Abstract

We report a technique for simultaneous label-free quantification of cytoplasmic hemoglobin Hb concentration and dynamic membrane fluctuation in individual red blood cells (RBCs). Spectroscopic phase microscopy equipped with three different coherent laser sources and a color detector records three wavelength-dependent quantitative phase images in a single shot of a color-coded hologram. Using molecular specific dispersion, we demonstrate the extraction of Hb concentration and the dynamic membrane fluctuation from individual RBCs.

© 2012 OSA

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  1. V. Ntziachristos, “Fluorescence molecular imaging,” Annu. Rev. Biomed. Eng. 8(1), 1–33 (2006).
    [CrossRef] [PubMed]
  2. S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
    [CrossRef] [PubMed]
  3. J. Stevens and W. Baier, “Refractometric determination of soluble solids in citrus juices,” Ind. Eng. Chem. Anal. Ed. 11(8), 447–449 (1939).
    [CrossRef]
  4. J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
    [CrossRef]
  5. G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw-Hill Professional, 2011).
  6. B. Kemper and G. von Bally, “Digital holographic microscopy for live cell applications and technical inspection,” Appl. Opt. 47(4), A52–A61 (2008).
    [CrossRef] [PubMed]
  7. B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
    [CrossRef] [PubMed]
  8. B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
    [CrossRef] [PubMed]
  9. M. K. Kim, Digital Holography and Microscopy: Principles, Techniques, and Applications (Springer Verlag, 2011).
  10. Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
    [CrossRef] [PubMed]
  11. M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
    [CrossRef] [PubMed]
  12. S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
    [CrossRef] [PubMed]
  13. Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
    [CrossRef] [PubMed]
  14. S. Bernet, A. Jesacher, S. Fürhapter, C. Maurer, and M. Ritsch-Marte, “Quantitative imaging of complex samples by spiral phase contrast microscopy,” Opt. Express 14(9), 3792–3805 (2006).
    [CrossRef] [PubMed]
  15. I. Yamaguchi, T. Matsumura, and J. Kato, “Phase-shifting color digital holography,” Opt. Lett. 27(13), 1108–1110 (2002).
    [CrossRef] [PubMed]
  16. G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
    [CrossRef] [PubMed]
  17. M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
    [CrossRef] [PubMed]
  18. H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
    [CrossRef] [PubMed]
  19. Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
    [CrossRef] [PubMed]
  20. Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
    [CrossRef] [PubMed]
  21. D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, and M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
    [CrossRef] [PubMed]
  22. Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
    [CrossRef] [PubMed]
  23. Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
    [CrossRef] [PubMed]
  24. Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
    [CrossRef] [PubMed]
  25. Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
    [CrossRef] [PubMed]
  26. G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
    [CrossRef] [PubMed]
  27. R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
    [CrossRef] [PubMed]
  28. Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
    [CrossRef] [PubMed]
  29. W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
    [CrossRef] [PubMed]
  30. J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
    [CrossRef] [PubMed]
  31. P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
    [CrossRef] [PubMed]
  32. B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
    [CrossRef] [PubMed]
  33. A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
    [CrossRef]
  34. C. Yang, A. Wax, I. Georgakoudi, E. B. Hanlon, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Interferometric phase-dispersion microscopy,” Opt. Lett. 25(20), 1526–1528 (2000).
    [CrossRef] [PubMed]
  35. Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
    [CrossRef] [PubMed]
  36. D. Fu, W. Choi, Y. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
    [CrossRef] [PubMed]
  37. M. Mir, K. Tangella, and G. Popescu, “Blood testing at the single cell level using quantitative phase and amplitude microscopy,” Biomed. Opt. Express 2(12), 3259–3266 (2011).
    [CrossRef] [PubMed]
  38. F. E. Robles, L. L. Satterwhite, and A. Wax, “Non-linear phase dispersion spectroscopy,” Opt. Lett. 36, 4665–4667 (2011).
  39. O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
    [CrossRef] [PubMed]
  40. M. Friebel and M. Meinke, “Model function to calculate the refractive index of native hemoglobin in the wavelength range of 250-1100 nm dependent on concentration,” Appl. Opt. 45(12), 2838–2842 (2006).
    [CrossRef] [PubMed]
  41. Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
    [CrossRef] [PubMed]
  42. G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
    [CrossRef] [PubMed]
  43. J. M. Desse, P. Picart, and P. Tankam, “Digital three-color holographic interferometry for flow analysis,” Opt. Express 16(8), 5471–5480 (2008).
    [CrossRef] [PubMed]
  44. N. Demoli, D. Vukicevic, and M. Torzynski, “Dynamic digital holographic interferometry with three wavelengths,” Opt. Express 11(7), 767–774 (2003).
    [CrossRef] [PubMed]
  45. P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
    [CrossRef]
  46. L. G. Krzewina and M. K. Kim, “Single-exposure optical sectioning by color structured illumination microscopy,” Opt. Lett. 31(4), 477–479 (2006).
    [CrossRef] [PubMed]
  47. Y. K. Park, C. A. Best, and G. Popescu, “Optical Sensing of Red Blood Cell Dynamics,” in Mechanobiology of Cell-cell and Cell-matrix Interactions(Springer, 2011), p. 279.
  48. G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
    [CrossRef] [PubMed]
  49. G. A. Barabino, M. O. Platt, and D. K. Kaul, “Sickle cell biomechanics,” Annu. Rev. Biomed. Eng. 12(1), 345–367 (2010).
    [CrossRef] [PubMed]
  50. Y. Kim, J. Higgins, R. Dasari, S. Suresh, and Y.-K. Park, “Light scatting spectroscopy of individla red blood cells from a sickle cell patient using Fourier Transfrom Light Scattering method,” J. Biomed. Opt. Lett. in press.
  51. S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
    [CrossRef] [PubMed]

