Abstract

We present an approach for rational design and optimization of plasmonic arrays for ultrasensitive surface enhanced infrared absorption (SEIRA) spectroscopy of specific protein analytes. Motivated by our previous work that demonstrated sub-attomole detection of surface-bound silk fibroin [Proc. Natl. Acad. Sci. U.S.A. 106, 19227 (2009)], we introduce here a general framework that allows for the numerical optimization of metamaterial sensor designs in order to maximize the absorbance signal. A critical feature of our method is the explicit compensation for the perturbative effects of the analyte's refractive index which alters the resonance frequency and line-shape of the metamaterial response, thereby leading to spectral distortion in SEIRA signatures. As an example, we leverage our method to optimize the geometry of periodic arrays of plasmonic nanoparticles on both Si and CaF2 substrates. The optimal geometries result in a three-order of magnitude absorbance enhancement compared to an unstructured Au layer, with the CaF2 substrate offering an additional factor of three enhancement in absorbance over a traditional Si substrate. The latter improvement arises from increase of near-field intensity over the Au nanobar surface for the lower index substrate. Finally, we perform sensitivity analysis for our optimized arrays to predict the effects of fabrication imperfections. We find that <20% deviation from the optimized absorbance response is readily achievable over large areas with modern nanofabrication techniques.

© 2012 OSA

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  1. R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
    [CrossRef] [PubMed]
  2. C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
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  4. J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
    [CrossRef] [PubMed]
  5. S. Wang, E. S. Forzani, and N. Tao, “Detection of heavy metal ions in water by high-resolution surface plasmon resonance spectroscopy combined with anodic stripping voltammetry,” Anal. Chem. 79(12), 4427–4432 (2007).
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2012 (1)

R. Forker, M. Gruenewald, and T. Fritz, “Optical differential reflectance spectroscopy on thin molecular films,” Annu. Rep. Sect. C Phys. Chem., March 9, (2012).
[CrossRef]

2011 (5)

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

V. Liberman, R. Adato, A. Mertiri, A. A. Yanik, K. Chen, T. H. Jeys, S. Erramilli, and H. Altug, “Angle-and polarization-dependent collective excitation of plasmonic nanoarrays for surface enhanced infrared spectroscopy,” Opt. Express 19(12), 11202–11212 (2011).
[CrossRef] [PubMed]

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

H. Arnolds, “Vibrational dynamics of adsorbates - Quo vadis?” Prog. Surf. Sci. 86(1-2), 1–40 (2011).
[CrossRef]

2010 (3)

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, C.-H. Wu, G. Shvets, and H. Altug, “Radiative engineering of plasmon lifetimes in embedded nanoantenna arrays,” Opt. Express 18(5), 4526–4537 (2010).
[CrossRef] [PubMed]

2009 (3)

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

2008 (3)

B. D. Lawrence, F. Omenetto, K. Chui, and D. L. Kaplan, “Processing methods to control silk fibroin film biomaterial features,” J. Mater. Sci. 43(21), 6967–6985 (2008).
[CrossRef]

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

2007 (2)

S. Wang, E. S. Forzani, and N. Tao, “Detection of heavy metal ions in water by high-resolution surface plasmon resonance spectroscopy combined with anodic stripping voltammetry,” Anal. Chem. 79(12), 4427–4432 (2007).
[CrossRef] [PubMed]

R. Bukasov and J. S. Shumaker-Parry, “Highly tunable infrared extinction properties of gold nanocrescents,” Nano Lett. 7(5), 1113–1118 (2007).
[CrossRef] [PubMed]

2005 (3)

A. J. Haes, L. Chang, W. L. Klein, and R. P. Van Duyne, “Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor,” J. Am. Chem. Soc. 127(7), 2264–2271 (2005).
[CrossRef] [PubMed]

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

2004 (2)

R. Qiang, R. L. Chen, and J. Chen, “Modeling Electrical Properties of Gold Films at Infrared Frequency Using FDTD Method,” Int. J. Infrared Millim. Waves 25(8), 1263–1270 (2004).
[CrossRef]

R. F. Aroca, D. J. Ross, and C. Domingo, “Surface-enhanced infrared spectroscopy,” Appl. Spectrosc. 58(11), 324–338 (2004).
[CrossRef] [PubMed]

1997 (1)

V. Silin and A. Plant, “Biotechnological applications of surface plasmon resonance,” Trends Biotechnol. 15(9), 353–359 (1997).
[CrossRef]

Adato, R.

