Abstract

Dynamic micro-bead arrays offer great flexibility and potential as sensing tools in various scientific fields. Two optical trapping techniques, the GPC method using a spatial light modulator and a mechanical scanning method using galvano mirrors, are combined in a hybrid optical tweezers system to handle dynamic micro-bead arrays. This system provides greater versatility while the GPC method creates massive micro-bead arrays in a 2D space, where the trapped beads can be manipulated smoothly and very quickly in a 3D space using the mechanical scanning method. Four typical examples are demonstrated in real time.

© 2011 OSA

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References

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  1. W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
    [CrossRef] [PubMed]
  2. A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
    [CrossRef] [PubMed]
  3. P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
    [CrossRef] [PubMed]
  4. H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
    [CrossRef] [PubMed]
  5. C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
    [CrossRef]
  6. D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
    [CrossRef] [PubMed]
  7. J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
    [CrossRef]
  8. R. L. Eriksen, V. R. Daria, and J. Glückstad, “Fully dynamic multiple-beam optical tweezers,” Opt. Express 10(14), 597–602 (2002).
    [PubMed]
  9. G. S. Sinclair, P. Jordan, J. Courtial, M. Padgett, J. Cooper, and Z. J. Laczik, “Assembly of 3-dimensional structures using programmable holographic optical tweezers,” Opt. Express 12(22), 5475–5480 (2004).
    [CrossRef] [PubMed]
  10. C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
    [CrossRef]
  11. Y. Tanaka, H. Kawada, S. Tsutsui, M. Ishikawa, and H. Kitajima, “Dynamic micro-bead arrays using optical tweezers combined with intelligent control techniques,” Opt. Express 17(26), 24102–24111 (2009).
    [CrossRef] [PubMed]
  12. R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
    [CrossRef] [PubMed]
  13. J. Glückstad and D. Palima, Generalized Phase Contrast (Springer, 2009), Chaps. 6 and 8.
  14. D. Palima and J. Glückstad, “Comparison of generalized phase contrast and computer generated holography for laser image projection,” Opt. Express 16(8), 5338–5349 (2008).
    [CrossRef] [PubMed]
  15. P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
    [CrossRef]
  16. P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
    [PubMed]
  17. Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
    [CrossRef] [PubMed]
  18. D. H. Ballard and C. M. Brown, Computer Vision (Prentice-Hall, 1982), Chaps. 3 and 4.
    [PubMed]
  19. Y. Tanaka, H. Kawada, K. Hirano, M. Ishikawa, and H. Kitajima, “Automated manipulation of non-spherical micro-objects using optical tweezers combined with image processing techniques,” Opt. Express 16(19), 15115–15122 (2008).
    [CrossRef] [PubMed]
  20. R. W. Applegate, J. Squier, T. Vestad, J. Oakey, and D. V. M. Marr, “Optical trapping, manipulation, and sorting of cells and colloids in microfluidic systems with diode laser bars,” Opt. Express 12(19), 4390–4398 (2004).
    [CrossRef] [PubMed]
  21. X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
    [CrossRef] [PubMed]
  22. C. Pacoret, R. Bowman, G. Gibson, S. Haliyo, D. Carberry, A. Bergander, S. Régnier, and M. Padgett, “Touching the microworld with force-feedback optical tweezers,” Opt. Express 17(12), 10259–10264 (2009).
    [CrossRef] [PubMed]

2009 (4)

Y. Tanaka, H. Kawada, S. Tsutsui, M. Ishikawa, and H. Kitajima, “Dynamic micro-bead arrays using optical tweezers combined with intelligent control techniques,” Opt. Express 17(26), 24102–24111 (2009).
[CrossRef] [PubMed]

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

C. Pacoret, R. Bowman, G. Gibson, S. Haliyo, D. Carberry, A. Bergander, S. Régnier, and M. Padgett, “Touching the microworld with force-feedback optical tweezers,” Opt. Express 17(12), 10259–10264 (2009).
[CrossRef] [PubMed]

2008 (2)

2007 (3)

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

2005 (2)

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
[CrossRef]

2004 (2)

2003 (2)

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
[CrossRef] [PubMed]

2002 (4)

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

R. L. Eriksen, V. R. Daria, and J. Glückstad, “Fully dynamic multiple-beam optical tweezers,” Opt. Express 10(14), 597–602 (2002).
[PubMed]

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
[PubMed]

2000 (1)

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

An, S. S.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Applegate, R. W.

Bergander, A.

Bowman, R.

Butler, J. P.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Carberry, D.

Cheng, M. C.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Chiou, P. Y.

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Cooper, J.