2012 (1)

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

2011 (10)

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[CrossRef] [PubMed]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
[CrossRef] [PubMed]

M. Mir, K. Tangella, and G. Popescu, “Blood testing at the single cell level using quantitative phase and amplitude microscopy,” Biomed. Opt. Express 2(12), 3259–3266 (2011).
[CrossRef] [PubMed]

F. E. Robles, L. L. Satterwhite, and A. Wax, “Non-linear phase dispersion spectroscopy,” Opt. Lett. 36, 4665–4667 (2011).

S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[CrossRef] [PubMed]

2010 (6)

D. Fu, W. Choi, Y. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

G. A. Barabino, M. O. Platt, and D. K. Kaul, “Sickle cell biomechanics,” Annu. Rev. Biomed. Eng. 12(1), 345–367 (2010).
[CrossRef] [PubMed]

2009 (6)

2008 (9)

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
[CrossRef] [PubMed]

J. M. Desse, P. Picart, and P. Tankam, “Digital three-color holographic interferometry for flow analysis,” Opt. Express 16(8), 5471–5480 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

B. Kemper and G. von Bally, “Digital holographic microscopy for live cell applications and technical inspection,” Appl. Opt. 47(4), A52–A61 (2008).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

2007 (3)

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

2006 (6)

2003 (1)

2002 (1)

2000 (1)

1999 (2)

P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
[CrossRef]

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[CrossRef]

1939 (1)

J. Stevens and W. Baier, “Refractometric determination of soluble solids in citrus juices,” Ind. Eng. Chem. Anal. Ed. 11(8), 447–449 (1939).
[CrossRef]

Aiken, M. L.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Amin, M. S.

Auth, T.

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Badizadegan, K.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
[CrossRef] [PubMed]

C. Yang, A. Wax, I. Georgakoudi, E. B. Hanlon, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Interferometric phase-dispersion microscopy,” Opt. Lett. 25(20), 1526–1528 (2000).
[CrossRef] [PubMed]

Baier, W.

J. Stevens and W. Baier, “Refractometric determination of soluble solids in citrus juices,” Ind. Eng. Chem. Anal. Ed. 11(8), 447–449 (1939).
[CrossRef]

Barabino, G. A.

G. A. Barabino, M. O. Platt, and D. K. Kaul, “Sickle cell biomechanics,” Annu. Rev. Biomed. Eng. 12(1), 345–367 (2010).
[CrossRef] [PubMed]

Barbul, A.

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Barman, I.

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Bashir, R.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Bednarz, M.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Bernet, S.

Best, C. A.

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Best-Popescu, C.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Best-Popescu, C. A.

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

Boppart, S. A.

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Boss, D.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

Brazhe, A.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Brazhe, N.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Brysgalova, N. Y.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Cano, E.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

Chandramohanadas, R.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Charrière, F.

Cheng, Z.

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Chiang, F. P.

P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
[CrossRef]

Cho, S.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Choi, W.

D. Fu, W. Choi, Y. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, and M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

Colomb, T.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

D’Angelo, J. A.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Dao, M.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Dasari, R.

Dasari, R. R.

