Abstract

We present a new method allowing the reconstruction of 3D time-domain diffuse optical tomography images, based on the time-dependent diffusion equation and an iterative algorithm (ART) using specific points on the temporal profiles. The first advantage of our method versus the full time-resolved scheme consists in considerably reducing the inverse problem resolution time. Secondly, in the presence of scattering heterogeneities, our method provides images of better quality comparatively to classical methods using full-time data or the first moments of the profiles.

© 2011 OSA

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    [CrossRef]
  32. R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions,” Appl. Phys. Lett. 69(27), 4162–4164 (1996).
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  33. R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging with diffusing light: an experimental study of the effect of background optical properties,” Appl. Opt. 37(16), 3564–3573 (1998).
    [CrossRef]
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    [CrossRef] [PubMed]
  35. V. Venugopal, J. Chen, F. Lesage, and X. Intes, “Full-field time-resolved fluorescence tomography of small animals,” Opt. Lett. 35(19), 3189–3191 (2010).
    [CrossRef] [PubMed]

2010 (2)

2009 (2)

F. Nouizi, R. Chabrier, M. Torregrossa, and P. Poulet, “3D modeling for solving forward model of no-contact fluorescence diffuse optical tomography method,” Proc. SPIE 7369, 73690C (2009).
[CrossRef]

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

2008 (2)

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

F. Gao, H. Zhao, L. Zhang, Y. Tanikawa, A. Marjono, and Y. Yamada, “A self-normalized, full time-resolved method for fluorescence diffuse optical tomography,” Opt. Express 16(17), 13104–13121 (2008).
[CrossRef] [PubMed]

2005 (2)

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[CrossRef] [PubMed]

X. Intes and B. Chance, “Non-PET functional imaging techniques: optical,” Radiol. Clin. North Am. 43(1), 221–234 (2005).
[CrossRef] [PubMed]

2003 (2)

J. C. Hebden, “Advances in optical imaging of the newborn infant brain,” Psychophysiology 40(4), 501–510 (2003).
[CrossRef] [PubMed]

M. Torregrossa, C. V. Zint, and P. Poulet, “Effects of prior MRI information on image reconstruction in diffuse optical tomography,” Proc. SPIE 5143, 29–40 (2003).
[CrossRef]

2002 (2)

Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
[CrossRef]

F. Gao, H. Zhao, and Y. Yamada, “Improvement of image quality in diffuse optical tomography by use of full time-resolved data,” Appl. Opt. 41(4), 778–791 (2002).
[CrossRef] [PubMed]

2000 (2)

F. Gao, P. Poulet, and Y. Yamada, “Simultaneous mapping of absorption and scattering coefficients from a three-dimensional model of time-resolved optical tomography,” Appl. Opt. 39(31), 5898–5910 (2000).
[CrossRef]

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

1999 (4)

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol. 44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

A. H. Hielscher, A. D. Klose, and K. M. Hanson, “Gradient-based iterative image reconstruction scheme for time-resolved optical tomography,” IEEE Trans. Med. Imaging 18(3), 262–271 (1999).
[CrossRef] [PubMed]

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[CrossRef]

1998 (2)

1997 (2)

1996 (3)

1995 (2)

S. R. Arridge, “Photon-measurement density functions. Part I: analytical forms,” Appl. Opt. 34(31), 7395–7409 (1995).
[CrossRef] [PubMed]

A. G. Yodh and B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48(3), 34–40 (1995).
[CrossRef]

1993 (2)

M. Schweiger, S. R. Arridge, and D. T. Delpy, “Application of the finite-element method for the forward and inverse models in optical tomography,” J. Math. Imaging Vis. 3(3), 263–283 (1993).
[CrossRef]

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

1992 (1)

S. R. Arridge, M. Schweiger, and D. T. Delpy, “Iterative reconstruction of near-infrared absorption images,” Proc. SPIE 1767, 372–383 (1992).
[CrossRef]

1989 (1)

1977 (1)

F. F. Jöbsis, “Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters,” Science 198(4323), 1264–1267 (1977).
[CrossRef] [PubMed]

’t Hooft, G. W.

