Abstract

We demonstrate and compare two image processing methods for visualization and analysis of three-dimensional optical coherence tomography (OCT) data acquired in eyes with different retinal pathologies. A method of retinal layer segmentation based on a multiple intensity thresholding algorithm was implemented in order to generate simultaneously outer retinal topography maps and reflectivity maps. We compare the applicability of the two methods to the diagnosis of retinal diseases and their progression. The data presented in this contribution were acquired with a high speed (25,000 A-scans/s), high resolution (4.5 µm) spectral OCT prototype instrument operating in the ophthalmology clinic.

© 2009 Optical Society of America

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2008 (7)

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

2007 (2)

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

U. M. Schmidt-Erfurth and C. Pruente, "Management of neovascular age-related macular degeneration," Prog. Retin Eye Res. 26, 437-451 (2007).
[CrossRef] [PubMed]

2006 (3)

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Pircher, E. Gotzinger, and C. K. Hitzenberger, "Dynamic focus in optical coherence tomography for retinal imaging," J. Biomed. Opt. 11, 054013 (2006).
[CrossRef] [PubMed]

2005 (4)

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452 (2005).
[CrossRef] [PubMed]

2004 (9)

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S.-H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

A. Chan, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Stage 0 macular holes—Observations by optical coherence tomography," Ophthalmology 111, 2027-2032 (2004).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

2003 (3)

2002 (2)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Y. Yasuno, S. Makita, Y. Sutoh, M. Itoh, and T. Yatagai, "Birefringence imaging of human skin by polarization-sensitive spectral interferometric optical coherence tomography," Opt. Lett. 27, 1803-1805 (2002).
[CrossRef]

2000 (1)

1998 (2)

A. G. Podoleanu, and D. A. Jackson, "Combined optical coherence tomograph and scanning laser ophthalmoscope," Electron. Lett. 34, 1088-1090 (1998).
[CrossRef]

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Ahlers, C.

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Ahnelt, P. K.

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

Anger, E. M.

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

Bajraszewski, T.

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Baumal, C. R.

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Bilonick, R. A.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

Bouma, B. E.

Boxer, A.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Carvalho, M.

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

Cense, B.

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S.-H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

Chan, A.

A. Chan, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Stage 0 macular holes—Observations by optical coherence tomography," Ophthalmology 111, 2027-2032 (2004).
[CrossRef] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Chen, R.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

Chen, R. W.

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

Chen, T. C.

Cowey, A.

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

Cucu, R. G.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

de Boer, J. F.

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S.-H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

Dobre, G. M.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

Drexler, W.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Duker, J. S.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

A. Chan, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Stage 0 macular holes—Observations by optical coherence tomography," Ophthalmology 111, 2027-2032 (2004).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

Dunne, S.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, and S. Dunne, "Three dimensional OCT images from retina and skin," Opt. Express 7, 292-298 (2000).
[CrossRef] [PubMed]

Endo, T.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Ergun, E.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

Evans, J. W.

Fercher, A. F.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Findl, O.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Fisher, Y.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Fitzke, F. W.

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

A. Chan, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Stage 0 macular holes—Observations by optical coherence tomography," Ophthalmology 111, 2027-2032 (2004).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Garcia, P.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Geitzenauer, W.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Gentile, R.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Georgopoulo, M.

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Golbaz, I.

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Gorczynska, I.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

Gotzinger, E.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

M. Pircher, E. Gotzinger, and C. K. Hitzenberger, "Dynamic focus in optical coherence tomography for retinal imaging," J. Biomed. Opt. 11, 054013 (2006).
[CrossRef] [PubMed]

Gregori, G.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hartl, I.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hermann, B.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Hitzenberger, C. K.

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

M. Pircher, E. Gotzinger, and C. K. Hitzenberger, "Dynamic focus in optical coherence tomography for retinal imaging," J. Biomed. Opt. 11, 054013 (2006).
[CrossRef] [PubMed]

C. K. Hitzenberger, P. Trost, P. W. Lo, and Q. Y. Zhou, "Three-dimensional imaging of the human retina by high-speed optical coherence tomography," Opt. Express 11, 2753-2761 (2003).
[CrossRef] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Huang, X. R.

Ishikawa, H.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

Itoh, M.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Y. Yasuno, S. Makita, Y. Sutoh, M. Itoh, and T. Yatagai, "Birefringence imaging of human skin by polarization-sensitive spectral interferometric optical coherence tomography," Opt. Lett. 27, 1803-1805 (2002).
[CrossRef]

Jackson, D. A.