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, Z. Yaqoob, R. R. Dasari, and M. Feld, “Quantitative dispersion microscopy,” Biomed. Opt. Express 1(2), 347–353 (2010).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, and M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[CrossRef] [PubMed]

C. Yang, A. Wax, I. Georgakoudi, E. B. Hanlon, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Interferometric phase-dispersion microscopy,” Opt. Lett. 25(20), 1526–1528 (2000).
[CrossRef] [PubMed]

de la Zerda, A.

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Debnath, S. K.

Deflores, L.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Demoli, N.

Depeursinge, C.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
[CrossRef] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Desse, J. M.

Dickinson, B. L.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Diez-Silva, M.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

Ding, H.

Ding, H. F.

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Douplik, A.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[CrossRef] [PubMed]

Emery, Y.

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Fang-Yen, C.

Feld, M.

Feld, M. S.

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, and M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[CrossRef] [PubMed]

C. Yang, A. Wax, I. Georgakoudi, E. B. Hanlon, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Interferometric phase-dispersion microscopy,” Opt. Lett. 25(20), 1526–1528 (2000).
[CrossRef] [PubMed]

Fiebiger, E.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Friebel, M.

Fu, D.

Fürhapter, S.

Gambhir, S. S.

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Garay, J.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Gauglitz, G.

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[CrossRef]

Georgakoudi, I.

Gheysens, O.

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Gillette, M. U.

Golding, I.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Gov, N. S.

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Hanlon, E. B.

Henle, M. L.

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Higgins, J.

Y. Kim, J. Higgins, R. Dasari, S. Suresh, and Y.-K. Park, “Light scatting spectroscopy of individla red blood cells from a sickle cell patient using Fourier Transfrom Light Scattering method,” J. Biomed. Opt. Lett. in press.

Homola, J.

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[CrossRef]

Hu, Q.

P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
[CrossRef]

Huang, P. S.

P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
[CrossRef]

Ikeda, T.

Jesacher, A.

Jin, F.

P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
[CrossRef]

Jourdain, P.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

Kato, J.

Kaul, D. K.

G. A. Barabino, M. O. Platt, and D. K. Kaul, “Sickle cell biomechanics,” Annu. Rev. Biomed. Eng. 12(1), 345–367 (2010).
[CrossRef] [PubMed]

Kemper, B.

Keren, S.

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Kim, M. K.

Kim, S.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Kim, Y.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Y. Kim, J. Higgins, R. Dasari, S. Suresh, and Y.-K. Park, “Light scatting spectroscopy of individla red blood cells from a sickle cell patient using Fourier Transfrom Light Scattering method,” J. Biomed. Opt. Lett. in press.

Korenstein, R.

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Krzewina, L. G.

Kühn, J.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

Kuriabova, T.

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Levin, G.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Levine, A. J.

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Li, A.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Liew, K.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Lim, C. T.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Lomakin, A.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Lue, N.

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

Lui, L.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Lykotrafitis, G.

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

Magistretti, P. J.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
[CrossRef] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Maksimov, G.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Marquet, P.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
[CrossRef] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Matsumura, T.

Maurer, C.

Meinke, M.

Millet, L.

Mir, M.

Morales, E.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Moratal, C.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

Nguyen, F.

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Ntziachristos, V.

V. Ntziachristos, “Fluorescence molecular imaging,” Annu. Rev. Biomed. Eng. 8(1), 1–33 (2006).
[CrossRef] [PubMed]

Oh, S.

Park, Y.

S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, and M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

Park, Y. K.

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
[CrossRef] [PubMed]

Park, Y.-K.

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

Y. Kim, J. Higgins, R. Dasari, S. Suresh, and Y.-K. Park, “Light scatting spectroscopy of individla red blood cells from a sickle cell patient using Fourier Transfrom Light Scattering method,” J. Biomed. Opt. Lett. in press.

Parshina, E. Y.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Pavillon, N.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

Picart, P.

Platt, M. O.

G. A. Barabino, M. O. Platt, and D. K. Kaul, “Sickle cell biomechanics,” Annu. Rev. Biomed. Eng. 12(1), 345–367 (2010).
[CrossRef] [PubMed]

Popescu, G.

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
[CrossRef] [PubMed]

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

M. Mir, K. Tangella, and G. Popescu, “Blood testing at the single cell level using quantitative phase and amplitude microscopy,” Biomed. Opt. Express 2(12), 3259–3266 (2011).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[CrossRef] [PubMed]

Prasanth, S. G.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Preiser, P. R.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Quinn, D.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Rappaz, B.