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

V. Liberman, R. Adato, A. Mertiri, A. A. Yanik, K. Chen, T. H. Jeys, S. Erramilli, and H. Altug, “Angle-and polarization-dependent collective excitation of plasmonic nanoarrays for surface enhanced infrared spectroscopy,” Opt. Express 19(12), 11202–11212 (2011).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, C.-H. Wu, G. Shvets, and H. Altug, “Radiative engineering of plasmon lifetimes in embedded nanoantenna arrays,” Opt. Express 18(5), 4526–4537 (2010).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Aizpurua, J.

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Altug, H.

V. Liberman, R. Adato, A. Mertiri, A. A. Yanik, K. Chen, T. H. Jeys, S. Erramilli, and H. Altug, “Angle-and polarization-dependent collective excitation of plasmonic nanoarrays for surface enhanced infrared spectroscopy,” Opt. Express 19(12), 11202–11212 (2011).
[CrossRef] [PubMed]

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, C.-H. Wu, G. Shvets, and H. Altug, “Radiative engineering of plasmon lifetimes in embedded nanoantenna arrays,” Opt. Express 18(5), 4526–4537 (2010).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Amsden, J. J.

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Anastassopoulou, J.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Anker, J. N.

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

Arju, N.

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

Arnolds, H.

H. Arnolds, “Vibrational dynamics of adsorbates - Quo vadis?” Prog. Surf. Sci. 86(1-2), 1–40 (2011).
[CrossRef]

Aroca, R. F.

R. F. Aroca, D. J. Ross, and C. Domingo, “Surface-enhanced infrared spectroscopy,” Appl. Spectrosc. 58(11), 324–338 (2004).
[CrossRef] [PubMed]

Bartal, G.

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

Bensebaa, F.

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

Boudreault, S.

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

Boukaki, E.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Boulet-Audet, M.

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

Buffeteau, T.

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

Bukasov, R.

R. Bukasov and J. S. Shumaker-Parry, “Highly tunable infrared extinction properties of gold nanocrescents,” Nano Lett. 7(5), 1113–1118 (2007).
[CrossRef] [PubMed]

Bushyager, N.

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

Chang, L.

A. J. Haes, L. Chang, W. L. Klein, and R. P. Van Duyne, “Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor,” J. Am. Chem. Soc. 127(7), 2264–2271 (2005).
[CrossRef] [PubMed]

Chen, J.

R. Qiang, R. L. Chen, and J. Chen, “Modeling Electrical Properties of Gold Films at Infrared Frequency Using FDTD Method,” Int. J. Infrared Millim. Waves 25(8), 1263–1270 (2004).
[CrossRef]

Chen, K.

Chen, R. L.

R. Qiang, R. L. Chen, and J. Chen, “Modeling Electrical Properties of Gold Films at Infrared Frequency Using FDTD Method,” Int. J. Infrared Millim. Waves 25(8), 1263–1270 (2004).
[CrossRef]

Chen, Y.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Chiou, H.-J.

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

Chui, K.

B. D. Lawrence, F. Omenetto, K. Chui, and D. L. Kaplan, “Processing methods to control silk fibroin film biomaterial features,” J. Mater. Sci. 43(21), 6967–6985 (2008).
[CrossRef]

Conti, C.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Cornelius, T. W.

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Cubukcu, E.

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

Dahlin, A. B.

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

Daugey, N.

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

Domingo, C.

R. F. Aroca, D. J. Ross, and C. Domingo, “Surface-enhanced infrared spectroscopy,” Appl. Spectrosc. 58(11), 324–338 (2004).
[CrossRef] [PubMed]

Erramilli, S.

