Abstract

Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment epithelium, can be detected. OCT using spectral/Fourier domain detection enables high speed, volumetric imaging of the macula, which provides comprehensive three-dimensional tomographic and morphologic information. We present a case series of AMD patients, from mild drusen to more advanced geographic atrophy and exudative AMD. Patients were imaged with a research prototype, ultrahigh resolution spectral/Fourier domain OCT instrument with 3.5 µm axial image resolution operating at 25,000 axial scans per second. These cases provide representative volumetric datasets of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms.

© 2009 Optical Society of America

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  1. D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
    [CrossRef] [PubMed]
  2. J.G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nature Biotechnology 21,1361-1367 (2003).
    [CrossRef] [PubMed]
  3. W. Drexler, U. Morgner, F.X. Kartner, C. Pitris, S.A. Boppart, X.D. Li, E.P. Ippen, and J.G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24,1221-1223 (1999).
    [CrossRef]
  4. W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
    [CrossRef] [PubMed]
  5. M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
    [CrossRef] [PubMed]
  6. E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
    [CrossRef] [PubMed]
  7. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
    [CrossRef] [PubMed]
  8. M.A. Choma, M.V. Sarunic, C.H. Yang, and J.A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11,2183-2189 (2003).
    [CrossRef] [PubMed]
  9. J.F. de Boer, B. Cense, B.H. Park, M.C. Pierce, G.J. Tearney, and B.E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-2069 (2003).
    [CrossRef] [PubMed]
  10. R. Leitgeb, C.K. Hitzenberger, and A.F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003).
    [CrossRef] [PubMed]
  11. M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
    [CrossRef] [PubMed]
  12. N.A. Nassif, B. Cense, B.H. Park, M.C. Pierce, S.H. Yun, B.E. Bouma, G.J. Tearney, T.C. Chen, and J.F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12,367-376 (2004).
    [CrossRef] [PubMed]
  13. B. Cense, N.A. Nassif, T.C. Chen, M.C. Pierce, S.H. Yun, B.H. Park, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12,2435-2447 (2004).
    [CrossRef] [PubMed]
  14. M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
    [CrossRef] [PubMed]
  15. J.S. Schuman, C.A. Puliafito, and J.G. Fujimoto, Optical coherence tomography of ocular diseases, 2nd edition. (Thorofare, NJ: Slack Inc, 2004).
  16. W. Drexler and J.G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res. 27,45-88 (2008).
    [CrossRef]
  17. W.R. Green and S.N. Key, 3rd, "Senile macular degeneration: a histopathologic study," Trans Am Ophthalmol Soc,  75180-254 (1977).
    [PubMed]
  18. R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
    [PubMed]
  19. D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
    [CrossRef] [PubMed]
  20. P.T. de Jong, "Age-related macular degeneration," N. Engl. J. Med. 355,1474-85 (2006).
    [CrossRef] [PubMed]
  21. J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
    [PubMed]
  22. M.P.S. Group, "Persistent and recurrent neovascularization after laser photocoagulation for subfoveal choroidal neovascularization of age-related macular degeneration. Macular Photocoagulation Study Group," Arch Ophthalmol. 112,489-99 (1994).
  23. M.P.S. Group, "Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. The influence of initial lesion size and initial visual acuity. Macular Photocoagulation Study Group," Arch Ophthalmol,  112,480-8 (1994).
  24. R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
    [CrossRef] [PubMed]
  25. P.J. Rosenfeld, R.M. Rich, and G.A. Lalwani, "Ranibizumab: Phase III Clinical Trial Results," Ophthalmol Clin North Am. 19,361-72 (2006).
    [PubMed]
  26. A. Abdelsalam, L. Del Priore, and M.A. Zarbin, "Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression," Surv Ophthalmol. 44,1-29 (1999).
    [CrossRef] [PubMed]
  27. M.A. Zarbin, "Current concepts in the pathogenesis of age-related macular degeneration," Arch Ophthalmol,  122,598-614 (2004).
    [CrossRef] [PubMed]
  28. C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
    [PubMed]
  29. M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
    [PubMed]
  30. M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
    [PubMed]
  31. J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
    [CrossRef] [PubMed]
  32. M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
    [PubMed]
  33. M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
    [CrossRef] [PubMed]
  34. W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
    [CrossRef] [PubMed]
  35. T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
    [CrossRef] [PubMed]
  36. T.H. Ko, J.G. Fujimoto, J.S. Schuman, L.A. Paunescu, A.M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J.S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 e1-15 (2005).
    [CrossRef] [PubMed]
  37. E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
    [CrossRef]
  38. M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
    [CrossRef] [PubMed]
  39. T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
    [CrossRef] [PubMed]
  40. L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
    [CrossRef]
  41. C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
    [CrossRef] [PubMed]
  42. A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
    [CrossRef] [PubMed]
  43. M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
    [CrossRef] [PubMed]
  44. V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
    [CrossRef] [PubMed]
  45. B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
    [CrossRef] [PubMed]
  46. U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
    [CrossRef] [PubMed]
  47. V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
    [CrossRef] [PubMed]
  48. V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
    [CrossRef] [PubMed]
  49. Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
    [CrossRef] [PubMed]
  50. S.L. Jiao, R. Knighton, X.R. Huang, G. Gregori, and C.A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13,444-452 (2005).
    [CrossRef] [PubMed]
  51. S.L. Jiao, C.Y. Wu, R.W. Knighton, G. Gregori, and C.A. Puliafito, "Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography," Opt. Express 14,3368-3376 (2006).
    [CrossRef] [PubMed]
  52. I. Gorczynska, V.J. Srinivasan, L.N. Vuong, R.W. Chen, J.J. Liu, E. Reichel, M. Wojtkowski, J.S. Schuman, J.S. Duker, and J.G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol. epub doi:10.1136 (2008).
    [PubMed]

