Abstract

An adaptive optics scanning laser ophthalmoscope (AO-SLO) is adapted to provide optical coherence tomography (OCT) imaging. The AO-SLO function is unchanged. The system uses the same light source, scanning optics, and adaptive optics in both imaging modes. The result is a dual-modal system that can acquire retinal images in both en face and cross-section planes at the single cell level. A new spectral shaping method is developed to reduce the large sidelobes in the coherence profile of the OCT imaging when a non-ideal source is used with a minimal introduction of noise. The technique uses a combination of two existing digital techniques. The thickness and position of the traditionally named inner segment/outer segment junction are measured from individual photoreceptors. In-vivo images of healthy and diseased human retinas are demonstrated.

© 2013 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. R. H. Webb, G. W. Hughes, and O. Pomerantzeff, “Flying spot TV ophthalmoscope,” Appl. Opt. 19(17), 2991–2997 (1980).
    [Crossref] [PubMed]
  2. R. H. Webb, G. W. Hughes, and F. C. Delori, “Confocal scanning laser ophthalmoscope,” Appl. Opt. 26(8), 1492–1499 (1987).
    [Crossref] [PubMed]
  3. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
    [Crossref] [PubMed]
  4. T. Wilson, Confocal Microscopy (Academic Press, 1990).
  5. A. Roorda, “Applications of adaptive optics scanning laser ophthalmoscopy,” Optom. Vis. Sci. 87(4), 260–268 (2010).
    [PubMed]
  6. R. Yadav, K. S. Lee, J. P. Rolland, J. M. Zavislan, J. V. Aquavella, and G. Yoon, “Micrometer axial resolution OCT for corneal imaging,” Biomed. Opt. Express 2(11), 3037–3046 (2011).
    [Crossref] [PubMed]
  7. W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 24(17), 1221–1223 (1999).
    [Crossref] [PubMed]
  8. A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. Hebert, and M. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
    [Crossref] [PubMed]
  9. B. Hermann, E. J. Fernández, A. Unterhuber, H. Sattmann, A. F. Fercher, W. Drexler, P. M. Prieto, and P. Artal, “Adaptive-optics ultrahigh-resolution optical coherence tomography,” Opt. Lett. 29(18), 2142–2144 (2004).
    [Crossref] [PubMed]
  10. W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
    [Crossref] [PubMed]
  11. J. Liang, D. R. Williams, and D. T. Miller, “Supernormal vision and high-resolution retinal imaging through adaptive optics,” J. Opt. Soc. Am. A 14(11), 2884–2892 (1997).
    [Crossref] [PubMed]
  12. Y. Zhang, S. Poonja, and A. Roorda, “MEMS-based adaptive optics scanning laser ophthalmoscopy,” Opt. Lett. 31(9), 1268–1270 (2006).
    [Crossref] [PubMed]
  13. Y. Zhang, S. Poonja, and A. Roorda, AOSLO: from Benchtop to Clinic, M. K. Giles, J. D. Gonglewski, and R. A. Carreras, eds. (2006), Vol. 6306, pp. 63060V1–63060V–11.
  14. S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, “Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope,” J. Opt. Soc. Am. A 24(5), 1313–1326 (2007).
    [Crossref] [PubMed]
  15. D. C. Chen, S. M. Jones, D. A. Silva, and S. S. Olivier, “High-resolution adaptive optics scanning laser ophthalmoscope with dual deformable mirrors,” J. Opt. Soc. Am. A 24(5), 1305–1312 (2007).
    [Crossref]
  16. D. C. Gray, W. Merigan, J. I. Wolfing, B. P. Gee, J. Porter, A. Dubra, T. H. Twietmeyer, K. Ahamd, R. Tumbar, F. Reinholz, and D. R. Williams, “In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells,” Opt. Express 14(16), 7144–7158 (2006).
    [Crossref] [PubMed]
  17. N. M. Putnam, D. X. Hammer, Y. Zhang, D. Merino, and A. Roorda, “Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy,” Opt. Express 18(24), 24902–24916 (2010).
    [Crossref] [PubMed]
  18. A. Dubra and Y. Sulai, “Reflective afocal broadband adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 2(6), 1757–1768 (2011).
    [Crossref] [PubMed]
  19. R. F. Cooper, A. M. Dubis, A. Pavaskar, J. Rha, A. Dubra, and J. Carroll, “Spatial and temporal variation of rod photoreceptor reflectance in the human retina,” Biomed. Opt. Express 2(9), 2577–2589 (2011).
    [Crossref] [PubMed]
  20. A. Dubra, Y. Sulai, J. L. Norris, R. F. Cooper, A. M. Dubis, D. R. Williams, and J. Carroll, “Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 2(7), 1864–1876 (2011).
    [Crossref] [PubMed]
  21. D. Merino, J. L. Duncan, P. Tiruveedhula, and A. Roorda, “Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope,” Biomed. Opt. Express 2(8), 2189–2201 (2011).
    [Crossref] [PubMed]
  22. Y. Zhang, J. Rha, R. Jonnal, and D. Miller, “Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina,” Opt. Express 13(12), 4792–4811 (2005).
    [Crossref] [PubMed]
  23. R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
    [Crossref] [PubMed]
  24. Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
    [Crossref] [PubMed]
  25. R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. Gao, and D. T. Miller, “In vivo functional imaging of human cone photoreceptors,” Opt. Express 15(24), 16141–16160 (2007).
    [Crossref]
  26. R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Oliver, and J. S. Werner, “Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions,” J. Opt. Soc. Am. A 24(5), 1373–1383 (2007).
    [Crossref] [PubMed]
  27. R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, “Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction,” Opt. Express 16(11), 8126–8143 (2008).
    [Crossref] [PubMed]
