Abstract

We present a fast photoacoustic imaging system based on an annular transducer array for detection of intraocular foreign bodies. An eight-channel data acquisition system is applied to capture the photoacoustic signals using multiplexing and the total time of data acquisition and transferring is within 3 s. A limited-view filtered back projection algorithm is used to reconstruct the photoacoustic images. Experimental models of intraocular metal and glass foreign bodies were constructed on ex vivo pig’s eyes and clear photoacoustic images of intraocular foreign bodies were obtained. Experimental results demonstrate the photoacoustic imaging system holds the potential for in clinic detecting the intraocular foreign bodies.

© 2013 OSA

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2011 (4)

Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. N. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held Photoacoustic probe adapted from a clinical ultrasound system for noninvasive sentinel lymph node imaging,” Phil. Trans. Royal Soc. A.369(1955), 4644–4650 (2011).
[CrossRef]

X. Cai, C. Kim, M. Pramanik, and L. V. Wang, “Photoacoustic tomography of foreign bodies in soft biological tissue,” J. Biomed. Opt.16(4), 046017–046021 (2011).
[CrossRef] [PubMed]

Q. Zh. Zhu, X. R. Ji, and D. Xing, “Full-field 3D photoacoustic imaging based on a plane transducer array and spatial phrase-controlled algorithm,” Med. Phys. Lett.38(3), 1561–1566 (2011).

2010 (7)

2009 (4)

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

M. Roumeliotis, P. Ephrat, J. Patrick, and J. J. L. Carson, “Development and characterization of an omnidirectional photoacoustic point source for calibration of a staring 3D photoacoustic imaging system,” Opt. Express17(17), 15228–15238 (2009).
[CrossRef] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express17(13), 10489–10498 (2009).
[CrossRef] [PubMed]

2008 (1)

S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE6856, 68560T (2008).

2007 (3)

2006 (2)

Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett.88(23), 231101 (2006).
[CrossRef]

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

2005 (3)

B. T. Cox, S. R. Arridge, K. P. K¨ostli, and P. C. Beard, “Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution,” Proc. SPIE5697, 49–55 (2005).
[CrossRef]

P. J. Holmes, J. R. Miller, R. Gutta, and P. J. Louis, “Intraoperative imaging techniques: A guide to retrieval of foreign bodies,” Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol.100(5), 614–618 (2005).
[CrossRef]

G. Ku, X. D. Wang, X. Y. Xie, G. Stoica, and L. V. Wang, “Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography,” Appl. Opt.44(5), 770–775 (2005).
[CrossRef] [PubMed]

2004 (2)

2003 (1)

2002 (1)

M. H. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging21(7), 814–822 (2002).
[CrossRef] [PubMed]

1999 (1)

D. DeAngelis, M. Howcroft, and I. Aslanides, “Siderosis bulbi with an undetectable intraocular foreign body,” Can. J. Ophthalmol.34(6), 341–342 (1999).
[PubMed]

1988 (1)

T. D. LoBue, T. A. Deutsch, J. Lobick, and D. A. Turner, “Detection and localization of nonmetallic intraocular foreign bodies by magnetic resonance imaging,” Arch. Ophthalmol.106(2), 260–261 (1988).
[CrossRef] [PubMed]

Aguirre, A.

Arridge, S. R.

B. T. Cox, S. R. Arridge, K. P. K¨ostli, and P. C. Beard, “Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution,” Proc. SPIE5697, 49–55 (2005).
[CrossRef]

Aslanides, I.

D. DeAngelis, M. Howcroft, and I. Aslanides, “Siderosis bulbi with an undetectable intraocular foreign body,” Can. J. Ophthalmol.34(6), 341–342 (1999).
[PubMed]

Bauer, D. R.

Beard, P. C.

B. T. Cox, S. R. Arridge, K. P. K¨ostli, and P. C. Beard, “Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution,” Proc. SPIE5697, 49–55 (2005).
[CrossRef]

Blumenkranz, M. S.

Bodapati, S.

A. de la Zerda, Y. M. Paulus, R. Teed, S. Bodapati, Y. Dollberg, B. T. Khuri-Yakub, M. S. Blumenkranz, D. M. Moshfeghi, and S. S. Gambhir, “Photoacoustic ocular imaging,” Opt. Lett.35(3), 270–272 (2010).
[CrossRef] [PubMed]

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Bornhop, D. J.

Cai, X.

