Abstract

We describe a color image reconstruction method that enables both direct visualization and direct digital image acquisition from one oral tissue by using various light sources and color compensating filters. In this method, the image of the oral tissue with white light emitting diodes (LEDs) with blue color compensating filter has a larger color difference between the normal and inflamed tissues. The enhanced visualization comes from the white light color mixing between the red normal tissue and bluish white light from the LEDs. With our method, we evaluate the perceived tissue reflectance in each pixel of the image and color reproduction with different illuminated spectra. Our approach to enhancement of visually perceived color difference between normal and inflamed oral tissue involves optimization of illumination and observation conditions by allowing a significant optical contrast of illuminated spectrum to reach the observer’s eyes. In comparison with a conventional daylight LED flashlight, a LED with blue filter as the illuminant for oral cavity detection enhances the color difference between normal and inflamed tissues by 32%.

© 2010 OSA

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
    [PubMed]
  2. J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
    [CrossRef] [PubMed]
  3. Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
    [CrossRef] [PubMed]
  4. M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
    [CrossRef] [PubMed]
  5. K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
    [CrossRef] [PubMed]
  6. M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
    [CrossRef] [PubMed]
  7. P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
    [CrossRef] [PubMed]
  8. E. Svistun, U. Utzinger, R. Jacob, R. K. Rebecca, A. El-Naggar, and A. Gillenwater, “Optimal visual perception and detection of oral cavity neoplasia reflectance and fluorescence,” Biomedical Topical Meeting, TuA3 (2002).
  9. D. Roblyer, C. Kurachi, A. El-Naggar, M. D. Williams, A. M. Gillenwater and R. Richards-Kortum, “Multispectral and hyperspectral in vivo imaging of the oral cavity for neoplastic tissue detection,” Biomedical Optics, BTuD1 (2008).
  10. S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
    [CrossRef] [PubMed]
  11. Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
    [CrossRef]
  12. T. N. Kanagawa, “Method and apparatus for outputting multi-band image,” Patent No. US 6885394 B1 (2005).
  13. G. Wyszecki, and W. Stiles, Color Science -- Concepts and Methods, Quantitative Data and Formulate (2nd Edition, Wiley, New York, 1982).
  14. http://www.kinoflo.com
  15. R. S. Berns, Principles of color technology (Wiley, 83-92, 2000).
  16. C. S. McCamy, “Correlated color temperature as an explicit function of chromaticity coordinates,” Color Res. Appl. 17(2), 142–144 (1992).
    [CrossRef]
  17. P. Green, and L. MacDonald, Colour Engineering: Achieving Device Independent Colour (Wiley, New York, 2002).
  18. A. Žukauskas, R. Vaicekauskas, and M. S. Shur, “Solid-state lamps with optimized color saturation ability,” Opt. Express 18(3), 2287–2295 (2010).
    [CrossRef] [PubMed]
  19. E. F. Schubert, Light-Emitting Diodes (2nd Edition, Cambridge, New York, 2006), p. 333-338.
  20. A. Žukauskas, M. S. Shur, and R. G aska, Introduction to Solid-State Lighting, (Wiley, New York, 2002), p. 119-121
  21. M. D. Fairchild, Color appearance models, page 122-125 (John Wiley & Sons, 2006).

2010 (1)

2008 (2)

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
[CrossRef] [PubMed]

2007 (1)

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

2006 (1)

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

2002 (2)

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[CrossRef] [PubMed]

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

2001 (1)

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

1999 (2)

M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
[PubMed]

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

1992 (1)

C. S. McCamy, “Correlated color temperature as an explicit function of chromaticity coordinates,” Color Res. Appl. 17(2), 142–144 (1992).
[CrossRef]

Chang, H. L.

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

Chaturvedi, P.

M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
[CrossRef] [PubMed]

Chen, E. R.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Chen, K. T.

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Chen, S. H.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Cheng, Y. T.

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

Gilhuly, T.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Gillenwater, A. M.

M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
[CrossRef] [PubMed]

Ho, M.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Hsu, K. H.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Jacques, S. L.

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[CrossRef] [PubMed]

Kilpatrick, D. R.

M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
[PubMed]

Komiya, Y.

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

Lane, P. M.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Lee, K.