Aronson, R.

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

Arridge, S. R.

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol. 44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[CrossRef]

S. R. Arridge, “Photon-measurement density functions. Part I: analytical forms,” Appl. Opt. 34(31), 7395–7409 (1995).
[CrossRef] [PubMed]

M. Schweiger, S. R. Arridge, and D. T. Delpy, “Application of the finite-element method for the forward and inverse models in optical tomography,” J. Math. Imaging Vis. 3(3), 263–283 (1993).
[CrossRef]

S. R. Arridge, M. Schweiger, and D. T. Delpy, “Iterative reconstruction of near-infrared absorption images,” Proc. SPIE 1767, 372–383 (1992).
[CrossRef]

Barbour, R. L.

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

Boas, D. A.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Bonner, R. F.

Carpenter, C. M.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

Cerussi, A. E.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Chabrier, R.

F. Nouizi, R. Chabrier, M. Torregrossa, and P. Poulet, “3D modeling for solving forward model of no-contact fluorescence diffuse optical tomography method,” Proc. SPIE 7369, 73690C (2009).
[CrossRef]

Chance, B.

X. Intes and B. Chance, “Non-PET functional imaging techniques: optical,” Radiol. Clin. North Am. 43(1), 221–234 (2005).
[CrossRef] [PubMed]

Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
[CrossRef]

A. G. Yodh and B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48(3), 34–40 (1995).
[CrossRef]

M. S. Patterson, B. Chance, and B. C. Wilson, “Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties,” Appl. Opt. 28(12), 2331–2336 (1989).
[CrossRef] [PubMed]

Chang, J. H.

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

Chen, J.

Chernomordik, V.

Colak, S. B.

Cubeddu, R.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging with diffusing light: an experimental study of the effect of background optical properties,” Appl. Opt. 37(16), 3564–3573 (1998).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions,” Appl. Phys. Lett. 69(27), 4162–4164 (1996).
[CrossRef]

Davis, S. C.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

Dehghani, H.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

Delpy, D. T.

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

M. Schweiger, S. R. Arridge, and D. T. Delpy, “Application of the finite-element method for the forward and inverse models in optical tomography,” J. Math. Imaging Vis. 3(3), 263–283 (1993).
[CrossRef]

S. R. Arridge, M. Schweiger, and D. T. Delpy, “Iterative reconstruction of near-infrared absorption images,” Proc. SPIE 1767, 372–383 (1992).
[CrossRef]

Eames, M. E.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

Eda, H.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Gandjbakhche, A. H.

Gao, F.

Graber, H. L.

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

Hanson, K. M.

A. H. Hielscher, A. D. Klose, and K. M. Hanson, “Gradient-based iterative image reconstruction scheme for time-resolved optical tomography,” IEEE Trans. Med. Imaging 18(3), 262–271 (1999).
[CrossRef] [PubMed]

Hebden, J. C.

J. C. Hebden, “Advances in optical imaging of the newborn infant brain,” Psychophysiology 40(4), 501–510 (2003).
[CrossRef] [PubMed]

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

A. H. Gandjbakhche, V. Chernomordik, J. C. Hebden, and R. Nossal, “Time-dependent contrast functions for quantitative imaging in time-resolved transillumination experiments,” Appl. Opt. 37(10), 1973–1981 (1998).
[CrossRef]

Hielscher, A. H.

A. H. Hielscher, A. D. Klose, and K. M. Hanson, “Gradient-based iterative image reconstruction scheme for time-resolved optical tomography,” IEEE Trans. Med. Imaging 18(3), 262–271 (1999).
[CrossRef] [PubMed]

Hillman, E. M. C.

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

Hünlich, R.

Intes, X.