X. Cai, C. Kim, M. Pramanik, and L. V. Wang, “Photoacoustic tomography of foreign bodies in soft biological tissue,” J. Biomed. Opt.16(4), 046017–046021 (2011).
[CrossRef] [PubMed]

Carson, J. J. L.

Chen, Q.

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, “Photoacoustic imaging with deconvolution algorithm,” Phys. Med. Biol.49(14), 3117–3124 (2004).
[CrossRef] [PubMed]

Chen, X.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Chen, Y. S.

Cohen, M. S.

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

Coniusteau, A.

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

Conjusteau, A.

S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE6856, 68560T (2008).

Cox, B. T.

B. T. Cox, S. R. Arridge, K. P. K¨ostli, and P. C. Beard, “Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution,” Proc. SPIE5697, 49–55 (2005).
[CrossRef]

Crystal, C. S.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Cui, H. Z.

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

Dai, H.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

de la Zerda, A.

DeAngelis, D.

D. DeAngelis, M. Howcroft, and I. Aslanides, “Siderosis bulbi with an undetectable intraocular foreign body,” Can. J. Ophthalmol.34(6), 341–342 (1999).
[PubMed]

Deutsch, T. A.

T. D. LoBue, T. A. Deutsch, J. Lobick, and D. A. Turner, “Detection and localization of nonmetallic intraocular foreign bodies by magnetic resonance imaging,” Arch. Ophthalmol.106(2), 260–261 (1988).
[CrossRef] [PubMed]

Dollberg, Y.

Emelianov, S.

Ephrat, P.

Ermilov, S. A.

S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE6856, 68560T (2008).

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

Erpelding, T. N.

C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held Photoacoustic probe adapted from a clinical ultrasound system for noninvasive sentinel lymph node imaging,” Phil. Trans. Royal Soc. A.369(1955), 4644–4650 (2011).
[CrossRef]

Fawzi, A.

Galanzha, E. I.

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Gambhir, S. S.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

A. de la Zerda, Y. M. Paulus, R. Teed, S. Bodapati, Y. Dollberg, B. T. Khuri-Yakub, M. S. Blumenkranz, D. M. Moshfeghi, and S. S. Gambhir, “Photoacoustic ocular imaging,” Opt. Lett.35(3), 270–272 (2010).
[CrossRef] [PubMed]

Gamelin, J.

Gharieb, R.

S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE6856, 68560T (2008).

Grogan, P.

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

Gu, H. M.

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

Guo, P. Y.

Gutta, R.

P. J. Holmes, J. R. Miller, R. Gutta, and P. J. Louis, “Intraoperative imaging techniques: A guide to retrieval of foreign bodies,” Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol.100(5), 614–618 (2005).
[CrossRef]

Hellums, J. S.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Henrichs, P. M.

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

Holmes, P. J.

P. J. Holmes, J. R. Miller, R. Gutta, and P. J. Louis, “Intraoperative imaging techniques: A guide to retrieval of foreign bodies,” Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol.100(5), 614–618 (2005).
[CrossRef]

Homan, K.

Howcroft, M.

D. DeAngelis, M. Howcroft, and I. Aslanides, “Siderosis bulbi with an undetectable intraocular foreign body,” Can. J. Ophthalmol.34(6), 341–342 (1999).
[PubMed]

Hu, J.

Hu, S.

Huang, F.

Jankovic, L.

C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held Photoacoustic probe adapted from a clinical ultrasound system for noninvasive sentinel lymph node imaging,” Phil. Trans. Royal Soc. A.369(1955), 4644–4650 (2011).
[CrossRef]

Ji, X. R.

Q. Zh. Zhu, X. R. Ji, and D. Xing, “Full-field 3D photoacoustic imaging based on a plane transducer array and spatial phrase-controlled algorithm,” Med. Phys. Lett.38(3), 1561–1566 (2011).

Jiang, H.

Jiang, M.

Jiao, S.

K¨ostli, K. P.

B. T. Cox, S. R. Arridge, K. P. K¨ostli, and P. C. Beard, “Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution,” Proc. SPIE5697, 49–55 (2005).
[CrossRef]

Kaylor, D. W.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Kelly, T.

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Khuri-Yakub, B. T.

