Real-time visualization of 3-D dynamic microscopic objects using optical diffraction tomography

Kyoohyun Kim; Kyung Sang Kim; HyunJoo Park; Jong Chul Ye; YongKeun Park

doi:10.1364/OE.21.032269

Real-time visualization of 3-D dynamic microscopic objects using optical diffraction tomography

Kyoohyun Kim, Kyung Sang Kim, HyunJoo Park, Jong Chul Ye, and YongKeun Park

Optics Express
Vol. 21,
Issue 26,
pp. 32269-32278
(2013)
•https://doi.org/10.1364/OE.21.032269

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Kyoohyun Kim, Kyung Sang Kim, HyunJoo Park, Jong Chul Ye, and YongKeun Park, "Real-time visualization of 3-D dynamic microscopic objects using optical diffraction tomography," Opt. Express 21, 32269-32278 (2013)

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Related Topics
Table of Contents Category
- Microscopy
Optics & Photonics Topics
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The topics in this list come from the OSA Optics and Photonics Topics applied to this article.
Previously assigned OCIS codes
- Medical optics and biotechnology (170.0170)
- Three-dimensional microscopy (180.6900)

About this Article
History
- Original Manuscript: October 7, 2013
- Revised Manuscript: November 30, 2013
- Manuscript Accepted: December 13, 2013
- Published: December 19, 2013
Virtual Issues
Virtual Journal for Biomedical Optics Vol. 9, Iss. 2

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Open Access

Abstract

3-D refractive index (RI) distribution is an intrinsic bio-marker for the chemical and structural information about biological cells. Here we develop an optical diffraction tomography technique for the real-time reconstruction of 3-D RI distribution, employing sparse angle illumination and a graphic processing unit (GPU) implementation. The execution time for the tomographic reconstruction is 0.21 s for 96³ voxels, which is 17 times faster than that of a conventional approach. We demonstrated the real-time visualization capability with imaging the dynamics of Brownian motion of an anisotropic colloidal dimer and the dynamic shape change in a red blood cell upon shear flow.

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[Crossref] [PubMed]
G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]
Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[Crossref] [PubMed]
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[Crossref] [PubMed]
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[Crossref] [PubMed]
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[Crossref] [PubMed]
G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]
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[Crossref] [PubMed]
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[Crossref] [PubMed]
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[Crossref] [PubMed]
K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

2014 (1)

K. Kim, H. Yoon, M. Diez-Silva, M. Dao, R. R. Dasari, and Y. Park, “High-resolution three-dimensional imaging of red blood cells parasitized by Plasmodium falciparum and in situ hemozoin crystals using optical diffraction tomography,” J. Biomed. Opt. 19(1), 011005 (2014).
[Crossref] [PubMed]

2013 (5)

K. Lee, K. Kim, J. Jung, J. H. Heo, S. Cho, S. Lee, G. Chang, Y. J. Jo, H. Park, and Y. K. Park, “Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications,” Sensors (Basel) 13(4), 4170–4191 (2013).
[Crossref] [PubMed]

T. Wu and J. J. Feng, “Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage,” Biomicrofluidics 7, 044115 (2013).

J. Fung and V. N. Manoharan, “Holographic Measurements of Anisotropic Three-Dimensional Diffusion of Colloidal Clusters,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 88(2), 020302 (2013).
[Crossref] [PubMed]

J. H. Jung, J. Jang, and Y. Park, “Spectro-refractometry of individual microscopic objects using swept-source quantitative phase imaging,” Anal. Chem. 85(21), 10519–10525 (2013).
[Crossref] [PubMed]

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

2012 (12)

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

M. Rinehart, Y. Z. Zhu, and A. Wax, “Quantitative phase spectroscopy,” Biomed. Opt. Express 3(5), 958–965 (2012).
[Crossref] [PubMed]

Y. Jang, J. Jang, and Y. Park, “Dynamic spectroscopic phase microscopy for quantifying hemoglobin concentration and dynamic membrane fluctuation in red blood cells,” Opt. Express 20(9), 9673–9681 (2012).
[Crossref] [PubMed]