2008 (4)

W. Drexler and J.G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res. 27,45-88 (2008).
[CrossRef]

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

2007 (1)

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

2006 (9)

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

P.T. de Jong, "Age-related macular degeneration," N. Engl. J. Med. 355,1474-85 (2006).
[CrossRef] [PubMed]

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

P.J. Rosenfeld, R.M. Rich, and G.A. Lalwani, "Ranibizumab: Phase III Clinical Trial Results," Ophthalmol Clin North Am. 19,361-72 (2006).
[PubMed]

S.L. Jiao, C.Y. Wu, R.W. Knighton, G. Gregori, and C.A. Puliafito, "Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography," Opt. Express 14,3368-3376 (2006).
[CrossRef] [PubMed]

2005 (5)

S.L. Jiao, R. Knighton, X.R. Huang, G. Gregori, and C.A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13,444-452 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

2004 (7)

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M.A. Zarbin, "Current concepts in the pathogenesis of age-related macular degeneration," Arch Ophthalmol,  122,598-614 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

B. Cense, N.A. Nassif, T.C. Chen, M.C. Pierce, S.H. Yun, B.H. Park, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12,2435-2447 (2004).
[CrossRef] [PubMed]

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

N.A. Nassif, B. Cense, B.H. Park, M.C. Pierce, S.H. Yun, B.E. Bouma, G.J. Tearney, T.C. Chen, and J.F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12,367-376 (2004).
[CrossRef] [PubMed]

2003 (7)

M.A. Choma, M.V. Sarunic, C.H. Yang, and J.A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11,2183-2189 (2003).
[CrossRef] [PubMed]

R. Leitgeb, C.K. Hitzenberger, and A.F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

J.F. de Boer, B. Cense, B.H. Park, M.C. Pierce, G.J. Tearney, and B.E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28,2067-2069 (2003).
[CrossRef] [PubMed]

J.G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nature Biotechnology 21,1361-1367 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

2002 (1)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

2001 (1)

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

1999 (2)

A. Abdelsalam, L. Del Priore, and M.A. Zarbin, "Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression," Surv Ophthalmol. 44,1-29 (1999).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, F.X. Kartner, C. Pitris, S.A. Boppart, X.D. Li, E.P. Ippen, and J.G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24,1221-1223 (1999).
[CrossRef]

1998 (1)

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

1997 (1)

R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
[PubMed]

1996 (1)

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

1995 (4)

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

1994 (2)

M.P.S. Group, "Persistent and recurrent neovascularization after laser photocoagulation for subfoveal choroidal neovascularization of age-related macular degeneration. Macular Photocoagulation Study Group," Arch Ophthalmol. 112,489-99 (1994).

