Abstract

We report on a novel hand-held imaging probe for real-time optoacoustic visualization of deep tissues in three dimensions. The system incorporates an annular two-dimensional array of ultrasonic sensors densely distributed on a spherical surface. Simultaneous recording and processing of time-resolved data from all the channels enables acquisition of entire volumetric data sets for each illumination laser pulse. The proposed solution utilizes a transparent membrane in order to allow efficient coupling of optoacoustically generated waves to the ultrasonic detectors while avoiding direct contact of the imaged object with the coupling medium. The hand-held approach further allows convenient handling of both pre-clinical experiments as well as clinical measurements in human subjects. Here we demonstrate an imaging speed of 10 volumetric frames per second with spatial resolution down to 200 micrometers in the imaged region while also achieving imaging depth of more than 1.5 cm in living tissues without signal averaging.

© 2013 Optical Society of America

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  1. D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
    [CrossRef] [PubMed]
  2. M. A. Pysz, S. S. Gambhir, and J. K. Willmann, “Molecular imaging: current status and emerging strategies,” Clin. Radiol.65(7), 500–516 (2010).
    [CrossRef] [PubMed]
  3. F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
    [CrossRef] [PubMed]
  4. C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
    [CrossRef] [PubMed]
  5. L. V. Wang and H.-I. Wu, Biomedical optics: principles and imaging (Wiley, 2007).
  6. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
    [CrossRef] [PubMed]
  7. P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
    [CrossRef] [PubMed]
  8. D. Razansky, “Multi-spectral optoacoustic tomography – volumetric color hearing in real time,” IEEE J. Sel. Top. Quantum Electron.18(3), 1234–1243 (2012).
    [CrossRef]
  9. E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
    [CrossRef] [PubMed]
  10. J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
    [CrossRef] [PubMed]
  11. L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
    [CrossRef] [PubMed]
  12. A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).
  13. J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
    [CrossRef] [PubMed]
  14. S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
    [CrossRef]
  15. R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
    [CrossRef] [PubMed]
  16. B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
    [CrossRef]
  17. J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
    [CrossRef] [PubMed]
  18. D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
    [CrossRef] [PubMed]
  19. Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
    [CrossRef] [PubMed]
  20. R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
    [CrossRef] [PubMed]
  21. D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
    [CrossRef] [PubMed]
  22. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
    [CrossRef] [PubMed]
  23. D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
    [CrossRef]
  24. A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, “Three-dimensional optoacoustic tomography at video rate,” Opt. Express20(20), 22712–22719 (2012).
    [CrossRef] [PubMed]
  25. M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
    [CrossRef] [PubMed]
  26. C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
    [CrossRef] [PubMed]
  27. P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
    [CrossRef] [PubMed]
  28. D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).
  29. A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
    [CrossRef]
  30. X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
    [CrossRef] [PubMed]
  31. A. Rosenthal, V. Ntziachristos, and D. Razansky, “Model-based optoacoustic inversion with arbitrary-shape detectors,” Med. Phys.38(7), 4285–4295 (2011).
    [CrossRef] [PubMed]
  32. X. L. Deán-Ben, D. Razansky, and V. Ntziachristos, “The effects of acoustic attenuation in optoacoustic signals,” Phys. Med. Biol.56(18), 6129–6148 (2011).
    [CrossRef] [PubMed]
  33. A. Rosenthal, V. Ntziachristos, and D. Razansky, “Optoacoustic methods for frequency calibration of ultrasonic sensors,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(2), 316–326 (2011).
    [CrossRef] [PubMed]
  34. X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt.17(11), 110504 (2012).
    [CrossRef] [PubMed]

2013 (4)

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

2012 (14)

X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt.17(11), 110504 (2012).
[CrossRef] [PubMed]

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, “Three-dimensional optoacoustic tomography at video rate,” Opt. Express20(20), 22712–22719 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
[CrossRef] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

D. Razansky, “Multi-spectral optoacoustic tomography – volumetric color hearing in real time,” IEEE J. Sel. Top. Quantum Electron.18(3), 1234–1243 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

2011 (5)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
[CrossRef] [PubMed]

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Model-based optoacoustic inversion with arbitrary-shape detectors,” Med. Phys.38(7), 4285–4295 (2011).
[CrossRef] [PubMed]