V. Liberman, R. Adato, A. Mertiri, A. A. Yanik, K. Chen, T. H. Jeys, S. Erramilli, and H. Altug, “Angle-and polarization-dependent collective excitation of plasmonic nanoarrays for surface enhanced infrared spectroscopy,” Opt. Express 19(12), 11202–11212 (2011).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Faid, K.

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

Ferraris, P.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Feuz, L.

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

Forker, R.

R. Forker, M. Gruenewald, and T. Fritz, “Optical differential reflectance spectroscopy on thin molecular films,” Annu. Rep. Sect. C Phys. Chem., March 9, (2012).
[CrossRef]

Forzani, E. S.

S. Wang, E. S. Forzani, and N. Tao, “Detection of heavy metal ions in water by high-resolution surface plasmon resonance spectroscopy combined with anodic stripping voltammetry,” Anal. Chem. 79(12), 4427–4432 (2007).
[CrossRef] [PubMed]

Fritz, T.

R. Forker, M. Gruenewald, and T. Fritz, “Optical differential reflectance spectroscopy on thin molecular films,” Annu. Rep. Sect. C Phys. Chem., March 9, (2012).
[CrossRef]

García-Etxarri, A.

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Giorgini, E.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Gruenewald, M.

R. Forker, M. Gruenewald, and T. Fritz, “Optical differential reflectance spectroscopy on thin molecular films,” Annu. Rep. Sect. C Phys. Chem., March 9, (2012).
[CrossRef]

Guo, B.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Haes, A. J.

A. J. Haes, L. Chang, W. L. Klein, and R. P. Van Duyne, “Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor,” J. Am. Chem. Soc. 127(7), 2264–2271 (2005).
[CrossRef] [PubMed]

Hall, W. P.

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

Hong, M. K.

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Höök, F.

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

Hsu, T. H.-S.

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

Jackson, R. S.

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

Jeys, T. H.

Jonsson, M. P.

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

Kalim, S.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Kaplan, D. L.

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

B. D. Lawrence, F. Omenetto, K. Chui, and D. L. Kaplan, “Processing methods to control silk fibroin film biomaterial features,” J. Mater. Sci. 43(21), 6967–6985 (2008).
[CrossRef]

Karim, S.

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Khanikaev, A. B.

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

Klein, W. L.

A. J. Haes, L. Chang, W. L. Klein, and R. P. Van Duyne, “Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor,” J. Am. Chem. Soc. 127(7), 2264–2271 (2005).
[CrossRef] [PubMed]

L’Ecuyer, P.

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

Lawrence, B. D.

B. D. Lawrence, F. Omenetto, K. Chui, and D. L. Kaplan, “Processing methods to control silk fibroin film biomaterial features,” J. Mater. Sci. 43(21), 6967–6985 (2008).
[CrossRef]

Liberman, V.

Lin, C.-C.

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

Lin, S.-Y.

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

Lyandres, O.

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

Martin, L. J.

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

Mertiri, A.

Neubrech, F.

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Obatoyinbo, A.

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

Omenetto, F.

B. D. Lawrence, F. Omenetto, K. Chui, and D. L. Kaplan, “Processing methods to control silk fibroin film biomaterial features,” J. Mater. Sci. 43(21), 6967–6985 (2008).
[CrossRef]

Omenetto, F. G.

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Ota, S.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Park, Y.-S.

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

Petronis, S.

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

Pézolet, M.

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

Plant, A.

V. Silin and A. Plant, “Biotechnological applications of surface plasmon resonance,” Trends Biotechnol. 15(9), 353–359 (1997).
[CrossRef]

Pucci, A.

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Py, C.

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

Qiang, R.

R. Qiang, R. L. Chen, and J. Chen, “Modeling Electrical Properties of Gold Films at Infrared Frequency Using FDTD Method,” Int. J. Infrared Millim. Waves 25(8), 1263–1270 (2004).
[CrossRef]

Rhodes, C.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Ross, D. J.

R. F. Aroca, D. J. Ross, and C. Domingo, “Surface-enhanced infrared spectroscopy,” Appl. Spectrosc. 58(11), 324–338 (2004).
[CrossRef] [PubMed]

Rubini, C.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Ryu, J.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Sabbatini, S.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Shah, N. C.