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, and S. Dunne, "Three dimensional OCT images from retina and skin," Opt. Express 7, 292-298 (2000).
[CrossRef] [PubMed]

A. G. Podoleanu, and D. A. Jackson, "Combined optical coherence tomograph and scanning laser ophthalmoscope," Electron. Lett. 34, 1088-1090 (1998).
[CrossRef]

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

Jiao, S. L.

Kaluzny, J. J.

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

Katada, C.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Knighton, R.

Ko, T.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Ko, T. H.

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Kowalczyk, A.

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Kowalevicz, A. M.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

Le, T.

Leitgeb, R.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Leitgeb, R. A.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Liu, J. J.

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

Lo, P. W.

Makita, S.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Y. Yasuno, S. Makita, Y. Sutoh, M. Itoh, and T. Yatagai, "Birefringence imaging of human skin by polarization-sensitive spectral interferometric optical coherence tomography," Opt. Lett. 27, 1803-1805 (2002).
[CrossRef]

Michels, S.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

Monson, B. K.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

Morgan, J. E.

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

Muldoon, T.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Mutoh, M.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Nassif, N. A.

Nieto, J.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Orlock, D.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Park, B. H.

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S.-H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

Paunescu, L. A.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Pierce, M. C.

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S.-H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

Pircher, M.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner, and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high-speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008).
[CrossRef]

M. Pircher, E. Gotzinger, and C. K. Hitzenberger, "Dynamic focus in optical coherence tomography for retinal imaging," J. Biomed. Opt. 11, 054013 (2006).
[CrossRef] [PubMed]

Podoleanu, A. G.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, and S. Dunne, "Three dimensional OCT images from retina and skin," Opt. Express 7, 292-298 (2000).
[CrossRef] [PubMed]

A. G. Podoleanu, and D. A. Jackson, "Combined optical coherence tomograph and scanning laser ophthalmoscope," Electron. Lett. 34, 1088-1090 (1998).
[CrossRef]

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

Polak, K.

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Pruente, C.

U. M. Schmidt-Erfurth and C. Pruente, "Management of neovascular age-related macular degeneration," Prog. Retin Eye Res. 26, 437-451 (2007).
[CrossRef] [PubMed]

Puliafito, C. A.

S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Reichel, E.

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Rogers, A. H.

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

Rogers, J. A.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, and S. Dunne, "Three dimensional OCT images from retina and skin," Opt. Express 7, 292-298 (2000).
[CrossRef] [PubMed]

Rosen, R.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Sattmann, H.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Schmetterer, L.

Schmidt-Erfurth, U.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

Schmidt-Erfurth, U. M.

U. M. Schmidt-Erfurth and C. Pruente, "Management of neovascular age-related macular degeneration," Prog. Retin Eye Res. 26, 437-451 (2007).
[CrossRef] [PubMed]

Scholda, C.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Schubert, C.

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

Schuman, J. S.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

A. Chan, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Stage 0 macular holes—Observations by optical coherence tomography," Ophthalmology 111, 2027-2032 (2004).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Seeger, M.

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

Sikorski, B.

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

Sikorski, B. L.

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

Simader, C.

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Srinivasan, V. J.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

Stingl, A.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Stock, G.

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Strasswimmer, J.

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

Stur, M.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Sutoh, Y.

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Szkulmowska, A.

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

Szkulmowski, M.

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

Takahashi, M.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Tearney, G. J.

Trost, P.

Unterhuber, A.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Vuong, L. N.

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

Walsh, J.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Webb, D. J.

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

Weitz, R.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Werner, J. S.

Will, D.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Wirtitsch, M.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Wirtitsch, M. G.

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

Witkin, A. J.

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

Wojtkowski, M.

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

Wollstein, G.

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

Yannuzzi, L. A.

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

Yasuno, Y.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Y. Yasuno, S. Makita, Y. Sutoh, M. Itoh, and T. Yatagai, "Birefringence imaging of human skin by polarization-sensitive spectral interferometric optical coherence tomography," Opt. Lett. 27, 1803-1805 (2002).
[CrossRef]

Yatagai, T.

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Y. Yasuno, S. Makita, Y. Sutoh, M. Itoh, and T. Yatagai, "Birefringence imaging of human skin by polarization-sensitive spectral interferometric optical coherence tomography," Opt. Lett. 27, 1803-1805 (2002).
[CrossRef]

Yun, S.-H.

Zawadzki, R. J.

Zhou, Q. Y.