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
[CrossRef] [PubMed]

Ritsch-Marte, M.

Robles, F. E.

Rogers, J.

Safran, S. A.

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Satterwhite, L. L.

Shen, Z.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Simanis, V.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

Stevens, J.

J. Stevens and W. Baier, “Refractometric determination of soluble solids in citrus juices,” Ind. Eng. Chem. Anal. Ed. 11(8), 447–449 (1939).
[CrossRef]

Summa, C. M.

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

Sung, Y.

Suresh, S.

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

Y. Kim, J. Higgins, R. Dasari, S. Suresh, and Y.-K. Park, “Light scatting spectroscopy of individla red blood cells from a sickle cell patient using Fourier Transfrom Light Scattering method,” J. Biomed. Opt. Lett. in press.

Sydoruk, O.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[CrossRef] [PubMed]

Tangella, K.

Tankam, P.

Torzynski, M.

Tuchin, V.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[CrossRef] [PubMed]

Unarunotai, S.

von Bally, G.

Vukicevic, D.

Wang, Z.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
[CrossRef] [PubMed]

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

Wax, A.

Yamaguchi, I.

Yamauchi, T.

Yang, C.

Yaqoob, Z.

Yee, S. S.

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[CrossRef]

Yusipovich, A.

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

Zavaleta, C.

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Zhernovaya, O.

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[CrossRef] [PubMed]

Am. J. Physiol. Cell Physiol. (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Annu. Rev. Biomed. Eng. (2)

V. Ntziachristos, “Fluorescence molecular imaging,” Annu. Rev. Biomed. Eng. 8(1), 1–33 (2006).
[CrossRef] [PubMed]

G. A. Barabino, M. O. Platt, and D. K. Kaul, “Sickle cell biomechanics,” Annu. Rev. Biomed. Eng. 12(1), 345–367 (2010).
[CrossRef] [PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (2)

Blood Cells Mol. Dis. (1)

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[CrossRef] [PubMed]

Cytometry A (1)

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73A(10), 895–903 (2008).
[CrossRef] [PubMed]

Ind. Eng. Chem. Anal. Ed. (1)

J. Stevens and W. Baier, “Refractometric determination of soluble solids in citrus juices,” Ind. Eng. Chem. Anal. Ed. 11(8), 447–449 (1939).
[CrossRef]

J. Appl. Phys. (1)

A. Yusipovich, E. Y. Parshina, N. Y. Brysgalova, A. Brazhe, N. Brazhe, A. Lomakin, G. Levin, and G. Maksimov, “Laser interference microscopy in erythrocyte study,” J. Appl. Phys. 105(10), 102037 (2009).
[CrossRef]

J. Biomed. Opt. (3)

Y. Park, C. A. Best-Popescu, R. R. Dasari, and G. Popescu, “Light scattering of human red blood cells during metabolic remodeling of the membrane,” J. Biomed. Opt. 16(1), 011013 (2011).
[CrossRef] [PubMed]

Y. Park, M. Diez-Silva, D. Fu, G. Popescu, W. Choi, I. Barman, S. Suresh, and M. S. Feld, “Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells,” J. Biomed. Opt. 15(2), 020506 (2010).
[CrossRef] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[CrossRef] [PubMed]

J. Biomed. Opt. Lett (1)

Y. Kim, J. Higgins, R. Dasari, S. Suresh, and Y.-K. Park, “Light scatting spectroscopy of individla red blood cells from a sickle cell patient using Fourier Transfrom Light Scattering method,” J. Biomed. Opt. Lett. in press.

J. Immunol. (1)

J. Garay, J. A. D’Angelo, Y. K. Park, C. M. Summa, M. L. Aiken, E. Morales, K. Badizadegan, E. Fiebiger, and B. L. Dickinson, “Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells,” J. Immunol. 185(6), 3227–3238 (2010).
[CrossRef] [PubMed]

J. Neurosci. (1)

P. Jourdain, N. Pavillon, C. Moratal, D. Boss, B. Rappaz, C. Depeursinge, P. Marquet, and P. J. Magistretti, “Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study,” J. Neurosci. 31(33), 11846–11854 (2011).
[CrossRef] [PubMed]

Nat. Methods (1)

W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods 4(9), 717–719 (2007).
[CrossRef] [PubMed]

Opt. Eng. (1)

