Abstract

The subject study demonstrates the imaging of cell activity by quantitatively assessing the motion of intracellular organelles and cell plasma membranes without any contrast agent. The low-coherent interferometric technique and phase-referenced phase shifting technique were integrated to reveal the depth-resolved distribution of intracellular motility. The transversal and vertical spatial resolutions were 0.56 μm and 0.93 μm, respectively, and the mechanical stability of the system was 1.2 nm. The motility of the cell was assessed by mean squared displacement (MSD) and we have compensated for the MSD by applying statistical noise analysis. Thus we show the significant change of intracellular motility after paraformaldehyde treatment in non-labeled cells.

© 2011 OSA

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2010 (1)

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed Opt. Express 1(2), 706–719 (2010).
[CrossRef] [PubMed]

2008 (4)

2007 (7)

2006 (2)

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

X. Li, T. Yamauchi, H. Iwai, Y. Yamashita, H. Zhang, and T. Hiruma, “Full-field quantitative phase imaging by white-light interferometry with active phase stabilization and its application to biological samples,” Opt. Lett. 31(12), 1830–1832 (2006).
[CrossRef] [PubMed]

2005 (5)

2004 (3)

2001 (2)

2000 (1)

1999 (1)

1995 (1)

1991 (1)

H. Qian, M. P. Sheetz, and E. L. Elson, “Single particle tracking. Analysis of diffusion and flow in two-dimensional systems,” Biophys. J. 60(4), 910–921 (1991).
[CrossRef] [PubMed]

1990 (1)

1989 (1)

A. W. Partin, J. S. Schoeniger, J. L. Mohler, and D. S. Coffey, “Fourier analysis of cell motility: correlation of motility with metastatic potential,” Proc. Natl. Acad. Sci. U.S.A. 86(4), 1254–1258 (1989).
[CrossRef] [PubMed]

1970 (1)

M. H. Gail and C. W. Boone, “The locomotion of mouse fibroblasts in tissue culture,” Biophys. J. 10(10), 980–993 (1970).
[CrossRef] [PubMed]

Adler, D. C.

Akkin, T.

Badizadegan, K.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics,” Opt. Lett. 26(16), 1271–1273 (2001).
[CrossRef] [PubMed]

Baker, J.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Banaszak Holl, M. M.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Beals, J.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Best, C. A.

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

Best-Popescu, C.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Best-Popescu, C. A.

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

Bielinska, A.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Boccara, A. C.

Boccara, C.

Boone, C. W.

M. H. Gail and C. W. Boone, “The locomotion of mouse fibroblasts in tissue culture,” Biophys. J. 10(10), 980–993 (1970).
[CrossRef] [PubMed]

Boppart, S. A.

Brophy, C. P.

Budor, A.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Bursac, N.

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed Opt. Express 1(2), 706–719 (2010).
[CrossRef] [PubMed]

Charrière, F.

Chu, M. C.

Coffey, D. S.

A. W. Partin, J. S. Schoeniger, J. L. Mohler, and D. S. Coffey, “Fourier analysis of cell motility: correlation of motility with metastatic potential,” Proc. Natl. Acad. Sci. U.S.A. 86(4), 1254–1258 (1989).
[CrossRef] [PubMed]

Colomb, T.

Creazzo, T. L.

Cuche, E.

Dasari, R. R.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

T. Ikeda, G. Popescu, R. R. Dasari, and M. S. Feld, “Hilbert phase microscopy for investigating fast dynamics in transparent systems,” Opt. Lett. 30(10), 1165–1167 (2005).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

C. Fang-Yen, M. C. Chu, H. S. Seung, R. R. Dasari, and M. S. Feld, “Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer,” Opt. Lett. 29(17), 2028–2030 (2004).
[CrossRef] [PubMed]

C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics,” Opt. Lett. 26(16), 1271–1273 (2001).
[CrossRef] [PubMed]

Davé, D.

Deflores, L.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Depeursinge, C.