B. Bhaduri and G. Popescu, “Derivative method for phase retrieval in off-axis quantitative phase imaging,” Opt. Lett. 37(11), 1868–1870 (2012).
[Crossref] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, and Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[Crossref] [PubMed]

X. J. Li, P. M. Vlahovska, and G. E. Karniadakis, “Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease,” Soft Matter 9(1), 28–37 (2012).
[Crossref] [PubMed]

H. S. Byun, T. R. Hillman, J. M. Higgins, M. Diez-Silva, Z. Peng, M. Dao, R. R. Dasari, S. Suresh, and Y. K. Park, “Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient,” Acta Biomater. 8(11), 4130–4138 (2012).
[Crossref] [PubMed]

S. Oh, C. Fang-Yen, W. Choi, Z. Yaqoob, D. Fu, Y. K. Park, R. R. Dassari, and M. S. Feld, “Label-Free Imaging of Membrane Potential Using Membrane Electromotility,” Biophys. J. 103(1), 11–18 (2012).
[Crossref] [PubMed]

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[Crossref] [PubMed]

K. V. Edmond, M. T. Elsesser, G. L. Hunter, D. J. Pine, and E. R. Weeks, “Decoupling of rotational and translational diffusion in supercooled colloidal fluids,” Proc. Natl. Acad. Sci. U.S.A. 109(44), 17891–17896 (2012).
[Crossref] [PubMed]

K. G. Phillips, S. L. Jacques, and O. J. T. McCarty, “Measurement of Single Cell Refractive Index, Dry Mass, Volume, and Density Using a Transillumination Microscope,” Phys. Rev. Lett. 109(11), 118105 (2012).
[Crossref] [PubMed]

Y. Sung, W. Choi, N. Lue, R. R. Dasari, and Z. Yaqoob, “Stain-Free Quantification of Chromosomes in Live Cells Using Regularized Tomographic Phase Microscopy,” PLoS ONE 7(11), e49502 (2012).
[Crossref] [PubMed]

2011 (10)

R. Chandramohanadas, Y. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[Crossref] [PubMed]

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

B. Kaoui, N. Tahiri, T. Biben, H. Ez-Zahraouy, A. Benyoussef, G. Biros, and C. Misbah, “Complexity of vesicle microcirculation,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 84(4), 041906 (2011).
[Crossref] [PubMed]

Y. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[Crossref] [PubMed]

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[Crossref] [PubMed]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Z. Wang, L. Millet, M. Mir, H. F. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
[Crossref] [PubMed]

J. Fung, K. E. Martin, R. W. Perry, D. M. Kaz, R. McGorty, and V. N. Manoharan, “Measuring translational, rotational, and vibrational dynamics in colloids with digital holographic microscopy,” Opt. Express 19(9), 8051–8065 (2011).
[Crossref] [PubMed]

H. Pham, H. F. Ding, N. Sobh, M. Do, S. Patel, and G. Popescu, “Off-axis quantitative phase imaging processing using CUDA: toward real-time applications,” Biomed. Opt. Express 2(7), 1781–1793 (2011).
[Crossref] [PubMed]

S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[Crossref] [PubMed]

2010 (4)

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[Crossref] [PubMed]

Y. K. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[Crossref] [PubMed]

Y. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[Crossref] [PubMed]

2009 (3)

Y. J. Sung, W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Optical diffraction tomography for high resolution live cell imaging,” Opt. Express 17(1), 266–277 (2009).
[Crossref] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[Crossref] [PubMed]

2008 (5)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

A. M. Bruckstein, M. Elad, and M. Zibulevsky, “On the Uniqueness of Nonnegative Sparse Solutions to Underdetermined Systems of Equations,” IEEE Trans. Inf. Theory 54(11), 4813–4820 (2008).
[Crossref]

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S. J. LaRoque, E. Y. Sidky, and X. Pan, “Accurate image reconstruction from few-view and limited-angle data in diffraction tomography,” J. Opt. Soc. Am. A 25(7), 1772–1782 (2008).
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2007 (2)

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
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D. Mukhija and M. J. Solomon, “Translational and rotational dynamics of colloidal rods by direct visualization with confocal microscopy,” J. Colloid Interface Sci. 314(1), 98–106 (2007).
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2006 (3)

