Abstract

Dynamic micro-bead arrays offer great flexibility and potential as sensing tools in various scientific fields. Two optical trapping techniques, the GPC method using a spatial light modulator and a mechanical scanning method using galvano mirrors, are combined in a hybrid optical tweezers system to handle dynamic micro-bead arrays. This system provides greater versatility while the GPC method creates massive micro-bead arrays in a 2D space, where the trapped beads can be manipulated smoothly and very quickly in a 3D space using the mechanical scanning method. Four typical examples are demonstrated in real time.

© 2011 OSA

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References

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  1. W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
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    [CrossRef] [PubMed]
  20. R. W. Applegate, J. Squier, T. Vestad, J. Oakey, and D. V. M. Marr, “Optical trapping, manipulation, and sorting of cells and colloids in microfluidic systems with diode laser bars,” Opt. Express 12(19), 4390–4398 (2004).
    [CrossRef] [PubMed]
  21. X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
    [CrossRef] [PubMed]
  22. C. Pacoret, R. Bowman, G. Gibson, S. Haliyo, D. Carberry, A. Bergander, S. Régnier, and M. Padgett, “Touching the microworld with force-feedback optical tweezers,” Opt. Express 17(12), 10259–10264 (2009).
    [CrossRef] [PubMed]

2009 (4)

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

C. Pacoret, R. Bowman, G. Gibson, S. Haliyo, D. Carberry, A. Bergander, S. Régnier, and M. Padgett, “Touching the microworld with force-feedback optical tweezers,” Opt. Express 17(12), 10259–10264 (2009).
[CrossRef] [PubMed]

Y. Tanaka, H. Kawada, S. Tsutsui, M. Ishikawa, and H. Kitajima, “Dynamic micro-bead arrays using optical tweezers combined with intelligent control techniques,” Opt. Express 17(26), 24102–24111 (2009).
[CrossRef] [PubMed]

2008 (2)

2007 (3)

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

2005 (2)

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
[CrossRef]

2004 (2)

2003 (2)

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
[CrossRef] [PubMed]

2002 (4)

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

R. L. Eriksen, V. R. Daria, and J. Glückstad, “Fully dynamic multiple-beam optical tweezers,” Opt. Express 10(14), 597–602 (2002).
[PubMed]

P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
[PubMed]

2000 (1)

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

An, S. S.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Applegate, R. W.

Bergander, A.

Bowman, R.

Butler, J. P.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Carberry, D.

Cheng, M. C.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Chiou, P. Y.

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Cooper, J.

Courtial, J.

Curtis, J. E.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Daria, V. R.

Deng, L.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Egelhaaf, S. U.

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Eriksen, R. L.

Fredberg, J. J.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Gerthoffer, W. T.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Gibson, G.

Glückstad, J.

Glueckstad, J.

Grier, D. G.

D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
[CrossRef] [PubMed]

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Haliyo, S.

Hanes, R. D. L.

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Hirano, K.

Huang, Y.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Ishikawa, M.

Jenkins, M. C.

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Jhiang, S. M.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Jordan, P.

Kambara, H.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Kawada, H.

Kitajima, H.

Kohara, Y.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Koss, B. A.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Laczik, Z. J.

Marr, D. V. M.

Marr, D. W. M.

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

Menq, C. H.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Mio, C.

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

Navajas, D.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Noda, H.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Oakey, J.

Ohta, A. T.

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Okano, K.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Onal, C. D.

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

Pacoret, C.

Padgett, M.

Palima, D.

Régnier, S.

Rodrigo, P. J.

P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
[CrossRef]

P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
[PubMed]

Sinclair, G. S.

Sitti, M.

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

Squier, J.

Takeuchi, S.

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

Tan, W.-H.

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

Tanaka, Y.

Terray, A.

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

Trepat, X.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Tschumperlin, D. J.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Tsutsui, S.

Vestad, T.

Wan, J.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Wu, M. C.