M.P.S. Group, "Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. The influence of initial lesion size and initial visual acuity. Macular Photocoagulation Study Group," Arch Ophthalmol,  112,480-8 (1994).

1991 (1)

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

1989 (1)

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

1977 (1)

W.R. Green and S.N. Key, 3rd, "Senile macular degeneration: a histopathologic study," Trans Am Ophthalmol Soc,  75180-254 (1977).
[PubMed]

Abdelsalam, A.

A. Abdelsalam, L. Del Priore, and M.A. Zarbin, "Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression," Surv Ophthalmol. 44,1-29 (1999).
[CrossRef] [PubMed]

Adler, D.C.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

Ahlers, C.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

Ahnelt, P.K.

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

Anger, E.M.

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

Arya, A.V.

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

Avery, R.L.

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

Bajraszewski, T.

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Baumal, C.R.

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

Bilonick, R.A.

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Boppart, S.A.

Bouma, B.E.

Bressler, N.M.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Bressler, S.B.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Cable, A.

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

Carvalho, M.

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

Castellarin, A.A.

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

Cense, B.

Chamberlin, J.A.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Chan, A.

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

Chang, W.

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Chen, R.

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Chen, T.C.

Chen, Y.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

Choma, M.A.

Coker, J.G.

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

Cowey, A.

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

de Boer, J.F.

de Jong, P.T.

P.T. de Jong, "Age-related macular degeneration," N. Engl. J. Med. 355,1474-85 (2006).
[CrossRef] [PubMed]

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Del Priore, L.

A. Abdelsalam, L. Del Priore, and M.A. Zarbin, "Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression," Surv Ophthalmol. 44,1-29 (1999).
[CrossRef] [PubMed]

Drexler, W.

W. Drexler and J.G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res. 27,45-88 (2008).
[CrossRef]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, F.X. Kartner, C. Pitris, S.A. Boppart, X.D. Li, E.P. Ippen, and J.G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24,1221-1223 (1999).
[CrossRef]

Duker, J.S.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

Elman, M.J.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Ergun, E.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

Fercher, A.F.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

R. Leitgeb, C.K. Hitzenberger, and A.F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Findl, O.

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Fine, S.L.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Flood, T.P.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Flotte, T.

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Friedman, D.S.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Fujimoto, J.G.

W. Drexler and J.G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res. 27,45-88 (2008).
[CrossRef]

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

J.G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nature Biotechnology 21,1361-1367 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, F.X. Kartner, C. Pitris, S.A. Boppart, X.D. Li, E.P. Ippen, and J.G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24,1221-1223 (1999).
[CrossRef]

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Ghanta, R.K.

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

Giust, M.J.

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

Gloesmann, M.

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

Gorczynska, I.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Green, W.R.

W.R. Green and S.N. Key, 3rd, "Senile macular degeneration: a histopathologic study," Trans Am Ophthalmol Soc,  75180-254 (1977).
[PubMed]

Gregori, G.

Gregory, K.

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Group, M.P.S.

M.P.S. Group, "Persistent and recurrent neovascularization after laser photocoagulation for subfoveal choroidal neovascularization of age-related macular degeneration. Macular Photocoagulation Study Group," Arch Ophthalmol. 112,489-99 (1994).

M.P.S. Group, "Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. The influence of initial lesion size and initial visual acuity. Macular Photocoagulation Study Group," Arch Ophthalmol,  112,480-8 (1994).

Hawkins, B.S.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Hee, M.R.

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Hermann, B.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Hitzenberger, C.K.

Huang, D.

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Huang, X.R.

Huber, R.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

Ippen, E.P.

Izatt, J.A.

