Abstract

The high prevalence of atherosclerosis and the corresponding derived morbidity drives the investigation of novel imaging tools for disease diagnosis and assessment. Multi-spectral optoacoustic tomography (MSOT) can resolve structural, hemodynamic and molecular parameters that relate to cardiovascular disease. Similarly to ultrasound imaging, optoacoustic (photoacoustic) imaging can be implemented as a handheld arrangement which further brings dissemination potential to point of care applications. Correspondingly, we experimentally investigate herein the performance of non-invasive optoacoustic scanning developed for carotid imaging, in phantoms and humans. The results demonstrate that traditional transducers employed in ultrasound imaging do not offer optimal MSOT imaging. Instead, feasibility to detect human carotids and carotid-sized vessels in clinically-relevant depths is better demonstrated with curved arrays and tomographic approaches.

© 2012 OSA

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  1. A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
    [CrossRef] [PubMed]
  2. A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
    [CrossRef] [PubMed]
  3. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
    [CrossRef] [PubMed]
  4. A. Rosencwaig and P. R. Griffiths, “Photoacoustics and Photoacoustic Spectroscopy,” Phys. Today34(6), 64–66 (1981).
    [CrossRef]
  5. R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
    [CrossRef] [PubMed]
  6. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
    [CrossRef] [PubMed]
  7. M. J. Colles, N. R. Geddes, and E. Mehdizadeh, “The optoacoustic effect,” Contemp. Phys.20(1), 11–36 (1979).
    [CrossRef]
  8. Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
    [CrossRef]
  9. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett.32(19), 2891–2893 (2007).
    [CrossRef] [PubMed]
  10. H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
    [CrossRef] [PubMed]
  11. A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett.35(14), 2475–2477 (2010).
    [CrossRef] [PubMed]
  12. A. A. Oraevsky, A. A. Karabutov, S. V. Solomatin, E. V. Savateeva, V. A. Andreev, Z. Gatalica, H. Singh, and R. D. Fleming, “Laser optoacoustic imaging of breast cancer in vivo,” in Biomedical Optoacoustics II, (SPIE, 2001), 6–15.
  13. J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
    [CrossRef] [PubMed]
  14. C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
    [CrossRef] [PubMed]
  15. C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
    [CrossRef] [PubMed]
  16. V. Ntziachristos and D. Razansky, “Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT),” Chem. Rev.110(5), 2783–2794 (2010).
    [CrossRef] [PubMed]
  17. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Mesoscopic imaging of fluorescent proteins using multi-spectral optoacoustic tomography (MSOT),” in (SPIE, 2009), 71770D–71776.
  18. A. Rosenthal, D. Razansky, and V. Ntziachristos, “Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography,” IEEE Trans. Med. Imaging29(6), 1275–1285 (2010).
    [CrossRef] [PubMed]
  19. A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
    [CrossRef] [PubMed]
  20. J. Glatz, N. C. Deliolanis, A. Buehler, D. Razansky, and V. Ntziachristos, “Blind source unmixing in multi-spectral optoacoustic tomography,” Opt. Express19(4), 3175–3184 (2011).
    [CrossRef] [PubMed]
  21. M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
    [CrossRef] [PubMed]
  22. V. Ntziachristos, A. Leroy-Willig, and B. Tavitian, Textbook of in vivo imaging in vertebrates (Wiley, 2007).
  23. M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
    [CrossRef] [PubMed]
  24. R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express17(24), 21414–21426 (2009).
    [CrossRef] [PubMed]

2011

A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
[CrossRef] [PubMed]

J. Glatz, N. C. Deliolanis, A. Buehler, D. Razansky, and V. Ntziachristos, “Blind source unmixing in multi-spectral optoacoustic tomography,” Opt. Express19(4), 3175–3184 (2011).
[CrossRef] [PubMed]

2010

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett.35(14), 2475–2477 (2010).
[CrossRef] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

V. Ntziachristos and D. Razansky, “Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT),” Chem. Rev.110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