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[CrossRef] [PubMed]

Li, C. M.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Li, Z. H.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Ling, P.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Liu, C. C.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

MacAulay, C. E.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Maher, K.

M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
[PubMed]

McCamy, C. S.

C. S. McCamy, “Correlated color temperature as an explicit function of chromaticity coordinates,” Color Res. Appl. 17(2), 142–144 (1992).
[CrossRef]

Murakami, Y.

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

Ng, S.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Oberste, M. S.

M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
[PubMed]

Obi, T.

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

Ohyama, N.

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

Pallansch, M. A.

M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
[PubMed]

Poh, C. F.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Rahman, M.

M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
[CrossRef] [PubMed]

Ramella-Roman, J. C.

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[CrossRef] [PubMed]

Richards-Kortum, R.

M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
[CrossRef] [PubMed]

Rosin, M. P.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Shen, F. H.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Shih, S. R.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Shur, M. S.

Su, I. J.

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

Tsai, H. P.

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

Tsai, S. F.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Tuan, Y. C.

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

Twu, S. J.

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Vaicekauskas, R.

Wang, J. R.

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Wang, S. T.

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

Whitehead, P.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Williams, P. M.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Yamaguchi, M.

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

Yan, J. J.

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

Yang, J. Y.

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

Yu, C. K.

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

Zeng, H.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Zhang, L.

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

Žukauskas, A.

Color Res. Appl. (1)

C. S. McCamy, “Correlated color temperature as an explicit function of chromaticity coordinates,” Color Res. Appl. 17(2), 142–144 (1992).
[CrossRef]

J. Biomed. Opt. (3)

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[CrossRef] [PubMed]

M. Rahman, P. Chaturvedi, A. M. Gillenwater, and R. Richards-Kortum, “Low-cost, multimodal, portable screening system for early detection of oral cancer,” J. Biomed. Opt. 13(3), 030502 (2008).
[CrossRef] [PubMed]

P. M. Lane, T. Gilhuly, P. Whitehead, H. Zeng, C. F. Poh, S. Ng, P. M. Williams, L. Zhang, M. P. Rosin, and C. E. MacAulay, “Simple device for the direct visualization of oral-cavity tissue fluorescence,” J. Biomed. Opt. 11(2), 024006 (2006).
[CrossRef] [PubMed]

J. Clin. Microbiol. (1)

J. R. Wang, Y. C. Tuan, H. P. Tsai, J. J. Yan, C. C. Liu, and I. J. Su, “Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000,” J. Clin. Microbiol. 40(1), 10–15 (2002).
[CrossRef] [PubMed]

J. Infect. Dis. (1)

Z. H. Li, C. M. Li, P. Ling, F. H. Shen, S. H. Chen, C. C. Liu, C. K. Yu, and S. H. Chen, “Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication,” J. Infect. Dis. 197(6), 854–857 (2008).
[CrossRef] [PubMed]

J. Virol. (1)

M. S. Oberste, K. Maher, D. R. Kilpatrick, and M. A. Pallansch, “Molecular evolution of the human enteroviruses: correlation of serotype with VP1 sequence and application to picornavirus classification,” J. Virol. 73(3), 1941–1948 (1999).
[PubMed]

N. Engl. J. Med. (1)

M. Ho, E. R. Chen, K. H. Hsu, S. J. Twu, K. T. Chen, S. F. Tsai, J. R. Wang, S. R. Shih, and Taiwan Enterovirus Epidemic Working Group, “An epidemic of enterovirus 71 infection in Taiwan,” N. Engl. J. Med. 341(13), 929–935 (1999).
[CrossRef] [PubMed]

Opt. Commun. (1)

Y. Murakami, T. Obi, M. Yamaguchi, N. Ohyama, and Y. Komiya, “Spectral reflectance estimation from multi-band image using color chart,” Opt. Commun. 188(1-4), 47–54 (2001).
[CrossRef]

Opt. Express (1)

Pediatrics (1)

K. T. Chen, H. L. Chang, S. T. Wang, Y. T. Cheng, and J. Y. Yang, “Epidemiologic features of hand-foot-mouth disease and herpangina caused by enterovirus 71 in Taiwan, 1998-2005,” Pediatrics 120(2), e244–e252 (2007).
[CrossRef] [PubMed]

Other (10)

E. Svistun, U. Utzinger, R. Jacob, R. K. Rebecca, A. El-Naggar, and A. Gillenwater, “Optimal visual perception and detection of oral cavity neoplasia reflectance and fluorescence,” Biomedical Topical Meeting, TuA3 (2002).