M.A. Choma, M.V. Sarunic, C.H. Yang, and J.A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11,2183-2189 (2003).
[CrossRef] [PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

Jensen, S.C.

R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
[PubMed]

Jiang, J.

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

Jiao, S.L.

Kaluzny, J.J.

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

Kartner, F.X.

Kärtner, F.X.

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

Kempen, J.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Key, S.N.

W.R. Green and S.N. Key, 3rd, "Senile macular degeneration: a histopathologic study," Trans Am Ophthalmol Soc,  75180-254 (1977).
[PubMed]

Klein, B.E.

R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
[PubMed]

Klein, R.

R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
[PubMed]

Knighton, R.

Knighton, R.W.

Ko, T.

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

Ko, T.H.

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Kowalczyk, A.

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Lalwani, G.A.

P.J. Rosenfeld, R.M. Rich, and G.A. Lalwani, "Ranibizumab: Phase III Clinical Trial Results," Ophthalmol Clin North Am. 19,361-72 (2006).
[PubMed]

Leitgeb, R.

R. Leitgeb, C.K. Hitzenberger, and A.F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11,889-894 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Leitgeb, R.A.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

Li, X.D.

Lin, C.P.

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Maguire, M.G.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

McCarty, C.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Meuer, S.M.

R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
[PubMed]

Michels, S.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

Mitchell, P.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Monson, B.K.

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Morgan, J.E.

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

Morgner, U.

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, F.X. Kartner, C. Pitris, S.A. Boppart, X.D. Li, E.P. Ippen, and J.G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24,1221-1223 (1999).
[CrossRef]

Munoz, B.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Murphy, R.P.

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

Nasir, M.A.

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

Nassif, N.A.

Nemesure, B.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

O'Colmain, B.J.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Park, B.H.

Paunescu, L.A.

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

Pedut-Kloizman, T.

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

Pieramici, D.J.

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

Pierce, M.C.

Pitris, C.

Potsaid, B.

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

Povazay, B.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

Puliafito, C.A.

S.L. Jiao, C.Y. Wu, R.W. Knighton, G. Gregori, and C.A. Puliafito, "Registration of high-density cross sectional images to the fundus image in spectral-domain ophthalmic optical coherence tomography," Opt. Express 14,3368-3376 (2006).
[CrossRef] [PubMed]

S.L. Jiao, R. Knighton, X.R. Huang, G. Gregori, and C.A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13,444-452 (2005).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Rabena, M.D.

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

Reichel, E.

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

Rich, R.M.

P.J. Rosenfeld, R.M. Rich, and G.A. Lalwani, "Ranibizumab: Phase III Clinical Trial Results," Ophthalmol Clin North Am. 19,361-72 (2006).
[PubMed]

Rogers, A.H.

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

Rosenfeld, P.J.

P.J. Rosenfeld, R.M. Rich, and G.A. Lalwani, "Ranibizumab: Phase III Clinical Trial Results," Ophthalmol Clin North Am. 19,361-72 (2006).
[PubMed]

Rutledge, B.

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

Sacu, S.

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

Sarunic, M.V.

Sattmann, H.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Schmidt-Erfurth, U.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

Scholda, C.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Schubert, C.

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

Schuman, J.S.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Sikorski, B.

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

Srinivasan, V.J.

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

Stinson, W.G.

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Stur, M.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Swanson, E.A.

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Szkulmowska, A.

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

Szkulmowski, M.

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

Targowski, P.

Tearney, G.J.

Tomany, S.C.

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

Unterhuber, A.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Wilkins, J.R.

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

Wirtitsch, M.

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Wirtitsch, M.G.

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

Witkin, A.J.

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

Wojtkowski, M.

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, and A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28,1745-1747 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

Wong, C.

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

Wu, C.Y.

Yang, C.H.

Yun, S.H.

Zarbin, M.A.

