Abstract

We report a first demonstration of two-photon endoscopic imaging with a lensless endoscope. The endoscope probe is a double-clad bundle of single-mode fibers; point excitation and scanning is achieved by coherent combining of femtosecond light pulses propagating in the single-mode fibers; and back-scattered two-photon signal is collected through the multi-mode inner cladding. We demonstrate the two-photon endoscope on a test sample of rhodamine 6G crystals.

© 2013 OSA

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2013 (3)

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode fiber,” Biomed. Opt. Express6, 260–270 (2013).
[CrossRef]

D. J. Richardson, J. M. Fini, and L. E. Nelson, “Space-division multiplexing in optical fibres,” Nat. Photonics7, 354–362 (2013).
[CrossRef]

E. R. Andresen, G. Bouwmans, S. Monneret, and H. Rigneault, “Toward endoscopes with no distal optics: video-rate scanning microscopy through a fiber bundle,” Opt. Lett.38, 609–611 (2013).
[CrossRef] [PubMed]

2012 (4)

J. Tang, R. N. Germain, and M. Cui, “Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique,” Proc. Natl. Acad. Sci. U.S.A.109, 8434–8439 (2012).
[CrossRef] [PubMed]

T. Cizmar and K. Dholakia, “Exploiting multimode waveguides for pure fibre-based imaging,” Nat. Commun.3, 1027 (2012).
[CrossRef] [PubMed]

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

2011 (5)

2010 (1)

2009 (2)

Y. Wu, Y. Leng, J. Xi, and X. Li, “Scanning all-fiber-optic endomicroscopy system for 3D nonlinear optical imaging of biological tissues,” Opt. Express17, 7907–7915 (2009).
[CrossRef] [PubMed]

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

2008 (2)

H. Bao, J. Allen, R. Pattie, R. Vance, and M. Gu, “Fast handheld two-photon fluorescence microendoscope with a 475 × 475 μ m field of view for in vivo imaging,” Opt. Lett.33, 1333–1335 (2008).
[CrossRef] [PubMed]

C. Labaune, D. Hulin, A. Galvanauskas, and G. Mourou, “On the feasability of a fiber-based inertial fusion laser driver,” Opt. Commun.281, 4075–4080 (2008).
[CrossRef]

2006 (3)

2005 (2)

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

T. Y. Fan, “Laser beam combining for high-power, high radiance sources,” IEEE J. Sel. Top. Quantum Electron.11, 567–577 (2005).
[CrossRef]

Ahn, Y. C.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Allen, J.

Andresen, E. R.

Bao, H.

Barthelemy, A.

Bellanger, C.

Bourderionnet, J.

Boussioutas, A.

Bouwmans, G.

Brignon, A.

Brown, C. M.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Chen, Z. P.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Cheung, E. L. M.

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

Choi, W.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Choi, Y.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Cizmar, T.

T. Cizmar and K. Dholakia, “Exploiting multimode waveguides for pure fibre-based imaging,” Nat. Commun.3, 1027 (2012).
[CrossRef] [PubMed]

Cocker, E. D.

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

Cranfield, C.

Cui, M.

J. Tang, R. N. Germain, and M. Cui, “Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique,” Proc. Natl. Acad. Sci. U.S.A.109, 8434–8439 (2012).
[CrossRef] [PubMed]

Dasari, R. R.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Dholakia, K.

T. Cizmar and K. Dholakia, “Exploiting multimode waveguides for pure fibre-based imaging,” Nat. Commun.3, 1027 (2012).
[CrossRef] [PubMed]

Dunsby, C.

Elahi, S. F.

S. F. Elahi and T. D. Wang, “Future and advances in endoscopy,” J. Biomed. Opt.4, 471–481 (2011).

Fan, T. Y.

T. Y. Fan, “Laser beam combining for high-power, high radiance sources,” IEEE J. Sel. Top. Quantum Electron.11, 567–577 (2005).
[CrossRef]

Fang-Yen, C.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Farahi, S.

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode fiber,” Biomed. Opt. Express6, 260–270 (2013).
[CrossRef]

Fini, J. M.

D. J. Richardson, J. M. Fini, and L. E. Nelson, “Space-division multiplexing in optical fibres,” Nat. Photonics7, 354–362 (2013).
[CrossRef]

Flusberg, B. A.

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

French, P. M. W.

Fu, L.

Galvanauskas, A.

C. Labaune, D. Hulin, A. Galvanauskas, and G. Mourou, “On the feasability of a fiber-based inertial fusion laser driver,” Opt. Commun.281, 4075–4080 (2008).
[CrossRef]

Germain, R. N.

J. Tang, R. N. Germain, and M. Cui, “Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique,” Proc. Natl. Acad. Sci. U.S.A.109, 8434–8439 (2012).
[CrossRef] [PubMed]

Gu, M.