  28. R. J. Zawadzki, S. M. Jones, S. Pilli, S. Balderas-Mata, D. Y. Kim, S. S. Olivier, and J. S. Werner, “Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging,” Biomed. Opt. Express 2(6), 1674–1686 (2011).
    [Crossref] [PubMed]
  29. E. J. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, “Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina,” Opt. Express 16(15), 11083–11094 (2008).
    [Crossref] [PubMed]
  30. D. T. Miller, O. P. Kocaoglu, Q. Wang, and S. Lee, “Adaptive optics and the eye (super resolution OCT),” Eye (Lond.) 25(3), 321–330 (2011).
    [Crossref] [PubMed]
  31. O. P. Kocaoglu, S. Lee, R. S. Jonnal, Q. Wang, A. E. Herde, J. C. Derby, W. Gao, and D. T. Miller, “Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics,” Biomed. Opt. Express 2(4), 748–763 (2011).
    [Crossref] [PubMed]
  32. J. I. W. Morgan, A. Dubra, R. Wolfe, W. H. Merigan, and D. R. Williams, “In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic,” Invest. Ophthalmol. Vis. Sci. 50(3), 1350–1359 (2008).
    [Crossref] [PubMed]
  33. D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, “Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy,” Opt. Express 14(8), 3345–3353 (2006).
    [Crossref] [PubMed]
  34. M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, “Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography,” Opt. Lett. 33(1), 22–24 (2008).
    [Crossref] [PubMed]
  35. M. Mujat, R. D. Ferguson, A. H. Patel, N. Iftimia, N. Lue, and D. X. Hammer, “High resolution multimodal clinical ophthalmic imaging system,” Opt. Express 18(11), 11607–11621 (2010).
    [Crossref] [PubMed]
  36. M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
    [Crossref] [PubMed]
  37. M. Pircher, E. Götzinger, H. Sattmann, R. A. Leitgeb, and C. K. Hitzenberger, “In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level,” Opt. Express 18(13), 13935–13944 (2010).
    [Crossref] [PubMed]
  38. R. Leitgeb, C. Hitzenberger, and A. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
    [Crossref] [PubMed]
  39. F. Spöler, S. Kray, P. Grychtol, B. Hermes, J. Bornemann, M. Först, and H. Kurz, “Simultaneous dual-band ultra-high resolution optical coherence tomography,” Opt. Express 15(17), 10832–10841 (2007).
    [Crossref] [PubMed]
  40. M. Szkulmowski, M. Wojtkowski, P. Targowski, and A. Kowalczyk, “Spectral shaping and least square iterative deconvolution in spectral OCT,” in Biomedical Optics 2004 (International Society for Optics and Photonics, 2004), pp. 424–431.
  41. M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
    [Crossref]
  42. H. C. Hendargo, M. Zhao, N. Shepherd, and J. A. Izatt, “Synthetic wavelength based phase unwrapping in spectral domain optical coherence tomography,” Opt. Express 17(7), 5039–5051 (2009).
    [Crossref] [PubMed]
  43. P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).
  44. B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
    [Crossref] [PubMed]
  45. Y. Zhang, X. Wang, and J. Wang, “High-Speed Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO),” in ARVO (2010), p. 2311/A561.
  46. Y. Zhang, X. Wang, R. Myers, J. Alexander, T. Ye, A. Roorda, and P. Gamlin, “Broad-Spectrum Adaptive Optics Scanning Laser Ophthalmoscopy,” in IOVS (2011), p. 52:ARVO E–Abstract 5869.
  47. K. Grieve, P. Tiruveedhula, Y. Zhang, and A. Roorda, “Multi-wavelength imaging with the adaptive optics scanning laser Ophthalmoscope,” Opt. Express 14(25), 12230–12242 (2006).
    [Crossref] [PubMed]
  48. P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
    [Crossref] [PubMed]
  49. F. C. Delori, R. H. Webb, D. H. Sliney, and American National Standards Institute, “Maximum permissible exposures for ocular safety (ANSI 2000), with emphasis on ophthalmic devices,” J. Opt. Soc. Am. A 24(5), 1250–1265 (2007).
    [Crossref] [PubMed]
  50. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
    [Crossref] [PubMed]
  51. P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process. 7(1), 27–41 (1998).
    [Crossref] [PubMed]
  52. M. D. Abramoff, P. J. Magalhães, and S. J. J. Ram, “Image processing with ImageJ,” Biophotonics International 11, 36–43 (2004).
  53. S. B. Stevenson and A. Roorda, “Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy,” Proc. SPIE 5688, 145–151 (2005).
    [Crossref]
  54. C. R. Vogel, D. W. Arathorn, A. Roorda, and A. Parker, “Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy,” Opt. Express 14(2), 487–497 (2006).
    [Crossref] [PubMed]
  55. R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
    [Crossref] [PubMed]
  56. C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
    [Crossref] [PubMed]
  57. M. Young, E. Lebed, Y. Jian, P. J. Mackenzie, M. F. Beg, and M. V. Sarunic, “Real-time high-speed volumetric imaging using compressive sampling optical coherence tomography,” Biomed. Opt. Express 2(9), 2690–2697 (2011).
    [Crossref] [PubMed]
  58. R. F. Spaide and C. A. Curcio, “Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model,” Retina 31(8), 1609–1619 (2011).
    [Crossref] [PubMed]
  59. A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
    [Crossref] [PubMed]
  60. R. F. Spaide, “Questioning Optical Coherence Tomography,” Ophthalmology 119, 2203–2204 (2012).
  61. W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res. 27(1), 45–88 (2008).
    [Crossref] [PubMed]
  62. B. Cense, N. Nassif, T. Chen, M. Pierce, S. H. Yun, B. Park, B. Bouma, G. Tearney, and J. de Boer, “Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography,” Opt. Express 12(11), 2435–2447 (2004).
    [Crossref] [PubMed]