V. Venugopal, J. Chen, F. Lesage, and X. Intes, “Full-field time-resolved fluorescence tomography of small animals,” Opt. Lett. 35(19), 3189–3191 (2010).
[CrossRef] [PubMed]

V. Venugopal, J. Chen, and X. Intes, “Development of an optical imaging platform for functional imaging of small animals using widefield excitation,” Biomed. Opt. Express 1(1), 143–156 (2010).
[CrossRef]

X. Intes and B. Chance, “Non-PET functional imaging techniques: optical,” Radiol. Clin. North Am. 43(1), 221–234 (2005).
[CrossRef] [PubMed]

Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
[CrossRef]

Ito, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Jiang, H.

Jöbsis, F. F.

F. F. Jöbsis, “Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters,” Science 198(4323), 1264–1267 (1977).
[CrossRef] [PubMed]

Klose, A. D.

A. H. Hielscher, A. D. Klose, and K. M. Hanson, “Gradient-based iterative image reconstruction scheme for time-resolved optical tomography,” IEEE Trans. Med. Imaging 18(3), 262–271 (1999).
[CrossRef] [PubMed]

Lech, G.

Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
[CrossRef]

Lesage, F.

Lin, Y.

Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
[CrossRef]

Marjono, A.

Melissen, J. B.

Model, R.

Nioka, S.

Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
[CrossRef]

Nossal, R.

Nouizi, F.

F. Nouizi, R. Chabrier, M. Torregrossa, and P. Poulet, “3D modeling for solving forward model of no-contact fluorescence diffuse optical tomography method,” Proc. SPIE 7369, 73690C (2009).
[CrossRef]

Ntziachristos, V.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[CrossRef] [PubMed]

Oda, I.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Oda, M.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Oikawa, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Orlt, M.

Osterberg, U. L.

Paasschens, J. C.

Papaioannou, D. G.

Patterson, M. S.

Paulsen, K. D.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13(2), 253–266 (1996).
[CrossRef]

Pifferi, A.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging with diffusing light: an experimental study of the effect of background optical properties,” Appl. Opt. 37(16), 3564–3573 (1998).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions,” Appl. Phys. Lett. 69(27), 4162–4164 (1996).
[CrossRef]

Pogue, B. W.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, “Optical image reconstruction using frequency-domain data: simulations and experiments,” J. Opt. Soc. Am. A 13(2), 253–266 (1996).
[CrossRef]

Poulet, P.

F. Nouizi, R. Chabrier, M. Torregrossa, and P. Poulet, “3D modeling for solving forward model of no-contact fluorescence diffuse optical tomography method,” Proc. SPIE 7369, 73690C (2009).
[CrossRef]

M. Torregrossa, C. V. Zint, and P. Poulet, “Effects of prior MRI information on image reconstruction in diffuse optical tomography,” Proc. SPIE 5143, 29–40 (2003).
[CrossRef]

F. Gao, P. Poulet, and Y. Yamada, “Simultaneous mapping of absorption and scattering coefficients from a three-dimensional model of time-resolved optical tomography,” Appl. Opt. 39(31), 5898–5910 (2000).
[CrossRef]

Ripoll, J.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[CrossRef] [PubMed]

Sassaroli, A.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Schmidt, F. E. R.

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

Schomberg, H.

Schweiger, M.

E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol. 44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

M. Schweiger, S. R. Arridge, and D. T. Delpy, “Application of the finite-element method for the forward and inverse models in optical tomography,” J. Math. Imaging Vis. 3(3), 263–283 (1993).
[CrossRef]

S. R. Arridge, M. Schweiger, and D. T. Delpy, “Iterative reconstruction of near-infrared absorption images,” Proc. SPIE 1767, 372–383 (1992).
[CrossRef]

Srinivasan, S.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

Takada, M.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Tamura, M.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Tanikawa, Y.

Taroni, P.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging with diffusing light: an experimental study of the effect of background optical properties,” Appl. Opt. 37(16), 3564–3573 (1998).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions,” Appl. Phys. Lett. 69(27), 4162–4164 (1996).
[CrossRef]

Torregrossa, M.