P. S. Huang, Q. Hu, F. Jin, and F. P. Chiang, “Color-encoded digital fringe projection technique for high-speed three-dimensional surface contouring,” Opt. Eng. 38(6), 1065 (1999).
[CrossRef]

Opt. Express (9)

J. M. Desse, P. Picart, and P. Tankam, “Digital three-color holographic interferometry for flow analysis,” Opt. Express 16(8), 5471–5480 (2008).
[CrossRef] [PubMed]

N. Demoli, D. Vukicevic, and M. Torzynski, “Dynamic digital holographic interferometry with three wavelengths,” Opt. Express 11(7), 767–774 (2003).
[CrossRef] [PubMed]

Y. K. Park, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Diffraction phase and fluorescence microscopy,” Opt. Express 14(18), 8263–8268 (2006).
[CrossRef] [PubMed]

Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
[CrossRef] [PubMed]

D. Fu, W. Choi, Y. Sung, S. Oh, Z. Yaqoob, Y. Park, R. R. Dasari, and M. S. Feld, “Ultraviolet refractometry using field-based light scattering spectroscopy,” Opt. Express 17(21), 18878–18886 (2009).
[CrossRef] [PubMed]

Y.-K. Park, W. Choi, Z. Yaqoob, R. Dasari, K. Badizadegan, and M. S. Feld, “Speckle-field digital holographic microscopy,” Opt. Express 17(15), 12285–12292 (2009).
[CrossRef] [PubMed]

M. S. Amin, Y. Park, N. Lue, R. R. Dasari, K. Badizadegan, M. S. Feld, and G. Popescu, “Microrheology of red blood cell membranes using dynamic scattering microscopy,” Opt. Express 15(25), 17001–17009 (2007).
[CrossRef] [PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[CrossRef] [PubMed]

S. Bernet, A. Jesacher, S. Fürhapter, C. Maurer, and M. Ritsch-Marte, “Quantitative imaging of complex samples by spiral phase contrast microscopy,” Opt. Express 14(9), 3792–3805 (2006).
[CrossRef] [PubMed]

Opt. Lett. (8)

I. Yamaguchi, T. Matsumura, and J. Kato, “Phase-shifting color digital holography,” Opt. Lett. 27(13), 1108–1110 (2002).
[CrossRef] [PubMed]

S. K. Debnath and Y. Park, “Real-time quantitative phase imaging with a spatial phase-shifting algorithm,” Opt. Lett. 36(23), 4677–4679 (2011).
[CrossRef] [PubMed]

B. Rappaz, F. Charrière, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Simultaneous cell morphometry and refractive index measurement with dual-wavelength digital holographic microscopy and dye-enhanced dispersion of perfusion medium,” Opt. Lett. 33(7), 744–746 (2008).
[CrossRef] [PubMed]

F. E. Robles, L. L. Satterwhite, and A. Wax, “Non-linear phase dispersion spectroscopy,” Opt. Lett. 36, 4665–4667 (2011).

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[CrossRef] [PubMed]

C. Yang, A. Wax, I. Georgakoudi, E. B. Hanlon, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Interferometric phase-dispersion microscopy,” Opt. Lett. 25(20), 1526–1528 (2000).
[CrossRef] [PubMed]

Y. Park, T. Yamauchi, W. Choi, R. Dasari, and M. S. Feld, “Spectroscopic phase microscopy for quantifying hemoglobin concentrations in intact red blood cells,” Opt. Lett. 34(23), 3668–3670 (2009).
[CrossRef] [PubMed]

L. G. Krzewina and M. K. Kim, “Single-exposure optical sectioning by color structured illumination microscopy,” Opt. Lett. 31(4), 477–479 (2006).
[CrossRef] [PubMed]

Phys. Med. Biol. (1)

O. Zhernovaya, O. Sydoruk, V. Tuchin, and A. Douplik, “The refractive index of human hemoglobin in the visible range,” Phys. Med. Biol. 56(13), 4013–4021 (2011).
[CrossRef] [PubMed]

Phys. Rev. E Stat. Nonlin. Soft Matter Phys. (2)

G. Popescu, Y. K. Park, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Coherence properties of red blood cell membrane motions,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 76(3), 031902 (2007).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Kuriabova, M. L. Henle, M. S. Feld, A. J. Levine, and G. Popescu, “Measurement of the nonlinear elasticity of red blood cell membranes,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 83(5), 051925 (2011).
[CrossRef] [PubMed]

Phys. Rev. Lett. (1)

H. F. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[CrossRef] [PubMed]

PLoS ONE (1)