2013 (1)

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

2012 (1)

R. F. Spaide, “Questioning Optical Coherence Tomography,” Ophthalmology 119, 2203–2204 (2012).

2011 (11)

D. T. Miller, O. P. Kocaoglu, Q. Wang, and S. Lee, “Adaptive optics and the eye (super resolution OCT),” Eye (Lond.) 25(3), 321–330 (2011).
[Crossref] [PubMed]

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

R. F. Spaide and C. A. Curcio, “Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model,” Retina 31(8), 1609–1619 (2011).
[Crossref] [PubMed]

O. P. Kocaoglu, S. Lee, R. S. Jonnal, Q. Wang, A. E. Herde, J. C. Derby, W. Gao, and D. T. Miller, “Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics,” Biomed. Opt. Express 2(4), 748–763 (2011).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. Pilli, S. Balderas-Mata, D. Y. Kim, S. S. Olivier, and J. S. Werner, “Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging,” Biomed. Opt. Express 2(6), 1674–1686 (2011).
[Crossref] [PubMed]

A. Dubra and Y. Sulai, “Reflective afocal broadband adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 2(6), 1757–1768 (2011).
[Crossref] [PubMed]

A. Dubra, Y. Sulai, J. L. Norris, R. F. Cooper, A. M. Dubis, D. R. Williams, and J. Carroll, “Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 2(7), 1864–1876 (2011).
[Crossref] [PubMed]

D. Merino, J. L. Duncan, P. Tiruveedhula, and A. Roorda, “Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope,” Biomed. Opt. Express 2(8), 2189–2201 (2011).
[Crossref] [PubMed]

R. F. Cooper, A. M. Dubis, A. Pavaskar, J. Rha, A. Dubra, and J. Carroll, “Spatial and temporal variation of rod photoreceptor reflectance in the human retina,” Biomed. Opt. Express 2(9), 2577–2589 (2011).
[Crossref] [PubMed]

M. Young, E. Lebed, Y. Jian, P. J. Mackenzie, M. F. Beg, and M. V. Sarunic, “Real-time high-speed volumetric imaging using compressive sampling optical coherence tomography,” Biomed. Opt. Express 2(9), 2690–2697 (2011).
[Crossref] [PubMed]

R. Yadav, K. S. Lee, J. P. Rolland, J. M. Zavislan, J. V. Aquavella, and G. Yoon, “Micrometer axial resolution OCT for corneal imaging,” Biomed. Opt. Express 2(11), 3037–3046 (2011).
[Crossref] [PubMed]

2010 (4)

2009 (1)

2008 (8)

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, “Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography,” Opt. Lett. 33(1), 22–24 (2008).
[Crossref] [PubMed]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, “Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction,” Opt. Express 16(11), 8126–8143 (2008).
[Crossref] [PubMed]

E. J. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, “Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina,” Opt. Express 16(15), 11083–11094 (2008).
[Crossref] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
[Crossref] [PubMed]

J. I. W. Morgan, A. Dubra, R. Wolfe, W. H. Merigan, and D. R. Williams, “In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic,” Invest. Ophthalmol. Vis. Sci. 50(3), 1350–1359 (2008).
[Crossref] [PubMed]

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res. 27(1), 45–88 (2008).
[Crossref] [PubMed]

R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
[Crossref] [PubMed]

2007 (7)

F. C. Delori, R. H. Webb, D. H. Sliney, and American National Standards Institute, “Maximum permissible exposures for ocular safety (ANSI 2000), with emphasis on ophthalmic devices,” J. Opt. Soc. Am. A 24(5), 1250–1265 (2007).
[Crossref] [PubMed]

D. C. Chen, S. M. Jones, D. A. Silva, and S. S. Olivier, “High-resolution adaptive optics scanning laser ophthalmoscope with dual deformable mirrors,” J. Opt. Soc. Am. A 24(5), 1305–1312 (2007).
[Crossref]

S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, “Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope,” J. Opt. Soc. Am. A 24(5), 1313–1326 (2007).
[Crossref] [PubMed]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Oliver, and J. S. Werner, “Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions,” J. Opt. Soc. Am. A 24(5), 1373–1383 (2007).
[Crossref] [PubMed]

F. Spöler, S. Kray, P. Grychtol, B. Hermes, J. Bornemann, M. Först, and H. Kurz, “Simultaneous dual-band ultra-high resolution optical coherence tomography,” Opt. Express 15(17), 10832–10841 (2007).
[Crossref] [PubMed]

R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. Gao, and D. T. Miller, “In vivo functional imaging of human cone photoreceptors,” Opt. Express 15(24), 16141–16160 (2007).
[Crossref]

M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
[Crossref] [PubMed]

2006 (6)

2005 (4)

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

S. B. Stevenson and A. Roorda, “Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy,” Proc. SPIE 5688, 145–151 (2005).
[Crossref]

Y. Zhang, J. Rha, R. Jonnal, and D. Miller, “Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina,” Opt. Express 13(12), 4792–4811 (2005).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[Crossref] [PubMed]

2004 (3)

2003 (1)

2002 (2)

A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. Hebert, and M. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
[Crossref] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

1999 (1)

1998 (1)

P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process. 7(1), 27–41 (1998).
[Crossref] [PubMed]

1997 (1)

1992 (1)

W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

1990 (1)

C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
[Crossref] [PubMed]

1987 (1)

1980 (1)

Abramoff, M. D.

