Abstract

We have created a 2.5-mm outer diameter integrated photo-acoustic and ultrasonic mini-probe which can be inserted into a standard video endoscope’s instrument channel. A small-diameter focused ultrasonic transducer made of PMN-PT provides adequate signal sensitivity, and enables miniaturization of the probe. Additionally, this new endoscopic probe utilizes the same scanning mirror and micromotor-based built-in actuator described in our previous reports; however, the length of the rigid distal section of the new probe has been further reduced to ~35 mm. This paper describes the technical details of the mini-probe and presents experimental results that both quantify the imaging performance and demonstrate its in vivo imaging capability, which suggests that it could work as a mini-probe for certain clinical applications.

© 2012 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
    [CrossRef] [PubMed]
  2. J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
    [CrossRef] [PubMed]
  3. A. A. Oraevsky and A. A. Karabutov, “Optoacoustic Tomography,” in Biomedical Photonics Handbook, T. Vo-Dinh, ed. (CRC Press, 2003).
  4. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
    [CrossRef] [PubMed]
  5. C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol.54(19), R59–R97 (2009).
    [CrossRef] [PubMed]
  6. P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
    [CrossRef] [PubMed]
  7. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
    [CrossRef] [PubMed]
  8. Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett.35(12), 2067–2069 (2010).
    [CrossRef] [PubMed]
  9. C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
    [CrossRef] [PubMed]
  10. A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011).
    [CrossRef] [PubMed]
  11. Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011).
    [CrossRef] [PubMed]
  12. S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett.36(7), 1134–1136 (2011).
    [CrossRef] [PubMed]
  13. J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010).
    [CrossRef] [PubMed]
  14. J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011).
    [CrossRef] [PubMed]
  15. M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009).
    [CrossRef] [PubMed]
  16. M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
    [CrossRef] [PubMed]
  17. S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt.15(1), 011101 (2010).
    [CrossRef] [PubMed]
  18. B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
    [CrossRef] [PubMed]
  19. J. L. Su, B. Wang, and S. Y. Emelianov, “Photoacoustic imaging of coronary artery stents,” Opt. Express17(22), 19894–19901 (2009).
    [CrossRef] [PubMed]
  20. A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010).
    [CrossRef] [PubMed]
  21. K. Jansen, A. F. van der Steen, H. M. van Beusekom, J. W. Oosterhuis, and G. van Soest, “Intravascular photoacoustic imaging of human coronary atherosclerosis,” Opt. Lett.36(5), 597–599 (2011).
    [CrossRef] [PubMed]
  22. E. Z. Zhang and P. C. Beard, “A miniature all-optical photoacoustic imaging probe,” Proc. SPIE7899, 78991F, 78991F-6 (2011).
    [CrossRef]
  23. B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, “All-optical scanhead for ultrasound and photoacoustic dual-modality imaging,” Opt. Express20(2), 1588–1596 (2012).
    [CrossRef] [PubMed]
  24. B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett.37(7), 1244–1246 (2012).
    [CrossRef] [PubMed]
  25. T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
    [CrossRef] [PubMed]
  26. Y. Yuan, S. Yang, and D. Xing, “Preclinical photoacoustic imaging endoscope based on acousto-optic coaxial system using ring transducer array,” Opt. Lett.35(13), 2266–2268 (2010).
    [CrossRef] [PubMed]
  27. J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
    [CrossRef]
  28. M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
    [CrossRef] [PubMed]
  29. X. Wang, W. W. Roberts, P. L. Carson, D. P. Wood, and J. B. Fowlkes, “Photoacoustic tomography: a potential new tool for prostate cancer,” Biomed. Opt. Express1(4), 1117–1126 (2010).
    [CrossRef] [PubMed]
  30. C. Sheaff and S. Ashkenazi, “A fiber optic optoacoustic ultrasound sensor for photoacoustic endoscopy,” in Proceedings of IEEE International Ultrasonics Symposium (Institute of Electrical and Electronics Engineers, San Diego, 2010), pp. 2135–2138.
  31. Y. Yang, X. Li, T. Wang, P. D. Kumavor, A. Aguirre, K. K. Shung, Q. Zhou, M. Sanders, M. Brewer, and Q. Zhu, “Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization,” Biomed. Opt. Express2(9), 2551–2561 (2011).
    [CrossRef] [PubMed]
  32. C. Dietrich, ed., Endoscopic Ultrasound: An Introductory Manual and Atlas (Thieme, New York, 2006).
  33. J. Menzel and W. Domschke, “Gastrointestinal miniprobe sonography: the current status,” Am. J. Gastroenterol.95(3), 605–616 (2000).
    [CrossRef] [PubMed]
  34. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
    [CrossRef] [PubMed]
  35. X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000).
    [CrossRef] [PubMed]
  36. X. Liu, M. J. Cobb, Y. Chen, M. B. Kimmey, and X. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Opt. Lett.29(15), 1763–1765 (2004).
    [CrossRef] [PubMed]
  37. S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
    [CrossRef] [PubMed]
  38. D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
    [CrossRef]
  39. H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
    [CrossRef] [PubMed]
  40. A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
    [CrossRef] [PubMed]
  41. R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
    [CrossRef] [PubMed]
  42. P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
    [CrossRef] [PubMed]
  43. L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
    [CrossRef] [PubMed]
  44. N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
    [CrossRef] [PubMed]
  45. J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
    [CrossRef] [PubMed]
  46. Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
    [CrossRef] [PubMed]
  47. Laser Institute of America, American National Standard for Safe Use of Lasers, ANSI Z136.1–2007 (American National Standards Institute, Inc., New York, NY, 2007).