M.A. Zarbin, "Current concepts in the pathogenesis of age-related macular degeneration," Arch Ophthalmol,  122,598-614 (2004).
[CrossRef] [PubMed]

A. Abdelsalam, L. Del Priore, and M.A. Zarbin, "Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression," Surv Ophthalmol. 44,1-29 (1999).
[CrossRef] [PubMed]

American Journal of Ophthalmology (2)

M.G. Wirtitsch, E. Ergun, B. Hermann, A. Unterhuber, M. Stur, C. Scholda, H. Sattmann, T.H. Ko, J.G. Fujimoto, and W. Drexler, "Ultrahigh resolution optical coherence tomography in macular dystrophy," American Journal of Ophthalmology 140,976-983 (2005).
[CrossRef] [PubMed]

A.J. Witkin, T.H. Ko, J.G. Fujimoto, A. Chan, W. Drexler, J.S. Schuman, E. Reichel, and J.S. Duker, "Ultra-high resolution optical coherence tomography assessment of photoreceptors in retinitis pigmentosa and related diseases," American Journal of Ophthalmology 142,945-952 (2006).
[CrossRef] [PubMed]

Arch Ophthalmol (2)

M.P.S. Group, "Visual outcome after laser photocoagulation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. The influence of initial lesion size and initial visual acuity. Macular Photocoagulation Study Group," Arch Ophthalmol,  112,480-8 (1994).

M.A. Zarbin, "Current concepts in the pathogenesis of age-related macular degeneration," Arch Ophthalmol,  122,598-614 (2004).
[CrossRef] [PubMed]

Arch Ophthalmol. (2)

D.S. Friedman, B.J. O'Colmain, B. Munoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, and J. Kempen, "Prevalence of age-related macular degeneration in the United States," Arch Ophthalmol. 122,564-72 (2004).
[CrossRef] [PubMed]

M.P.S. Group, "Persistent and recurrent neovascularization after laser photocoagulation for subfoveal choroidal neovascularization of age-related macular degeneration. Macular Photocoagulation Study Group," Arch Ophthalmol. 112,489-99 (1994).

Arch. Ophthalmol. (1)

T.H. Ko, A.J. Witkin, J.G. Fujimoto, A. Chan, A.H. Rogers, C.R. Baumal, J.S. Schuman, W. Drexler, E. Reichel, and J.S. Duker, "Ultrahigh-resolution optical coherence tomography of surgically closed macular holes," Arch. Ophthalmol. 124,827-836 (2006).
[CrossRef] [PubMed]

Archives of Ophthalmology (2)

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, B. Rutledge, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Quantitative assessment of macular edema with optical coherence tomography," Archives of Ophthalmology 113,1019-1029 (1995).
[PubMed]

W. Drexler, H. Sattmann, B. Hermann, T.H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J.G. Fujimoto, and A.F. Fercher, "Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography," Archives of Ophthalmology 121,695-706 (2003).
[CrossRef] [PubMed]

Current Opinion in Ophthalmology (1)

J.S. Schuman, M.R. Hee, A.V. Arya, T. Pedut-Kloizman, C.A. Puliafito, J.G. Fujimoto, and E.A. Swanson, "Optical coherence tomography: a new tool for glaucoma diagnosis," Current Opinion in Ophthalmology 6,89-95 (1995).
[CrossRef] [PubMed]

Experimental Eye Research (1)

E.M. Anger, A. Unterhuber, B. Hermann, H. Sattmann, C. Schubert, J.E. Morgan, A. Cowey, P.K. Ahnelt, and W. Drexler, "Ultrahigh resolution optical coherence tomography of the monkey fovea. Identification of retinal sublayers by correlation with semithin histology sections," Experimental Eye Research 78,1117-25 (2004).
[CrossRef] [PubMed]

Investigative Ophthalmology & Visual Science (5)

V.J. Srinivasan, B.K. Monson, M. Wojtkowski, R.A. Bilonick, I. Gorczynska, R. Chen, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 49,1571-1579 (2008).
[CrossRef] [PubMed]

M. Gloesmann, B. Hermann, C. Schubert, H. Sattmann, P.K. Ahnelt, and W. Drexler, "Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 44,1696-703 (2003).
[CrossRef] [PubMed]