M. D. Abramoff, P. J. Magalhães, and S. J. J. Ram, “Image processing with ImageJ,” Biophotonics International 11, 36–43 (2004).

Ahamd, K.

Ahnelt, P. K.

An, L.

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Aquavella, J. V.

Arathorn, D. W.

Artal, P.

Ashman, R.

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

Bajraszewski, T.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

Balderas-Mata, S.

Baumann, B.

Bedggood, P.

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

Beg, M. F.

Bird, A. C.

W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
[Crossref] [PubMed]

Boppart, S. A.

Bornemann, J.

Bouma, B.

Bower, B. A.

Bradu, A.

Burns, S. A.

Cable, A.

Campbell, M.

Capps, A. G.

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

Carroll, J.

Cense, B.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chen, D. C.

Chen, T.

Chen, Y.

Choi, S.

Choi, S. S.

Cooper, R. F.

Curcio, C. A.

R. F. Spaide and C. A. Curcio, “Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model,” Retina 31(8), 1609–1619 (2011).
[Crossref] [PubMed]

C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
[Crossref] [PubMed]

Daaboul, M.

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

Dainty, C.

de Boer, J.

Delori, F. C.

Derby, J. C.

Donnelly Iii, W.

Drexler, W.

Dubis, A. M.

Dubra, A.

Duncan, J. L.

Elsner, A. E.

et,

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Evans, J. W.

Fercher, A.

Fercher, A. F.

B. Hermann, E. J. Fernández, A. Unterhuber, H. Sattmann, A. F. Fercher, W. Drexler, P. M. Prieto, and P. Artal, “Adaptive-optics ultrahigh-resolution optical coherence tomography,” Opt. Lett. 29(18), 2142–2144 (2004).
[Crossref] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

Ferguson, D.

Ferguson, R. D.

Fernández, E. J.

Fitzke, F. W.

W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Först, M.

Fujimoto, J. G.

Gao, W.

Gee, B. P.

Gorczynska, I.

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
[Crossref] [PubMed]

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

Götzinger, E.

Gray, D. C.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Grieve, K.

Grychtol, P.

Hammer, D. X.

Hebert, T.

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hendargo, H. C.

Hendrickson, A. E.

C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
[Crossref] [PubMed]

Herde, A. E.

Hermann, B.

Hermes, B.

Hitzenberger, C.

Hitzenberger, C. K.

Hofer, B.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hughes, G. W.

Hunter, A. A.

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

Iftimia, N.

Ippen, E. P.

Izatt, J. A.

Jian, Y.

Jiang, J.

Jones, S.

Jones, S. M.

Jonnal, R.

Jonnal, R. S.

Kalina, R. E.

C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
[Crossref] [PubMed]

Kärtner, F. X.

Kim, D. Y.

Kocaoglu, O. P.

Koizumi, H.

R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
[Crossref] [PubMed]

Kowalczyk, A.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

Kray, S.

Kurz, H.

Laut, S.

Lebed, E.

Lee, K. S.

Lee, S.

Leitgeb, R.

R. Leitgeb, C. Hitzenberger, and A. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
[Crossref] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

Leitgeb, R. A.

Li, P.

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Li, X. D.

Liang, J.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lin, P. L.

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Lue, N.

Mackenzie, P. J.

Magalhães, P. J.

M. D. Abramoff, P. J. Magalhães, and S. J. J. Ram, “Image processing with ImageJ,” Biophotonics International 11, 36–43 (2004).

Marshall, J.

W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
[Crossref] [PubMed]

Merigan, W.

Merigan, W. H.

J. I. W. Morgan, A. Dubra, R. Wolfe, W. H. Merigan, and D. R. Williams, “In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic,” Invest. Ophthalmol. Vis. Sci. 50(3), 1350–1359 (2008).
[Crossref] [PubMed]

Merino, D.

Metha, A.

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

Miller, D.

Miller, D. T.

Morgan, J. I. W.

J. I. W. Morgan, A. Dubra, R. Wolfe, W. H. Merigan, and D. R. Williams, “In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic,” Invest. Ophthalmol. Vis. Sci. 50(3), 1350–1359 (2008).
[Crossref] [PubMed]

Morgner, U.

Morse, L. S.

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

Mujat, M.

Nassif, N.

Norris, J. L.

Oliver, S. S.

Olivier, S.

Olivier, S. S.

Panorgias, A.

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

Park, B.

Parker, A.

Patel, A. H.

Pavaskar, A.

Pierce, M.

Pilli, S.

Pircher, M.

Pitris, C.

Podoleanu, A. G.

Pomerantzeff, O.

Poonja, S.

Porter, J.

Potsaid, B.

Považay, B.

Pozonni, M. C.

R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
[Crossref] [PubMed]

Pozzoni, M. C.

R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
[Crossref] [PubMed]

Prieto, P. M.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Putnam, N. M.

Queener, H.

Radzewicz, C.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

Ram, S. J. J.

M. D. Abramoff, P. J. Magalhães, and S. J. J. Ram, “Image processing with ImageJ,” Biophotonics International 11, 36–43 (2004).

Reinholz, F.

Rha, J.

Rolland, J. P.

Romero-Borja, F.

Roorda, A.