S. A. Alexandrov, T. R. Hillman, T. Gutzler, and D. D. Sampson, “Synthetic aperture fourier holographic optical microscopy,” Phys. Rev. Lett. 97(16), 168102 (2006).
[Crossref] [PubMed]

F. Charrière, A. Marian, F. Montfort, J. Kuehn, T. Colomb, E. Cuche, P. Marquet, and C. Depeursinge, “Cell refractive index tomography by digital holographic microscopy,” Opt. Lett. 31(2), 178–180 (2006).
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Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

2005 (1)

J. A. Conchello and J. W. Lichtman, “Optical sectioning microscopy,” Nat. Methods 2(12), 920–931 (2005).
[Crossref] [PubMed]

2003 (1)

D. J. Stephens and V. J. Allan, “Light Microscopy Techniques for Live Cell Imaging,” Science 300(5616), 82–86 (2003).
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2002 (1)

V. Lauer, “New approach to optical diffraction tomography yielding a vector equation of diffraction tomography and a novel tomographic microscope,” J. Microsc. 205(2), 165–176 (2002).
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2000 (1)

E. Cuche, P. Marquet, and C. Depeursinge, “Spatial filtering for zero-order and twin-image elimination in digital off-axis holography,” Appl. Opt. 39(23), 4070–4075 (2000).
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1974 (1)

N. Mohandas, R. M. Hochmuth, and E. E. Spaeth, “Adhesion of red cells to foreign surfaces in the presence of flow,” J. Biomed. Mater. Res. 8(2), 119–136 (1974).
[Crossref] [PubMed]

1969 (1)

E. Wolf, “Three-dimensional structure determination of semi-transparent objects from holographic data,” Opt. Commun. 1(153), 4 (1969).
[Crossref]

Aiken, M. L.

Alexandrov, S. A.

S. A. Alexandrov, T. R. Hillman, T. Gutzler, and D. D. Sampson, “Synthetic aperture fourier holographic optical microscopy,” Phys. Rev. Lett. 97(16), 168102 (2006).
[Crossref] [PubMed]

Allan, V. J.

D. J. Stephens and V. J. Allan, “Light Microscopy Techniques for Live Cell Imaging,” Science 300(5616), 82–86 (2003).
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Alsayed, A. M.

Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

Auth, T.

Badizadegan, K.

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
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Bailleul, J.

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Best, C. A.

Best-Popescu, C.

Bhaduri, B.

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

B. Bhaduri and G. Popescu, “Derivative method for phase retrieval in off-axis quantitative phase imaging,” Opt. Lett. 37(11), 1868–1870 (2012).
[Crossref] [PubMed]

Biben, T.

Biros, G.

Bruckstein, A. M.

Byun, H. S.

Chandramohanadas, R.

Chang, G.

Charrière, F.

Cho, S.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[Crossref] [PubMed]

Choi, W.

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

Choi, W. S.

Colomb, T.

Conchello, J. A.

J. A. Conchello and J. W. Lichtman, “Optical sectioning microscopy,” Nat. Methods 2(12), 920–931 (2005).
[Crossref] [PubMed]

Cuche, E.

E. Cuche, P. Marquet, and C. Depeursinge, “Spatial filtering for zero-order and twin-image elimination in digital off-axis holography,” Appl. Opt. 39(23), 4070–4075 (2000).
[Crossref] [PubMed]

D’Angelo, J. A.

Dao, M.

Dasari, R.

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

Dasari, R. R.

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

Dassari, R. R.

Debailleul, M.

Debnath, S. K.

S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[Crossref] [PubMed]

Deflores, L.

Depeursinge, C.

E. Cuche, P. Marquet, and C. Depeursinge, “Spatial filtering for zero-order and twin-image elimination in digital off-axis holography,” Appl. Opt. 39(23), 4070–4075 (2000).
[Crossref] [PubMed]

Dickinson, B. L.

Diez-Silva, M.

Ding, H. F.

Do, M.

Douplik, A.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[Crossref] [PubMed]

Edmond, K. V.

Elad, M.

Elsesser, M. T.

Ez-Zahraouy, H.

Fang-Yen, C.

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

Feld, M.

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

Feld, M. S.