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T.H. Ko, H. Sattmann, C. Scholda, J.G. Fujimoto, M. Stur, and W. Drexler, "Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography," Investigative Ophthalmology & Visual Science 46,310-316 (2005).
[CrossRef]

V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head," Investigative Ophthalmology & Visual Science 49,5103-5110 (2008).
[CrossRef] [PubMed]

U. Schmidt-Erfurth, R.A. Leitgeb, S. Michels, B. Povazay, S. Sacu, B. Hermann, C. Ahlers, H. Sattmann, C. Scholda, A.F. Fercher, and W. Drexler, "Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases," Investigative Ophthalmology & Visual Science 46,3393-3402 (2005).
[CrossRef] [PubMed]

J Biomed Opt. (1)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A.F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J Biomed Opt. 7,457-463 (2002).
[CrossRef] [PubMed]

J. Biomed. Opt. (1)

Q1. M. Szkulmowski, M. Wojtkowski, B. Sikorski, T. Bajraszewski, V.J. Srinivasan, A. Szkulmowska, J.J. Kaluzny, J.G. Fujimoto, and A. Kowalczyk, "Analysis of posterior retinal layers in spectral optical coherence tomography images of the normal retina and retinal pathologies," J. Biomed. Opt. 12, (2007).
[CrossRef] [PubMed]

N. Engl. J. Med. (1)

P.T. de Jong, "Age-related macular degeneration," N. Engl. J. Med. 355,1474-85 (2006).
[CrossRef] [PubMed]

Nature Biotechnology (1)

J.G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nature Biotechnology 21,1361-1367 (2003).
[CrossRef] [PubMed]

Nature Medicine (1)

W. Drexler, U. Morgner, R.K. Ghanta, F.X. Kärtner, J.S. Schuman, and J.G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nature Medicine 7,502-507 (2001).
[CrossRef] [PubMed]

Ophthalmol Clin North Am. (1)

P.J. Rosenfeld, R.M. Rich, and G.A. Lalwani, "Ranibizumab: Phase III Clinical Trial Results," Ophthalmol Clin North Am. 19,361-72 (2006).
[PubMed]

Ophthalmology (10)

R.L. Avery, D.J. Pieramici, M.D. Rabena, A.A. Castellarin, M.A. Nasir, and M.J. Giust, "Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration," Ophthalmology 113,363-372 (2006).
[CrossRef] [PubMed]

C.A. Puliafito, M.R. Hee, C.P. Lin, E. Reichel, J.S. Schuman, J.S. Duker, J.A. Izatt, E.A. Swanson, and J.G. Fujimoto, "Imaging of macular diseases with optical coherence tomography," Ophthalmology 102,217-229 (1995).
[PubMed]

M.R. Hee, C.R. Baumal, C.A. Puliafito, J.S. Duker, E. Reichel, J.R. Wilkins, J.G. Coker, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of age-related macular degeneration and choroidal neovascularization," Ophthalmology 103,1260-1270 (1996).
[PubMed]

M.R. Hee, C.A. Puliafito, C. Wong, J.S. Duker, E. Reichel, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Optical coherence tomography of macular holes," Ophthalmology 102,748-756 (1995).
[PubMed]

J.A. Chamberlin, N.M. Bressler, S.B. Bressler, M.J. Elman, R.P. Murphy, T.P. Flood, B.S. Hawkins, M.G. Maguire, and S.L. Fine, "The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group," Ophthalmology 96,1526-34 (1989).
[PubMed]

R. Klein, B.E. Klein, S.C. Jensen, and S.M. Meuer, "The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study," Ophthalmology 104,7-21 (1997).
[PubMed]

M. Wojtkowski, V. Srinivasan, J.G. Fujimoto, T. Ko, J.S. Schuman, A. Kowalczyk, and J.S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112,1734-1746 (2005).
[CrossRef] [PubMed]

T.H. Ko, J.G. Fujimoto, J.S. Duker, L.A. Paunescu, W. Drexler, C.R. Baumal, C.A. Puliafito, E. Reichel, A.H. Rogers, and J.S. Schuman, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular hole pathology and repair," Ophthalmology 111,2033-2043 (2004).
[CrossRef] [PubMed]

