Abstract

Lipid is a common constituent in atherosclerotic plaques. The location and area of the lipid region is closely related to the progression of the disease. Intravascular photoacoustic (IVPA) imaging, a minimally invasive imaging modality, can spatially resolve the optical absorption property of arterial tissue. Based on the distinct optical absorption spectrum of fat in the near infrared wavelength range, spectroscopic IVPA imaging may distinguish lipid from other water-based tissue types in the atherosclerotic artery. In this study, a bench-top spectroscopic IVPA imaging system was used to ex-vivo image both atherosclerotic and normal rabbit aortas. By combing the spectroscopic IVPA image with the intravascular ultrasound (IVUS) image, lipid regions in the aorta were identified. The results demonstrated that IVUS-guided spectroscopic IVPA imaging is a promising tool to differentiate lipid in atherosclerosis.

© 2010 OSA

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2010 (1)

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum. 81(1), 1–7 (2010).
[CrossRef]

2009 (2)

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE 7177, 71770A (2009).
[CrossRef]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

2008 (2)

2007 (3)

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[CrossRef]

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

2006 (2)

E. Falk, “Pathogenesis of atherosclerosis,” J. Am. Coll. Cardiol. 47(8Suppl), C7–C12 (2006).
[CrossRef] [PubMed]

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

2004 (1)

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

2003 (1)

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

2001 (1)

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng. 21, 7–14 (2001).

2000 (1)

S. Tsimikas, B. P. Shortal, J. L. Witztum, and W. Palinski, “In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression,” Arterioscler. Thromb. Vasc. Biol. 20(3), 689–697 (2000).
[CrossRef] [PubMed]

1999 (1)

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

1996 (1)

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Aglyamov, S.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Aglyamov, S. R.

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

Allen, T. J.

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE 7177, 71770A (2009).
[CrossRef]

Amirian, J. H.

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express 16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

Anderson, R. R.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Beard, P.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[CrossRef]

Beard, P. C.

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE 7177, 71770A (2009).
[CrossRef]

Benson, S. V.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Buja, L. M.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Burke, A.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Casscells, S. W.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Chandler, W.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Chen, J. C.

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng. 21, 7–14 (2001).

Cornhill, J. F.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Delpy, D.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[CrossRef]

Dorschel, K.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Douglas, D. R.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Dylla, H. F.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Elwell, C.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[CrossRef]

Emelianov, S.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Emelianov, S. Y.

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum. 81(1), 1–7 (2010).
[CrossRef]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express 16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

Falk, E.

E. Falk, “Pathogenesis of atherosclerosis,” J. Am. Coll. Cardiol. 47(8Suppl), C7–C12 (2006).
[CrossRef] [PubMed]

Farinelli, W.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Fayad, Z. A.

J. Sanz and Z. A. Fayad, “Imaging of atherosclerotic cardiovascular disease,” Nature 451(7181), 953–957 (2008).
[CrossRef] [PubMed]

Friebel, M.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Fuster, V.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Gubeli, J.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Hahn, A.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Herderick, E. E.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Jang, I. K.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Jordan, K.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Karpiouk, A.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Karpiouk, A. B.

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum. 81(1), 1–7 (2010).
[CrossRef]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Katocs, A. S.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Kolodgie, F. D.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Largis, E. E.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Larson, T.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Laubach, H.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Laufer, J.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[CrossRef]

Lee, S. J.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Litovsky, S.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Litovsky, S. H.

Lowe, H. C.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

MacNeill, B. D.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Madjid, M.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Manstein, D.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Motamedi, M.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Muller, G.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Naghavi, M.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Neil, G. R.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Oraevsky, A.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Palinski, W.

S. Tsimikas, B. P. Shortal, J. L. Witztum, and W. Palinski, “In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression,” Arterioscler. Thromb. Vasc. Biol. 20(3), 689–697 (2000).
[CrossRef] [PubMed]

Roggan, A.

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

Sanz, J.

J. Sanz and Z. A. Fayad, “Imaging of atherosclerotic cardiovascular disease,” Nature 451(7181), 953–957 (2008).
[CrossRef] [PubMed]

Schmitt, R.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Scott, W.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Sethuraman, S.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express 16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Shah, J.

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

Shinn, M.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Shortal, B. P.