A. Rosenthal, D. Razansky, and V. Ntziachristos, “Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography,” IEEE Trans. Med. Imaging29(6), 1275–1285 (2010).
[CrossRef] [PubMed]

2009

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express17(24), 21414–21426 (2009).
[CrossRef] [PubMed]

2008

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

2007

2005

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
[CrossRef] [PubMed]

2004

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

2003

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

2002

A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
[CrossRef] [PubMed]

1995

R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
[CrossRef] [PubMed]

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

1981

A. Rosencwaig and P. R. Griffiths, “Photoacoustics and Photoacoustic Spectroscopy,” Phys. Today34(6), 64–66 (1981).
[CrossRef]

1979

M. J. Colles, N. R. Geddes, and E. Mehdizadeh, “The optoacoustic effect,” Contemp. Phys.20(1), 11–36 (1979).
[CrossRef]

Aikawa, E.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

Appledorn, C. R.

R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
[CrossRef] [PubMed]

Branchereau, A.

A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
[CrossRef] [PubMed]

Brecht, H.-P.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

Buehler, A.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Cinà, C. S.

A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
[CrossRef] [PubMed]

Clase, C. M.

A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
[CrossRef] [PubMed]

Colles, M. J.

M. J. Colles, N. R. Geddes, and E. Mehdizadeh, “The optoacoustic effect,” Contemp. Phys.20(1), 11–36 (1979).
[CrossRef]

Conjusteau, A.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

Corbillon, E.

A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
[CrossRef] [PubMed]

de Kleine, R. H.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

Deliolanis, N. C.

Dima, A.

A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
[CrossRef] [PubMed]

Eilert-Zell, K.

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

Ermilov, S. A.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

Erpelding, T. N.

et,

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Fang, Y. R.

R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
[CrossRef] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Frenz, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

Fronheiser, M.

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

Fronheiser, M. P.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

Geddes, N. R.

M. J. Colles, N. R. Geddes, and E. Mehdizadeh, “The optoacoustic effect,” Contemp. Phys.20(1), 11–36 (1979).
[CrossRef]

Gill, K. L.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

Glatz, J.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Griffiths, P. R.

A. Rosencwaig and P. R. Griffiths, “Photoacoustics and Photoacoustic Spectroscopy,” Phys. Today34(6), 64–66 (1981).
[CrossRef]

Haisch, C.

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Herzog, E.

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

Jahromi, A. S.

A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
[CrossRef] [PubMed]

Jankovic, L.

Jetzfellner, T.

A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
[CrossRef] [PubMed]

Kim, C.

Kirsch, D. G.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

Kruger, R. A.

R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
[CrossRef] [PubMed]

Ku, G.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

Lepoutre, A.

A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
[CrossRef] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Liu, P.

R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
[CrossRef] [PubMed]

Liu, Y.

A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
[CrossRef] [PubMed]

Long, A.

A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
[CrossRef] [PubMed]

Ma, R.

Mehdizadeh, E.

M. J. Colles, N. R. Geddes, and E. Mehdizadeh, “The optoacoustic effect,” Contemp. Phys.20(1), 11–36 (1979).
[CrossRef]

Mehta, K.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

Menzenbach, P.

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

Niedre, M. J.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

Niessner, R.

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

Ntziachristos, V.

J. Glatz, N. C. Deliolanis, A. Buehler, D. Razansky, and V. Ntziachristos, “Blind source unmixing in multi-spectral optoacoustic tomography,” Opt. Express19(4), 3175–3184 (2011).
[CrossRef] [PubMed]

A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
[CrossRef] [PubMed]

V. Ntziachristos and D. Razansky, “Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT),” Chem. Rev.110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

A. Rosenthal, D. Razansky, and V. Ntziachristos, “Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography,” IEEE Trans. Med. Imaging29(6), 1275–1285 (2010).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett.35(14), 2475–2477 (2010).
[CrossRef] [PubMed]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express17(24), 21414–21426 (2009).
[CrossRef] [PubMed]

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett.32(19), 2891–2893 (2007).
[CrossRef] [PubMed]

O'Neal, D. P.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

Oraevsky, A. A.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Pashley, M. D.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Razansky, D.