2012

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

B. Y. Hsieh, S. L. Chen, T. Ling, L. J. Guo, and P. C. Li, “All-optical scanhead for ultrasound and photoacoustic dual-modality imaging,” Opt. Express20(2), 1588–1596 (2012).
[CrossRef] [PubMed]

B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett.37(7), 1244–1246 (2012).
[CrossRef] [PubMed]

2011

K. Jansen, A. F. van der Steen, H. M. van Beusekom, J. W. Oosterhuis, and G. van Soest, “Intravascular photoacoustic imaging of human coronary atherosclerosis,” Opt. Lett.36(5), 597–599 (2011).
[CrossRef] [PubMed]

A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011).
[CrossRef] [PubMed]

Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011).
[CrossRef] [PubMed]

S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett.36(7), 1134–1136 (2011).
[CrossRef] [PubMed]

Y. Yang, X. Li, T. Wang, P. D. Kumavor, A. Aguirre, K. K. Shung, Q. Zhou, M. Sanders, M. Brewer, and Q. Zhu, “Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization,” Biomed. Opt. Express2(9), 2551–2561 (2011).
[CrossRef] [PubMed]

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

E. Z. Zhang and P. C. Beard, “A miniature all-optical photoacoustic imaging probe,” Proc. SPIE7899, 78991F, 78991F-6 (2011).
[CrossRef]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
[CrossRef] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011).
[CrossRef] [PubMed]

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

2010

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt.15(1), 011101 (2010).
[CrossRef] [PubMed]

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010).
[CrossRef] [PubMed]

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010).
[CrossRef] [PubMed]

Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett.35(12), 2067–2069 (2010).
[CrossRef] [PubMed]

Y. Yuan, S. Yang, and D. Xing, “Preclinical photoacoustic imaging endoscope based on acousto-optic coaxial system using ring transducer array,” Opt. Lett.35(13), 2266–2268 (2010).
[CrossRef] [PubMed]

X. Wang, W. W. Roberts, P. L. Carson, D. P. Wood, and J. B. Fowlkes, “Photoacoustic tomography: a potential new tool for prostate cancer,” Biomed. Opt. Express1(4), 1117–1126 (2010).
[CrossRef] [PubMed]

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

2009

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
[CrossRef] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol.54(19), R59–R97 (2009).
[CrossRef] [PubMed]

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009).
[CrossRef] [PubMed]

J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
[CrossRef] [PubMed]

