Abstract

Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about scattering phase function is preserved. Our group has shown the ability to measure the spatial backscattering impulse response function along with depth-selective optical properties in tissue ex-vivo using LEBS. Here we report the design and implementation of a lens-free fiber optic LEBS probe capable of providing depth-limited measurements of the reduced scattering coefficient in-vivo. Experimental measurements combined with Monte Carlo simulation of scattering phantoms consisting of polystyrene microspheres in water are used to validate the performance of the probe. Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom.

© 2012 OSA

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2011 (3)

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, N. N. Mutyal, A. J. Radosevich, and V. Backman, “Multiple scattering model for the penetration depth of low-coherence enhanced backscattering,” J. Biomed. Opt.16(9), 097006 (2011).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

2010 (1)

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

2009 (2)

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

J. D. Rogers, I. R. Capoğlu, and V. Backman, “Nonscalar elastic light scattering from continuous random media in the Born approximation,” Opt. Lett.34(12), 1891–1893 (2009).
[CrossRef] [PubMed]

2008 (1)

2006 (1)

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

2005 (3)

2004 (2)

2002 (1)

C. Booth, G. Brady, and C. S. Potten, “Crowd control in the crypt,” Nat. Med.8(12), 1360–1361 (2002).
[CrossRef] [PubMed]

1998 (1)

G. A. Wagnières, W. M. Star, and B. C. Wilson, “In vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol.68(5), 603–632 (1998).
[PubMed]

1997 (1)

1993 (1)

A. Richter, K. Yang, F. Richter, H. T. Lynch, and M. Lipkin, “Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia,” Cancer Lett.74(1-2), 65–68 (1993).
[CrossRef] [PubMed]

1954 (1)

R. Barer and S. Joseph, “Refractometry of living cells,” J. Microscop. Sci.s3–95, 399–423 (1954).

Amelink, A.

Arifler, D.

Backman, V.

V. Turzhitsky, N. N. Mutyal, A. J. Radosevich, and V. Backman, “Multiple scattering model for the penetration depth of low-coherence enhanced backscattering,” J. Biomed. Opt.16(9), 097006 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

J. D. Rogers, I. R. Capoğlu, and V. Backman, “Nonscalar elastic light scattering from continuous random media in the Born approximation,” Opt. Lett.34(12), 1891–1893 (2009).
[CrossRef] [PubMed]

Y. L. Kim, Y. Liu, V. M. Turzhitsky, R. K. Wali, H. K. Roy, and V. Backman, “Depth-resolved low-coherence enhanced backscattering,” Opt. Lett.30(7), 741–743 (2005).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Bard, M. P. L.

Barer, R.

R. Barer and S. Joseph, “Refractometry of living cells,” J. Microscop. Sci.s3–95, 399–423 (1954).

Bender, J. E.

Bigio, I. J.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Bloom, S. L.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Bogovejic, A.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Booth, C.

C. Booth, G. Brady, and C. S. Potten, “Crowd control in the crypt,” Nat. Med.8(12), 1360–1361 (2002).
[CrossRef] [PubMed]

Bown, S. G.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Brady, G.

C. Booth, G. Brady, and C. S. Potten, “Crowd control in the crypt,” Nat. Med.8(12), 1360–1361 (2002).
[CrossRef] [PubMed]

Brand, R. E.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Brightwell, A.

Burgers, S. A.

Bydlon, T.

Capoglu, I. R.

Çapoglu, I. R.

Carnohan, M.

Chang, S. K.

Cottone, G.

Dhar, A.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Fang, Q.

Fu, H.

Gillenwater, A. M.

Goldberg, M. J.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Gomes, A. J.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Hussain, I. A.

Jacques, S. L.

Jameel, M.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Ji, Y.

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Johnson, K. S.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Jones, L. R.

Joseph, S.

R. Barer and S. Joseph, “Refractometry of living cells,” J. Microscop. Sci.s3–95, 399–423 (1954).

Kim, Y.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Kim, Y. L.

Knight, B.

Kromine, A.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Lin, S. P.

Lipkin, M.

A. Richter, K. Yang, F. Richter, H. T. Lynch, and M. Lipkin, “Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia,” Cancer Lett.74(1-2), 65–68 (1993).
[CrossRef] [PubMed]

Liu, Y.

Lovat, L. B.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Lynch, H. T.

A. Richter, K. Yang, F. Richter, H. T. Lynch, and M. Lipkin, “Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia,” Cancer Lett.74(1-2), 65–68 (1993).
[CrossRef] [PubMed]

Mack, V.