D. Roblyer, C. Kurachi, A. El-Naggar, M. D. Williams, A. M. Gillenwater and R. Richards-Kortum, “Multispectral and hyperspectral in vivo imaging of the oral cavity for neoplastic tissue detection,” Biomedical Optics, BTuD1 (2008).

T. N. Kanagawa, “Method and apparatus for outputting multi-band image,” Patent No. US 6885394 B1 (2005).

G. Wyszecki, and W. Stiles, Color Science -- Concepts and Methods, Quantitative Data and Formulate (2nd Edition, Wiley, New York, 1982).

http://www.kinoflo.com

R. S. Berns, Principles of color technology (Wiley, 83-92, 2000).

P. Green, and L. MacDonald, Colour Engineering: Achieving Device Independent Colour (Wiley, New York, 2002).

E. F. Schubert, Light-Emitting Diodes (2nd Edition, Cambridge, New York, 2006), p. 333-338.

A. Žukauskas, M. S. Shur, and R. G aska, Introduction to Solid-State Lighting, (Wiley, New York, 2002), p. 119-121

M. D. Fairchild, Color appearance models, page 122-125 (John Wiley & Sons, 2006).

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (8)

Fig. 1
Fig. 1

Schematic diagram of this method which is used for estimating the spectral reflectance of each pixel of an image by using a digital camera and a set of color compensating filters.

Fig. 2
Fig. 2

Original spectra (pink curves) and reconstructed spectra (blue curves) of color checkers for (a) red, (b) green, (c) blue, and (d) yellow using the estimation processes of spectral reflectance curves from multispectral image data.

Fig. 3
Fig. 3

Color difference between the original reflectance functions and reconstructed reflectance functions of the 24 color patches under an artificial solar illuminant lamp.

Fig. 4
Fig. 4

Color images from camera under fluorescent lamps (a) and tungsten lamps (b). The color image reproduction (c) is under replacing the light source of (a) with tungsten lamps.

Fig. 5
Fig. 5

Output spectra of colored light sources: an LED flashlight alone and combined successively with four different colored filters, and a tungsten flashlight.

Fig. 6
Fig. 6

(a) CIE 1931 chromaticity diagram; (b) Chromaticities of five light sources, in which color points move away in the direction determined by which color compensating filter is on the LED flashlight. NTSC is color range from National Television System Committee.

Fig. 7
Fig. 7

Color images of an oral cavity with one dysplasia (left) with LED illuminant. The enlargements of the dysplasia under different illuminants: (A) LED flashlight, (B) LED with red color compensating filter, (C) LED with green color compensating filter, (D) LED with blue color compensating filter, (E) LED with yellow color compensating filter, and (F) tungsten flashlight.

Fig. 8
Fig. 8

Estimated spectral radiometric quantity of (a) normal and (b) inflamed oral tissue are under various illuminants using the multispectral image reproduction method.

Tables (1)

Tables Icon

Table 1 Calculation results of color difference between normal and inflamed tissue under various color light sources.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

X = k 380 n m 780 n m S ( λ ) x ¯ ( λ ) d λ , Y = k 380 n m 780 n m S ( λ ) y ¯ ( λ ) d λ , Z = k 380 n m 780 n m S ( λ ) z ¯ ( λ ) d λ
k = 100 380 780 S ( λ ) y ¯ ( λ ) d λ
L * = 116 ( Y / Y n ) 1 / 3 16 a * = 500 [ ( X / X n ) 1 / 3 ( Y / Y n ) 1 / 3 ] b * = 200 [ ( Y / Y n ) 1 / 3 ( Z / Z n ) 1 / 3 ] w h e r e f ( I ) = I 1 / 3 f o r I > 0.008856 o t h e r w i s e f ( I ) = 7.787 I + 16 / 116
Δ E * a b = ( L * 1 L * 2 ) 2 + ( a * 1 a * 2 ) 2 + ( b * 1 b * 2 ) 2

Metrics