M.R. Hee, C.A. Puliafito, J.S. Duker, E. Reichel, J.G. Coker, J.R. Wilkins, J.S. Schuman, E.A. Swanson, and J.G. Fujimoto, "Topography of diabetic macular edema with optical coherence tomography," Ophthalmology 105,360-370 (1998).
[CrossRef] [PubMed]

L.A. Paunescu, T.H. Ko, J.S. Duker, A. Chan, W. Drexler, J.S. Schuman, and J.G. Fujimoto, "Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography," Ophthalmology 113,48-57 (2006).
[CrossRef]

Ophthalmology. (1)

V.J. Srinivasan, M. Wojtkowski, A.J. Witkin, J.S. Duker, T.H. Ko, M. Carvalho, J.S. Schuman, A. Kowalczyk, and J.G. Fujimoto, "High-definition and 3-dimensional imaging of macular pathologies with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology.,  113,2054-2065 (2006).
[CrossRef] [PubMed]

Opt Express (1)

B. Potsaid, I. Gorczynska, V.J. Srinivasan, Y. Chen, J. Jiang, A. Cable, and J.G. Fujimoto, "Ultrahigh speed spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second," Opt Express 16,15149-15169 (2008).
[CrossRef] [PubMed]

Opt. Express (6)

Opt. Lett. (3)

Optics Express (1)

M. Wojtkowski, V.J. Srinivasan, T.H. Ko, J.G. Fujimoto, A. Kowalczyk, and J.S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Optics Express 12,2404-2422 (2004).
[CrossRef] [PubMed]

Prog Retin Eye Res. (1)

W. Drexler and J.G. Fujimoto, "State-of-the-art retinal optical coherence tomography," Prog Retin Eye Res. 27,45-88 (2008).
[CrossRef]

Retina (1)

C. Scholda, M. Wirtitsch, B. Hermann, A. Unterhuber, E. Ergun, H. Sattmann, T.H. Ko, J.G. Fujimoto, A.F. Fercher, M. Stur, U. Schmidt-Erfurth, and W. Drexler, "Ultrahigh resolution optical coherence tomography of macular holes," Retina 26,1034-1041 (2006).
[CrossRef] [PubMed]

Science (1)

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J.G. Fujimoto, "Optical Coherence Tomography," Science 254,1178-1181 (1991).
[CrossRef] [PubMed]

Surv Ophthalmol. (1)

A. Abdelsalam, L. Del Priore, and M.A. Zarbin, "Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression," Surv Ophthalmol. 44,1-29 (1999).
[CrossRef] [PubMed]

Trans Am Ophthalmol Soc (1)

W.R. Green and S.N. Key, 3rd, "Senile macular degeneration: a histopathologic study," Trans Am Ophthalmol Soc,  75180-254 (1977).
[PubMed]

Other (3)

J.S. Schuman, C.A. Puliafito, and J.G. Fujimoto, Optical coherence tomography of ocular diseases, 2nd edition. (Thorofare, NJ: Slack Inc, 2004).

T.H. Ko, J.G. Fujimoto, J.S. Schuman, L.A. Paunescu, A.M. Kowalevicz, I. Hartl, W. Drexler, G. Wollstein, H. Ishikawa, and J.S. Duker, "Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology," Ophthalmology 112, 1922 e1-15 (2005).
[CrossRef] [PubMed]

I. Gorczynska, V.J. Srinivasan, L.N. Vuong, R.W. Chen, J.J. Liu, E. Reichel, M. Wojtkowski, J.S. Schuman, J.S. Duker, and J.G. Fujimoto, "Projection OCT fundus imaging for visualizing outer retinal pathology in non-exudative age related macular degeneration," Br. J. Ophthalmol. epub doi:10.1136 (2008).
[PubMed]

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Figures (8)

Fig. 1.
Fig. 1.