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

Shumaker-Parry, J. S.

R. Bukasov and J. S. Shumaker-Parry, “Highly tunable infrared extinction properties of gold nanocrescents,” Nano Lett. 7(5), 1113–1118 (2007).
[CrossRef] [PubMed]

Shvets, G.

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, C.-H. Wu, G. Shvets, and H. Altug, “Radiative engineering of plasmon lifetimes in embedded nanoantenna arrays,” Opt. Express 18(5), 4526–4537 (2010).
[CrossRef] [PubMed]

Silin, V.

V. Silin and A. Plant, “Biotechnological applications of surface plasmon resonance,” Trends Biotechnol. 15(9), 353–359 (1997).
[CrossRef]

Staiculescu, D.

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

Tague, T. J.

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

Tao, N.

S. Wang, E. S. Forzani, and N. Tao, “Detection of heavy metal ions in water by high-resolution surface plasmon resonance spectroscopy combined with anodic stripping voltammetry,” Anal. Chem. 79(12), 4427–4432 (2007).
[CrossRef] [PubMed]

Teitell, M. A.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Tentzeris, M. M.

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

Theophanides, T.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Tosi, G.

J. Anastassopoulou, E. Boukaki, C. Conti, P. Ferraris, E. Giorgini, C. Rubini, S. Sabbatini, T. Theophanides, and G. Tosi, “Microimaging FT-IR spectroscopy on pathological breast tissues,” Vib. Spectrosc. 51(2), 270–275 (2009).
[CrossRef]

Van Duyne, R. P.

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

A. J. Haes, L. Chang, W. L. Klein, and R. P. Van Duyne, “Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor,” J. Am. Chem. Soc. 127(7), 2264–2271 (2005).
[CrossRef] [PubMed]

Wang, S.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

S. Wang, E. S. Forzani, and N. Tao, “Detection of heavy metal ions in water by high-resolution surface plasmon resonance spectroscopy combined with anodic stripping voltammetry,” Anal. Chem. 79(12), 4427–4432 (2007).
[CrossRef] [PubMed]

Wu, C.

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

Wu, C.-H.

Wu, T.-K.

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

Xiong, Y.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Yanik, A. A.

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

V. Liberman, R. Adato, A. Mertiri, A. A. Yanik, K. Chen, T. H. Jeys, S. Erramilli, and H. Altug, “Angle-and polarization-dependent collective excitation of plasmonic nanoarrays for surface enhanced infrared spectroscopy,” Opt. Express 19(12), 11202–11212 (2011).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, C.-H. Wu, G. Shvets, and H. Altug, “Radiative engineering of plasmon lifetimes in embedded nanoantenna arrays,” Opt. Express 18(5), 4526–4537 (2010).
[CrossRef] [PubMed]

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Zeng, L.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Zhang, S.

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

Zhang, X.

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

Zhao, J.

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

Anal. Chem. (2)

S. Wang, E. S. Forzani, and N. Tao, “Detection of heavy metal ions in water by high-resolution surface plasmon resonance spectroscopy combined with anodic stripping voltammetry,” Anal. Chem. 79(12), 4427–4432 (2007).
[CrossRef] [PubMed]

M. P. Jonsson, A. B. Dahlin, L. Feuz, S. Petronis, and F. Höök, “Locally functionalized short-range ordered nanoplasmonic pores for bioanalytical sensing,” Anal. Chem. 82(5), 2087–2094 (2010).
[CrossRef] [PubMed]

Annu. Rep. Sect. C Phys. Chem. (1)

R. Forker, M. Gruenewald, and T. Fritz, “Optical differential reflectance spectroscopy on thin molecular films,” Annu. Rep. Sect. C Phys. Chem., March 9, (2012).
[CrossRef]

Appl. Phys. Lett. (1)

E. Cubukcu, S. Zhang, Y.-S. Park, G. Bartal, and X. Zhang, “Split ring resonator sensors for infrared detection of single molecular monolayers,” Appl. Phys. Lett. 95(4), 043113 (2009).
[CrossRef]