Marcu, L.

Mutyal, N.

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Mutyal, N. N.

V. Turzhitsky, N. N. Mutyal, A. J. Radosevich, and V. Backman, “Multiple scattering model for the penetration depth of low-coherence enhanced backscattering,” J. Biomed. Opt.16(9), 097006 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

Novelli, M. R.

A. Dhar, K. S. Johnson, M. R. Novelli, S. G. Bown, I. J. Bigio, L. B. Lovat, and S. L. Bloom, “Elastic scattering spectroscopy for the diagnosis of colonic lesions: initial results of a novel optical biopsy technique,” Gastrointest. Endosc.63(2), 257–261 (2006).
[CrossRef] [PubMed]

Papaioannou, T.

Pavlova, I.

Potten, C. S.

C. Booth, G. Brady, and C. S. Potten, “Crowd control in the crypt,” Nat. Med.8(12), 1360–1361 (2002).
[CrossRef] [PubMed]

Pradhan, P.

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Prahl, S. A.

Preyer, N. W.

Radosevich, A. J.

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, N. N. Mutyal, A. J. Radosevich, and V. Backman, “Multiple scattering model for the penetration depth of low-coherence enhanced backscattering,” J. Biomed. Opt.16(9), 097006 (2011).
[CrossRef] [PubMed]

Ramanujam, N.

Ramella-Roman, J. C.

Richards-Kortum, R.

Richter, A.

A. Richter, K. Yang, F. Richter, H. T. Lynch, and M. Lipkin, “Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia,” Cancer Lett.74(1-2), 65–68 (1993).
[CrossRef] [PubMed]

Richter, F.

A. Richter, K. Yang, F. Richter, H. T. Lynch, and M. Lipkin, “Morphological and morphometric measurements in colorectal mucosa of subjects at increased risk for colonic neoplasia,” Cancer Lett.74(1-2), 65–68 (1993).
[CrossRef] [PubMed]

Rogers, J. D.

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

J. D. Rogers, I. R. Capoğlu, and V. Backman, “Nonscalar elastic light scattering from continuous random media in the Born approximation,” Opt. Lett.34(12), 1891–1893 (2009).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Ross, R.

Roy, H. K.

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

Y. L. Kim, Y. Liu, V. M. Turzhitsky, R. K. Wali, H. K. Roy, and V. Backman, “Depth-resolved low-coherence enhanced backscattering,” Opt. Lett.30(7), 741–743 (2005).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Schwarz, R. A.

Star, W. M.

G. A. Wagnières, W. M. Star, and B. C. Wilson, “In vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol.68(5), 603–632 (1998).
[PubMed]

Sterenborg, H. J. C. M.

Stoyneva, V.

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Tittel, F. K.

Turzhitsky, V.

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, N. N. Mutyal, A. J. Radosevich, and V. Backman, “Multiple scattering model for the penetration depth of low-coherence enhanced backscattering,” J. Biomed. Opt.16(9), 097006 (2011).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. N. Mutyal, P. Pradhan, I. R. Çapoğlu, and V. Backman, “Alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation,” Opt. Express19(13), 11922–11931 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
[CrossRef] [PubMed]

J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

Turzhitsky, V. M.

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H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
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H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res.69(10), 4476–4483 (2009).
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J. D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, Y. Ji, H. K. Roy, and V. Backman, “Polarized enhanced backscattering spectroscopy for characterization of biological tissues at sub-diffusion length- scales,” IEEE J. Sel. Top. Quantum Electron. (to be published).

V. Turzhitsky, J. D. Rogers, N. N. Mutyal, H. K. Roy, and V. Backman, “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering,” IEEE J. Sel. Top. Quantum Electron.16(3), 619–626 (2010).
[CrossRef] [PubMed]

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V. Turzhitsky, N. N. Mutyal, A. J. Radosevich, and V. Backman, “Multiple scattering model for the penetration depth of low-coherence enhanced backscattering,” J. Biomed. Opt.16(9), 097006 (2011).
[CrossRef] [PubMed]

V. Turzhitsky, A. J. Radosevich, J. D. Rogers, N. N. Mutyal, and V. Backman, “Measurement of optical scattering properties with low-coherence enhanced backscattering spectroscopy,” J. Biomed. Opt.16(6), 067007 (2011).
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G. A. Wagnières, W. M. Star, and B. C. Wilson, “In vivo fluorescence spectroscopy and imaging for oncological applications,” Photochem. Photobiol.68(5), 603–632 (1998).
[PubMed]

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