Drexler, W.

Dubois, A.

Ellerbee, A. K.

Elson, E. L.

H. Qian, M. P. Sheetz, and E. L. Elson, “Single particle tracking. Analysis of diffusion and flow in two-dimensional systems,” Biophys. J. 60(4), 910–921 (1991).
[CrossRef] [PubMed]

Emery, Y.

Fabritius, T.

Fang-Yen, C.

Farrant, D. I.

Feld, M. S.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

T. Ikeda, G. Popescu, R. R. Dasari, and M. S. Feld, “Hilbert phase microscopy for investigating fast dynamics in transparent systems,” Opt. Lett. 30(10), 1165–1167 (2005).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

C. Fang-Yen, M. C. Chu, H. S. Seung, R. R. Dasari, and M. S. Feld, “Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer,” Opt. Lett. 29(17), 2028–2030 (2004).
[CrossRef] [PubMed]

C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics,” Opt. Lett. 26(16), 1271–1273 (2001).
[CrossRef] [PubMed]

Feldman, M. D.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Fujimoto, J. G.

Gail, M. H.

M. H. Gail and C. W. Boone, “The locomotion of mouse fibroblasts in tissue culture,” Biophys. J. 10(10), 980–993 (1970).
[CrossRef] [PubMed]

Goda, K.

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

Grieve, K.

Hahn, M. S.

Hessler, J. A.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Hibino, K.

Hiruma, T.

Huang, S. W.

Huber, R.

Ikeda, T.

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

T. Ikeda, G. Popescu, R. R. Dasari, and M. S. Feld, “Hilbert phase microscopy for investigating fast dynamics in transparent systems,” Opt. Lett. 30(10), 1165–1167 (2005).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

Ippen, E. P.

Iwai, H.

Izatt, J. A.

Jeong, K.

Kang, H. W.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Kärtner, F. X.

Keleshian, A. M.

P. C. Zhang, A. M. Keleshian, and F. Sachs, “Voltage-induced membrane movement,” Nature 413(6854), 428–432 (2001).
[CrossRef] [PubMed]

Kim, J.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Kühn, J.

Laposata, M.

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

Larkin, K. G.

Lecaque, R.

Li, X.

Li, X. D.

Lue, N.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Magistretti, P.

Magistretti, P. J.

Makita, S.

Manley, S.

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

Marquet, P.

Mecke, A.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Milner, T.

Milner, T. E.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Miwa, M.

Mohler, J. L.

A. W. Partin, J. S. Schoeniger, J. L. Mohler, and D. S. Coffey, “Fourier analysis of cell motility: correlation of motility with metastatic potential,” Proc. Natl. Acad. Sci. U.S.A. 86(4), 1254–1258 (1989).
[CrossRef] [PubMed]

Moneron, G.

Montfort, F.

Morgner, U.

Nolte, D. D.

Oh, J.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Oreb, B. F.

Orr, B. G.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Park, Y.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Partin, A. W.

A. W. Partin, J. S. Schoeniger, J. L. Mohler, and D. S. Coffey, “Fourier analysis of cell motility: correlation of motility with metastatic potential,” Proc. Natl. Acad. Sci. U.S.A. 86(4), 1254–1258 (1989).
[CrossRef] [PubMed]

Pitris, C.

Popescu, G.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

T. Ikeda, G. Popescu, R. R. Dasari, and M. S. Feld, “Hilbert phase microscopy for investigating fast dynamics in transparent systems,” Opt. Lett. 30(10), 1165–1167 (2005).
[CrossRef] [PubMed]

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

Putchakayala, K.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Qian, H.

H. Qian, M. P. Sheetz, and E. L. Elson, “Single particle tracking. Analysis of diffusion and flow in two-dimensional systems,” Biophys. J. 60(4), 910–921 (1991).
[CrossRef] [PubMed]

Rappaz, B.

Rieger, D.

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Rylander Iii, H.

Sachs, F.