Rosencwaig, A.

A. Rosencwaig and P. R. Griffiths, “Photoacoustics and Photoacoustic Spectroscopy,” Phys. Today34(6), 64–66 (1981).
[CrossRef]

Rosenthal, A.

A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
[CrossRef] [PubMed]

A. Rosenthal, D. Razansky, and V. Ntziachristos, “Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography,” IEEE Trans. Med. Imaging29(6), 1275–1285 (2010).
[CrossRef] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Stoica, G.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Su, R.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Taruttis, A.

Vinegoni, C.

Vogel, M. M.

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

Wang, L. V.

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express1(1), 278–284 (2010).
[CrossRef] [PubMed]

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Wang, X.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Wang, Y.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

Weissleder, R.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

Xie, X.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Anal. Bioanal. Chem.

C. Haisch, K. Eilert-Zell, M. M. Vogel, P. Menzenbach, and R. Niessner, “Combined optoacoustic/ultrasound system for tomographic absorption measurements: possibilities and limitations,” Anal. Bioanal. Chem.397(4), 1503–1510 (2010).
[CrossRef] [PubMed]

Biomed. Opt. Express

Chem. Rev.

V. Ntziachristos and D. Razansky, “Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT),” Chem. Rev.110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

Contemp. Phys.

M. J. Colles, N. R. Geddes, and E. Mehdizadeh, “The optoacoustic effect,” Contemp. Phys.20(1), 11–36 (1979).
[CrossRef]

Eur. J. Vasc. Endovasc. Surg.

A. Long, A. Lepoutre, E. Corbillon, and A. Branchereau, “Critical Review of Non- or Minimally Invasive Methods (Duplex Ultrasonography, MR- and CT-angiography) for Evaluating Stenosis of the Proximal Internal Carotid Artery,” Eur. J. Vasc. Endovasc. Surg.24(1), 43–52 (2002).
[CrossRef] [PubMed]

IEEE Trans. Med. Imaging

A. Rosenthal, D. Razansky, and V. Ntziachristos, “Fast semi-analytical model-based acoustic inversion for quantitative optoacoustic tomography,” IEEE Trans. Med. Imaging29(6), 1275–1285 (2010).
[CrossRef] [PubMed]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging24(4), 436–440 (2005).
[CrossRef] [PubMed]

J. Biomed. Opt.

M. P. Fronheiser, S. A. Ermilov, H.-P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt.15(2), 021305–021307 (2010).
[CrossRef] [PubMed]

H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt.14(6), 064007–064008 (2009).
[CrossRef] [PubMed]

J. Vasc. Surg.

A. S. Jahromi, C. S. Cinà, Y. Liu, and C. M. Clase, “Sensitivity and specificity of color duplex ultrasound measurement in the estimation of internal carotid artery stenosis: a systematic review and meta-analysis,” J. Vasc. Surg.41(6), 962–972 (2005).
[CrossRef] [PubMed]

Med. Phys.

R. A. Kruger, P. Liu, Y. R. Fang, and C. R. Appledorn, “Photoacoustic ultrasound (PAUS)--Reconstruction tomography,” Med. Phys.22(10), 1605–1609 (1995).
[CrossRef] [PubMed]

A. Buehler, A. Rosenthal, T. Jetzfellner, A. Dima, D. Razansky, and V. Ntziachristos, “Model-based optoacoustic inversions with incomplete projection data,” Med. Phys.38(3), 1694–1704 (2011).
[CrossRef] [PubMed]

Nano Lett.