D. Merino, J. L. Duncan, P. Tiruveedhula, and A. Roorda, “Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope,” Biomed. Opt. Express 2(8), 2189–2201 (2011).
[Crossref] [PubMed]

N. M. Putnam, D. X. Hammer, Y. Zhang, D. Merino, and A. Roorda, “Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy,” Opt. Express 18(24), 24902–24916 (2010).
[Crossref] [PubMed]

A. Roorda, “Applications of adaptive optics scanning laser ophthalmoscopy,” Optom. Vis. Sci. 87(4), 260–268 (2010).
[PubMed]

C. R. Vogel, D. W. Arathorn, A. Roorda, and A. Parker, “Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy,” Opt. Express 14(2), 487–497 (2006).
[Crossref] [PubMed]

Y. Zhang, S. Poonja, and A. Roorda, “MEMS-based adaptive optics scanning laser ophthalmoscopy,” Opt. Lett. 31(9), 1268–1270 (2006).
[Crossref] [PubMed]

K. Grieve, P. Tiruveedhula, Y. Zhang, and A. Roorda, “Multi-wavelength imaging with the adaptive optics scanning laser Ophthalmoscope,” Opt. Express 14(25), 12230–12242 (2006).
[Crossref] [PubMed]

S. B. Stevenson and A. Roorda, “Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy,” Proc. SPIE 5688, 145–151 (2005).
[Crossref]

A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. Hebert, and M. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
[Crossref] [PubMed]

Ruttimann, U. E.

P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process. 7(1), 27–41 (1998).
[Crossref] [PubMed]

Sarunic, M. V.

Sattmann, H.

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Shen, A. T. T.

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Shen, T.

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Shepherd, N.

Silva, D. A.

Sliney, D. H.

Sloan, K. R.

C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
[Crossref] [PubMed]

Smith, G.

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

Spaide, R. F.

R. F. Spaide, “Questioning Optical Coherence Tomography,” Ophthalmology 119, 2203–2204 (2012).

R. F. Spaide and C. A. Curcio, “Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model,” Retina 31(8), 1609–1619 (2011).
[Crossref] [PubMed]

R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
[Crossref] [PubMed]

Spöler, F.

Srinivasan, V. J.

Stevenson, S. B.

S. B. Stevenson and A. Roorda, “Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy,” Proc. SPIE 5688, 145–151 (2005).
[Crossref]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Sulai, Y.

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Szkulmowski, M.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

Targowski, P.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

Tearney, G.

Thévenaz, P.

P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process. 7(1), 27–41 (1998).
[Crossref] [PubMed]

Tiruveedhula, P.

Tumbar, R.

Twietmeyer, T. H.

Unser, M.

P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process. 7(1), 27–41 (1998).
[Crossref] [PubMed]

Unterhuber, A.

Vogel, C. R.

Wang, Q.

Wang, R.

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Wasilewski, W.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

Webb, R. H.

Werner, J. S.

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. Pilli, S. Balderas-Mata, D. Y. Kim, S. S. Olivier, and J. S. Werner, “Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging,” Biomed. Opt. Express 2(6), 1674–1686 (2011).
[Crossref] [PubMed]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, “Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction,” Opt. Express 16(11), 8126–8143 (2008).
[Crossref] [PubMed]

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, “Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography,” Opt. Lett. 33(1), 22–24 (2008).
[Crossref] [PubMed]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Oliver, and J. S. Werner, “Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions,” J. Opt. Soc. Am. A 24(5), 1373–1383 (2007).
[Crossref] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[Crossref] [PubMed]

Williams, D. R.

Wojtkowski, M.

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

Wolfe, R.

J. I. W. Morgan, A. Dubra, R. Wolfe, W. H. Merigan, and D. R. Williams, “In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic,” Invest. Ophthalmol. Vis. Sci. 50(3), 1350–1359 (2008).
[Crossref] [PubMed]

Wolfing, J. I.

Woon, W. H.

W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
[Crossref] [PubMed]

Yadav, R.

Yoon, G.

Young, M.

Yun, S. H.

Zavislan, J. M.

Zawadzki, R. J.

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. Pilli, S. Balderas-Mata, D. Y. Kim, S. S. Olivier, and J. S. Werner, “Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging,” Biomed. Opt. Express 2(6), 1674–1686 (2011).
[Crossref] [PubMed]

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, “Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography,” Opt. Lett. 33(1), 22–24 (2008).
[Crossref] [PubMed]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, “Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction,” Opt. Express 16(11), 8126–8143 (2008).
[Crossref] [PubMed]

R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Oliver, and J. S. Werner, “Adaptive optics-optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions,” J. Opt. Soc. Am. A 24(5), 1373–1383 (2007).
[Crossref] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[Crossref] [PubMed]

Zhang, Y.

N. M. Putnam, D. X. Hammer, Y. Zhang, D. Merino, and A. Roorda, “Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy,” Opt. Express 18(24), 24902–24916 (2010).
[Crossref] [PubMed]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, “Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction,” Opt. Express 16(11), 8126–8143 (2008).
[Crossref] [PubMed]

R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. Gao, and D. T. Miller, “In vivo functional imaging of human cone photoreceptors,” Opt. Express 15(24), 16141–16160 (2007).
[Crossref]

K. Grieve, P. Tiruveedhula, Y. Zhang, and A. Roorda, “Multi-wavelength imaging with the adaptive optics scanning laser Ophthalmoscope,” Opt. Express 14(25), 12230–12242 (2006).
[Crossref] [PubMed]

Y. Zhang, S. Poonja, and A. Roorda, “MEMS-based adaptive optics scanning laser ophthalmoscopy,” Opt. Lett. 31(9), 1268–1270 (2006).
[Crossref] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
[Crossref] [PubMed]

Y. Zhang, J. Rha, R. Jonnal, and D. Miller, “Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina,” Opt. Express 13(12), 4792–4811 (2005).
[Crossref] [PubMed]

Zhao, M.