Ultrahigh resolution, spectral/Fourier domain OCT volumetric dataset and fundus photograph of the right eye of a 54 year old male subject with mild dry AMD (View 1). The en face OCT fundus image (top-left) is generated by axial summation of the 3D-OCT dataset. Color fundus photo (bottom-left) showing the location of the 3D-OCT volumetric data. Three OCT cross-sectional images are selected from superior to inferior near fovea to show representative pathology. The positions of the OCT images are marked with black arrows on the en face OCT fundus image. Discrete drusen can be seen in the fundus images and in corresponding positions in the OCT cross-sectional images. Ultrahigh resolution enables most of the individual retinal layers to be resolved. RNFL: retinal nerve fiber layer, GCL: ganglion cell layer, OPL: outer plexiform layer, ONL: outer nuclear layer, IPL: inner plexiform layer, INL: inner nuclear layer, ELM: external limiting membrane, IS/OS: photoreceptor inner and outer segment junction, RPE: retinal pigmented epithelium, and CH: choroid.

Fig. 2.
Fig. 2.

Image data from the right eye of a 58 year old female subject diagnosed with dry AMD in both eyes (View 2). Her right eye had a visual acuity of 20/25. The OCT cross-sectional images show elevation of the RPE due to drusen and changes in the photoreceptor inner and outer segment (IS/OS) boundary (thin arrows). Bruch’s membrane appears under the area with large drusen deposits (solid arrows), but is not visible in the normal areas of the retina.

Fig. 3.
Fig. 3.

Image data from the left eye of a 60 year old female subject with dry AMD diagnosed in both eyes (View 3). Both en face OCT fundus image (left) and cross-sectional OCT (right) images show that the soft drusen have started to coalesce and form larger, confluent drusen. Three selected OCT cross-sectional images (right) clearly show the confluent drusen. Bruch’s membrane cannot be identified as distinct from the drusen. The en face OCT fundus image also shows the smooth border between confluent drusen.

Fig. 4.
Fig. 4.

Image data from the left eye of a 91 year old female subject with AMD (View 4). A large retinal pigment epithelial detachment (PED) can be seen in the macula. The subject had a visual acuity of counting fingers at 5 feet (CF5’). The cross-sectional OCT images show many irregular scattering features and loss of photoreceptor integrity as evidenced by disruption of the photoreceptor inner and outer segment (IS/OS) boundary. Bruch’s membrane is visible under the PED (solid arrow), but would not be visible in a normal retina. The inner retina is distorted by the elevation of the RPE and photoreceptors. Atrophy of the outer nuclear layer is also evident.

Fig. 5.
Fig. 5.

Image data from the right eye of a 67 year old male with dry AMD (View 5). Drusen deposit creates identifiable RPE and photoreceptor irregularities. The hyperscattering signal from the choroid beneath the lesion implies RPE atrophy. The IS/OS junction and RPE were no longer separable for UHR-OCT frames from the lesion area. Instead, the Bruch’s membrane appeared under the RPE with a smooth contour.

Fig. 6.
Fig. 6.

Image data from the left eye of an 84 year old female subject diagnosed with geographic atrophy and a visual acuity of 20/160 (View 6). Hyper-scattering appears on OCT images beneath the disrupted photoreceptor /RPE layers where Bruch’s membrane can be easily identified. Both color photo and en face image of OCT demonstrate similar highly scattering area of RPE atrophy.

Fig. 7.
Fig. 7.

Image data from the right eye of a 77 year old female subject with wet AMD (View 7). Visual acuity was counting fingers at four feet. Fluorescein angiograms at 67 seconds (B) and 5 minutes and 8 seconds (C) indicate the development of choroidal neovascularization. A large volume of intraretinal fluid (small arrows) was identified from the OCT frames. The fluid developed over a large PED where the bottom arrow points the detached Bruch’s membrane.

Fig. 8.
Fig. 8.

Image data from the same 77 year old female subject as in Fig. 7, after treatment with intravitreal ranibizumab (View 8). Visual acuity was counting fingers at five feet. OCT images show clearly reduced fluid volumes. Fluorescein angiography was not performed at this examination. The en face OCT fundus view exhibits a more uniform scattering intensity compared to that before treatment (Fig. 7).

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