J. L. Su, B. Wang, and S. Y. Emelianov, “Photoacoustic imaging of coronary artery stents,” Opt. Express17(22), 19894–19901 (2009).
[CrossRef] [PubMed]

2008

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

2007

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

2004

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

X. Liu, M. J. Cobb, Y. Chen, M. B. Kimmey, and X. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Opt. Lett.29(15), 1763–1765 (2004).
[CrossRef] [PubMed]

2000

X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000).
[CrossRef] [PubMed]

J. Menzel and W. Domschke, “Gastrointestinal miniprobe sonography: the current status,” Am. J. Gastroenterol.95(3), 605–616 (2000).
[CrossRef] [PubMed]

1997

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Adler, D. C.

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

Aguirre, A.

Allen, T. J.

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

Ameri, H.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Amirian, J.

Backer, J. M.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Backer, M. V.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Barton, J. K.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
[CrossRef] [PubMed]

Beard, P. C.

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

E. Z. Zhang and P. C. Beard, “A miniature all-optical photoacoustic imaging probe,” Proc. SPIE7899, 78991F, 78991F-6 (2011).
[CrossRef]

Bell, B. A.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Bennett, A.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Boppart, S. A.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Bouma, B. E.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Brecht, H. P.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Brewer, M.

Brezinski, M. E.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Bright, S.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Brown, W. J.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Burg, J.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Cai, X.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

Cannata, J. M.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Carretta, E.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Carson, P. L.

Chan, R. C.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Chatni, M. R.

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

Chen, R.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

Chen, S. L.

Chen, Y.

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

X. Liu, M. J. Cobb, Y. Chen, M. B. Kimmey, and X. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Opt. Lett.29(15), 1763–1765 (2004).
[CrossRef] [PubMed]

Chudoba, C.

Chung, E.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Chuttani, R.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Cobb, M. J.

Conjusteau, A.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Connolly, J.

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

Cornelius, L. A.

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

Danielli, A.

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011).
[CrossRef] [PubMed]

de Boer, J. F.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Delaney, P.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Dellon, E. S.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Desjardins, A. E.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Dhillon, A. P.

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

Domschke, W.

J. Menzel and W. Domschke, “Gastrointestinal miniprobe sonography: the current status,” Am. J. Gastroenterol.95(3), 605–616 (2000).
[CrossRef] [PubMed]

Emelianov, S.

Emelianov, S. Y.

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010).
[CrossRef] [PubMed]

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

J. L. Su, B. Wang, and S. Y. Emelianov, “Photoacoustic imaging of coronary artery stents,” Opt. Express17(22), 19894–19901 (2009).
[CrossRef] [PubMed]

Enders, M.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Ermilov, S. A.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Evans, J. A.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Favazza, C.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

Favazza, C. P.

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011).
[CrossRef] [PubMed]

Fowlkes, J. B.

Fronheiser, M.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Fujimoto, J. G.

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Fukumura, D.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Galanko, J.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Galle, P. R.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Gebhart, S. C.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Gnaendiger, J.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Goldblum, J. R.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Goldsmith, J. D.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Gottlieb, E. J.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Guo, L.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Guo, L. J.

Guo, Z.

Hall, A.

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

Han, P.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Hanlon, E. B.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Hsieh, B. Y.

Hu, S.

Huber, R.

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

Humayun, M. S.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Hung, K. E.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Itani, S.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Itzkan, I.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Jaffer, F. A.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Jain, R. K.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Janell, D.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Jang, I. K.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Jansen, K.

Karpiouk, A.

Karpiouk, A. B.

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010).
[CrossRef] [PubMed]

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

Kiesslich, R.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Kim, J. W.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Kim, P.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Kimmey, M. B.

Ko, T.

Kucherlapati, R.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Kumavor, P. D.

Leyden, J.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Li, C.

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol.54(19), R59–R97 (2009).
[CrossRef] [PubMed]

Li, P. C.

Li, X.

Ling, T.

Litovsky, S.

Liu, X.

Madanick, R. D.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Maslov, K.

Maslov, K. I.