Courtial, J.

Curtis, J. E.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Daria, V. R.

Deng, L.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Egelhaaf, S. U.

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Eriksen, R. L.

Fredberg, J. J.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Gerthoffer, W. T.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Gibson, G.

Glückstad, J.

Glueckstad, J.

Grier, D. G.

D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
[CrossRef] [PubMed]

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Haliyo, S.

Hanes, R. D. L.

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Hirano, K.

Huang, Y.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Ishikawa, M.

Jenkins, M. C.

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Jhiang, S. M.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Jordan, P.

Kambara, H.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Kawada, H.

Kitajima, H.

Kohara, Y.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Koss, B. A.

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Laczik, Z. J.

Marr, D. V. M.

Marr, D. W. M.

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

Menq, C. H.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Mio, C.

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

Navajas, D.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Noda, H.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Oakey, J.

Ohta, A. T.

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Okano, K.

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Onal, C. D.

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

Pacoret, C.

Padgett, M.

Palima, D.

Régnier, S.

Rodrigo, P. J.

P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
[CrossRef]

P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
[PubMed]

Sinclair, G. S.

Sitti, M.

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

Squier, J.

Takeuchi, S.

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

Tan, W.-H.

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

Tanaka, Y.

Terray, A.

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

Trepat, X.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Tschumperlin, D. J.

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Tsutsui, S.

Vestad, T.

Wan, J.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Wu, M. C.

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

Zhang, Z.

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

Adv. Mater. (Deerfield Beach Fla.) (1)

C. Mio and D. W. M. Marr, “Optical trapping for the manipulation of colloidal particles,” Adv. Mater. (Deerfield Beach Fla.) 12(12), 917–920 (2000).
[CrossRef]

Anal. Chem. (1)

H. Noda, Y. Kohara, K. Okano, and H. Kambara, “Automated bead alignment apparatus using a single bead capturing technique for fabrication of a miniaturized bead-based DNA probe array,” Anal. Chem. 75(13), 3250–3255 (2003).
[CrossRef] [PubMed]

Appl. Phys. Lett. (1)

P. J. Rodrigo, V. R. Daria, and J. Glückstad, “Four-dimensional optical manipulation of colloidal particles,” Appl. Phys. Lett. 86(7), 074103 (2005).
[CrossRef]

IEEE Trans. Contr. Syst. Technol. (1)

C. D. Onal and M. Sitti, “Visual servoing-based autonomous 2-D manipulation of microparticles using a nanoprobe,” IEEE Trans. Contr. Syst. Technol. 15(5), 842–852 (2007).
[CrossRef]

Nature (3)

D. G. Grier, “A revolution in optical manipulation,” Nature 424(6950), 810–816 (2003).
[CrossRef] [PubMed]

P. Y. Chiou, A. T. Ohta, and M. C. Wu, “Massively parallel manipulation of single cells and microparticles using optical images,” Nature 436(7049), 370–372 (2005).
[CrossRef] [PubMed]

X. Trepat, L. Deng, S. S. An, D. Navajas, D. J. Tschumperlin, W. T. Gerthoffer, J. P. Butler, and J. J. Fredberg, “Universal physical responses to stretch in the living cell,” Nature 447(7144), 592–595 (2007).
[CrossRef] [PubMed]

Opt. Commun. (1)

J. E. Curtis, B. A. Koss, and D. G. Grier, “Dynamic holographic optical tweezers,” Opt. Commun. 207(1–6), 169–175 (2002).
[CrossRef]

Opt. Express (8)

R. L. Eriksen, V. R. Daria, and J. Glückstad, “Fully dynamic multiple-beam optical tweezers,” Opt. Express 10(14), 597–602 (2002).
[PubMed]

G. S. Sinclair, P. Jordan, J. Courtial, M. Padgett, J. Cooper, and Z. J. Laczik, “Assembly of 3-dimensional structures using programmable holographic optical tweezers,” Opt. Express 12(22), 5475–5480 (2004).
[CrossRef] [PubMed]

Y. Tanaka, H. Kawada, S. Tsutsui, M. Ishikawa, and H. Kitajima, “Dynamic micro-bead arrays using optical tweezers combined with intelligent control techniques,” Opt. Express 17(26), 24102–24111 (2009).
[CrossRef] [PubMed]

D. Palima and J. Glückstad, “Comparison of generalized phase contrast and computer generated holography for laser image projection,” Opt. Express 16(8), 5338–5349 (2008).
[CrossRef] [PubMed]

P. J. Rodrigo, R. L. Eriksen, V. R. Daria, and J. Glueckstad, “Interactive light-driven and parallel manipulation of inhomogeneous particles,” Opt. Express 10(26), 1550–1556 (2002).
[PubMed]