Appl. Spectrosc. (1)

R. F. Aroca, D. J. Ross, and C. Domingo, “Surface-enhanced infrared spectroscopy,” Appl. Spectrosc. 58(11), 324–338 (2004).
[CrossRef] [PubMed]

Appl. Surf. Sci. (1)

F. Bensebaa, P. L’Ecuyer, K. Faid, C. Py, T. J. Tague, and R. S. Jackson, “Grazing angle infrared microspectroscopy of micropatterned self-assembled monolayers,” Appl. Surf. Sci. 243(1-4), 238–244 (2005).
[CrossRef]

IEEE Trans. Antenn. Propag. (1)

D. Staiculescu, N. Bushyager, A. Obatoyinbo, L. J. Martin, and M. M. Tentzeris, “Design and optimization of 3-D compact stripline and microstrip Bluetooth/WLAN balun architectures using the design of experiments technique,” IEEE Trans. Antenn. Propag. 53(5), 1805–1812 (2005).
[CrossRef]

Int. J. Infrared Millim. Waves (1)

R. Qiang, R. L. Chen, and J. Chen, “Modeling Electrical Properties of Gold Films at Infrared Frequency Using FDTD Method,” Int. J. Infrared Millim. Waves 25(8), 1263–1270 (2004).
[CrossRef]

J. Am. Chem. Soc. (1)

A. J. Haes, L. Chang, W. L. Klein, and R. P. Van Duyne, “Detection of a biomarker for Alzheimer’s disease from synthetic and clinical samples using a nanoscale optical biosensor,” J. Am. Chem. Soc. 127(7), 2264–2271 (2005).
[CrossRef] [PubMed]

J. Mater. Sci. (1)

B. D. Lawrence, F. Omenetto, K. Chui, and D. L. Kaplan, “Processing methods to control silk fibroin film biomaterial features,” J. Mater. Sci. 43(21), 6967–6985 (2008).
[CrossRef]

J. Phys. Chem. B (1)

M. Boulet-Audet, T. Buffeteau, S. Boudreault, N. Daugey, and M. Pézolet, “Quantitative determination of band distortions in diamond attenuated total reflectance infrared spectra,” J. Phys. Chem. B 114(24), 8255–8261 (2010).
[CrossRef] [PubMed]

Nano Lett. (2)

R. Bukasov and J. S. Shumaker-Parry, “Highly tunable infrared extinction properties of gold nanocrescents,” Nano Lett. 7(5), 1113–1118 (2007).
[CrossRef] [PubMed]

S. Wang, S. Ota, B. Guo, J. Ryu, C. Rhodes, Y. Xiong, S. Kalim, L. Zeng, Y. Chen, M. A. Teitell, and X. Zhang, “Subcellular resolution mapping of endogenous cytokine secretion by nano-plasmonic-resonator sensor array,” Nano Lett. 11(8), 3431–3434 (2011).
[CrossRef] [PubMed]

Nat. Mater. (2)

C. Wu, A. B. Khanikaev, R. Adato, N. Arju, A. A. Yanik, H. Altug, and G. Shvets, “Fano-resonant asymmetric metamaterials for ultrasensitive spectroscopy and identification of molecular monolayers,” Nat. Mater. 11(1), 69–75 (2011).
[CrossRef] [PubMed]

J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7(6), 442–453 (2008).
[CrossRef] [PubMed]

Opt. Express (2)

Phys. Rev. Lett. (1)

F. Neubrech, A. Pucci, T. W. Cornelius, S. Karim, A. García-Etxarri, and J. Aizpurua, “Resonant plasmonic and vibrational coupling in a tailored nanoantenna for infrared detection,” Phys. Rev. Lett. 101(15), 157403 (2008).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

R. Adato, A. A. Yanik, J. J. Amsden, D. L. Kaplan, F. G. Omenetto, M. K. Hong, S. Erramilli, and H. Altug, “Ultra-sensitive vibrational spectroscopy of protein monolayers with plasmonic nanoantenna arrays,” Proc. Natl. Acad. Sci. U.S.A. 106(46), 19227–19232 (2009).
[CrossRef] [PubMed]