A. de la Zerda, Y. M. Paulus, R. Teed, S. Bodapati, Y. Dollberg, B. T. Khuri-Yakub, M. S. Blumenkranz, D. M. Moshfeghi, and S. S. Gambhir, “Photoacoustic ocular imaging,” Opt. Lett.35(3), 270–272 (2010).
[CrossRef] [PubMed]

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Kim, C.

X. Cai, C. Kim, M. Pramanik, and L. V. Wang, “Photoacoustic tomography of foreign bodies in soft biological tissue,” J. Biomed. Opt.16(4), 046017–046021 (2011).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held Photoacoustic probe adapted from a clinical ultrasound system for noninvasive sentinel lymph node imaging,” Phil. Trans. Royal Soc. A.369(1955), 4644–4650 (2011).
[CrossRef]

Kim, J. W.

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Kim, S.

Ku, G.

Lacewell, R.

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

Levsky, M. E.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Liu, Z.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Lobick, J.

T. D. LoBue, T. A. Deutsch, J. Lobick, and D. A. Turner, “Detection and localization of nonmetallic intraocular foreign bodies by magnetic resonance imaging,” Arch. Ophthalmol.106(2), 260–261 (1988).
[CrossRef] [PubMed]

LoBue, T. D.

T. D. LoBue, T. A. Deutsch, J. Lobick, and D. A. Turner, “Detection and localization of nonmetallic intraocular foreign bodies by magnetic resonance imaging,” Arch. Ophthalmol.106(2), 260–261 (1988).
[CrossRef] [PubMed]

Louis, P. J.

P. J. Holmes, J. R. Miller, R. Gutta, and P. J. Louis, “Intraoperative imaging techniques: A guide to retrieval of foreign bodies,” Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol.100(5), 614–618 (2005).
[CrossRef]

Mallidi, S.

Maslov, K.

Masneri, D. A.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Maurudis, A.

Mehta, K.

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

Miller, J. R.

P. J. Holmes, J. R. Miller, R. Gutta, and P. J. Louis, “Intraoperative imaging techniques: A guide to retrieval of foreign bodies,” Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol.100(5), 614–618 (2005).
[CrossRef]

Miller, M. A.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Montilla, L. G.

Moshfeghi, D. M.

Olafsson, R.

Oraevsky, A. A.

S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE6856, 68560T (2008).

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

Pang, Y. J.

Patrick, J.

Paulus, Y. M.

Pramanik, M.

X. Cai, C. Kim, M. Pramanik, and L. V. Wang, “Photoacoustic tomography of foreign bodies in soft biological tissue,” J. Biomed. Opt.16(4), 046017–046021 (2011).
[CrossRef] [PubMed]

Puliafito, C. A.

Rao, B.

Roumeliotis, M.

Samadi, A. K.

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

Shashkov, E. V.

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Shung, K. K.

Staley, J.

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

Stoica, G.

Teed, R.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

A. de la Zerda, Y. M. Paulus, R. Teed, S. Bodapati, Y. Dollberg, B. T. Khuri-Yakub, M. S. Blumenkranz, D. M. Moshfeghi, and S. S. Gambhir, “Photoacoustic ocular imaging,” Opt. Lett.35(3), 270–272 (2010).
[CrossRef] [PubMed]

Turner, D. A.

T. D. LoBue, T. A. Deutsch, J. Lobick, and D. A. Turner, “Detection and localization of nonmetallic intraocular foreign bodies by magnetic resonance imaging,” Arch. Ophthalmol.106(2), 260–261 (1988).
[CrossRef] [PubMed]

Vaithilingam, S.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Wang, B.

Wang, L. V.

X. Cai, C. Kim, M. Pramanik, and L. V. Wang, “Photoacoustic tomography of foreign bodies in soft biological tissue,” J. Biomed. Opt.16(4), 046017–046021 (2011).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held Photoacoustic probe adapted from a clinical ultrasound system for noninvasive sentinel lymph node imaging,” Phil. Trans. Royal Soc. A.369(1955), 4644–4650 (2011).
[CrossRef]

Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. N. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011).
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S. Hu, B. Rao, K. Maslov, and L. V. Wang, “Label-free photoacoustic ophthalmic angiography,” Opt. Lett.35(1), 1–3 (2010).
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J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express17(13), 10489–10498 (2009).
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G. Ku, X. D. Wang, X. Y. Xie, G. Stoica, and L. V. Wang, “Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography,” Appl. Opt.44(5), 770–775 (2005).
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X. D. Wang, G. Ku, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, “Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent,” Opt. Lett.29(7), 730–732 (2004).
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X. D. Wang, Y. J. Pang, G. Ku, G. Stoica, and L. V. Wang, “Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact,” Opt. Lett.28(19), 1739–1741 (2003).
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M. H. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging21(7), 814–822 (2002).
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Wang, Q.