X. L. Deán-Ben, D. Razansky, and V. Ntziachristos, “The effects of acoustic attenuation in optoacoustic signals,” Phys. Med. Biol.56(18), 6129–6148 (2011).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Optoacoustic methods for frequency calibration of ultrasonic sensors,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(2), 316–326 (2011).
[CrossRef] [PubMed]

2010 (6)

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
[CrossRef]

M. A. Pysz, S. S. Gambhir, and J. K. Willmann, “Molecular imaging: current status and emerging strategies,” Clin. Radiol.65(7), 500–516 (2010).
[CrossRef] [PubMed]

F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
[CrossRef] [PubMed]

2009 (2)

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
[CrossRef] [PubMed]

2007 (1)

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

2004 (1)

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
[CrossRef] [PubMed]

Aguirre, A.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Aichler, M.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Ale, A.

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

Alqasemi, U.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Ambartsoumian, G.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
[CrossRef] [PubMed]

Ardeshirpour, Y.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Beard, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
[CrossRef] [PubMed]

Beard, P. C.

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

Beziere, N.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

Bohndiek, S.

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

Brecht, H. P.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

Buehler, A.

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, “Three-dimensional optoacoustic tomography at video rate,” Opt. Express20(20), 22712–22719 (2012).
[CrossRef] [PubMed]

Cai, X.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Chen, R.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Cheng, J. X.

L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
[CrossRef] [PubMed]

Claussen, J.

Conjusteau, A.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

Cox, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Davis, S. C.

F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
[CrossRef] [PubMed]

Dean-Ben, X. L.

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

Deán-Ben, X. L.

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt.17(11), 110504 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
[CrossRef] [PubMed]

A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, “Three-dimensional optoacoustic tomography at video rate,” Opt. Express20(20), 22712–22719 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, D. Razansky, and V. Ntziachristos, “The effects of acoustic attenuation in optoacoustic signals,” Phys. Med. Biol.56(18), 6129–6148 (2011).
[CrossRef] [PubMed]

Del Rio, S. P.

D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
[CrossRef]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Deliolanis, N. C.

D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
[CrossRef] [PubMed]

Demchenko, A. V.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Distel, M.

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

Doyle, R. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Dragulescu-Andrasi, A.

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

Ermilov, S. A.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

Erpelding, T. N.

Favazza, C.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Fronheiser, M.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

Fronheiser, M. P.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

Gambhir, S. S.

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

M. A. Pysz, S. S. Gambhir, and J. K. Willmann, “Molecular imaging: current status and emerging strategies,” Clin. Radiol.65(7), 500–516 (2010).
[CrossRef] [PubMed]

Gamelin, J.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Haag, R.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Harlaar, N. J.

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

Herzog, E.

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

Hillebrands, J. L.

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Jankovic, L.

Johnson, P.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Johnson, S. P.

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

Kim, C.

Kosanke, K.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Kruger, R. A.

D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
[CrossRef]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Kuchment, P.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
[CrossRef] [PubMed]

Kumavor, P. D.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Lam, R. B.

D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
[CrossRef]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Laufer, J.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Laufer, J. G.

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

Leblond, F.

F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
[CrossRef] [PubMed]

Licha, K.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Lutich, A. A.

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

Ma, R.

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

Manohar, S.

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

Maslov, K.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Maslov, K. I.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Mehta, K.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

Nasiriavanaki, M.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Ntziachristos, V.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
[CrossRef] [PubMed]

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
[CrossRef] [PubMed]

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt.17(11), 110504 (2012).
[CrossRef] [PubMed]

A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, “Three-dimensional optoacoustic tomography at video rate,” Opt. Express20(20), 22712–22719 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, D. Razansky, and V. Ntziachristos, “The effects of acoustic attenuation in optoacoustic signals,” Phys. Med. Biol.56(18), 6129–6148 (2011).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Optoacoustic methods for frequency calibration of ultrasonic sensors,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(2), 316–326 (2011).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Model-based optoacoustic inversion with arbitrary-shape detectors,” Med. Phys.38(7), 4285–4295 (2011).
[CrossRef] [PubMed]

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

Oraevsky, A. A.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

Pashley, M. D.

Pedley, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Pedley, R. B.

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

Perrimon, N.

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

Piras, D.

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

Pitsouli, C.

