Abstract

A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast ( + 18 dB), the photoacoustic spectrum was consistent with the elevated near infrared absorption of GNRs. The versatile imaging platform potentially accelerates development of photoacoustic contrast agents and drug delivery for cancer imaging and therapy.

© 2010 OSA

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2009 (5)

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009).
[CrossRef] [PubMed]

E. D. Agdeppa and M. E. Spilker, “A review of imaging agent development,” AAPS J. 11(2), 286–299 (2009).
[CrossRef] [PubMed]

L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009).
[CrossRef] [PubMed]

C. H. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[CrossRef] [PubMed]

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

2008 (1)

2007 (2)

C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007).
[CrossRef] [PubMed]

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

2006 (1)

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006).
[CrossRef] [PubMed]

2005 (1)

J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005).
[CrossRef]

1999 (2)

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

1950 (1)

G. H. Algire and J. U. Schlegel, “Circulatory reactions in photodynamic action,” J. Cell. Comp. Physiol. 35(1), 95–110 (1950).
[CrossRef]

1949 (1)

G. H. Algire and F. Y. Legallais, “Recent developments in the transparent-chamber technique as adapted to the mouse,” J. Natl. Cancer Inst. 10(2), 225–253, 8 (1949).
[PubMed]

Agarwal, A.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

Agdeppa, E. D.

E. D. Agdeppa and M. E. Spilker, “A review of imaging agent development,” AAPS J. 11(2), 286–299 (2009).
[CrossRef] [PubMed]

Algire, G. H.

G. H. Algire and J. U. Schlegel, “Circulatory reactions in photodynamic action,” J. Cell. Comp. Physiol. 35(1), 95–110 (1950).
[CrossRef]

G. H. Algire and F. Y. Legallais, “Recent developments in the transparent-chamber technique as adapted to the mouse,” J. Natl. Cancer Inst. 10(2), 225–253, 8 (1949).
[PubMed]

Anyrhambatla, G.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Ashkenazi, S.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

Barrett, H. H.

L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009).
[CrossRef] [PubMed]

Borelli, M.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Braun, R. D.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Cable, A.

Chen, L. Y.

L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009).
[CrossRef] [PubMed]

Corry, P.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Day, K. C.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

Day, M.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

Dewhirst, M. W.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Emelianov, S.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Evans, S. M.

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Gatenby, R. A.

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006).
[CrossRef] [PubMed]

Gawlinski, E. T.

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006).
[CrossRef] [PubMed]

Gillies, R. J.

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006).
[CrossRef] [PubMed]

Gmitro, A. F.

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006).
[CrossRef] [PubMed]

Gobar, L. S.

L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009).
[CrossRef] [PubMed]

Hao, Y. P.

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009).
[CrossRef] [PubMed]

Huang, Q.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Huang, S. W.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007).
[CrossRef] [PubMed]

Jemal, A.

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009).
[CrossRef] [PubMed]

Jiang, J.

Joshi, P. P.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Karpiouk, A.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Kaylor, B.

R. A. Gatenby, E. T. Gawlinski, A. F. Gmitro, B. Kaylor, and R. J. Gillies, “Acid-mediated tumor invasion: a multidisciplinary study,” Cancer Res. 66(10), 5216–5223 (2006).
[CrossRef] [PubMed]

Khurana, M.

Klitzman, B.

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Knowles, N. G.

L. Y. Chen, L. S. Gobar, N. G. Knowles, D. W. Wilson, and H. H. Barrett, “Direct Charged-Particle Imaging System Using an Ultra-Thin Phosphor: Physical Characterization and Dynamic Applications,” IEEE Trans. Nucl. Sci. 56(5), 2628–2635 (2009).
[CrossRef] [PubMed]

Kong, G. H.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Kotov, N.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

Lanzen, J.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Larson, T.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Legallais, F. Y.

G. H. Algire and F. Y. Legallais, “Recent developments in the transparent-chamber technique as adapted to the mouse,” J. Natl. Cancer Inst. 10(2), 225–253, 8 (1949).
[PubMed]

Leung, M. K. K.

Li, C. H.

C. H. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[CrossRef] [PubMed]

Li, C. Y.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Li, P. C.

C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007).
[CrossRef] [PubMed]

Liao, C. K.

C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007).
[CrossRef] [PubMed]

Liz-Marzan, L. M.

J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005).
[CrossRef]

Mallidi, S.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Mariampillai, A.

Moriyama, E. H.

Mulvaney, P.

J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005).
[CrossRef]

Munce, N. R.

O'Donnell, M.

A. Agarwal, S. W. Huang, M. O'Donnell, K. C. Day, M. Day, N. Kotov, and S. Ashkenazi, “Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging,” J. Appl. Phys. 102(6), 064701 (2007).
[CrossRef] [PubMed]

Ong, E. T.

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Pastoriza-Santos, I.

J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005).
[CrossRef]

Perez-Juste, J.

J. Perez-Juste, I. Pastoriza-Santos, L. M. Liz-Marzan, and P. Mulvaney, “Gold nanorods: Synthesis, characterization and applications,” Coord. Chem. Rev. 249(17-18), 1870–1901 (2005).
[CrossRef]

Schlegel, J. U.

G. H. Algire and J. U. Schlegel, “Circulatory reactions in photodynamic action,” J. Cell. Comp. Physiol. 35(1), 95–110 (1950).
[CrossRef]

Shan, S. Q.

Q. Huang, S. Q. Shan, R. D. Braun, J. Lanzen, G. Anyrhambatla, G. H. Kong, M. Borelli, P. Corry, M. W. Dewhirst, and C. Y. Li, “Noninvasive visualization of tumors in rodent dorsal skin window chambers,” Nat. Biotechnol. 17(10), 1033–1035 (1999).
[CrossRef] [PubMed]

Siegel, R.

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009).
[CrossRef] [PubMed]

Smith, B.

M. W. Dewhirst, E. T. Ong, R. D. Braun, B. Smith, B. Klitzman, S. M. Evans, and D. Wilson, “Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia,” Br. J. Cancer 79(11/12), 1717–1722 (1999).
[CrossRef] [PubMed]

Sokolov, K.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Spilker, M. E.

E. D. Agdeppa and M. E. Spilker, “A review of imaging agent development,” AAPS J. 11(2), 286–299 (2009).
[CrossRef] [PubMed]

Standish, B. A.

Tam, J.

S. Mallidi, T. Larson, J. Tam, P. P. Joshi, A. Karpiouk, K. Sokolov, and S. Emelianov, “Multiwavelength photoacoustic imaging and plasmon resonance coupling of gold nanoparticles for selective detection of cancer,” Nano Lett. 9(8), 2825–2831 (2009).
[CrossRef] [PubMed]

Thun, M. J.

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009).
[CrossRef] [PubMed]

Vitkin, I. A.

Wang, L. V.

C. H. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[CrossRef] [PubMed]

Ward, E.

A. Jemal, R. Siegel, E. Ward, Y. P. Hao, J. Q. Xu, and M. J. Thun, “Cancer statistics, 2009,” CA Cancer J. Clin. 59(4), 225–249 (2009).
[CrossRef] [PubMed]

Wei, C. W.

C. K. Liao, S. W. Huang, C. W. Wei, and P. C. Li, “Nanorod-based flow estimation using a high-frame-rate photoacoustic imaging system,” J. Biomed. Opt. 12(6), 064006 (2007).
[CrossRef] [PubMed]

Wilson, B. C.

Wilson, D.

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