Am. J. Ophthalmol. (1)

R. F. Spaide, H. Koizumi, M. C. Pozzoni, and M. C. Pozonni, “Enhanced depth imaging spectral-domain optical coherence tomography,” Am. J. Ophthalmol. 146(4), 496–500 (2008).
[Crossref] [PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (9)

R. Yadav, K. S. Lee, J. P. Rolland, J. M. Zavislan, J. V. Aquavella, and G. Yoon, “Micrometer axial resolution OCT for corneal imaging,” Biomed. Opt. Express 2(11), 3037–3046 (2011).
[Crossref] [PubMed]

A. Dubra and Y. Sulai, “Reflective afocal broadband adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 2(6), 1757–1768 (2011).
[Crossref] [PubMed]

R. F. Cooper, A. M. Dubis, A. Pavaskar, J. Rha, A. Dubra, and J. Carroll, “Spatial and temporal variation of rod photoreceptor reflectance in the human retina,” Biomed. Opt. Express 2(9), 2577–2589 (2011).
[Crossref] [PubMed]

A. Dubra, Y. Sulai, J. L. Norris, R. F. Cooper, A. M. Dubis, D. R. Williams, and J. Carroll, “Noninvasive imaging of the human rod photoreceptor mosaic using a confocal adaptive optics scanning ophthalmoscope,” Biomed. Opt. Express 2(7), 1864–1876 (2011).
[Crossref] [PubMed]

D. Merino, J. L. Duncan, P. Tiruveedhula, and A. Roorda, “Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope,” Biomed. Opt. Express 2(8), 2189–2201 (2011).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. Pilli, S. Balderas-Mata, D. Y. Kim, S. S. Olivier, and J. S. Werner, “Integrated adaptive optics optical coherence tomography and adaptive optics scanning laser ophthalmoscope system for simultaneous cellular resolution in vivo retinal imaging,” Biomed. Opt. Express 2(6), 1674–1686 (2011).
[Crossref] [PubMed]

O. P. Kocaoglu, S. Lee, R. S. Jonnal, Q. Wang, A. E. Herde, J. C. Derby, W. Gao, and D. T. Miller, “Imaging cone photoreceptors in three dimensions and in time using ultrahigh resolution optical coherence tomography with adaptive optics,” Biomed. Opt. Express 2(4), 748–763 (2011).
[Crossref] [PubMed]

M. Young, E. Lebed, Y. Jian, P. J. Mackenzie, M. F. Beg, and M. V. Sarunic, “Real-time high-speed volumetric imaging using compressive sampling optical coherence tomography,” Biomed. Opt. Express 2(9), 2690–2697 (2011).
[Crossref] [PubMed]

P. L. Lin, A. T. T. Shen, R. Wang, L. An, P. Li, and T. Shen, “High speed spectral domain optical coherence tomography for retinal imaging at 500,000 A-lines per second,” Biomed. Opt. Express 2, 21–31 (2011).

Biophotonics International (1)

M. D. Abramoff, P. J. Magalhães, and S. J. J. Ram, “Image processing with ImageJ,” Biophotonics International 11, 36–43 (2004).

Br. J. Ophthalmol. (1)

W. H. Woon, F. W. Fitzke, A. C. Bird, and J. Marshall, “Confocal imaging of the fundus using a scanning laser ophthalmoscope,” Br. J. Ophthalmol. 76(8), 470–474 (1992).
[Crossref] [PubMed]

Eye (Lond.) (1)

D. T. Miller, O. P. Kocaoglu, Q. Wang, and S. Lee, “Adaptive optics and the eye (super resolution OCT),” Eye (Lond.) 25(3), 321–330 (2011).
[Crossref] [PubMed]

IEEE Trans. Image Process. (1)

P. Thévenaz, U. E. Ruttimann, and M. Unser, “A pyramid approach to subpixel registration based on intensity,” IEEE Trans. Image Process. 7(1), 27–41 (1998).
[Crossref] [PubMed]

Invest. Ophthalmol. Vis. Sci. (2)

A. Panorgias, R. J. Zawadzki, A. G. Capps, A. A. Hunter, L. S. Morse, and J. S. Werner, “Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy,” Invest. Ophthalmol. Vis. Sci. 54(6), 4372–4384 (2013).
[Crossref] [PubMed]

J. I. W. Morgan, A. Dubra, R. Wolfe, W. H. Merigan, and D. R. Williams, “In vivo autofluorescence imaging of the human and macaque retinal pigment epithelial cell mosaic,” Invest. Ophthalmol. Vis. Sci. 50(3), 1350–1359 (2008).
[Crossref] [PubMed]

J. Biomed. Opt. (2)

P. Bedggood, M. Daaboul, R. Ashman, G. Smith, and A. Metha, “Characteristics of the human isoplanatic patch and implications for adaptive optics retinal imaging,” J. Biomed. Opt. 13(2), 024008 (2008).
[Crossref] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by Fourier domain optical coherence tomography,” J. Biomed. Opt. 7(3), 457–463 (2002).
[Crossref] [PubMed]

J. Comp. Neurol. (1)

C. A. Curcio, K. R. Sloan, R. E. Kalina, and A. E. Hendrickson, “Human photoreceptor topography,” J. Comp. Neurol. 292(4), 497–523 (1990).
[Crossref] [PubMed]