P. C. Zhang, A. M. Keleshian, and F. Sachs, “Voltage-induced membrane movement,” Nature 413(6854), 428–432 (2001).
[CrossRef] [PubMed]

Sanghi, P.

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Satterwhite, L. L.

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed Opt. Express 1(2), 706–719 (2010).
[CrossRef] [PubMed]

Schoeniger, J. S.

A. W. Partin, J. S. Schoeniger, J. L. Mohler, and D. S. Coffey, “Fourier analysis of cell motility: correlation of motility with metastatic potential,” Proc. Natl. Acad. Sci. U.S.A. 86(4), 1254–1258 (1989).
[CrossRef] [PubMed]

Selb, J.

Seung, H. S.

Shaked, N. T.

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed Opt. Express 1(2), 706–719 (2010).
[CrossRef] [PubMed]

Sheetz, M. P.

H. Qian, M. P. Sheetz, and E. L. Elson, “Single particle tracking. Analysis of diffusion and flow in two-dimensional systems,” Biophys. J. 60(4), 910–921 (1991).
[CrossRef] [PubMed]

Suresh, S.

S. Suresh, “Biomechanics and biophysics of cancer cells,” Acta Biomater. 3(4), 413–438 (2007).
[CrossRef] [PubMed]

Turek, J. J.

Vabre, L.

Wax, A.

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed Opt. Express 1(2), 706–719 (2010).
[CrossRef] [PubMed]

C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics,” Opt. Lett. 26(16), 1271–1273 (2001).
[CrossRef] [PubMed]

Yamashita, Y.

Yamauchi, T.

Yang, C.

Yasuno, Y.

Zhang, H.

Zhang, P. C.

P. C. Zhang, A. M. Keleshian, and F. Sachs, “Voltage-induced membrane movement,” Nature 413(6854), 428–432 (2001).
[CrossRef] [PubMed]

Acta Biomater. (1)

S. Suresh, “Biomechanics and biophysics of cancer cells,” Acta Biomater. 3(4), 413–438 (2007).
[CrossRef] [PubMed]

Am. J. Physiol. Cell Physiol. (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[CrossRef] [PubMed]

Appl. Opt. (3)

Biomed Opt. Express (1)

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed Opt. Express 1(2), 706–719 (2010).
[CrossRef] [PubMed]

Biophys. J. (2)

M. H. Gail and C. W. Boone, “The locomotion of mouse fibroblasts in tissue culture,” Biophys. J. 10(10), 980–993 (1970).
[CrossRef] [PubMed]

H. Qian, M. P. Sheetz, and E. L. Elson, “Single particle tracking. Analysis of diffusion and flow in two-dimensional systems,” Biophys. J. 60(4), 910–921 (1991).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

G. Popescu, T. Ikeda, C. A. Best, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Erythrocyte structure and dynamics quantified by Hilbert phase microscopy,” J. Biomed. Opt. 10(6), 060503 (2005).
[CrossRef] [PubMed]

J. Opt. Soc. Am. A (2)

Langmuir (1)

J. A. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. Baker., “Atomic force microscopy study of early morphological changes during apoptosis,” Langmuir 21(20), 9280–9286 (2005).
[CrossRef] [PubMed]

Lasers Surg. Med. (1)

J. Oh, M. D. Feldman, J. Kim, H. W. Kang, P. Sanghi, and T. E. Milner, “Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography,” Lasers Surg. Med. 39(3), 266–272 (2007).
[CrossRef] [PubMed]

Nature (1)

P. C. Zhang, A. M. Keleshian, and F. Sachs, “Voltage-induced membrane movement,” Nature 413(6854), 428–432 (2001).
[CrossRef] [PubMed]

Opt. Express (8)

T. Akkin, D. Davé, T. Milner, and H. Rylander Iii, “Detection of neural activity using phase-sensitive optical low-coherence reflectometry,” Opt. Express 12(11), 2377–2386 (2004).
[CrossRef] [PubMed]