Am. J. Ophthalmol. (1)

M. G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T. H. Ko, J. G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," Am. J. Ophthalmol. 140, 976-983 (2005).
[CrossRef] [PubMed]

Appl. Phys. Lett. (1)

Y. Yasuno, S. Makita, T. Endo, M. Itoh, T. Yatagai, M. Takahashi, C. Katada, and M. Mutoh, "Polarization-sensitive complex Fourier domain optical coherence tomography for Jones matrix imaging of biological samples," Appl. Phys. Lett. 85, 3023-3025 (2004).
[CrossRef]

Arch. Ophthalmol. (1)

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Arch. Ophthalmol. 121, 695-706 (2003).
[CrossRef] [PubMed]

Br. J. Ophthalmol. (3)

I. Gorczynska, V. J. Srinivasan, L. N. Vuong, R. W. Chen, J. J. Liu, E. Reichel, M. Wojtkowski, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol.(accepted2008, electronic version available).
[PubMed]

B. L. Sikorski, M. Wojtkowski, J. J. Kaluzny, M. Szkulmowski, and A. Kowalczyk, "Correlation of spectral optical coherence tomography with fluorescein and indocyanine green angiography in multiple evanescent white dot syndrome," Br. J. Ophthalmol. 92, 1552-1557 (2008).
[CrossRef] [PubMed]

S. Michels, M. Pircher, W. Geitzenauer, C. Simader, E. Gotzinger, O. Findl, U. Schmidt-Erfurth, and C. K. Hitzenberger, "Value of polarisation-sensitive optical coherence tomography in diseases affecting the retinal pigment epithelium," Br. J. Ophthalmol. 92, 204-209 (2008).
[CrossRef] [PubMed]

Electron. Lett. (1)

A. G. Podoleanu, and D. A. Jackson, "Combined optical coherence tomograph and scanning laser ophthalmoscope," Electron. Lett. 34, 1088-1090 (1998).
[CrossRef]

Exp. Eye Res. (1)

E. M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J. E. Morgan, A. Cowey, P. K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Exp. Eye Res. 78, 1117-1125 (2004).
[CrossRef] [PubMed]

Invest. Ophthalmol. Vis. Sci. (1)

V. J. Srinivasan, B. K. Monson, M. Wojtkowski, R. A. Bilonick, I. Gorczynska, R. Chen, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 49, 1571-1579 (2008).
[CrossRef] [PubMed]

J. Biomed. Opt. (6)

M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V. J. Srinivasan, A. Szkulmowska, J. J. Kaluzny, J. G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, 041207 (2007).
[CrossRef] [PubMed]

A. G. Podoleanu, M. Seeger, G. M. Dobre, D. J. Webb, D. A. Jackson, and F. W. Fitzke, "Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry," J. Biomed. Opt. 3, 12-20 (1998).
[CrossRef]

M. Pircher, E. Gotzinger, and C. K. Hitzenberger, "Dynamic focus in optical coherence tomography for retinal imaging," J. Biomed. Opt. 11, 054013 (2006).
[CrossRef] [PubMed]

A. G. Podoleanu, G. M. Dobre, R. G. Cucu, R. Rosen, P. Garcia, J. Nieto, D. Will, R. Gentile, T. Muldoon, J. Walsh, L. A. Yannuzzi, Y. Fisher, D. Orlock, R. Weitz, J. A. Rogers, S. Dunne, and A. Boxer, "Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy," J. Biomed. Opt. 9, 86-93 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002).
[CrossRef] [PubMed]

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, and J. F. de Boer, "Birefringence measurements in human skin using polarization-sensitive optical coherence tomography," J. Biomed. Opt. 9, 287-291 (2004).
[CrossRef] [PubMed]

Ophthalmic Surg. Lasers Imaging (1)

J. J. Kaluzny, M. Wojtkowski, B. L. Sikorski, M. Szkulmowski, A. Szkulmowska, T. Bajraszewski, J. G. Fujimoto, J. S. Duker, J. S. Schuman, and A. Kowalczyk, "Analysis of the outer retina reconstructed by high-resolution, three-dimensional spectral domain optical coherence tomography," Ophthalmic Surg. Lasers Imaging 39, S30-S36 (2008).

Ophthalmologe (1)

C. Ahlers, W. Geitzenauer, C. Simader, G. Stock, I. Golbaz, K. Polak, M. Georgopoulo, and U. Schmidt-Erfurth, "New perspectives in diagnostics. High-resolution optical coherence tomography for age-related macular degeneration," Ophthalmologe 105, 248-254 (2008).
[CrossRef]

Ophthalmology (5)

T. H. Ko, J. G. Fujimoto, J. S. Schuman, L. A. Paunescu, A. M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J. S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 (2005).
[CrossRef] [PubMed]

A. Chan, J. S. Duker, J. S. Schuman, and J. G. Fujimoto, "Stage 0 macular holes—Observations by optical coherence tomography," Ophthalmology 111, 2027-2032 (2004).
[CrossRef] [PubMed]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111, 2033-2043 (2004).
[CrossRef] [PubMed]