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

Feng, J. J.

T. Wu and J. J. Feng, “Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage,” Biomicrofluidics 7, 044115 (2013).

Fiebiger, E.

Fu, D.

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

Fung, J.

Garay, J.

Gillette, M. U.

Golding, I.

Gov, N. S.

Gutzler, T.

S. A. Alexandrov, T. R. Hillman, T. Gutzler, and D. D. Sampson, “Synthetic aperture fourier holographic optical microscopy,” Phys. Rev. Lett. 97(16), 168102 (2006).
[Crossref] [PubMed]

Haeberlé, O.

Han, Y.

Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

Henle, M. L.

Heo, J. H.

Higgins, J. M.

Hillman, T. R.

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

S. A. Alexandrov, T. R. Hillman, T. Gutzler, and D. D. Sampson, “Synthetic aperture fourier holographic optical microscopy,” Phys. Rev. Lett. 97(16), 168102 (2006).
[Crossref] [PubMed]

Hochmuth, R. M.

N. Mohandas, R. M. Hochmuth, and E. E. Spaeth, “Adhesion of red cells to foreign surfaces in the presence of flow,” J. Biomed. Mater. Res. 8(2), 119–136 (1974).
[Crossref] [PubMed]

Holbrow, C. J.

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

Hunter, G. L.

Jacques, S. L.

Jang, J.

Jang, Y.

Jo, Y. J.

Jung, J.

Jung, J. H.

Kaoui, B.

Karniadakis, G. E.

Kaz, D. M.

Kim, S.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[Crossref] [PubMed]

Kim, Y.

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, and Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[Crossref] [PubMed]

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[Crossref] [PubMed]

Kuehn, J.

Kuriabova, T.

LaRoque, S. J.

Lauer, V.

Lee, K.

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

Lee, S.

Levine, A. J.

Li, A.

Li, X. J.

Lichtman, J. W.

J. A. Conchello and J. W. Lichtman, “Optical sectioning microscopy,” Nat. Methods 2(12), 920–931 (2005).
[Crossref] [PubMed]

Liew, K.

Lim, C. T.

Liu, H.

Lubensky, T. C.

Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

Lue, N.

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

Lui, L.

Lykotrafitis, G.

Manoharan, V. N.

Marian, A.

Marquet, P.

E. Cuche, P. Marquet, and C. Depeursinge, “Spatial filtering for zero-order and twin-image elimination in digital off-axis holography,” Appl. Opt. 39(23), 4070–4075 (2000).
[Crossref] [PubMed]

Martin, K. E.

McCarty, O. J. T.

McGorty, R.

Millet, L.

Min, B.

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

Mir, M.

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

Misbah, C.

Mohandas, N.

N. Mohandas, R. M. Hochmuth, and E. E. Spaeth, “Adhesion of red cells to foreign surfaces in the presence of flow,” J. Biomed. Mater. Res. 8(2), 119–136 (1974).
[Crossref] [PubMed]

Montfort, F.

Morales, E.

Mukhija, D.

Nobili, M.

Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

Oh, S.

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

Pan, X.

Park, H.

H. Yu, H. Park, Y. Kim, M. W. Kim, and Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[Crossref] [PubMed]

Park, Y.

K. Lee, H.-D. Kim, K. Kim, Y. Kim, T. R. Hillman, B. Min, and Y. Park, “Synthetic Fourier transform light scattering,” Opt. Express 21(19), 22453–22463 (2013).
[Crossref] [PubMed]

H. Yu, H. Park, Y. Kim, M. W. Kim, and Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[Crossref] [PubMed]

S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[Crossref] [PubMed]

Park, Y. K.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[Crossref] [PubMed]

Park, Y.-K.

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

Patel, S.

Peng, Z.

Perry, R. W.

Pham, H.

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

Phillips, K. G.

Pine, D. J.

Popescu, G.

B. Bhaduri, H. Pham, M. Mir, and G. Popescu, “Diffraction phase microscopy with white light,” Opt. Lett. 37(6), 1094–1096 (2012).
[Crossref] [PubMed]

B. Bhaduri and G. Popescu, “Derivative method for phase retrieval in off-axis quantitative phase imaging,” Opt. Lett. 37(11), 1868–1870 (2012).
[Crossref] [PubMed]

Prasanth, S. G.