C. Pacoret, R. Bowman, G. Gibson, S. Haliyo, D. Carberry, A. Bergander, S. Régnier, and M. Padgett, “Touching the microworld with force-feedback optical tweezers,” Opt. Express 17(12), 10259–10264 (2009).
[CrossRef] [PubMed]

Y. Tanaka, H. Kawada, K. Hirano, M. Ishikawa, and H. Kitajima, “Automated manipulation of non-spherical micro-objects using optical tweezers combined with image processing techniques,” Opt. Express 16(19), 15115–15122 (2008).
[CrossRef] [PubMed]

R. W. Applegate, J. Squier, T. Vestad, J. Oakey, and D. V. M. Marr, “Optical trapping, manipulation, and sorting of cells and colloids in microfluidic systems with diode laser bars,” Opt. Express 12(19), 4390–4398 (2004).
[CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

W.-H. Tan and S. Takeuchi, “A trap-and-release integrated microfluidic system for dynamic microarray applications,” Proc. Natl. Acad. Sci. U.S.A. 104(4), 1146–1151 (2007).
[CrossRef] [PubMed]

Rev. Sci. Instrum. (2)

Y. Huang, J. Wan, M. C. Cheng, Z. Zhang, S. M. Jhiang, and C. H. Menq, “Three-axis rapid steering of optically propelled micro/nanoparticles,” Rev. Sci. Instrum. 80(6), 063107 (2009).
[CrossRef] [PubMed]

R. D. L. Hanes, M. C. Jenkins, and S. U. Egelhaaf, “Combined holographic-mechanical optical tweezers: construction, optimization, and calibration,” Rev. Sci. Instrum. 80(8), 083703 (2009).
[CrossRef] [PubMed]

Science (1)

A. Terray, J. Oakey, and D. W. M. Marr, “Microfluidic control using colloidal devices,” Science 296(5574), 1841–1844 (2002).
[CrossRef] [PubMed]

Other (2)

D. H. Ballard and C. M. Brown, Computer Vision (Prentice-Hall, 1982), Chaps. 3 and 4.
[PubMed]

J. Glückstad and D. Palima, Generalized Phase Contrast (Springer, 2009), Chaps. 6 and 8.

Supplementary Material (4)

» Media 1: MOV (1886 KB)     
» Media 2: MOV (1138 KB)     
» Media 3: MOV (1853 KB)     
» Media 4: MOV (2726 KB)     

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Figures (5)

Fig. 1
Fig. 1

Schematic diagram of a hybrid system combined GPC optical tweezers (orange beam) and GM scanning tweezers (red beam) for interactive/automatic handling of dynamic arrays.

Fig. 2
Fig. 2

(Media 1) Video frame sequence of interactive manipulation of micro-beads to assemble and handle a massive array. Inset in (a) shows the 14 × 14 matrix pattern of disk-shaped beams and its irradiation area (dotted circle) in imaging plane, with GPC tweezers. (b-c): The elements of the array are taken out one by one from the 12 × 12 array using the PC-mouse controlled GM scanning tweezers.

Fig. 3
Fig. 3

(Media 2) Video frame sequence of the interactive manipulation of a 2 × 2 array in a 2.5D space. The 2 × 2 array is controlled by the time-sharing synchronized scanning technique while the 24 beads form a square with GPC tweezers. (f): Movements of the 2 × 2 array in cross-sectional view, where yellow circles denote the 2 × 2 array.

Fig. 4
Fig. 4

(Media 3) Video frame sequence of the high-speed manipulation of the elements of micro-bead arrays forming the four sets of a 4 × 4 array with GPC tweezers. Four beads indicated by numbers in (a) are sequentially manipulated at super-high speeds along the paths indicated by black arrows in (b) and (c). The accompanying movie is in real time, not accelerated.

Fig. 5
Fig. 5

(Media 4) Video frame sequence of the parallel manipulation of the elements of micro-bead arrays forming the two sets of a 4 × 4 array. (a)–(d): Full-automated assembling of two sets of a 4 × 4 array using the GPC tweezers. (d)–(f): Sixteen beads forming an upper 4 × 4 array are transported one by one using the GM scanning tweezers at super-high speeds while another sixteen beads forming a lower 4 × 4 array are simultaneously transported using the GPC tweezers. Inset in each figure shows the 2D pattern of disk-shaped beams generated by the GPC method. The accompanying movie is in real time, not accelerated.

Equations (1)

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d PCF = λ 2 ( n λ 1 ) ,

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