Abstract

Using optoacoustic excitation, a complete volumetric tomographic data sets from the imaged object can in principle be generated with a single interrogating laser pulse. Thus, optoacoustic imaging intrinsically has the potential for fast three-dimensional imaging. We have developed a system capable of acquiring volumetric optoacoustic data in real time and showcase in this work the undocumented capacity to generate high resolution three-dimensional optoacoustic images at a rate of 10Hz, currently mainly limited by the pulse repetition rate of the excitation laser.

© 2012 OSA

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  1. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
    [CrossRef] [PubMed]
  2. M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
    [CrossRef]
  3. V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
    [CrossRef] [PubMed]
  4. V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
    [CrossRef] [PubMed]
  5. L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
    [CrossRef] [PubMed]
  6. L. V. Wang, “Tutorial on photoacoustic microscopy and computed tomography,” IEEE J. Sel. Top. Quantum Electron. 14(1), 171–179 (2008).
    [CrossRef]
  7. D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc. 6(8), 1121–1129 (2011).
    [CrossRef] [PubMed]
  8. R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
    [CrossRef] [PubMed]
  9. D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
    [CrossRef]
  10. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett. 32(19), 2891–2893 (2007).
    [CrossRef] [PubMed]
  11. D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol. 54(9), 2769–2777 (2009).
    [CrossRef] [PubMed]
  12. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
    [CrossRef] [PubMed]
  13. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
    [CrossRef] [PubMed]
  14. B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
    [CrossRef] [PubMed]
  15. A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010).
    [CrossRef] [PubMed]
  16. R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
    [CrossRef] [PubMed]
  17. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
    [CrossRef] [PubMed]
  18. P. Ephrat, M. Roumeliotis, F. S. Prato, and J. J. L. Carson, “Four-dimensional photoacoustic imaging of moving targets,” Opt. Express 16(26), 21570–21581 (2008).
    [CrossRef] [PubMed]
  19. X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
    [CrossRef] [PubMed]
  20. J. A. Jensen, “Field: A program for simulating ultrasound systems,” Med. Biol. Eng. Comput. 34, 351–353 (1996).
    [PubMed]
  21. J. A. Jensen and N. B. Svendsen, “Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 39(2), 262–267 (1992).
    [CrossRef] [PubMed]
  22. M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 67(5), 056605 (2003).
    [CrossRef] [PubMed]
  23. S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics 20(16), 2857–2859 (2004).
    [CrossRef] [PubMed]

2011 (2)

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc. 6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
[CrossRef] [PubMed]

2010 (4)

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
[CrossRef] [PubMed]

V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010).
[CrossRef] [PubMed]

2009 (7)

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[CrossRef] [PubMed]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol. 54(9), 2769–2777 (2009).
[CrossRef] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[CrossRef] [PubMed]

2008 (3)

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

L. V. Wang, “Tutorial on photoacoustic microscopy and computed tomography,” IEEE J. Sel. Top. Quantum Electron. 14(1), 171–179 (2008).
[CrossRef]

P. Ephrat, M. Roumeliotis, F. S. Prato, and J. J. L. Carson, “Four-dimensional photoacoustic imaging of moving targets,” Opt. Express 16(26), 21570–21581 (2008).
[CrossRef] [PubMed]

2007 (1)

2006 (1)

M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

2004 (2)

S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics 20(16), 2857–2859 (2004).
[CrossRef] [PubMed]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

2003 (1)

M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 67(5), 056605 (2003).
[CrossRef] [PubMed]

1996 (1)

J. A. Jensen, “Field: A program for simulating ultrasound systems,” Med. Biol. Eng. Comput. 34, 351–353 (1996).
[PubMed]

1992 (1)

J. A. Jensen and N. B. Svendsen, “Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 39(2), 262–267 (1992).
[CrossRef] [PubMed]

Aguirre, A.

Bogue, M. A.

S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics 20(16), 2857–2859 (2004).
[CrossRef] [PubMed]

Brecht, H. P.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

Buehler, A.

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc. 6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010).
[CrossRef] [PubMed]

Carson, J. J. L.

Chen, Q.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Churchill, G. A.

S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics 20(16), 2857–2859 (2004).
[CrossRef] [PubMed]

Conjusteau, A.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Dean-Ben, X. L.

X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
[CrossRef] [PubMed]

Del Rio, S. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Distel, M.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

Doyle, R. P.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Ephrat, P.

Ermilov, S. A.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Fronheiser, M.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

Gamelin, J.

Grubb, S. C.

S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics 20(16), 2857–2859 (2004).
[CrossRef] [PubMed]

Guo, P. Y.

Herzog, E.

Huang, F.

Jensen, J. A.

J. A. Jensen, “Field: A program for simulating ultrasound systems,” Med. Biol. Eng. Comput. 34, 351–353 (1996).
[PubMed]

J. A. Jensen and N. B. Svendsen, “Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 39(2), 262–267 (1992).
[CrossRef] [PubMed]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Koster, R. W.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

Kruger, R. A.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Lam, R. B.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Ma, R.