Preiser, P. R.

Quinn, D.

Rinehart, M.

M. Rinehart, Y. Z. Zhu, and A. Wax, “Quantitative phase spectroscopy,” Biomed. Opt. Express 3(5), 958–965 (2012).
[Crossref] [PubMed]

Rogers, J.

Safran, S. A.

Sampson, D. D.

S. A. Alexandrov, T. R. Hillman, T. Gutzler, and D. D. Sampson, “Synthetic aperture fourier holographic optical microscopy,” Phys. Rev. Lett. 97(16), 168102 (2006).
[Crossref] [PubMed]

Shen, Z.

Sidky, E. Y.

Simon, B.

Sobh, N.

Solomon, M. J.

Spaeth, E. E.

N. Mohandas, R. M. Hochmuth, and E. E. Spaeth, “Adhesion of red cells to foreign surfaces in the presence of flow,” J. Biomed. Mater. Res. 8(2), 119–136 (1974).
[Crossref] [PubMed]

Stephens, D. J.

D. J. Stephens and V. J. Allan, “Light Microscopy Techniques for Live Cell Imaging,” Science 300(5616), 82–86 (2003).
[Crossref] [PubMed]

Summa, C. M.

Sung, Y.

Sung, Y. J.

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

Suresh, S.

Sydoruk, O.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[Crossref] [PubMed]

Tahiri, N.

Tuchin, V.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[Crossref] [PubMed]

Unarunotai, S.

Vlahovska, P. M.

Wang, Z.

Wax, A.

M. Rinehart, Y. Z. Zhu, and A. Wax, “Quantitative phase spectroscopy,” Biomed. Opt. Express 3(5), 958–965 (2012).
[Crossref] [PubMed]

Weeks, E. R.

Wolf, E.

E. Wolf, “Three-dimensional structure determination of semi-transparent objects from holographic data,” Opt. Commun. 1(153), 4 (1969).
[Crossref]

Wu, T.

T. Wu and J. J. Feng, “Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage,” Biomicrofluidics 7, 044115 (2013).

Yamauchi, T.

Yaqoob, Z.

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[Crossref] [PubMed]

Yodh, A. G.

Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

Yoon, H.

Yu, H.

H. Yu, H. Park, Y. Kim, M. W. Kim, and Y. Park, “Fourier-transform light scattering of individual colloidal clusters,” Opt. Lett. 37(13), 2577–2579 (2012).
[Crossref] [PubMed]

Zhang, J.

Y. Han, A. M. Alsayed, M. Nobili, J. Zhang, T. C. Lubensky, and A. G. Yodh, “Brownian motion of an ellipsoid,” Science 314(5799), 626–630 (2006).
[Crossref] [PubMed]

Zhernovaya, O.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[Crossref] [PubMed]

Zhu, Y. Z.

M. Rinehart, Y. Z. Zhu, and A. Wax, “Quantitative phase spectroscopy,” Biomed. Opt. Express 3(5), 958–965 (2012).
[Crossref] [PubMed]

Zibulevsky, M.

Acta Biomater. (1)

Am. J. Physiol. Cell Physiol. (1)

Anal. Chem. (1)

Appl. Opt. (1)

E. Cuche, P. Marquet, and C. Depeursinge, “Spatial filtering for zero-order and twin-image elimination in digital off-axis holography,” Appl. Opt. 39(23), 4070–4075 (2000).
[Crossref] [PubMed]

Biomed. Opt. Express (3)

D. Fu, W. Choi, Y. J. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[Crossref] [PubMed]

M. Rinehart, Y. Z. Zhu, and A. Wax, “Quantitative phase spectroscopy,” Biomed. Opt. Express 3(5), 958–965 (2012).
[Crossref] [PubMed]

Biomicrofluidics (1)

T. Wu and J. J. Feng, “Simulation of malaria-infected red blood cells in microfluidic channels: Passage and blockage,” Biomicrofluidics 7, 044115 (2013).

