Abstract

We introduce the use of a birefringent crystal with lensless digital holography to create an on-chip differential interference contrast (DIC) microscope. Using an incoherent source with a large aperture, in-line holograms of micro-objects are created, which interact with a uniaxial crystal and an absorbing polarizer, encoding differential interference contrast information of the objects on the chip. Despite the fact that a unit fringe magnification and an incoherent source with a large aperture have been used, holographic digital processing of such holograms rapidly recovers the differential phase contrast image of the specimen over a large field-of-view of ~24 mm2.

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2008 (1)

X. Cui, M. Lew, and C. Yang, “Quantitative differential interference contrast microscopy based on structured-aperture interference,” Appl. Phys. Lett. 93(9), 091113 (2008).
[CrossRef]

2007 (2)

2006 (5)

2005 (1)

2004 (1)

2002 (2)

G. Pedrini and H. Tiziani, “Short-coherence digital microscopy by use of a lensless holographic imaging system,” Appl. Opt. 41(22), 4489–4496 (2002).
[CrossRef]

E. D. Barone-Nugent, A. Barty, and K. A. Nugent, “Quantitative phase-amplitude microscopy I: optical microscopy,” J. Microsc. 206(3), 194–203 (2002).
[CrossRef]

2001 (1)

W. Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer, “Digital in-line holography for biological applications,” Proc. Natl. Acad. Sci. U.S.A. 98(20), 11301–11305 (2001).
[CrossRef]

2000 (1)

K. Buse and M. Luennemann, “3D imaging: wave front sensing utilizing a birefringent crystal,” Phys. Rev. Lett. 85(16), 3385–3387 (2000).
[CrossRef]

1992 (1)

1985 (1)

1978 (1)

1967 (1)

1955 (1)

G. Nomarski, “Differential microinterferometer with polarized light,” J. Phys. Radium 16, 9s–13s (1955).

1942 (1)

F. Zernike, “Phase-contrast, a new method for microscopic observation of transparent objects. Part II,” Physica 9(10), 974–986 (1942).
[CrossRef]

Alferi, D.

Avendaño-Alejo, M.

Badizadegan, K.

Barone-Nugent, E. D.

E. D. Barone-Nugent, A. Barty, and K. A. Nugent, “Quantitative phase-amplitude microscopy I: optical microscopy,” J. Microsc. 206(3), 194–203 (2002).
[CrossRef]

Barty, A.

E. D. Barone-Nugent, A. Barty, and K. A. Nugent, “Quantitative phase-amplitude microscopy I: optical microscopy,” J. Microsc. 206(3), 194–203 (2002).
[CrossRef]

Bernet, S.

Boyer, K.

Buse, K.

K. Buse and M. Luennemann, “3D imaging: wave front sensing utilizing a birefringent crystal,” Phys. Rev. Lett. 85(16), 3385–3387 (2000).
[CrossRef]

Choi, W.

Cui, X.

X. Cui, M. Lew, and C. Yang, “Quantitative differential interference contrast microscopy based on structured-aperture interference,” Appl. Phys. Lett. 93(9), 091113 (2008).
[CrossRef]

Cullen, D.

Dasari, R. R.

De Nicola, S.

De Petrocellis, L.

Feld, M. S.

Ferraro, P.

Fienup, J. R.

Finizio, A.

Fürhapter, S.

Garcia-Sucerquia, J.

Haddad, W.

Ikeda, T.

Jericho, M. H.

J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, “Immersion digital in-line holographic microscopy,” Opt. Lett. 31(9), 1211–1213 (2006).
[CrossRef]

W. Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer, “Digital in-line holography for biological applications,” Proc. Natl. Acad. Sci. U.S.A. 98(20), 11301–11305 (2001).
[CrossRef]

Jesacher, A.

Kim, M.

Kreuzer, H. J.

J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, “Immersion digital in-line holographic microscopy,” Opt. Lett. 31(9), 1211–1213 (2006).
[CrossRef]

W. Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer, “Digital in-line holography for biological applications,” Proc. Natl. Acad. Sci. U.S.A. 98(20), 11301–11305 (2001).
[CrossRef]

Lew, M.