Wang, X. D.

Wang, Y.

Wegiel, M. A.

Witte, R. S.

Xia, Y. N.

Xiang, L. Z.

D. W. Yang, D. Xing, S. H. Yang, and L. Z. Xiang, “Fast full-view photoacoustic imaging by combined scanning with a linear transducer array,” Opt. Express15(23), 15566–15575 (2007).
[CrossRef] [PubMed]

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

Xie, X. Y.

Xing, D.

Q. Zh. Zhu, X. R. Ji, and D. Xing, “Full-field 3D photoacoustic imaging based on a plane transducer array and spatial phrase-controlled algorithm,” Med. Phys. Lett.38(3), 1561–1566 (2011).

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

D. W. Yang, D. Xing, S. H. Yang, and L. Z. Xiang, “Fast full-view photoacoustic imaging by combined scanning with a linear transducer array,” Opt. Express15(23), 15566–15575 (2007).
[CrossRef] [PubMed]

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, “Photoacoustic imaging with deconvolution algorithm,” Phys. Med. Biol.49(14), 3117–3124 (2004).
[CrossRef] [PubMed]

Xu, M. H.

M. H. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging21(7), 814–822 (2002).
[CrossRef] [PubMed]

Yang, D. W.

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

D. W. Yang, D. Xing, S. H. Yang, and L. Z. Xiang, “Fast full-view photoacoustic imaging by combined scanning with a linear transducer array,” Opt. Express15(23), 15566–15575 (2007).
[CrossRef] [PubMed]

Yang, L.

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Yang, S. H.

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

D. W. Yang, D. Xing, S. H. Yang, and L. Z. Xiang, “Fast full-view photoacoustic imaging by combined scanning with a linear transducer array,” Opt. Express15(23), 15566–15575 (2007).
[CrossRef] [PubMed]

Yang, X. M.

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

Young, S. E.

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Yuan, Z.

Zeng, L. M.

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

Zeng, Y. G.

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, “Photoacoustic imaging with deconvolution algorithm,” Phys. Med. Biol.49(14), 3117–3124 (2004).
[CrossRef] [PubMed]

Zerda, A.

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Zhang, H. F.

Zhang, Y.

Zharov, V. P.

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Zhou, Q.

Zhu, Q.

Zhu, Q. Zh.

Q. Zh. Zhu, X. R. Ji, and D. Xing, “Full-field 3D photoacoustic imaging based on a plane transducer array and spatial phrase-controlled algorithm,” Med. Phys. Lett.38(3), 1561–1566 (2011).

Appl. Opt. (1)

Appl. Phys. Lett. (1)

Z. Yuan and H. Jiang, “Quantitative photoacoustic tomography: Recovery of optical absorption coefficient maps of heterogeneous media,” Appl. Phys. Lett.88(23), 231101 (2006).
[CrossRef]

Arch. Ophthalmol. (1)

T. D. LoBue, T. A. Deutsch, J. Lobick, and D. A. Turner, “Detection and localization of nonmetallic intraocular foreign bodies by magnetic resonance imaging,” Arch. Ophthalmol.106(2), 260–261 (1988).
[CrossRef] [PubMed]

Can. J. Ophthalmol. (1)

D. DeAngelis, M. Howcroft, and I. Aslanides, “Siderosis bulbi with an undetectable intraocular foreign body,” Can. J. Ophthalmol.34(6), 341–342 (1999).
[PubMed]

IEEE Trans. Med. Imaging (1)

M. H. Xu and L. V. Wang, “Time-domain reconstruction for thermoacoustic tomography in a spherical geometry,” IEEE Trans. Med. Imaging21(7), 814–822 (2002).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

X. Cai, C. Kim, M. Pramanik, and L. V. Wang, “Photoacoustic tomography of foreign bodies in soft biological tissue,” J. Biomed. Opt.16(4), 046017–046021 (2011).
[CrossRef] [PubMed]

J. Staley, P. Grogan, A. K. Samadi, H. Z. Cui, M. S. Cohen, and X. M. Yang, “Growth of melanoma brain tumors monitored by photoacoustic microscopy,” J. Biomed. Opt.15(4), 040510 (2010).
[CrossRef] [PubMed]