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

Pogue, B. W.

F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
[CrossRef] [PubMed]

Pysz, M. A.

M. A. Pysz, S. S. Gambhir, and J. K. Willmann, “Molecular imaging: current status and emerging strategies,” Clin. Radiol.65(7), 500–516 (2010).
[CrossRef] [PubMed]

Queiros, D.

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

Razansky, D.

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
[CrossRef] [PubMed]

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
[CrossRef] [PubMed]

D. Razansky, “Multi-spectral optoacoustic tomography – volumetric color hearing in real time,” IEEE J. Sel. Top. Quantum Electron.18(3), 1234–1243 (2012).
[CrossRef]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt.17(11), 110504 (2012).
[CrossRef] [PubMed]

A. Buehler, X. L. Deán-Ben, J. Claussen, V. Ntziachristos, and D. Razansky, “Three-dimensional optoacoustic tomography at video rate,” Opt. Express20(20), 22712–22719 (2012).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Optoacoustic methods for frequency calibration of ultrasonic sensors,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(2), 316–326 (2011).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Model-based optoacoustic inversion with arbitrary-shape detectors,” Med. Phys.38(7), 4285–4295 (2011).
[CrossRef] [PubMed]

X. L. Deán-Ben, D. Razansky, and V. Ntziachristos, “The effects of acoustic attenuation in optoacoustic signals,” Phys. Med. Biol.56(18), 6129–6148 (2011).
[CrossRef] [PubMed]

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

Reinecke, D. R.

D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
[CrossRef]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Rosenthal, A.

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Model-based optoacoustic inversion with arbitrary-shape detectors,” Med. Phys.38(7), 4285–4295 (2011).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Optoacoustic methods for frequency calibration of ultrasonic sensors,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(2), 316–326 (2011).
[CrossRef] [PubMed]

Rummeny, E.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Sasportas, L. S.

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

Shung, K. K.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Smith, B. A.

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

Steenbergen, W.

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

Su, R.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

Taruttis, A.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

Tavakoli, B.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Tong, L.

L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
[CrossRef] [PubMed]

Treeby, B.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Tsytsarev, V.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Valdés, P. A.

F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
[CrossRef] [PubMed]

van Dam, G. M.

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

Van de Sompel, D.

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

van Hespen, J. C. G.

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

Vinegoni, C.

D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
[CrossRef] [PubMed]

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

Walch, A.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Wang, L. V.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
[CrossRef] [PubMed]

Wei, A.

L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
[CrossRef] [PubMed]

Wei, Q. S.

L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
[CrossRef] [PubMed]

Wildgruber, M.

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

Willmann, J. K.

M. A. Pysz, S. S. Gambhir, and J. K. Willmann, “Molecular imaging: current status and emerging strategies,” Clin. Radiol.65(7), 500–516 (2010).
[CrossRef] [PubMed]

Xia, B.

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

Xia, J.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Xu, C.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Xu, Y.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
[CrossRef] [PubMed]

Yang, J. M.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Yang, Y.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Yao, J.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Yao, J. J.

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Zanganeh, S.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Zeebregts, C. J.

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

Zhang, E.

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

Zhang, E. Z.

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

Zhou, Q.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Zhu, Q.

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

Biomed. Opt. Express (1)

Clin. Radiol. (1)

M. A. Pysz, S. S. Gambhir, and J. K. Willmann, “Molecular imaging: current status and emerging strategies,” Clin. Radiol.65(7), 500–516 (2010).
[CrossRef] [PubMed]

Curr. Pharm. Biotechnol. (1)

D. Razansky, N. C. Deliolanis, C. Vinegoni, and V. Ntziachristos, “Deep tissue optical and optoacoustic molecular imaging technologies for pre-clinical research and drug discovery,” Curr. Pharm. Biotechnol.13(4), 504–522 (2012).
[CrossRef] [PubMed]

Eur. J. Cancer (1)

S. P. Johnson, J. G. Laufer, E. Z. Zhang, P. C. Beard, and R. B. Pedley, “Determination of differential tumour vascular pathophysiology in vivo by photoacoustic imaging,” Eur. J. Cancer48, S186–S187 (2012).
[CrossRef]

Eur. J. Nucl. Med. Mol. Imag. Res. (1)

A. Buehler, E. Herzog, A. Ale, B. A. Smith, V. Ntziachristos, and D. Razansky, “High resolution targeting of tumor apoptosis in living mice by means of multispectral optoacoustic tomography,” Eur. J. Nucl. Med. Mol. Imag. Res.2, 14 (2012).