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010).
[CrossRef] [PubMed]

McCarthy, J. R.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

McLaren, W.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Menzel, J.

J. Menzel and W. Domschke, “Gastrointestinal miniprobe sonography: the current status,” Am. J. Gastroenterol.95(3), 605–616 (2000).
[CrossRef] [PubMed]

Mizoguchi, A.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Modell, M. D.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Morse, T.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Motamedi, M.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Nafe, B.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Namati, E.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Neurath, M. F.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Nishioka, N. S.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Ntziachristos, V.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Oh, W. Y.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Oosterhuis, J. W.

Oraevsky, A. A.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Overholt, B. F.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Owen, J. S.

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

Ozden, N.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Panjehpour, M.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Perelman, L. T.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Pitris, C.

X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Pleskow, D. K.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Polglase, A.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Pramanik, M.

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009).
[CrossRef] [PubMed]

Qiu, L.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Rice, P. F.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Rinehart, M. T.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Roberts, W. W.

Sacks, A.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Sanders, M.

Schmitt, J.

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

Shaheen, N. J.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Shi, Y.

Shishkov, M.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Shubochkin, R.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Shung, K. K.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Y. Yang, X. Li, T. Wang, P. D. Kumavor, A. Aguirre, K. K. Shung, Q. Zhou, M. Sanders, M. Brewer, and Q. Zhu, “Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization,” Biomed. Opt. Express2(9), 2551–2561 (2011).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
[CrossRef] [PubMed]

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Smalling, R.

Smalling, R. W.

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

Sokolov, K. V.

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

Southern, J. F.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Su, J. L.

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

J. L. Su, B. Wang, and S. Y. Emelianov, “Photoacoustic imaging of coronary artery stents,” Opt. Express17(22), 19894–19901 (2009).
[CrossRef] [PubMed]

Su, R.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Sun, L.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Suter, M. J.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Taber, L. A.

Tearney, G. J.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Terry, N. G.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Thomas, S.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Trembath, D.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Vakoc, B. J.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

van Beusekom, H. M.

van der Steen, A. F.

van Soest, G.

Vieth, M.

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

Vitkin, E.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Wang, B.

B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett.37(7), 1244–1246 (2012).
[CrossRef] [PubMed]

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010).
[CrossRef] [PubMed]

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

J. L. Su, B. Wang, and S. Y. Emelianov, “Photoacoustic imaging of coronary artery stents,” Opt. Express17(22), 19894–19901 (2009).
[CrossRef] [PubMed]

Wang, L. V.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett.36(7), 1134–1136 (2011).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011).
[CrossRef] [PubMed]

Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011).
[CrossRef] [PubMed]

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt.15(1), 011101 (2010).
[CrossRef] [PubMed]

Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett.35(12), 2067–2069 (2010).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010).
[CrossRef] [PubMed]

J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
[CrossRef] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol.54(19), R59–R97 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
[CrossRef] [PubMed]

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

Wang, T.

Wang, X.

Wang, Y.

Watson, J. M.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Wax, A.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Weichsel, J.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Winkler, A. M.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Wood, D. P.

Woosley, J. T.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Xia, Y.

Xing, D.

Xu, X.

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Yamashita, H.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Yang, H. C.

Yang, J. M.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
[CrossRef] [PubMed]

Yang, S.

Yang, Y.

Yao, J.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010).
[CrossRef] [PubMed]

Yaseen, M. A.

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Yeager, D.

Yoo, H.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

Yuan, Y.

Yun, S. H.

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

Zhang, E. Z.

E. Z. Zhang and P. C. Beard, “A miniature all-optical photoacoustic imaging probe,” Proc. SPIE7899, 78991F, 78991F-6 (2011).
[CrossRef]

Zhang, Y.

Zhou, Q.

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

Y. Yang, X. Li, T. Wang, P. D. Kumavor, A. Aguirre, K. K. Shung, Q. Zhou, M. Sanders, M. Brewer, and Q. Zhu, “Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization,” Biomed. Opt. Express2(9), 2551–2561 (2011).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
[CrossRef] [PubMed]

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Zhu, Q.