Y. Wang, X. Xie, X. Wang, G. Ku, K. L. Gill, D. P. O'Neal, G. Stoica, and L. V. Wang, “Photoacoustic Tomography of a Nanoshell Contrast Agent in the in Vivo Rat Brain,” Nano Lett.4(9), 1689–1692 (2004).
[CrossRef]

Nat. Biotechnol.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

Phys. Today

A. Rosencwaig and P. R. Griffiths, “Photoacoustics and Photoacoustic Spectroscopy,” Phys. Today34(6), 64–66 (1981).
[CrossRef]

Proc. Natl. Acad. Sci. U.S.A.

M. J. Niedre, R. H. de Kleine, E. Aikawa, D. G. Kirsch, R. Weissleder, and V. Ntziachristos, “Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo,” Proc. Natl. Acad. Sci. U.S.A.105(49), 19126–19131 (2008).
[CrossRef] [PubMed]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991).
[CrossRef] [PubMed]

Other

A. A. Oraevsky, A. A. Karabutov, S. V. Solomatin, E. V. Savateeva, V. A. Andreev, Z. Gatalica, H. Singh, and R. D. Fleming, “Laser optoacoustic imaging of breast cancer in vivo,” in Biomedical Optoacoustics II, (SPIE, 2001), 6–15.

V. Ntziachristos, A. Leroy-Willig, and B. Tavitian, Textbook of in vivo imaging in vertebrates (Wiley, 2007).

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Mesoscopic imaging of fluorescent proteins using multi-spectral optoacoustic tomography (MSOT),” in (SPIE, 2009), 71770D–71776.

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Figures (7)

Fig. 1
Fig. 1

Detection geometries: (a) L7 linear ultrasound array; (b) curved array. (c) Illumination and detection pattern.

Fig. 2
Fig. 2

Phantom properties: (a) Type A configuration. (b) Type B configuration. (c) Porcine muscle phantom. (d) Spectra of employed absorbers.

Fig. 3
Fig. 3

Optoacoustic signal of absorber(s) within inner tube(s) from (a) phantom A1, (b) phantom B1.

Fig. 4
Fig. 4

Curved array reconstructions. The first row shows single wavelength images of (a) phantom A1, (b) phantom A2, (c) phantom A3. The second row shows the distribution of ink from (d) phantom B1, (e) phantom B2, (f) phantom B3. Grayscale represents a single wavelength image, whereby the color overlay shows the resolved ink concentration. The third row shows the distribution of AF750 from (g) phantom B1, (h) phantom B2, (i) phantom B3. Grayscale images are the same as in the second row; however the color overlay shows the AF750 concentration.

Fig. 5
Fig. 5

Linear array reconstructions. The first row shows single wavelength images of (a) phantom A1, (b) phantom A2, (c) phantom A3. The second row shows the distribution of ink from (d) phantom B1, (e) phantom B2, (f) phantom B3. Grayscale represents a single wavelength image, whereby the color overlay shows the resolved ink concentration. The third row shows the distribution of AF750 from (g) phantom B1, (h) phantom B2, (i) phantom B3. Grayscale images are the same as in the second row; however the color overlay shows the AF750 concentration.

Fig. 6
Fig. 6

Cross-sections showing lower arm vasculature of a male volunteer 7 cm from the elbow – axes are given in mm. (a) Optoacoustic image using the curved array assembly. (b) Directional DUS image indicating positive flow in yellow/red; negative flow in green/blue. Annotations: 1.Skin surface; 2.Intermediate antebrachial vein; 3.Radial artery.

Fig. 7
Fig. 7

Cross-sections showing cardio-vasculature of a female volunteer at the lower neck level – axes are given in mm. (a) Optoacoustic image using a curved array assembly. (b) Directional DUS image indicating positive flow in yellow/red; negative flow in green/blue. Annotations: 1.Skin surface; 2.Common carotid; 3.Internal jugular vein; 4.External jugular vein.

Tables (2)

Tables Icon

Table 1 Optical Properties of Employed Phantoms at 750 nm

Tables Icon

Table 2 Achievable SNR

Metrics