J. Emerg. Med. (1)

C. S. Crystal, D. A. Masneri, J. S. Hellums, D. W. Kaylor, S. E. Young, M. A. Miller, and M. E. Levsky, “Bedside ultrasound for the detection of soft tissue foreign bodies: A cadaveric study,” J. Emerg. Med.36(4), 377–380 (2009).
[CrossRef] [PubMed]

Med. Phys. (1)

L. M. Zeng, D. Xing, H. M. Gu, D. W. Yang, S. H. Yang, and L. Z. Xiang, “High antinoise photoacoustic tomography based on a modified filtered back projection algorithm with combination wavelet,” Med. Phys.34(2), 556–563 (2007).
[CrossRef] [PubMed]

Med. Phys. Lett. (1)

Q. Zh. Zhu, X. R. Ji, and D. Xing, “Full-field 3D photoacoustic imaging based on a plane transducer array and spatial phrase-controlled algorithm,” Med. Phys. Lett.38(3), 1561–1566 (2011).

Nano Lett. (1)

A. Zerda, Z. Liu, S. Bodapati, R. Teed, S. Vaithilingam, B. T. Khuri-Yakub, X. Chen, H. Dai, and S. S. Gambhir, “Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice,” Nano Lett.10(6), 2168–2172 (2010).
[CrossRef] [PubMed]

Nat. Nanotechnol. (1)

E. I. Galanzha, E. V. Shashkov, T. Kelly, J. W. Kim, L. Yang, and V. P. Zharov, “In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells,” Nat. Nanotechnol.4(12), 855–860 (2009).
[CrossRef] [PubMed]

Opt. Express (6)

Opt. Lett. (6)

Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol. (1)

P. J. Holmes, J. R. Miller, R. Gutta, and P. J. Louis, “Intraoperative imaging techniques: A guide to retrieval of foreign bodies,” Oral Surg.,Oral Med.,Oral Pathol., Oral Radiol. Endodontol.100(5), 614–618 (2005).
[CrossRef]

Phil. Trans. Royal Soc. A. (1)

C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held Photoacoustic probe adapted from a clinical ultrasound system for noninvasive sentinel lymph node imaging,” Phil. Trans. Royal Soc. A.369(1955), 4644–4650 (2011).
[CrossRef]

Phys. Med. Biol. (1)

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, “Photoacoustic imaging with deconvolution algorithm,” Phys. Med. Biol.49(14), 3117–3124 (2004).
[CrossRef] [PubMed]

Proc. SPIE (2)

S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE6856, 68560T (2008).

B. T. Cox, S. R. Arridge, K. P. K¨ostli, and P. C. Beard, “Quantitative photoacoustic imaging: fitting a model of light transport to the initial pressure distribution,” Proc. SPIE5697, 49–55 (2005).
[CrossRef]

Other (2)

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs, and A. A. Oraevsky, “128-channel laser optoacoustic imaging system for breast cancer diagnostics,” Proc. SPIE 6086, 608609 (2006).

American National Standards Institute (ANSI), “American national standard for the safe use of lasers,” Standard Z136.1–2007 (Laser Institute of America, Orlando, FL, 2007).

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Figures (5)

Fig. 1
Fig. 1

Block diagram of the annular array photoacoustic system. Definitions: FPGA = field programmable gate array, MUX = multiplexer.

Fig. 2
Fig. 2

(a) The photoacoustic reconstructed image of the phantom with the hair rod, the inserted is the photograph of phantom; Fig. 2(b) is the normalization line profile of the reconstruction image shown in Fig. 2(a) with y = 8mm.

Fig. 3
Fig. 3

2D photoacoustic image of the pig’s eye and the inserted is the photograph of the pig’s eye.

Fig. 4
Fig. 4

(a) is the photoacoustic image of the intraocular copper-wire foreign body and the inserted is the photograph of the copper wire. Figure 4(b) is the ultrasound image of the intraocular copper-wire foreign body.

Fig. 5
Fig. 5

(a) Photoacoustic image of the black glass intraocular foreign body, and the inserted is the photograph of the glass; (b) ultrasound image of the black glass intraocular foreign body.

Equations (2)

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s(i,j)= n=1 N D n (θ) p n (t+ τ n )
D(θ)= sin(πasin(θ)) πd λ sin(θ)

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