X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
[CrossRef] [PubMed]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

Maurudis, A.

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

Ntziachristos, V.

X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
[CrossRef] [PubMed]

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc. 6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
[CrossRef] [PubMed]

V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol. 54(9), 2769–2777 (2009).
[CrossRef] [PubMed]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
[CrossRef] [PubMed]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett. 32(19), 2891–2893 (2007).
[CrossRef] [PubMed]

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

Perrimon, N.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

Prato, F. S.

Razansky, D.

X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
[CrossRef] [PubMed]

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc. 6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol. 54(9), 2769–2777 (2009).
[CrossRef] [PubMed]

R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
[CrossRef] [PubMed]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett. 32(19), 2891–2893 (2007).
[CrossRef] [PubMed]

Reinecke, D. R.

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

Roumeliotis, M.

Su, R.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

Svendsen, N. B.

J. A. Jensen and N. B. Svendsen, “Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 39(2), 262–267 (1992).
[CrossRef] [PubMed]

Tan, Y.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Taruttis, A.

Vinegoni, C.

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol. 54(9), 2769–2777 (2009).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Multispectral photoacoustic imaging of fluorochromes in small animals,” Opt. Lett. 32(19), 2891–2893 (2007).
[CrossRef] [PubMed]

Wang, L. H. V.

M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

Wang, L. V.

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[CrossRef] [PubMed]

J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Y. Guo, L. V. Wang, and Q. Zhu, “A real-time photoacoustic tomography system for small animals,” Opt. Express 17(13), 10489–10498 (2009).
[CrossRef] [PubMed]

L. V. Wang, “Tutorial on photoacoustic microscopy and computed tomography,” IEEE J. Sel. Top. Quantum Electron. 14(1), 171–179 (2008).
[CrossRef]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 67(5), 056605 (2003).
[CrossRef] [PubMed]

Wang, Y.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Xing, D.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Xu, M.

M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 67(5), 056605 (2003).
[CrossRef] [PubMed]

Xu, M. H.

M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

Yin, B. Z.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Zeng, Y. G.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Zhu, Q.

Bioinformatics (1)

S. C. Grubb, G. A. Churchill, and M. A. Bogue, “A collaborative database of inbred mouse strain characteristics,” Bioinformatics 20(16), 2857–2859 (2004).
[CrossRef] [PubMed]

Chem. Rev. (1)

V. Ntziachristos and D. Razansky, “Molecular imaging by means of multispectral optoacoustic tomography (MSOT),” Chem. Rev. 110(5), 2783–2794 (2010).
[CrossRef] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

L. V. Wang, “Tutorial on photoacoustic microscopy and computed tomography,” IEEE J. Sel. Top. Quantum Electron. 14(1), 171–179 (2008).
[CrossRef]

IEEE Trans. Med. Imaging (1)

X. L. Dean-Ben, R. Ma, D. Razansky, and V. Ntziachristos, “Statistical approach for optoacoustic image reconstruction in the presence of strong acoustic heterogeneities,” IEEE Trans. Med. Imaging 30(2), 401–408 (2011).
[CrossRef] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

J. A. Jensen and N. B. Svendsen, “Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 39(2), 262–267 (1992).
[CrossRef] [PubMed]

J. Biomed. Opt. (2)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[CrossRef] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[CrossRef] [PubMed]

Med. Biol. Eng. Comput. (1)

J. A. Jensen, “Field: A program for simulating ultrasound systems,” Med. Biol. Eng. Comput. 34, 351–353 (1996).
[PubMed]

Med. Phys. (2)

R. A. Kruger, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and R. P. Doyle, “Photoacoustic angiography of the breast,” Med. Phys. 37(11), 6096–6100 (2010).
[CrossRef] [PubMed]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
[CrossRef] [PubMed]

Nat. Methods (1)

V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
[CrossRef] [PubMed]

Nat. Photonics (2)

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[CrossRef] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Koster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[CrossRef]

Nat. Protoc. (1)

D. Razansky, A. Buehler, and V. Ntziachristos, “Volumetric real-time multispectral optoacoustic tomography of biomarkers,” Nat. Protoc. 6(8), 1121–1129 (2011).
[CrossRef] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Phys. Med. Biol. (2)

D. Razansky, C. Vinegoni, and V. Ntziachristos, “Imaging of mesoscopic-scale organisms using selective-plane optoacoustic tomography,” Phys. Med. Biol. 54(9), 2769–2777 (2009).
[CrossRef] [PubMed]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004).
[CrossRef] [PubMed]

Phys. Rev. E Stat. Nonlin. Soft Matter Phys. (1)

M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 67(5), 056605 (2003).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (1)

M. H. Xu and L. H. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[CrossRef]

Supplementary Material (5)

» Media 1: MOV (65 KB)     
» Media 2: MOV (77 KB)     
» Media 3: MOV (115 KB)     
» Media 4: MOV (283 KB)     
» Media 5: MOV (276 KB)     

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