F. Nouizi, R. Chabrier, M. Torregrossa, and P. Poulet, “3D modeling for solving forward model of no-contact fluorescence diffuse optical tomography method,” Proc. SPIE 7369, 73690C (2009).
[CrossRef]

M. Torregrossa, C. V. Zint, and P. Poulet, “Effects of prior MRI information on image reconstruction in diffuse optical tomography,” Proc. SPIE 5143, 29–40 (2003).
[CrossRef]

Torricelli, A.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging with diffusing light: an experimental study of the effect of background optical properties,” Appl. Opt. 37(16), 3564–3573 (1998).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions,” Appl. Phys. Lett. 69(27), 4162–4164 (1996).
[CrossRef]

Tromberg, B. J.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Tsuchiya, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Tsunazawa, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Valentini, G.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging with diffusing light: an experimental study of the effect of background optical properties,” Appl. Opt. 37(16), 3564–3573 (1998).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Imaging of optical inhomogeneities in highly diffusive media: Discrimination between scattering and absorption contributions,” Appl. Phys. Lett. 69(27), 4162–4164 (1996).
[CrossRef]

van Asten, N. A.

van der Mark, M. B.

Venugopal, V.

Wada, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Walzel, M.

Wang, L. V.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[CrossRef] [PubMed]

Wang, Y.

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

Weiss, G. H.

Weissleder, R.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[CrossRef] [PubMed]

Wilson, B. C.

Yalavarthy, P. K.

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
[CrossRef]

Yamada, Y.

Yamashita, Y.

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
[CrossRef]

Yodh, A. G.

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

A. G. Yodh and B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48(3), 34–40 (1995).
[CrossRef]

Zhang, L.

Zhao, H.

Zint, C. V.

M. Torregrossa, C. V. Zint, and P. Poulet, “Effects of prior MRI information on image reconstruction in diffuse optical tomography,” Proc. SPIE 5143, 29–40 (2003).
[CrossRef]

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F. Gao, P. Poulet, and Y. Yamada, “Simultaneous mapping of absorption and scattering coefficients from a three-dimensional model of time-resolved optical tomography,” Appl. Opt. 39(31), 5898–5910 (2000).
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F. Gao, H. Zhao, and Y. Yamada, “Improvement of image quality in diffuse optical tomography by use of full time-resolved data,” Appl. Opt. 41(4), 778–791 (2002).
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[CrossRef]

Biomed. Opt. Express (1)

Commun. Numer. Methods Eng. (1)

H. Dehghani, M. E. Eames, P. K. Yalavarthy, S. C. Davis, S. Srinivasan, C. M. Carpenter, B. W. Pogue, and K. D. Paulsen, “Near infrared optical tomography using NIRFAST: algorithm for numerical model and image reconstruction,” Commun. Numer. Methods Eng. 25(6), 711–732 (2009).
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IEEE Trans. Med. Imaging (1)

A. H. Hielscher, A. D. Klose, and K. M. Hanson, “Gradient-based iterative image reconstruction scheme for time-resolved optical tomography,” IEEE Trans. Med. Imaging 18(3), 262–271 (1999).
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Inverse Probl. (1)

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
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J. Math. Imaging Vis. (1)

M. Schweiger, S. R. Arridge, and D. T. Delpy, “Application of the finite-element method for the forward and inverse models in optical tomography,” J. Math. Imaging Vis. 3(3), 263–283 (1993).
[CrossRef]

J. Opt. Soc. Am. A (2)

Med. Phys. (1)

B. J. Tromberg, B. W. Pogue, K. D. Paulsen, A. G. Yodh, D. A. Boas, and A. E. Cerussi, “Assessing the future of diffuse optical imaging technologies for breast cancer management,” Med. Phys. 35(6), 2443–2451 (2008).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (1)

Phys. Med. Biol. (1)

M. Schweiger and S. R. Arridge, “Application of temporal filters to time resolved data in optical tomography,” Phys. Med. Biol. 44(7), 1699–1717 (1999).
[CrossRef] [PubMed]

Phys. Today (1)

A. G. Yodh and B. Chance, “Spectroscopy and imaging with diffusing light,” Phys. Today 48(3), 34–40 (1995).
[CrossRef]

Proc. SPIE (4)