V. J. Srinivasan, M. Wojtkowski, A. J. Witkin, J. S. Duker, T. H. Ko, M. Carvalho, J. S. Schuman, A. Kowalczyk, and J. G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 113, 2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Opt. Express (7)

A. G. Podoleanu, J. A. Rogers, D. A. Jackson, and S. Dunne, "Three dimensional OCT images from retina and skin," Opt. Express 7, 292-298 (2000).
[CrossRef] [PubMed]

C. K. Hitzenberger, P. Trost, P. W. Lo, and Q. Y. Zhou, "Three-dimensional imaging of the human retina by high-speed optical coherence tomography," Opt. Express 11, 2753-2761 (2003).
[CrossRef] [PubMed]

R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution high-speed Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004).
[CrossRef] [PubMed]

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S.-H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004).
[CrossRef] [PubMed]

S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452 (2005).
[CrossRef] [PubMed]

Opt. Lett. (2)

Prog. Retin Eye Res. (1)

U. M. Schmidt-Erfurth and C. Pruente, "Management of neovascular age-related macular degeneration," Prog. Retin Eye Res. 26, 437-451 (2007).
[CrossRef] [PubMed]

Retina (1)

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T. H. Ko, J. G. Fujimoto, A. F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26, 1034-1041 (2006).
[CrossRef] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Other (2)

J. C. Russ, The Image Processing Handbook (CRC Press, 2002).

A. R. Weeks, The Fundamentals of Electronic Image Processing, (SPIE Press and IEEE Press, 1996).

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Figures (11)

Fig. 1.
Fig. 1.

a. Schematic diagram of the spectral optical coherence tomography instrument. b. Photograph of the prototype SOCT instrument operating in the ophthalmology clinic.

Fig. 2.
Fig. 2.

a. Image processing procedures applied to OCT data acquired in normal retina: I. definition of the first region of interest (ROI); II. automatic generation of a smooth curve corresponding to the shape of the outer retinal contour (ORC); the order of the polynomial fit is adjusted manually; III. flattening and cropping the cross-sectional images with respect to the ORC and definition of the second ROI; IV. automatic segmentation of the entire set of threedimensional data and identification of lines representing the basal part of the RPE and the IS/OS junction. b. Contour maps representing the distance between the RPE and the outer retinal contour (RPE topography), ORC and IS/OS (IS/OS topography), and the RPE to IS/OS thickness. c. Generation of reflectivity maps: outer retina is divided into two regions (RDZ-I and RDZ-II) indicated by yellow lines. Axial summation of the RDZ-I and RDZ-II generates corresponding reflectivity maps.

Fig. 3.
Fig. 3.

Three-dimensional data acquired in a healthy eye. Left panel: macula (View 1), right panel: optic disk (View 2).

Fig. 4.
Fig. 4.

Comparison of retinal topography mapping with reflectivity mapping in non-exudative age related macular degeneration. Soft drusen in 76 year-old patient are visualized in the crosssectional image and five SOCT maps. Full three-dimensional dataset is accessible via OSA ISP (View 3).

Fig. 5.
Fig. 5.

Results of a follow up (30 months) imaging of the 76 year-old patient with soft drusen. Drusen growth can be assessed by comparison of OCT maps with the corresponding maps in Fig. 4. Full three-dimensional dataset is accessible via OSA ISP (View 4).

Fig. 6.
Fig. 6.

Comparison of retinal topography mapping with reflectivity mapping: confluent drusen, 61 year-old patient. Full three-dimensional dataset is accessible via OSA ISP (View 5).

Fig. 7.
Fig. 7.

Results of a follow up (12 months) imaging of the 61 year-old patient with confluent drusen. Full three-dimensional dataset is accessible via OSA ISP (View 6).

Fig. 8.
Fig. 8.

Comparison of retinal topography mapping with reflectivity mapping: choroidal neovascularisation in age related macular degeneration, 66 year-old patient. Full three-dimensional dataset is accessible via OSA ISP (View 7).

Fig. 9.
Fig. 9.

Results of a follow up (22 months) imaging of the 66 year-old patient with choroidal neovascularisation in age related macular degeneration. Full three-dimensional dataset is accessible via OSA ISP (View 8).

Fig. 10.
Fig. 10.

Comparison of retinal topography mapping with reflectivity mapping: elevations of neurosensory retina in the chronic central serous chorioretinopathy, 43 year-old patient. Full three-dimensional dataset is accessible via OSA ISP (View 9).

Fig. 11.
Fig. 11.

Comparison of retinal topography mapping with reflectivity mapping: elevations of neurosensory retina in retinal detachment, 17 year-old patient. Full three-dimensional dataset is accessible via OSA ISP (View 10).

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