Zhu, Y.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Ziefle, C. G.

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

Am. J. Gastroenterol.

J. Menzel and W. Domschke, “Gastrointestinal miniprobe sonography: the current status,” Am. J. Gastroenterol.95(3), 605–616 (2000).
[CrossRef] [PubMed]

Biomed. Opt. Express

Gastroenterology

R. Kiesslich, J. Burg, M. Vieth, J. Gnaendiger, M. Enders, P. Delaney, A. Polglase, W. McLaren, D. Janell, S. Thomas, B. Nafe, P. R. Galle, and M. F. Neurath, “Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo,” Gastroenterology127(3), 706–713 (2004).
[CrossRef] [PubMed]

N. G. Terry, Y. Zhu, M. T. Rinehart, W. J. Brown, S. C. Gebhart, S. Bright, E. Carretta, C. G. Ziefle, M. Panjehpour, J. Galanko, R. D. Madanick, E. S. Dellon, D. Trembath, A. Bennett, J. R. Goldblum, B. F. Overholt, J. T. Woosley, N. J. Shaheen, and A. Wax, “Detection of dysplasia in Barrett’s esophagus with in vivo depth-resolved nuclear morphology measurements,” Gastroenterology140(1), 42–50 (2011).
[CrossRef] [PubMed]

IEEE J. Quantum Electron.

B. Wang, J. L. Su, A. B. Karpiouk, K. V. Sokolov, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging,” IEEE J. Quantum Electron.16(3), 588–599 (2010).
[CrossRef] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control

Q. Zhou, X. Xu, E. J. Gottlieb, L. Sun, J. M. Cannata, H. Ameri, M. S. Humayun, P. Han, and K. K. Shung, “PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control54(3), 668–675 (2007).
[CrossRef] [PubMed]

Interface Focus

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011).
[CrossRef] [PubMed]

J. Biomed. Opt.

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt.16(2), 026004 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “Label-free oxygen-metabolic photoacoustic microscopy in vivo,” J. Biomed. Opt.16(7), 076003 (2011).
[CrossRef] [PubMed]

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt.14(5), 054024 (2009).
[CrossRef] [PubMed]

M. R. Chatni, J. Yao, A. Danielli, C. P. Favazza, K. I. Maslov, and L. V. Wang, “Functional photoacoustic microscopy of pH,” J. Biomed. Opt.16(10), 100503 (2011).
[CrossRef] [PubMed]

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt.15(1), 011101 (2010).
[CrossRef] [PubMed]

T. J. Allen, A. Hall, A. P. Dhillon, J. S. Owen, and P. C. Beard, “Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range,” J. Biomed. Opt.17(6), 061209 (2012).
[CrossRef] [PubMed]

M. A. Yaseen, S. A. Ermilov, H. P. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. A. Bell, M. Motamedi, and A. A. Oraevsky, “Optoacoustic imaging of the prostate: development toward image-guided biopsy,” J. Biomed. Opt.15(2), 021310 (2010).
[CrossRef] [PubMed]

Med. Phys.

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys.35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

Mol. Imaging Biol.

A. M. Winkler, P. F. Rice, J. Weichsel, J. M. Watson, M. V. Backer, J. M. Backer, and J. K. Barton, “In vivo, dual-modality OCT/LIF imaging using a novel VEGF receptor-targeted NIR fluorescent probe in the AOM-treated mouse model,” Mol. Imaging Biol.13(6), 1173–1182 (2011).
[CrossRef] [PubMed]

Nat. Med.

