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Plasmonic chiral contrast agents for optical coherence tomography: numerical study

Kalpesh B. Mehta and Nanguang Chen

Open Access Open Access

Abstract

Optical coherence tomography (OCT) is a widely used morphological imaging modality. Various contrast agents, which change localized optical properties, are used to extend the applicability of OCT, where intrinsic contrast is not sufficient. In this paper we propose the use of a dual-rod gold nano-structure as a polarization sensitive contrast agent. Using numerical simulation, we demonstrated that the proposed structure has tunable chiral response. Enhanced cross-section due to Plasmon resonance in gold nanoparticles, along with the chiral behavior can provide enhanced detection sensitivity. The proposed contrast agents may extend the applicability of OCT to the problems that require the molecular contrast with enhanced sensitivity.

©2011 Optical Society of America

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Figures (8)
Fig. 1
Fig. 1 A Three dimensional chiral structure, Dimensions of gold nanorods ( L , W ) determines resonance wavelength, Dand θ r controls chirality.

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Fig. 2
Fig. 2 Differential Scattering Cross section for the particle for LCP and RCP incident lights for single particle Dimensions of the particle used in the simulation are: (a) L = 70 nm, W = 30 nm, D = 68 nm, θr = 45° (b) L = 175 nm, W = 30 nm, D = 81 nm, θr = 45°, NA = 0.35.

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Fig. 3
Fig. 3 (a), (c) Averaged differential scattering cross section obtained by rotating the particles at finite steps ( 0 0 to 180 o ) (b), (d) CIDS calculated using the averaged backscattered field intensities for LCP and RCP lights. Dimensions for (a) and (b): L = 70 nm, W = 30 nm, D = 68 nm, θr = 45°, Dimensions for (c) and (d): L = 175 nm, W = 30 nm, D = 81 nm, θr = 45°, NA = 0.35.

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Fig. 4
Fig. 4 Effect of Phase retradation of media (Birefringence induced) on Normalized difference in reflectivity, Dimensions for (a): L = 70 nm, W = 30 nm, D = 68 nm, θr = 45°, Dimensions for (b): L = 175 nm, W = 30 nm, D = 81 nm, θr = 45°, NA = 0.35.

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Fig. 5
Fig. 5 Effect of dielectric layer width change on normalized difference in reflectivity (a): L = 70 nm, W = 30 nm, D = 68 nm, θr = 45°, Dimensions for (b): L = 175 nm, W = 30 nm, D = 81 nm, θr = 45°, NA = 0.35.

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Fig. 6
Fig. 6 Chirality tuning by changing θr CIDS obtained for θr = 0°, 45°, 90° and θr = 135°.

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Fig. 7
Fig. 7 Single detector Circular polarization sensitive OCT, PC: Manual fiber polarization controller, C1, C2: Fiber collimator, QWP1, QWP2: Quarter wave plates, RM: Reference mirror, I: Free space Isolator.

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Fig. 8
Fig. 8 Overview of nanoparticles fabrication method.

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Equations (5)

Equations on this page are rendered with MathJax. Learn more.

C I D S ( ω ) = I L C P ( ω ) − I R C P ( ω ) I L C P ( ω ) + I R C P ( ω )
I ( ω ) = | ∫ ϕ = 0 2 π ∫ θ = 180 − α 2 180 + α 2 E → ( ω , θ , ϕ ) sin ( θ ) d ϕ d θ | 2
R ∝ ∫ ω [ ∫ ϕ = 0 2 π ∫ θ = 180 − α 2 180 + α 2 I ( ω , θ , ϕ ) sin ( θ ) d ϕ d θ ] . P S D ( ω ) d ω
Δ R = R L − R R R L + R R
σ d s c ( ω ) = ∫ ϕ = 0 2 π ∫ θ = 180 − α 2 180 + α 2 P b a c k s c a t t e r d ( ω , θ , ϕ ) sin ( θ ) d ϕ d θ I i n c ( ω )
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