Hulin, D.

C. Labaune, D. Hulin, A. Galvanauskas, and G. Mourou, “On the feasability of a fiber-based inertial fusion laser driver,” Opt. Commun.281, 4075–4080 (2008).
[CrossRef]

Jain, A.

Jeremy, R.

Jung, J. C.

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

Jung, W. G.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Kim, M.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Kobat, D.

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Labaune, C.

C. Labaune, D. Hulin, A. Galvanauskas, and G. Mourou, “On the feasability of a fiber-based inertial fusion laser driver,” Opt. Commun.281, 4075–4080 (2008).
[CrossRef]

Lee, K. J.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

LeFort, C.

Leng, Y.

Li, X.

Louradour, F.

MacDonald, D. J.

Mansuryan, T.

McCormick, D.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Mohanan, S.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

Monneret, S.

Moser, C.

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode fiber,” Biomed. Opt. Express6, 260–270 (2013).
[CrossRef]

Mourou, G.

C. Labaune, D. Hulin, A. Galvanauskas, and G. Mourou, “On the feasability of a fiber-based inertial fusion laser driver,” Opt. Commun.281, 4075–4080 (2008).
[CrossRef]

Myaing, M. R.

Neil, M. A. A.

Nelson, L. E.

D. J. Richardson, J. M. Fini, and L. E. Nelson, “Space-division multiplexing in optical fibres,” Nat. Photonics7, 354–362 (2013).
[CrossRef]

Ouzonov, D. G.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

Ouzounov, D. G.

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Papadopoulos, I. N.

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode fiber,” Biomed. Opt. Express6, 260–270 (2013).
[CrossRef]

Paterson, C.

Pattie, R.

Pavlova, I.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Piyawattanametha, W.

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

Primot, J.

Psaltis, D.

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode fiber,” Biomed. Opt. Express6, 260–270 (2013).
[CrossRef]

Richardson, D. J.

D. J. Richardson, J. M. Fini, and L. E. Nelson, “Space-division multiplexing in optical fibres,” Nat. Photonics7, 354–362 (2013).
[CrossRef]

Rigneault, H.

Rivera, D. R.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Russell, P. S. J.

Russell, S.

Schnitzer, M. J.

B. A. Flusberg, E. D. Cocker, W. Piyawattanametha, J. C. Jung, E. L. M. Cheung, and M. J. Schnitzer, “Fiber-optic fluorescence imaging,” Nat. Methods2, 941–950 (2005).
[CrossRef] [PubMed]

Su, J. P.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Tang, J.

J. Tang, R. N. Germain, and M. Cui, “Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique,” Proc. Natl. Acad. Sci. U.S.A.109, 8434–8439 (2012).
[CrossRef] [PubMed]

Tang, S.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Thompson, A. J.

Tromberg, B. J.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Vance, R.

Wang, T. D.

S. F. Elahi and T. D. Wang, “Future and advances in endoscopy,” J. Biomed. Opt.4, 471–481 (2011).

Webb, W. W.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Williams, W. O.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

Wu, Y.

Xi, J.

Xie, H.

Xie, T. Q.

S. Tang, W. G. Jung, D. McCormick, T. Q. Xie, J. P. Su, Y. C. Ahn, B. J. Tromberg, and Z. P. Chen, “Design an implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning,” J. Biomed. Opt.14, 34005 (2009).
[CrossRef]

Xu, C.

C. M. Brown, D. R. Rivera, I. Pavlova, D. G. Ouzonov, W. O. Williams, S. Mohanan, W. W. Webb, and C. Xu, “In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope,” J. Biomed. Opt.17, 040505 (2012).
[CrossRef] [PubMed]

D. R. Rivera, C. M. Brown, D. G. Ouzounov, I. Pavlova, D. Kobat, W. W. Webb, and C. Xu, “Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue,” Proc. Natl. Acad. Sci. U.S.A.108, 17598–17603 (2011).
[CrossRef] [PubMed]

Yang, T. D.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Yoon, C.

Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, “Scanner-Free and Wide-Field Endoscopic Imaging by Using a Single Multimode Optical Fiber,” Phys. Rev. Lett.109, 203901 (2012).
[CrossRef] [PubMed]

Biomed. Opt. Express (1)

I. N. Papadopoulos, S. Farahi, C. Moser, and D. Psaltis, “High-resolution, lensless endoscope based on digital scanning through a multimode fiber,” Biomed. Opt. Express6, 260–270 (2013).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron. (1)

T. Y. Fan, “Laser beam combining for high-power, high radiance sources,” IEEE J. Sel. Top. Quantum Electron.11, 567–577 (2005).
[CrossRef]

J. Biomed. Opt. (3)

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