H. Yoo, J. W. Kim, M. Shishkov, E. Namati, T. Morse, R. Shubochkin, J. R. McCarthy, V. Ntziachristos, B. E. Bouma, F. A. Jaffer, and G. J. Tearney, “Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo,” Nat. Med.17(12), 1680–1684 (2011).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med.12(12), 1429–1433 (2007).
[CrossRef] [PubMed]

J. M. Yang, C. Favazza, R. Chen, J. Yao, X. Cai, K. Maslov, Q. Zhou, K. K. Shung, and L. V. Wang, “Simultaneous functional photoacoustic and ultrasonic endoscopy of internal organs in vivo,” Nat. Med.18(8), 1297–1302 (2012).
[CrossRef] [PubMed]

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med.16(5), 603–606, 1p, 606 (2010).
[CrossRef] [PubMed]

Nat. Methods

P. Kim, E. Chung, H. Yamashita, K. E. Hung, A. Mizoguchi, R. Kucherlapati, D. Fukumura, R. K. Jain, and S. H. Yun, “In vivo wide-area cellular imaging by side-view endomicroscopy,” Nat. Methods7(4), 303–305 (2010).
[CrossRef] [PubMed]

Nat. Photonics

D. C. Adler, Y. Chen, R. Huber, J. Schmitt, J. Connolly, and J. G. Fujimoto, “Three-dimensional endomicroscopy using optical coherence tomography,” Nat. Photonics1(12), 709–716 (2007).
[CrossRef]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009).
[CrossRef] [PubMed]

Opt. Express

Opt. Lett.

B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett.37(7), 1244–1246 (2012).
[CrossRef] [PubMed]

X. Li, C. Chudoba, T. Ko, C. Pitris, and J. G. Fujimoto, “Imaging needle for optical coherence tomography,” Opt. Lett.25(20), 1520–1522 (2000).
[CrossRef] [PubMed]

X. Liu, M. J. Cobb, Y. Chen, M. B. Kimmey, and X. Li, “Rapid-scanning forward-imaging miniature endoscope for real-time optical coherence tomography,” Opt. Lett.29(15), 1763–1765 (2004).
[CrossRef] [PubMed]

J. M. Yang, K. Maslov, H. C. Yang, Q. Zhou, K. K. Shung, and L. V. Wang, “Photoacoustic endoscopy,” Opt. Lett.34(10), 1591–1593 (2009).
[CrossRef] [PubMed]

K. Jansen, A. F. van der Steen, H. M. van Beusekom, J. W. Oosterhuis, and G. van Soest, “Intravascular photoacoustic imaging of human coronary atherosclerosis,” Opt. Lett.36(5), 597–599 (2011).
[CrossRef] [PubMed]

A. Danielli, C. P. Favazza, K. Maslov, and L. V. Wang, “Single-wavelength functional photoacoustic microscopy in biological tissue,” Opt. Lett.36(5), 769–771 (2011).
[CrossRef] [PubMed]

Y. Wang, S. Hu, K. Maslov, Y. Zhang, Y. Xia, and L. V. Wang, “In vivo integrated photoacoustic and confocal microscopy of hemoglobin oxygen saturation and oxygen partial pressure,” Opt. Lett.36(7), 1029–1031 (2011).
[CrossRef] [PubMed]

S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett.36(7), 1134–1136 (2011).
[CrossRef] [PubMed]

J. Yao, K. I. Maslov, Y. Shi, L. A. Taber, and L. V. Wang, “In vivo photoacoustic imaging of transverse blood flow by using Doppler broadening of bandwidth,” Opt. Lett.35(9), 1419–1421 (2010).
[CrossRef] [PubMed]

Z. Guo, S. Hu, and L. V. Wang, “Calibration-free absolute quantification of optical absorption coefficients using acoustic spectra in 3D photoacoustic microscopy of biological tissue,” Opt. Lett.35(12), 2067–2069 (2010).
[CrossRef] [PubMed]

Y. Yuan, S. Yang, and D. Xing, “Preclinical photoacoustic imaging endoscope based on acousto-optic coaxial system using ring transducer array,” Opt. Lett.35(13), 2266–2268 (2010).
[CrossRef] [PubMed]

Phys. Med. Biol.