IEEE J. Sel. Top. Quantum Electron. (1)

D. Razansky, “Multi-spectral optoacoustic tomography – volumetric color hearing in real time,” IEEE J. Sel. Top. Quantum Electron.18(3), 1234–1243 (2012).
[CrossRef]

IEEE Trans. Med. Imaging (1)

X. L. Deán-Ben, A. Buehler, V. Ntziachristos, and D. Razansky, “Accurate model-based reconstruction algorithm for three-dimensional optoacoustic tomography,” IEEE Trans. Med. Imaging31(10), 1922–1928 (2012).
[CrossRef] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Optoacoustic methods for frequency calibration of ultrasonic sensors,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control58(2), 316–326 (2011).
[CrossRef] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
[CrossRef] [PubMed]

J. Biomed. Opt. (6)

J. Laufer, P. Johnson, E. Zhang, B. Treeby, B. Cox, B. Pedley, and P. Beard, “In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy,” J. Biomed. Opt.17(5), 056016 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt.17(11), 110504 (2012).
[CrossRef] [PubMed]

P. D. Kumavor, C. Xu, A. Aguirre, J. Gamelin, Y. Ardeshirpour, B. Tavakoli, S. Zanganeh, U. Alqasemi, Y. Yang, and Q. Zhu, “Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system,” J. Biomed. Opt.16(4), 046010 (2011).
[CrossRef] [PubMed]

D. Queiros, X. L. Dean-Ben, A. Buehler, D. Razansky, A. Rosenthal, and V. Ntziachristos, “Modeling the shape of cylindrically focused transducers in three-dimensional optoacoustic tomography,” J. Biomed. Opt.18(7) 076014 (2013).

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007 (2009).
[CrossRef] [PubMed]

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305 (2010).
[CrossRef] [PubMed]

J. Photochem. Photobiol. B (1)

F. Leblond, S. C. Davis, P. A. Valdés, and B. W. Pogue, “Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications,” J. Photochem. Photobiol. B98(1), 77–94 (2010).
[CrossRef] [PubMed]

Med. Phys. (3)

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys.31(4), 724–733 (2004).
[CrossRef] [PubMed]

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys.37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

A. Rosenthal, V. Ntziachristos, and D. Razansky, “Model-based optoacoustic inversion with arbitrary-shape detectors,” Med. Phys.38(7), 4285–4295 (2011).
[CrossRef] [PubMed]

Mol. Imaging Biol. (1)

D. Razansky, N. J. Harlaar, J. L. Hillebrands, A. Taruttis, E. Herzog, C. J. Zeebregts, G. M. van Dam, and V. Ntziachristos, “Multispectral optoacoustic tomography of matrix metalloproteinase activity in vulnerable human carotid plaques,” Mol. Imaging Biol.14(3), 277–285 (2012).
[CrossRef] [PubMed]

Nat. Med. (1)

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Nat. Methods (1)

C. Vinegoni, C. Pitsouli, D. Razansky, N. Perrimon, and V. Ntziachristos, “In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography,” Nat. Methods5(1), 45–47 (2007).
[CrossRef] [PubMed]

Neuroimage (1)

J. J. Yao, J. Xia, K. I. Maslov, M. Nasiriavanaki, V. Tsytsarev, A. V. Demchenko, and L. V. Wang, “Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo,” Neuroimage64, 257–266 (2013).
[CrossRef] [PubMed]

Opt. Express (1)

Photoacoustics (2)

A. Taruttis, M. Wildgruber, K. Kosanke, N. Beziere, K. Licha, R. Haag, M. Aichler, A. Walch, E. Rummeny, and V. Ntziachristos, “Multispectral optoacoustic tomography of myocardial infarction,” Photoacoustics1(1), 3–8 (2013).
[CrossRef]

B. Xia, D. Piras, J. C. G. van Hespen, W. Steenbergen, and S. Manohar, “A new acoustic lens material for large area detectors in photoacoustic breast tomography,” Photoacoustics1(2), 9–18 (2013).
[CrossRef]

