Boppart, and K. S. Suslick, “Tumor targeting by surface-modified protein microspheres,” J. Am. Chem. Soc.128(11), 3472–3473 (2006).
[CrossRef] [PubMed]

A. L. Oldenburg, F. J. J. Toublan, K. S. Suslick, A. Wei, and S. A. Boppart, “Magnetomotive contrast for in vivo optical coherence tomography,” Opt. Express13(17), 6597–6614 (2005).
[CrossRef] [PubMed]

T. M. Lee, A. L. Oldenburg, S. Sitafalwalla, D. L. Marks, W. Luo, F. J. Toublan, K. S. Suslick, and S. A. Boppart, “Engineered microsphere contrast agents for optical coherence tomography,” Opt. Lett.28(17), 1546–1548 (2003).
[CrossRef] [PubMed]

Suter, M. J.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Sutton, B. P.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

Swanson, E. A.

E. A. Swanson, D. Huang, M. R. Hee, J. G. Fujimoto, C. P. Lin, and C. A. Puliafito, “High-speed optical coherence domain reflectometry,” Opt. Lett.17(2), 151–153 (1992).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Tanaka, A.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

Tearney, G. J.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, “Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,” Opt. Lett.21(7), 543–545 (1996).
[CrossRef] [PubMed]

Toublan, F. J.

Toublan, F. J. J.

Vakoc, B. J.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Waxman, S.

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

Wei, A.

Weissman, N. J.

Weisz, G.

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

Xu, C.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt.10(4), 041208 (2005).
[CrossRef] [PubMed]

IEEE J. Sel. Top. Quantum Electron.

R. John, E. J. Chaney, and S. A. Boppart, “Dynamics of magnetic nanoparticle-based contrast agents in tissues tracked using magnetomotive optical coherence tomography,” IEEE J. Sel. Top. Quantum Electron.16(3), 691–697 (2010).
[CrossRef]

J. Am. Chem. Soc.

F. J. Toublan, S. A. Boppart, and K. S. Suslick, “Tumor targeting by surface-modified protein microspheres,” J. Am. Chem. Soc.128(11), 3472–3473 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Marks, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt.10(4), 041208 (2005).
[CrossRef] [PubMed]

JACC Cardiovasc. Imaging

G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W. Y. Oh, L. A. Bartlett, M. Rosenberg, and B. E. Bouma, “Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging,” JACC Cardiovasc. Imaging1(6), 752–761 (2008).
[CrossRef] [PubMed]

M. J. Suter, S. K. Nadkarni, G. Weisz, A. Tanaka, F. A. Jaffer, B. E. Bouma, and G. J. Tearney, “Intravascular optical imaging technology for investigating the coronary artery,” JACC Cardiovasc. Imaging4(9), 1022–1039 (2011).
[CrossRef] [PubMed]

Mol. Imaging Biol.

R. John, F. T. Nguyen, K. J. Kolbeck, E. J. Chaney, M. Marjanovic, K. S. Suslick, and S. A. Boppart, “Targeted multifunctional multimodal protein-shell microspheres as cancer imaging contrast agents,” Mol. Imaging Biol.14(1), 17–24 (2012).
[CrossRef] [PubMed]

Nanotechnology

J. Kim, J. Oh, T. E. Milner, and J. S. Nelson, “Imaging nanoparticle flow using magneto-motive optical Doppler tomography,” Nanotechnology18(3), 035504 (2007).
[CrossRef] [PubMed]

M. Mehrmohammadi, M. Qu, L. L. Ma, D. K. Romanovicz, K. P. Johnston, K. V. Sokolov, and S. Y. Emelianov, “Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles,” Nanotechnology22(41), 415105 (2011).
[CrossRef] [PubMed]

J. Oh, M. D. Feldman, J. Kim, C. Condit, S. Emelianov, and T. E. Milner, “Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound,” Nanotechnology17(16), 4183–4190 (2006).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys. Med. Biol.

A. L. Oldenburg and S. A. Boppart, “Resonant acoustic spectroscopy of soft tissues using embedded magnetomotive nanotransducers and optical coherence tomography,” Phys. Med. Biol.55(4), 1189–1201 (2010).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A.

R. John, R. Rezaeipoor, S. G. Adie, E. J. Chaney, A. L. Oldenburg, M. Marjanovic, J. P. Haldar, B. P. Sutton, and S. A. Boppart, “In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes,” Proc. Natl. Acad. Sci. U.S.A.107(18), 8085–8090 (2010).
[CrossRef] [PubMed]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

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