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol.54(19), R59–R97 (2009).
[CrossRef] [PubMed]

Proc. SPIE

E. Z. Zhang and P. C. Beard, “A miniature all-optical photoacoustic imaging probe,” Proc. SPIE7899, 78991F, 78991F-6 (2011).
[CrossRef]

J. M. Yang, C. Favazza, R. Chen, J. Yao, K. Maslov, X. Cai, Q. Zhou, K. K. Shung, and L. V. Wang, “Volumetric photoacoustic endoscopy of upper gastrointestinal tract: ultrasonic transducer technology development,” Proc. SPIE7899, 78990D, 78990D-6 (2011).
[CrossRef]

Rev. Sci. Instrum.

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum.81(1), 014901 (2010).
[CrossRef] [PubMed]

Science

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997).
[CrossRef] [PubMed]

Other

Laser Institute of America, American National Standard for Safe Use of Lasers, ANSI Z136.1–2007 (American National Standards Institute, Inc., New York, NY, 2007).

C. Dietrich, ed., Endoscopic Ultrasound: An Introductory Manual and Atlas (Thieme, New York, 2006).

A. A. Oraevsky and A. A. Karabutov, “Optoacoustic Tomography,” in Biomedical Photonics Handbook, T. Vo-Dinh, ed. (CRC Press, 2003).

C. Sheaff and S. Ashkenazi, “A fiber optic optoacoustic ultrasound sensor for photoacoustic endoscopy,” in Proceedings of IEEE International Ultrasonics Symposium (Institute of Electrical and Electronics Engineers, San Diego, 2010), pp. 2135–2138.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1

(a) Photo of the integrated PAE-EUS mini-probe’s rigid distal end (2.5 mm diameter and ~35 mm length). (b) Schematic of the mini-probe. GM, geared micromotor; GP, glass partition; JB, jewel bearings; MN, magnets; OF, optical fiber; PM, plastic membrane (imaging window); SM, scanning mirror; SW, signal wire; UST, ultrasonic transducer; WM, water medium. (c) Optical fiber and US transducer unit. (d) Scanning mirror unit. (e) Micromotor unit. In (c)–(d), the scale bars represent 2 mm. (f) Block diagram showing the peripheral systems of the mini-probe.

Fig. 2
Fig. 2

(a) Schematic of the PMN-PT focused US transducer. (b) Front view of the implemented US transducer, showing the optical fiber located at the center. Scale bar, 500 µm. (c) Diagram showing the dimensions of the plastic acoustic lens, membrane position, and targeted working distance. (d) Simulated two-dimensional (2D) transmission acoustic field of the focused US transducer. The –6dB beam diameter at the 4-mm focal distance is ~80 µm. The vertical and horizontal axes represent transverse and radial (axial) distances from the US transducer.

Fig. 3
Fig. 3

(a) Typical US pulse-echo A-line signal of a tungsten wire: raw data and Hilbert-transformed or enveloped signal. (b) Acoustic frequency distribution of the waveform shown in (a). (c, d) PA and US B-scan images of a 20-µm thick tungsten wire. (e) PA and US radial point-spread-functions (PSFs) of the tungsten wire. (f) PA and US transverse PSFs of the tungsten wire. (g) Radial resolution vs. target distance. (h) Transverse resolution vs. target distance.

Fig. 4
Fig. 4

(a) Three-dimensionally-rendered PAE-EUS structural image from a rat colon acquired in vivo over a 4 cm range with a 10 mm image diameter (3.7 mm radial imaging depth). The right-hand side ( + z axis) and lower portion (–y axis) of the image correspond to the anus and the ventral side of the animal, respectively. The horizontal and vertical scale bars represent 5 mm. (b, c) PA and US radial-maximum amplitude projection images of (a). The vertical axis corresponds to the angular field-of-view, covering ~310°, and the horizontal axis corresponds to the pullback length of 4 cm. Scale bars represent 5 mm (only for the horizontal direction). (d) A representative x-y slice near the location indicated by the arrow in (a). (e) A longitudinal slice of the image volume of (a). All the PA and US signals are mapped on a linear scale, and the horizontal and vertical scale bars represent 5 mm and 1 mm, respectively.

Fig. 5
Fig. 5

Photos of the mini-probe positioned fully within (a) and projecting from (b) the 3.7-mm instrument channel of a video endoscope. The scale bars represent 1 cm.

Metrics