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Zhang, Z.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Adv. Mater. (Deerfield Beach Fla.) (1)

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

Anal. Chem. (1)

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Appl. Phys. Lett. (1)

P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
[CrossRef]

IEEE Trans. Contr. Syst. Technol. (1)

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

Nature (3)

D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
[CrossRef] [PubMed]

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Opt. Commun. (1)

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Opt. Express (8)

R. L. Eriksen, V. R. Daria, and J. Glückstad, “Fully dynamic multiple-beam optical tweezers,” Opt. Express 10(14), 597–602 (2002).
[PubMed]

P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
[PubMed]

R. W. Applegate, J. Squier, T. Vestad, J. Oakey, and D. V. M. Marr, “Optical trapping, manipulation, and sorting of cells and colloids in microfluidic systems with diode laser bars,” Opt. Express 12(19), 4390–4398 (2004).
[CrossRef] [PubMed]

G. S. Sinclair, P. Jordan, J. Courtial, M. Padgett, J. Cooper, and Z. J. Laczik, “Assembly of 3-dimensional structures using programmable holographic optical tweezers,” Opt. Express 12(22), 5475–5480 (2004).
[CrossRef] [PubMed]

D. Palima and J. Glückstad, “Comparison of generalized phase contrast and computer generated holography for laser image projection,” Opt. Express 16(8), 5338–5349 (2008).
[CrossRef] [PubMed]

Y. Tanaka, H. Kawada, K. Hirano, M. Ishikawa, and H. Kitajima, “Automated manipulation of non-spherical micro-objects using optical tweezers combined with image processing techniques,” Opt. Express 16(19), 15115–15122 (2008).
[CrossRef] [PubMed]

C. Pacoret, R. Bowman, G. Gibson, S. Haliyo, D. Carberry, A. Bergander, S. Régnier, and M. Padgett, “Touching the microworld with force-feedback optical tweezers,” Opt. Express 17(12), 10259–10264 (2009).
[CrossRef] [PubMed]

Y. Tanaka, H. Kawada, S. Tsutsui, M. Ishikawa, and H. Kitajima, “Dynamic micro-bead arrays using optical tweezers combined with intelligent control techniques,” Opt. Express 17(26), 24102–24111 (2009).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (2)

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Science (1)

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

Other (2)

J. Glückstad and D. Palima, Generalized Phase Contrast (Springer, 2009), Chaps. 6 and 8.

D. H. Ballard and C. M. Brown, Computer Vision (Prentice-Hall, 1982), Chaps. 3 and 4.
[PubMed]

Supplementary Material (4)

» Media 1: MOV (1886 KB)     
» Media 2: MOV (1138 KB)     
» Media 3: MOV (1853 KB)     
» Media 4: MOV (2726 KB)     

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Figures (5)

Fig. 1
Fig. 1

Schematic diagram of a hybrid system combined GPC optical tweezers (orange beam) and GM scanning tweezers (red beam) for interactive/automatic handling of dynamic arrays.

Fig. 2
Fig. 2

(Media 1) Video frame sequence of interactive manipulation of micro-beads to assemble and handle a massive array. Inset in (a) shows the 14 × 14 matrix pattern of disk-shaped beams and its irradiation area (dotted circle) in imaging plane, with GPC tweezers. (b-c): The elements of the array are taken out one by one from the 12 × 12 array using the PC-mouse controlled GM scanning tweezers.

Fig. 3
Fig. 3

(Media 2) Video frame sequence of the interactive manipulation of a 2 × 2 array in a 2.5D space. The 2 × 2 array is controlled by the time-sharing synchronized scanning technique while the 24 beads form a square with GPC tweezers. (f): Movements of the 2 × 2 array in cross-sectional view, where yellow circles denote the 2 × 2 array.

Fig. 4
Fig. 4

(Media 3) Video frame sequence of the high-speed manipulation of the elements of micro-bead arrays forming the four sets of a 4 × 4 array with GPC tweezers. Four beads indicated by numbers in (a) are sequentially manipulated at super-high speeds along the paths indicated by black arrows in (b) and (c). The accompanying movie is in real time, not accelerated.

Fig. 5
Fig. 5

(Media 4) Video frame sequence of the parallel manipulation of the elements of micro-bead arrays forming the two sets of a 4 × 4 array. (a)–(d): Full-automated assembling of two sets of a 4 × 4 array using the GPC tweezers. (d)–(f): Sixteen beads forming an upper 4 × 4 array are transported one by one using the GM scanning tweezers at super-high speeds while another sixteen beads forming a lower 4 × 4 array are simultaneously transported using the GPC tweezers. Inset in each figure shows the 2D pattern of disk-shaped beams generated by the GPC method. The accompanying movie is in real time, not accelerated.

Equations (1)

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d PCF = λ 2 ( n λ 1 ) ,

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