S. Tsimikas, B. P. Shortal, J. L. Witztum, and W. Palinski, “In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression,” Arterioscler. Thromb. Vasc. Biol. 20(3), 689–697 (2000).
[CrossRef] [PubMed]

Smalling, R. W.

S. Sethuraman, J. H. Amirian, S. H. Litovsky, R. W. Smalling, and S. Y. Emelianov, “Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques,” Opt. Express 16(5), 3362–3367 (2008).
[CrossRef] [PubMed]

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

Sokolov, K.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Su, J. L.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Takano, M.

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

Tsai, C. L.

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng. 21, 7–14 (2001).

Tsimikas, S.

S. Tsimikas, B. P. Shortal, J. L. Witztum, and W. Palinski, “In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression,” Arterioscler. Thromb. Vasc. Biol. 20(3), 689–697 (2000).
[CrossRef] [PubMed]

Vela, D.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Virmani, R.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Wang, B.

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum. 81(1), 1–7 (2010).
[CrossRef]

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Wang, W. J.

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng. 21, 7–14 (2001).

Willerson, J. T.

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Williams, G. P.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Witztum, J. L.

S. Tsimikas, B. P. Shortal, J. L. Witztum, and W. Palinski, “In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression,” Arterioscler. Thromb. Vasc. Biol. 20(3), 689–697 (2000).
[CrossRef] [PubMed]

Wrenn, S. M.

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

Yantsen, E.

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Yaroslavsky, A. N.

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Arch. Pathol. Lab. Med. (1)

D. Vela, L. M. Buja, M. Madjid, A. Burke, M. Naghavi, J. T. Willerson, S. W. Casscells, and S. Litovsky, “The role of periadventitial fat in atherosclerosis,” Arch. Pathol. Lab. Med. 131(3), 481–487 (2007).
[PubMed]

Arterioscler. Thromb. Vasc. Biol. (3)

S. Tsimikas, B. P. Shortal, J. L. Witztum, and W. Palinski, “In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression,” Arterioscler. Thromb. Vasc. Biol. 20(3), 689–697 (2000).
[CrossRef] [PubMed]

B. D. MacNeill, H. C. Lowe, M. Takano, V. Fuster, and I. K. Jang, “Intravascular modalities for detection of vulnerable plaque: current status,” Arterioscler. Thromb. Vasc. Biol. 23(8), 1333–1342 (2003).
[CrossRef] [PubMed]

F. D. Kolodgie, A. S. Katocs, E. E. Largis, S. M. Wrenn, J. F. Cornhill, E. E. Herderick, S. J. Lee, and R. Virmani, “Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type,” Arterioscler. Thromb. Vasc. Biol. 16(12), 1454–1464 (1996).
[CrossRef] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

S. Sethuraman, S. R. Aglyamov, J. H. Amirian, R. W. Smalling, and S. Y. Emelianov, “Intravascular photoacoustic imaging using an IVUS imaging catheter,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 54(5), 978–986 (2007).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol. (1)

E. Falk, “Pathogenesis of atherosclerosis,” J. Am. Coll. Cardiol. 47(8Suppl), C7–C12 (2006).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, “Optical properties of circulating human blood in the wavelength range 400–2500 nm,” J. Biomed. Opt. 4(1), 36–46 (1999).
[CrossRef]

J. Med. Biol. Eng. (1)

C. L. Tsai, J. C. Chen, and W. J. Wang, “Near-infrared absorption property of biological soft tissue constituents,” J. Med. Biol. Eng. 21, 7–14 (2001).

Lasers Surg. Med. (1)

R. R. Anderson, W. Farinelli, H. Laubach, D. Manstein, A. N. Yaroslavsky, J. Gubeli, K. Jordan, G. R. Neil, M. Shinn, W. Chandler, G. P. Williams, S. V. Benson, D. R. Douglas, and H. F. Dylla, “Selective photothermolysis of lipid-rich tissues: a free electron laser study,” Lasers Surg. Med. 38(10), 913–919 (2006).
[CrossRef] [PubMed]

Nano Lett. (1)