J. Opt. Soc. Am. A (5)

Ophthalmology (1)

R. F. Spaide, “Questioning Optical Coherence Tomography,” Ophthalmology 119, 2203–2204 (2012).

Opt. Commun. (1)

M. Szkulmowski, M. Wojtkowski, T. Bajraszewski, I. Gorczyńska, P. Targowski, W. Wasilewski, A. Kowalczyk, and C. Radzewicz, “Quality improvement for high resolution in vivo images by spectral domain optical coherence tomography with supercontinuum source,” Opt. Commun. 246(4-6), 569–578 (2005).
[Crossref]

Opt. Express (20)

H. C. Hendargo, M. Zhao, N. Shepherd, and J. A. Izatt, “Synthetic wavelength based phase unwrapping in spectral domain optical coherence tomography,” Opt. Express 17(7), 5039–5051 (2009).
[Crossref] [PubMed]

M. Mujat, R. D. Ferguson, A. H. Patel, N. Iftimia, N. Lue, and D. X. Hammer, “High resolution multimodal clinical ophthalmic imaging system,” Opt. Express 18(11), 11607–11621 (2010).
[Crossref] [PubMed]

M. Pircher, B. Baumann, E. Götzinger, H. Sattmann, and C. K. Hitzenberger, “Simultaneous SLO/OCT imaging of the human retina with axial eye motion correction,” Opt. Express 15(25), 16922–16932 (2007).
[Crossref] [PubMed]

M. Pircher, E. Götzinger, H. Sattmann, R. A. Leitgeb, and C. K. Hitzenberger, “In vivo investigation of human cone photoreceptors with SLO/OCT in combination with 3D motion correction on a cellular level,” Opt. Express 18(13), 13935–13944 (2010).
[Crossref] [PubMed]

R. Leitgeb, C. Hitzenberger, and A. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
[Crossref] [PubMed]

F. Spöler, S. Kray, P. Grychtol, B. Hermes, J. Bornemann, M. Först, and H. Kurz, “Simultaneous dual-band ultra-high resolution optical coherence tomography,” Opt. Express 15(17), 10832–10841 (2007).
[Crossref] [PubMed]

K. Grieve, P. Tiruveedhula, Y. Zhang, and A. Roorda, “Multi-wavelength imaging with the adaptive optics scanning laser Ophthalmoscope,” Opt. Express 14(25), 12230–12242 (2006).
[Crossref] [PubMed]

B. Potsaid, I. Gorczynska, V. J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J. G. Fujimoto, “Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second,” Opt. Express 16(19), 15149–15169 (2008).
[Crossref] [PubMed]

B. Cense, N. Nassif, T. Chen, M. Pierce, S. H. Yun, B. Park, B. Bouma, G. Tearney, and J. de Boer, “Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography,” Opt. Express 12(11), 2435–2447 (2004).
[Crossref] [PubMed]

C. R. Vogel, D. W. Arathorn, A. Roorda, and A. Parker, “Retinal motion estimation in adaptive optics scanning laser ophthalmoscopy,” Opt. Express 14(2), 487–497 (2006).
[Crossref] [PubMed]

D. C. Gray, W. Merigan, J. I. Wolfing, B. P. Gee, J. Porter, A. Dubra, T. H. Twietmeyer, K. Ahamd, R. Tumbar, F. Reinholz, and D. R. Williams, “In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells,” Opt. Express 14(16), 7144–7158 (2006).
[Crossref] [PubMed]

N. M. Putnam, D. X. Hammer, Y. Zhang, D. Merino, and A. Roorda, “Modeling the foveal cone mosaic imaged with adaptive optics scanning laser ophthalmoscopy,” Opt. Express 18(24), 24902–24916 (2010).
[Crossref] [PubMed]

A. Roorda, F. Romero-Borja, W. Donnelly Iii, H. Queener, T. Hebert, and M. Campbell, “Adaptive optics scanning laser ophthalmoscopy,” Opt. Express 10(9), 405–412 (2002).
[Crossref] [PubMed]

R. J. Zawadzki, B. Cense, Y. Zhang, S. S. Choi, D. T. Miller, and J. S. Werner, “Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction,” Opt. Express 16(11), 8126–8143 (2008).
[Crossref] [PubMed]

E. J. Fernández, B. Hermann, B. Považay, A. Unterhuber, H. Sattmann, B. Hofer, P. K. Ahnelt, and W. Drexler, “Ultrahigh resolution optical coherence tomography and pancorrection for cellular imaging of the living human retina,” Opt. Express 16(15), 11083–11094 (2008).
[Crossref] [PubMed]

D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, “Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy,” Opt. Express 14(8), 3345–3353 (2006).
[Crossref] [PubMed]

Y. Zhang, J. Rha, R. Jonnal, and D. Miller, “Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina,” Opt. Express 13(12), 4792–4811 (2005).
[Crossref] [PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[Crossref] [PubMed]

Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, “High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography,” Opt. Express 14(10), 4380–4394 (2006).
[Crossref] [PubMed]

R. S. Jonnal, J. Rha, Y. Zhang, B. Cense, W. Gao, and D. T. Miller, “In vivo functional imaging of human cone photoreceptors,” Opt. Express 15(24), 16141–16160 (2007).
[Crossref]

Opt. Lett. (4)

Optom. Vis. Sci. (1)

A. Roorda, “Applications of adaptive optics scanning laser ophthalmoscopy,” Optom. Vis. Sci. 87(4), 260–268 (2010).
[PubMed]

Proc. SPIE (1)

S. B. Stevenson and A. Roorda, “Correcting for miniature eye movements in high resolution scanning laser ophthalmoscopy,” Proc. SPIE 5688, 145–151 (2005).
[Crossref]

Prog. Retin. Eye Res. (1)

W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res. 27(1), 45–88 (2008).
[Crossref] [PubMed]

Retina (1)

R. F. Spaide and C. A. Curcio, “Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model,” Retina 31(8), 1609–1619 (2011).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Other (5)

T. Wilson, Confocal Microscopy (Academic Press, 1990).

Y. Zhang, S. Poonja, and A. Roorda, AOSLO: from Benchtop to Clinic, M. K. Giles, J. D. Gonglewski, and R. A. Carreras, eds. (2006), Vol. 6306, pp. 63060V1–63060V–11.