X. Cui, M. Lew, and C. Yang, “Quantitative differential interference contrast microscopy based on structured-aperture interference,” Appl. Phys. Lett. 93(9), 091113 (2008).
[CrossRef]

Lo, C. M.

Longworth, J.

Lue, N.

Luennemann, M.

K. Buse and M. Luennemann, “3D imaging: wave front sensing utilizing a birefringent crystal,” Phys. Rev. Lett. 85(16), 3385–3387 (2000).
[CrossRef]

Mann, C.

Maurer, C.

McPherson, A.

Meinertzhagen, I. A.

W. Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer, “Digital in-line holography for biological applications,” Proc. Natl. Acad. Sci. U.S.A. 98(20), 11301–11305 (2001).
[CrossRef]

Nomarski, G.

G. Nomarski, “Differential microinterferometer with polarized light,” J. Phys. Radium 16, 9s–13s (1955).

Nugent, K. A.

E. D. Barone-Nugent, A. Barty, and K. A. Nugent, “Quantitative phase-amplitude microscopy I: optical microscopy,” J. Microsc. 206(3), 194–203 (2002).
[CrossRef]

Park, Y. K.

Pedrini, G.

Piano, E.

Pierattini, G.

Pontiggia, C.

Popescu, G.

Psaltis, D.

Repetto, L.

Rhodes, C.

Ritsch-Marte, M.

Rosete-Aguilar, M.

Sheridan, J. T.

Sherman, G. C.

Sirat, G.

Situ, G.

Solem, H.

Tiziani, H.

Xu, W.

J. Garcia-Sucerquia, W. Xu, M. H. Jericho, and H. J. Kreuzer, “Immersion digital in-line holographic microscopy,” Opt. Lett. 31(9), 1211–1213 (2006).
[CrossRef]

W. Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer, “Digital in-line holography for biological applications,” Proc. Natl. Acad. Sci. U.S.A. 98(20), 11301–11305 (2001).
[CrossRef]

Yang, C.

X. Cui, M. Lew, and C. Yang, “Quantitative differential interference contrast microscopy based on structured-aperture interference,” Appl. Phys. Lett. 93(9), 091113 (2008).
[CrossRef]

Yu, L.

Zernike, F.

F. Zernike, “Phase-contrast, a new method for microscopic observation of transparent objects. Part II,” Physica 9(10), 974–986 (1942).
[CrossRef]

Appl. Opt. (3)

Appl. Phys. Lett. (1)

X. Cui, M. Lew, and C. Yang, “Quantitative differential interference contrast microscopy based on structured-aperture interference,” Appl. Phys. Lett. 93(9), 091113 (2008).
[CrossRef]

J. Microsc. (1)

E. D. Barone-Nugent, A. Barty, and K. A. Nugent, “Quantitative phase-amplitude microscopy I: optical microscopy,” J. Microsc. 206(3), 194–203 (2002).
[CrossRef]

J. Opt. Soc. Am. (1)

J. Opt. Soc. Am. A (1)

J. Phys. Radium (1)

G. Nomarski, “Differential microinterferometer with polarized light,” J. Phys. Radium 16, 9s–13s (1955).

Opt. Express (3)

Opt. Lett. (6)

Phys. Rev. Lett. (1)

K. Buse and M. Luennemann, “3D imaging: wave front sensing utilizing a birefringent crystal,” Phys. Rev. Lett. 85(16), 3385–3387 (2000).
[CrossRef]

Physica (1)

F. Zernike, “Phase-contrast, a new method for microscopic observation of transparent objects. Part II,” Physica 9(10), 974–986 (1942).
[CrossRef]

Proc. Natl. Acad. Sci. U.S.A. (1)

W. Xu, M. H. Jericho, I. A. Meinertzhagen, and H. J. Kreuzer, “Digital in-line holography for biological applications,” Proc. Natl. Acad. Sci. U.S.A. 98(20), 11301–11305 (2001).
[CrossRef]

Other (2)

M. Pluta, Specialized Methods, Vol. 2 of Advanced light microscopy (Elsevier, New York, 1989), Chap. 7.

G. Popescu, “Quantitative phase imaging of nanoscale cell structure and dynamics,” Methods in Cell Biology, Edited by B. Jena (Elsevier, 2008)

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