F. Nouizi, R. Chabrier, M. Torregrossa, and P. Poulet, “3D modeling for solving forward model of no-contact fluorescence diffuse optical tomography method,” Proc. SPIE 7369, 73690C (2009).
[CrossRef]

M. Torregrossa, C. V. Zint, and P. Poulet, “Effects of prior MRI information on image reconstruction in diffuse optical tomography,” Proc. SPIE 5143, 29–40 (2003).
[CrossRef]

S. R. Arridge, M. Schweiger, and D. T. Delpy, “Iterative reconstruction of near-infrared absorption images,” Proc. SPIE 1767, 372–383 (1992).
[CrossRef]

R. L. Barbour, H. L. Graber, Y. Wang, J. H. Chang, and R. Aronson, “A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data,” Proc. SPIE IS11, 87–120 (1993).

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J. C. Hebden, “Advances in optical imaging of the newborn infant brain,” Psychophysiology 40(4), 501–510 (2003).
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Y. Lin, G. Lech, S. Nioka, X. Intes, and B. Chance, “Noninvasive, low-noise, fast imaging of blood volume and deoxygenation changes in muscles using light-emitting diode continuous-wave imager,” Rev. Sci. Instrum. 73(8), 3065–3074 (2002).
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E. M. C. Hillman, J. C. Hebden, F. E. R. Schmidt, S. R. Arridge, M. Schweiger, H. Dehghani, and D. T. Delpy, “Calibration techniques and datatype extraction for time-resolved optical tomography,” Rev. Sci. Instrum. 71(9), 3415–3427 (2000).
[CrossRef]

H. Eda, I. Oda, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, and M. Tamura, “Multichannel time-resolved optical tomographic imaging system,” Rev. Sci. Instrum. 70(9), 3595–3602 (1999).
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Figures (8)

Fig. 1
Fig. 1

3D mesh of the numerical phantom showing the 2 rods.

Fig. 2
Fig. 2

Choice of the points used in the optimization process according to method 2 (left) and method 3 (right). Methods described in section 4.2 and 4.3.

Fig. 3
Fig. 3

Photon-density map inside object_2 (slice at x = 0), 1ns after the light pulse and position of the 3 detection fibers at 135°, 180° and −135° from the exciting fiber (F1) (left), the temporal profiles detected (right).

Fig. 4
Fig. 4

Column 1: true and reconstructed μa, column 2: true and reconstructed μs’, using method 2 with Δµs’ ≠ 0. Slice at x = 0.

Fig. 5
Fig. 5

Column 1: true and reconstructed μa, column 2: true and reconstructed μs’, using method 1, 2, 3 respectively. Slice at x = 0.

Fig. 6
Fig. 6

Profiles of μa (left) and μ’s (right) along the z-axis.

Fig. 7
Fig. 7

Column 1: true and reconstructed μa, column 2: true and reconstructed μs’, using method 1, 2, 3 respectively. Slice at x = 0.

Fig. 8
Fig. 8

Profiles of μa (left) and μs’ (right) along the z-axis.

Tables (2)

Tables Icon

Table 1 Errors and Crosstalk on the Reconstructed µa, µs’ Maps of Object_1, Slice at x=0

Tables Icon

Table 2 Errors and Crosstalk on the Reconstructed µa, µs’ Maps of Object_2, Slice at x=0

Equations (9)

Equations on this page are rendered with MathJax. Learn more.

{ Γ } = F [ { μ a , μ s ' } ]
u ( r , t ) t κ u ( r , t ) + μ a c u ( r , t ) = δ ( t , r 0 )
n κ u ( r , t ) + q u ( r , t ) = 0
S N R ( t ) = N ( t )
E s , d = 0 Γ s , d ( t ) d t
t s , d = 1 E s , d 0 t Γ s , d ( t ) d t
{ μ a , μ s ' } = F 1 [ { T P S F } ]
Δ x = D λ Δ D J ( D ) Δ x J ( D ) T J ( D ) T
E d a t a = 100 P R O I d a t a t r u e ( i ) d a t a r e c o ( i ) d a t a t r u e ( i )

Metrics