Prog. Surf. Sci. (1)

H. Arnolds, “Vibrational dynamics of adsorbates - Quo vadis?” Prog. Surf. Sci. 86(1-2), 1–40 (2011).
[CrossRef]

Spectroscopy (1)

S.-Y. Lin, T.-K. Wu, H.-J. Chiou, T. H.-S. Hsu, and C.-C. Lin, “Infrared microspectroscopic imaging as a probing tool to fast distinguish chemical compositions in calcified deposits of prostatic calculi and calcific tendonitis,” Spectroscopy 25(5), 207–216 (2011).
[CrossRef]

Trends Biotechnol. (1)

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Figures (11)

Fig. 1
Fig. 1

Real and imaginary parts of refractive index of silk fibroin as measured in a previous work [17].

Fig. 2
Fig. 2

Simulated absorbance response from a fibroin film for a range of thicknesses from 5 to 200 nm on an unstructured Au film.

Fig. 3
Fig. 3

Coverage geometry for a film on a substrate defining planar (A) and conformal (B) cases. Incident light direction is shown by large solid arrows.

Fig. 4
Fig. 4

Simulated absorbance response of a reference nanoplasmonic array covered with a 100-nm thick planar fibroin layer. A) Reflectance of a bare and fibroin-covered surface. The dashed vertical line (near 5.5 μm) indicates the position of the (1,0) diffracted edge (see Eq. (7)). B) Absorbance response from Eq. (3).

Fig. 5
Fig. 5

Computed Aref from Eq. (4) for several values of the reference refractive index. Dashed lines for each trace in the vicinity of the 6.0-μm peaks highlight position of the baseline.

Fig. 6
Fig. 6

Computed absorbance for fibroin-covered nanoplasmonic array whose dimensions have been optimized for A) Amide I absorbance and B) Amide II absorbance.

Fig. 7
Fig. 7

Computed reflectance of a bare (Rbare), a 100-nm thick reference-layer covered (Rref) and a 100-nm fibroin covered (Rcov) nanoplasmonic arrays for the optimized geometry of Fig. 6(A). The dashed vertical line indicates the position of the (1,0) diffractive edge according to Eq. (7).

Fig. 8
Fig. 8

Averaged absorbance over 6- and 6.55-μm peaks with increasing layer thicknesses (right vertical axis) for Si substrate. Also shown is the corresponding absorbance signal enhancement over that from a bare Au layer of Fig. 2 (left vertical axis). The solid and dashed lines are drawn to guide the eye.

Fig. 9
Fig. 9

Computed absorbance for an Amide I optimized fibroin-covered nanoplasmonic array on CaF2 substrate. A) Absorbance vs. wavelength for varying overlayer thicknesses and B) Averaged absorbance vs. thickness (right vertical axis) and a corresponding absorbance signal enhancement over that from a bare Au layer (left vertical axis). The solid and dashed lines are drawn to guide the eye.

Fig. 10
Fig. 10

(A) Area-averaged normalized field intensity, normalized to incident field, for cut planes, parallel to the substrate for nanobars on Si and CaF2 substrate as a function of plane distance from substrate. (B) Geometry of the cut planes with respect to the substrate and the unit cell of the nanobar array.

Fig. 11
Fig. 11

Response surface of 6-μm absorbance peak from the DOE-driven simulations for length vs. period for the nanoplasmonic arrays near their optimized conditions for the 100-nm thick fibroin film. A) Si substrate for the conditions of Table 1, Column 1 and B) CaF2 substrate for the conditions of Table 1, Column 3. The off-axis width variables are set to the optimized values.

Tables (1)

Tables Icon

Table 1 Optimized Array Dimensions (μm)

Equations (7)

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A | μ Q | 0 2 | E | 2
A Au =log( R bare,Au R cov,Au )
A array =log( R bare R cov )
A ref =log( R ref R cov )
λ res = 2 m n eff L+C
L= λ res C 2 n eff
d c = λ res n sub

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