K. Jeong, J. J. Turek, and D. D. Nolte, “Volumetric motility-contrast imaging of tissue response to cytoskeletal anti-cancer drugs,” Opt. Express 15(21), 14057–14064 (2007).
[CrossRef] [PubMed]

D. C. Adler, S. W. Huang, R. Huber, and J. G. Fujimoto, “Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography,” Opt. Express 16(7), 4376–4393 (2008).
[CrossRef] [PubMed]

S. Makita, T. Fabritius, and Y. Yasuno, “Full-range, high-speed, high-resolution 1 microm spectral-domain optical coherence tomography using BM-scan for volumetric imaging of the human posterior eye,” Opt. Express 16(12), 8406–8420 (2008).
[CrossRef] [PubMed]

T. Yamauchi, H. Iwai, M. Miwa, and Y. Yamashita, “Low-coherent quantitative phase microscope for nanometer-scale measurement of living cells morphology,” Opt. Express 16(16), 12227–12238 (2008).
[CrossRef] [PubMed]

B. Rappaz, P. Marquet, E. Cuche, Y. Emery, C. Depeursinge, and P. Magistretti, “Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy,” Opt. Express 13(23), 9361–9373 (2005).
[CrossRef] [PubMed]

J. Kühn, T. Colomb, F. Montfort, F. Charrière, Y. Emery, E. Cuche, P. Marquet, and C. Depeursinge, “Real-time dual-wavelength digital holographic microscopy with a single hologram acquisition,” Opt. Express 15(12), 7231–7242 (2007).
[CrossRef] [PubMed]

A. K. Ellerbee, T. L. Creazzo, and J. A. Izatt, “Investigating nanoscale cellular dynamics with cross-sectional spectral domain phase microscopy,” Opt. Express 15(13), 8115–8124 (2007).
[CrossRef] [PubMed]

Opt. Lett. (7)

X. Li, T. Yamauchi, H. Iwai, Y. Yamashita, H. Zhang, and T. Hiruma, “Full-field quantitative phase imaging by white-light interferometry with active phase stabilization and its application to biological samples,” Opt. Lett. 31(12), 1830–1832 (2006).
[CrossRef] [PubMed]

D. C. Adler, R. Huber, and J. G. Fujimoto, “Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers,” Opt. Lett. 32(6), 626–628 (2007).
[CrossRef] [PubMed]

C. Yang, A. Wax, M. S. Hahn, K. Badizadegan, R. R. Dasari, and M. S. Feld, “Phase-referenced interferometer with subwavelength and subhertz sensitivity applied to the study of cell membrane dynamics,” Opt. Lett. 26(16), 1271–1273 (2001).
[CrossRef] [PubMed]

C. Fang-Yen, M. C. Chu, H. S. Seung, R. R. Dasari, and M. S. Feld, “Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer,” Opt. Lett. 29(17), 2028–2030 (2004).
[CrossRef] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[CrossRef] [PubMed]

T. Ikeda, G. Popescu, R. R. Dasari, and M. S. Feld, “Hilbert phase microscopy for investigating fast dynamics in transparent systems,” Opt. Lett. 30(10), 1165–1167 (2005).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett. 24(17), 1221–1223 (1999).
[CrossRef] [PubMed]

Phys. Rev. Lett. (1)

G. Popescu, T. Ikeda, K. Goda, C. A. Best-Popescu, M. Laposata, S. Manley, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Optical measurement of cell membrane tension,” Phys. Rev. Lett. 97(21), 218101 (2006).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

A. W. Partin, J. S. Schoeniger, J. L. Mohler, and D. S. Coffey, “Fourier analysis of cell motility: correlation of motility with metastatic potential,” Proc. Natl. Acad. Sci. U.S.A. 86(4), 1254–1258 (1989).
[CrossRef] [PubMed]

Other (1)

K. Creath, “V Phase-Measurement Interferometry Techniques,” in Progress in Optics, E. Wolf, ed. (Elsevier, 1988), pp. 349–393.

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