M. Szkulmowski, M. Wojtkowski, P. Targowski, and A. Kowalczyk, “Spectral shaping and least square iterative deconvolution in spectral OCT,” in Biomedical Optics 2004 (International Society for Optics and Photonics, 2004), pp. 424–431.

Y. Zhang, X. Wang, and J. Wang, “High-Speed Adaptive Optics Scanning Laser Ophthalmoscope (AOSLO),” in ARVO (2010), p. 2311/A561.

Y. Zhang, X. Wang, R. Myers, J. Alexander, T. Ye, A. Roorda, and P. Gamlin, “Broad-Spectrum Adaptive Optics Scanning Laser Ophthalmoscopy,” in IOVS (2011), p. 52:ARVO E–Abstract 5869.

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (7)

Fig. 1
Fig. 1

A schematic diagram of the presented system. The parts highlighted in blue were added to the system to facilitate OCT imaging. L1-8; lenses, S1-8 Spherical mirrors, DC1-3; dichroic mirrors, BS; beamsplitter, HS; Horizontal scanner, VS; vertical scanner, DM; deformable mirror, BF; bandpass filter, WS; wavefront sensor, CP1 and 2; confocal pinholes, FM; flip mirror, M1-3; plane mirrors.

Fig. 2
Fig. 2

(a). Spectra obtained from averaging all 512 lines used to generate an image. Figure 2(b) Normalized coherence profiles from an average of 512 A-scans. For both graphs; black- raw spectrum, red- window method, green- function method, blue- combined method. In this case, the coherence profiles of the function and combined methods are almost identical and very close to an ideal Gaussian shape.

Fig. 3
Fig. 3

Retinal images taken a 4° nasal to the fovea center from a subject (#1) in good retinal health. The images are from the same B-scans and have been processed identically, but the image on the right was spectrally shaped and the image on the left was not. The red and yellow arrows point to features discussed in the main text. The images are in logarithmic grey scale. These images were taken with the outer retina closest to zero optical path difference, minimizing the sensitivity loss to the choroid and inner retina due to roll-off [55]. The images were taken at a frame rate of 50 Hz and are average of 5 frames.

Fig. 4
Fig. 4

Examples of AO-OCT retinal images with the adaptive optics switched off (left) and on (right). The image was taken at 4° temporal eccentricity to the fovea centre in subject (#2) who is in good retinal health. The frame rate is 100 Hz, and 5 frames are averaged in both images. The images have a linear grey scale.

Fig. 5
Fig. 5

AO-OCT B-scan of a healthy retina (subject #3). 2° nasal from the central fovea with the focus at the photoreceptors. The image is displayed with a linear grey scale. The frame rate was 50 Hz and this is an average of 7 images. The scale, indicated by the bar has a 1:1 vertical/horizontal ratio and has been corrected for the refractive index of retinal tissue (assumed to be n = 1.33). The marked layers are RNFL; retinal nerve fiber layer, GCL; ganglion cell layer, IPL; inner plexiform layer, INL; inner nuclear layer, OPL; outer plexiform layer, ONL; outer nuclear layer, ELM; external limiting membrane, IS/OS: inner segment/outer segment junction; EZ: ellipsoid zone; OST; outer segment tips, RPE-BrM; retinal pigment epithelium/Bruch’s membrane complex, Ch; Choroid. The IS/OS and the OST are also claimed as the EZ (ellipsoidal zone) and the IDZ (interdigitation zone), respectively.

Fig. 6
Fig. 6

AO-SLO thumbnails (middle) taken from an AO-SLO montage (top) and AO-OCT (bottom) images taken at different retinal eccentricities from subject #3 in good retinal health. The bright spots in the AO-SLO images are cone photoreceptors. Each AO-SLO image is a registered set of 20 AO-corrected images. All images have been corrected for distortions due to eye movements and the nonlinear scan [54]. The arrows on the AO-SLO images indicate the position and direction of the OCT scan, the arrow direction corresponds to right to left in the OCT images. The green squares on the SLO montage show where the enlarged SLO images are located.

Fig. 7
Fig. 7

Images of a large druse at the fovea. Left panel is the AO-SLO image, showing the retina overlying the drusen with significantly reduced reflectivity. Outside the dark area, the contiguous reflective spots are cone photoreceptors (Ph). The red arrow marks where the AO-OCT B scan was taken. The arrow direction shows the right to left direction of the AO-OCT image (right panel). The AO-OCT image has a 1° field of view. The label Ph shows preserved photoreceptors and the label DrC shows the core of the druse in both the SLO and OCT images.

Tables (3)

Tables Icon

Table 1 The FWHM, e−2 width and relative SNR of the three methods

Tables Icon

Table 2 Measurement of the cone spacing from OCT images

Tables Icon

Table 3 Measurement of the IS/OS (EZ) thickness

Metrics