Biophys. J. (1)

Blood Cells Mol. Dis. (1)

IEEE Trans. Inf. Theory (1)

J. Biomed. Mater. Res. (1)

N. Mohandas, R. M. Hochmuth, and E. E. Spaeth, “Adhesion of red cells to foreign surfaces in the presence of flow,” J. Biomed. Mater. Res. 8(2), 119–136 (1974).
[Crossref] [PubMed]

J. Biomed. Opt. (2)

C. Fang-Yen, W. Choi, Y. J. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, “Video-rate tomographic phase microscopy,” J. Biomed. Opt. 16(1), 011005 (2011).
[Crossref] [PubMed]

J. Colloid Interface Sci. (1)

J. Immunol. (1)

J. Microsc. (1)

J. Opt. Soc. Am. A (1)

Nat. Methods (2)

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[Crossref] [PubMed]

J. A. Conchello and J. W. Lichtman, “Optical sectioning microscopy,” Nat. Methods 2(12), 920–931 (2005).
[Crossref] [PubMed]

Opt. Commun. (1)

E. Wolf, “Three-dimensional structure determination of semi-transparent objects from holographic data,” Opt. Commun. 1(153), 4 (1969).
[Crossref]

Opt. Express (6)

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Supplementary Material (2)

» Media 1: MPG (2640 KB)

» Media 2: MPG (1064 KB)

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Fig. 1 The schematic diagram of real-time tomography. (a) Experimental setup for illuminating samples from different angles. (b) Retrieved phase of a typical RBC from 10 different illumination angles. (c) Retrieved complex optical fields are transferred to GPU memory, and the 2-D Fourier transform of each complex field is mapped in 3-D Fourier space according to Fourier diffraction theory. (d) An iterative non-negative constraint processing method is implemented for filling the rest of 3-D space. (e) A 3-D inverse Fourier transform yields 3-D complex RI distribution of a RBC. The scale bar in (b) indicates 5 μm.

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Fig. 2 (a) Cross-correlation coefficient of 3-D RI tomograms reconstructed from 500 illuminations and a reduced number of illuminations. The inset shows the same data in log scale. (b) Cross-sectional images of the x-y plane of the reconstructed tomogram with the cross-correlation coefficients as a function of the number of illuminations used for the reconstruction. The red box indicates the tomogram reconstructed with 10 illuminations.

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Fig. 3 3-D rendering of the RI surfaces of (a) a polystyrene bead and (e) a RBC. For visualization purpose, the threshold for the iso-surfaces is set to the 70% of the maximum RI value. (b-d) cross-sectional slices of RI distribution of the polystyrene bead in the x-y, y-z and x-z planes, respectively. (f-h) cross-sectional slices of RI distribution of the RBC in the x-y, y-z and x-z planes, respectively.

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Fig. 4 The real-time measurement and visualization of the 3-D trajectory and orientation of Brownian motion of a PMMA dimer. Colored lines indicate orientation of the dimer in each tomogram. Each color corresponds to the position in the z-axis. Black dashed lines indicate the trajectory of dimer centroids. The dimer in the initial and final positions are indicated as a red and blue isosurface, respectively. Real-time visualization of the Brownian motion of the dimer is presented in Media 1.

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Fig. 5 Reconstructed 3-D RI tomogram for a RBC under a flow rate along the applied flow direction (a). The RBC in (b) stationary fluid, (c) accelerating flow rate with the maximum rate, and (d) decelerating fluid with zero rate. (left) 3D rendering of the RI surfaces of RBCs (three right panels) Optical phase delay of red blood cells in the x-y, x-z and y-z planes, respectively. The dashed lines indicate the initial shape of the RBC. Real-time visualization of the motion of the RBC under the shear flow is also presented in Media 2.

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Tables (1)

Table 1 Computation Time for Tomogram Reconstruction using CPU and GPU

View Table

	CPU		GPU
# of Voxels	Whole views (s)	Few-view (s)	Whole views (s)	Few-view (s)
96³	3.59 ± 0.004	1.38 ± 0.003	3.63 ± 0.022	0.21 ± 0.006
128³	7.38 ± 0.022	3.37 ± 0.006	4.39 ± 0.018	0.34 ± 0.006
256³	47.67 ± 0.260	27.09 ± 0.272	9.95 ± 0.042	2.00 ± 0.004