R. Chandramohanadas, Y. K. Park, L. Lui, A. Li, D. Quinn, K. Liew, M. Diez-Silva, Y. Sung, M. Dao, C. T. Lim, P. R. Preiser, and S. Suresh, “Biophysics of malarial parasite exit from infected erythrocytes,” PLoS ONE 6(6), e20869 (2011).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (5)

Y.-K. Park, M. Diez-Silva, G. Popescu, G. Lykotrafitis, W. Choi, M. S. Feld, and S. Suresh, “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum,” Proc. Natl. Acad. Sci. U.S.A. 105(37), 13730–13735 (2008).
[CrossRef] [PubMed]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[CrossRef] [PubMed]

S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir, “Noninvasive molecular imaging of small living subjects using Raman spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 105(15), 5844–5849 (2008).
[CrossRef] [PubMed]

Y. Park, C. A. Best, K. Badizadegan, R. R. Dasari, M. S. Feld, T. Kuriabova, M. L. Henle, A. J. Levine, and G. Popescu, “Measurement of red blood cell mechanics during morphological changes,” Proc. Natl. Acad. Sci. U.S.A. 107(15), 6731–6736 (2010).
[CrossRef] [PubMed]

Y. K. Park, C. A. Best, T. Auth, N. S. Gov, S. A. Safran, G. Popescu, S. Suresh, and M. S. Feld, “Metabolic remodeling of the human red blood cell membrane,” Proc. Natl. Acad. Sci. U.S.A. 107(4), 1289–1294 (2010).
[CrossRef] [PubMed]

Sens. Actuators B Chem. (1)

J. Homola, S. S. Yee, and G. Gauglitz, “Surface plasmon resonance sensors: review,” Sens. Actuators B Chem. 54(1-2), 3–15 (1999).
[CrossRef]

Trends Biotechnol. (1)

S. Cho, S. Kim, Y. Kim, and Y. K. Park, “Optical imaging techniques for the study of malaria,” Trends Biotechnol. 30(2), 71–79 (2012).
[CrossRef] [PubMed]

Other (3)

Y. K. Park, C. A. Best, and G. Popescu, “Optical Sensing of Red Blood Cell Dynamics,” in Mechanobiology of Cell-cell and Cell-matrix Interactions(Springer, 2011), p. 279.

G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw-Hill Professional, 2011).

M. K. Kim, Digital Holography and Microscopy: Principles, Techniques, and Applications (Springer Verlag, 2011).

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Figures (5)

Fig. 1
Fig. 1

Experimental setup for dSPM. (a) The dynamic SPM is based on the conventional DPM with different coherent laser sources (633/532/450 nm). (b) Bayer image of red blood cell and retrieved RGB channel images.

Fig. 2
Fig. 2

Amplitude and phase images of RBC in RGB channels, (a)-(c) interferograms for red, green, and blue colors decomposed from one Bayer color image, (d)-(f) amplitude and (g)-(i) phase images for red, green, and blue channels, respectively. Scale bars in (a)-(i) are 5 µm.

Fig. 3
Fig. 3

(a) Retrieved height and (b) Hb concentration maps of single RBC, respectively. The height and Hb concentration maps were only calculate for the RBC area. Scale bars are 5 µm.

Fig. 4
Fig. 4

(a) MCV, (b) MCHC, and (c) MCH values measured from 24 individual RBCs. Each circle symbol in A represent the quantity measured from individual RBCs. Graphs show the median (central horizontal line), standard deviations (box), and minimum and maximum values (vertical lines).

Fig. 5
Fig. 5

(a) Average height map of an RBC from the dynamic holograms measured for 22 seconds with 20 fps, (b) height fluctuations of A, B, C during 11 seconds.

Equations (7)

Equations on this page are rendered with MathJax. Learn more.

Δϕ= 2π λ Γ Δn (x,y,z)d
Δϕ(x,y)=2πΔnh(x,y)/λ
Δn=α( λ )C( x,y )+ n X ( x,y;λ )
Δ ϕ i (x,y)= 2π λ i ( α( λ i )C(x,y)+ n X (x,y;λ) )h(x,y),fori=1,2,3.
min ( C, n X ) [ std( C, n X ) ]s.t.{ Δ ϕ i ( x,y )= 2π / λ i Δ n i h( x,y ) 20<C<50 (g/dl) 0.001< n X <0.01 0.1<h<3 (μm) ,i=1,2,3.
MCV= h(x,y)dA
MCHC= C( x,y )dA / dA

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