B. Wang, E. Yantsen, T. Larson, A. B. Karpiouk, S. Sethuraman, J. L. Su, K. Sokolov, and S. Y. Emelianov, “Plasmonic intravascular photoacoustic imaging for detection of macrophages in atherosclerotic plaques,” Nano Lett. 9(6), 2212–2217 (2009).
[CrossRef]

Nature (1)

J. Sanz and Z. A. Fayad, “Imaging of atherosclerotic cardiovascular disease,” Nature 451(7181), 953–957 (2008).
[CrossRef] [PubMed]

Opt. Express (1)

Phys. Med. Biol. (1)

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[CrossRef]

Proc. SPIE (2)

S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, W. Scott, R. Schmitt, M. Motamedi, A. Karpiouk, and A. Oraevsky, “Combined ultrasound, optoacoustic, and elasticity imaging,” Proc. SPIE 5320, 101–112 (2004).
[CrossRef]

T. J. Allen and P. C. Beard, “Photoacoustic characterisation of vascular tissue at NIR wavelengths,” Proc. SPIE 7177, 71770A (2009).
[CrossRef]

Rev. Sci. Instrum. (1)

A. B. Karpiouk, B. Wang, and S. Y. Emelianov, “Development of a catheter for combined intravascular ultrasound and photoacoustic imaging,” Rev. Sci. Instrum. 81(1), 1–7 (2010).
[CrossRef]

Other (5)

S. A. Prahl, “Optical properties spectra compiled by Scott Prahl” (2001), retrieved 2009, http://omlc.ogi.edu/spectra/ .

S. Mallidi, T. Larson, J. Tam, P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. (2009).

S. Kim, S. Park, S. R. Aglyamov, M. O'Donnell, and S. Y. Emelianov, “Improvement of displacement estimation using autocorrelation,” Proc. International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity, 58 (2008).

D. Lloyd-Jones, R. Adams, M. Carnethon, G. De Simone, T. B. Ferguson, K. Flegal, E. Ford, K. Furie, A. Go, and K. Greenlund, “Heart disease and stroke statistics-2009 update. A report from the American Heart Association statistics committee and stroke statistics subcommittee,” Circulation (2008).

A. A. Oraevsky, and A. A. Karabutov, Optoacoustic tomography, Biomedical Photonics Handbook (CRC Press, 2003), Vol. 34, pp. 1–34.

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Figures (6)

Fig. 1
Fig. 1

Optical absorption spectra of various tissue types [12,13].

Fig. 2
Fig. 2

IVUS-guided multi-wavelength IVPA imaging system.

Fig. 3
Fig. 3

Image processing algorithm for analysis of multi-wavelength IVPA and IVUS data.

Fig. 4
Fig. 4

Cross-sectional (a,d) IVUS, (b,e) 1200-nm IVPA, and (c,f) combined IVUS/IVPA images of the diseased and normal aorta. The IVUS and IVPA images are displayed using 40 dB dynamic range.

Fig. 5
Fig. 5

Cross-sectional IVPA images of (a) diseased and (b) normal aortas obtained using 1200 nm wavelength. (c) Comparison of the wavelength-dependent photoacoustic responses from the lipid-rich area of the atherosclerotic plaque (region 1) and media-adventitial layer of diseased (region 2) and normal (region 3) aortas.

Fig. 6
Fig. 6

Combined IVUS and spectroscopic IVPA images and corresponding histological slices of the diseased atherosclerotic aorta (a-c) and normal (i.e., control) aorta (d-e). Lipid-rich regions (orange color) were identified from multi-wavelength photoacoustic imaging and displayed over the IVUS images. Lipid-rich regions were detected in the thickened intima layer of the diseased aorta (a) confirmed by Oil red O stain for lipid (b) and H&E stain (c). In contrast, spectroscopic IVPA imaging (d) and tissue histology (e and f) show insignificant lipid-rich regions in normal rabbit aorta. Both normal and diseased aortas show some insignificant deposits of lipid in the periadventitia.

Equations (2)

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Δ S i , j = 1 S i , j ( λ 1 ) ( S i , j ( λ l ) S i , j ( λ 1 ) λ l λ 1 )         ,
E ( i , j ) = k | S i , j ( λ k ) S i , j ( λ 1 ) S i , j ( λ 1 ) ( λ k λ 1 ) Δ S i , j | , k = 2 , 3 , ... , l 1.

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