Photochem. Photobiol. (1)

L. Tong, Q. S. Wei, A. Wei, and J. X. Cheng, “Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects,” Photochem. Photobiol.85(1), 21–32 (2009).
[CrossRef] [PubMed]

Phys. Med. Biol. (2)

R. Ma, M. Distel, X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Non-invasive whole-body imaging of adult zebrafish with optoacoustic tomography,” Phys. Med. Biol.57(22), 7227–7237 (2012).
[CrossRef] [PubMed]

X. L. Deán-Ben, D. Razansky, and V. Ntziachristos, “The effects of acoustic attenuation in optoacoustic signals,” Phys. Med. Biol.56(18), 6129–6148 (2011).
[CrossRef] [PubMed]

PLoS ONE (1)

D. Van de Sompel, L. S. Sasportas, A. Dragulescu-Andrasi, S. Bohndiek, and S. S. Gambhir, “Improving image quality by accounting for changes in water temperature during a photoacoustic tomography scan,” PLoS ONE7(10), e45337 (2012).
[CrossRef] [PubMed]

Proc. SPIE (1)

D. R. Reinecke, R. A. Kruger, R. B. Lam, and S. P. Del Rio, “Co-registered photoacoustic, thermoacoustic and ultrasound mouse imaging,” Proc. SPIE7564, 756420 (2010).
[CrossRef]

Radiology (1)

E. Herzog, A. Taruttis, N. Beziere, A. A. Lutich, D. Razansky, and V. Ntziachristos, “Optical imaging of cancer heterogeneity with multispectral optoacoustic tomography,” Radiology263(2), 461–468 (2012).
[CrossRef] [PubMed]

Science (1)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

Other (1)

L. V. Wang and H.-I. Wu, Biomedical optics: principles and imaging (Wiley, 2007).

Supplementary Material (2)

» Media 1: AVI (785 KB)     
» Media 2: MP4 (3445 KB)     

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Figures (5)

Fig. 1
Fig. 1

The portable spherical array probe for volumetric real-time optoacoustic imaging. (a) Side view of the location of the transducer elements (blue points) and the corresponding effective imaging region of the array (red square). (b) Top-view showing the shape of the individual piezoelectric detection elements. (c) Frequency response of the individual elements for a point source located in the centre of the spherical surface. (d) Combined sensitivity field for three different acoustic frequencies. (e) Dimensions of the effective imaging region as a function of the frequency emitted by the optical absorbers. (f) Photograph of the probe.

Fig. 2
Fig. 2

Simulated optoacoustic reconstructions of parabolic optical absorbers. The images represent cross-sections in the plane y=0. (a) Theoretical distribution of the optical absorbers. (b) Reconstruction obtained by assuming point detectors. (c) Reconstruction obtained with point detectors by further convolving the detected pressure variation with the impulse response of the transducer elements. (d) Reconstruction obtained by averaging the detected pressure variations over the effective active area of the elements.

Fig. 3
Fig. 3

Experimental determination of the spatial resolution. (a) Cross-section (normal to the z axis) from the reconstructed volumetric image of a 50 µm diameter sphere located in the centre of the sphere. (b) Cross-section normal to the y axis. (c) Cross-section normal to the x axis. The insets show the corresponding one-dimensional profiles in the direction normal to the cross-sectional planes (the position of the profiles are indicated with a red dot). The estimated resolution for the z, y and x directions are plotted in (d), (e) and (f) as a function of the position of the microsphere on the x and z axes.

Fig. 4
Fig. 4

Real-time monitoring of blood injection into a tube located approximately at 15 mm depth within a phantom mimicking optical and acoustic properties of soft tissues. All images were acquired with a single laser pulse without signal averaging. (a) Schematic representation of the experimental set-up. (b) Reconstructed images (represented as three-dimensional transparency views) for eight different time instants (See Media 1).

Fig. 5
Fig. 5

Hand-held imaging experiment in a human volunteer. The images were acquired with a single laser pulse without signal averaging. (a) Three-dimensional transparency view of two different tomographic reconstructions. (b) Maximum intensity projections along the x direction. Vessels at a depth of more than 1.5 cm are clearly visible.

Equations (1)

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S(r')=mod{ r exp(ik|r'r|)dr}mod{ j exp(ik|r' r j |)Δ r j } ,

Metrics