Abstract

This work is related to the development of phase-sensitive methodologies in Surface Plasmon Resonance (SPR) biosensing. We take advantage of a specific angular dependence of phase of light, reflected under SPR geometry, on parameters of the SPR-supporting metal, and propose a polarimetry-based methodology to easily determine the optimal calibration zero point, corresponding to the maximal phase sensitivity. The proposed methodology can significantly facilitate the calibration of the system in field and multi-channel sensing, broaden the dynamic range, as well as contribute to the development of feedback loops.

© 2009 Optical Society of America

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References

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  1. B. Liedberg, C. Nylander, and I. Lundstrom, "Biosensing with surface plasmon resonance - how it all started, " Biosens. Bioelectron. 10, i-ix (1995).
    [CrossRef] [PubMed]
  2. B. Liedberg, C. Nylander, and I. Lundstrum, "Surface plasmon resonance for gas detection and biosensing," Sens. Actuators B 4, 299-304 (1983).
    [CrossRef]
  3. L.M. Zhang and D. Uttamchandani, "Optical chemical sensing employing surface plasmon resonance, " Electron. Lett. 23, 1469-1470 (1988).
    [CrossRef]
  4. P. Schuck, "Use of surface plasmon resonance to probe the equilibrium and dynamic aspects of interactions between biological macromolecules, " Annu. Rev. Biophys. Biomol. Struct. 26, 541-566 (1997).
    [CrossRef] [PubMed]
  5. P. B. Garland, "Optical evanescent wave methods for the study of biomolecular interactions, " Q. Rev. Biophys. 29, 91-117 (1996).
    [CrossRef] [PubMed]
  6. P. N. Prasad, Introduction to Biophotonics (Wiley-Interscience, New Jersey, 2003).
    [CrossRef]
  7. A. V. Kabashin and P. I. Nikitin, "Interferometer based on a surface-plasmon resonance for sensor applications, Quant. Electron. 27, 653-654 (1997).
    [CrossRef]
  8. A.V. Kabashin and P. I. Nikitin, "Surface plasmon resonance interferometer for bio- and chemical-sensors," Opt. Commun. 150, 5-8 (1998).
    [CrossRef]
  9. A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging," Appl. Phys. Lett. 75, 3917-3919 (1999).
    [CrossRef]
  10. S. Shen, T. Liu, and J. Guo, "Optical Phase-Shift Detection of Surface Plasmon Resonance, Appl. Opt. 37, 1747-1751 (1998).
    [CrossRef]
  11. A. G. Notcovich, V. Zhuk, and S. G. Lipson, "Surface plasmon resonance phase imaging, Appl. Phys. Lett. 76, 1665-1667 (2000).
    [CrossRef]
  12. H. P. Ho and W.W Lam, "Application of differential phase measurement technique to surface plasmon resonance sensors," Sens. Actuators B 96, 554-559 (2003).
    [CrossRef]
  13. C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
    [CrossRef]
  14. S. Y. Wu, H. P. Ho, W. C. Law, C. Lin, and S. K. Kong, "Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach-Zehnder configuration, " Opt. Lett. 29, 2378-2380 (2004).
    [CrossRef] [PubMed]
  15. A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
    [CrossRef]
  16. R. Naraoka and K. Kajikawa, "Phase detection of surface plasmon resonance using rotating analyzer method," Sens. Actuators B 107, 952-956 (2005).
    [CrossRef]
  17. P. Chiang, J. Lin, R. Chang, S. Su, and P.T. Leung, "High-resolution angular measurement using surface-plasmon-resonance via phase interrogation at optimal incident wavelengths, " Opt. Lett. 30, 2727-2729 (2005).
    [CrossRef] [PubMed]
  18. P. P. Markowicz, W. C. Law, A. Baev, P. Prasad, S. Patskovsky, and A. V. Kabashin, "Phase-sensitive time-modulated surface plasmon resonance polarimetry for wide dynamic range biosensing," Opt. Express 15, 1745 (2007).
    [CrossRef] [PubMed]
  19. A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
    [CrossRef]
  20. A. V. Kabashin, V. E. Kochergin, and P. I. Nikitin, "Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast," Sens. Actuators B 54, 51-56 (1999).
    [CrossRef]
  21. S. Patskovsky, M. Meunier, and A. V. Kabashin, "Surface plasmon resonance polarizator for biosensing and imaging," Optics Commun. 281,5492 (2008).
    [CrossRef]
  22. V. M. Agranovich and D. L. Mills (Eds) Surface polaritons (North Holland, Amsterdam, 1982).

2008 (1)

S. Patskovsky, M. Meunier, and A. V. Kabashin, "Surface plasmon resonance polarizator for biosensing and imaging," Optics Commun. 281,5492 (2008).
[CrossRef]

2007 (1)

2005 (2)

2004 (2)

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
[CrossRef]

S. Y. Wu, H. P. Ho, W. C. Law, C. Lin, and S. K. Kong, "Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach-Zehnder configuration, " Opt. Lett. 29, 2378-2380 (2004).
[CrossRef] [PubMed]

2003 (2)

H. P. Ho and W.W Lam, "Application of differential phase measurement technique to surface plasmon resonance sensors," Sens. Actuators B 96, 554-559 (2003).
[CrossRef]

C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
[CrossRef]

2000 (1)

A. G. Notcovich, V. Zhuk, and S. G. Lipson, "Surface plasmon resonance phase imaging, Appl. Phys. Lett. 76, 1665-1667 (2000).
[CrossRef]

1999 (2)

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging," Appl. Phys. Lett. 75, 3917-3919 (1999).
[CrossRef]

A. V. Kabashin, V. E. Kochergin, and P. I. Nikitin, "Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast," Sens. Actuators B 54, 51-56 (1999).
[CrossRef]

1998 (3)

A.V. Kabashin and P. I. Nikitin, "Surface plasmon resonance interferometer for bio- and chemical-sensors," Opt. Commun. 150, 5-8 (1998).
[CrossRef]

A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
[CrossRef]

S. Shen, T. Liu, and J. Guo, "Optical Phase-Shift Detection of Surface Plasmon Resonance, Appl. Opt. 37, 1747-1751 (1998).
[CrossRef]

1997 (2)

A. V. Kabashin and P. I. Nikitin, "Interferometer based on a surface-plasmon resonance for sensor applications, Quant. Electron. 27, 653-654 (1997).
[CrossRef]

P. Schuck, "Use of surface plasmon resonance to probe the equilibrium and dynamic aspects of interactions between biological macromolecules, " Annu. Rev. Biophys. Biomol. Struct. 26, 541-566 (1997).
[CrossRef] [PubMed]

1996 (1)

P. B. Garland, "Optical evanescent wave methods for the study of biomolecular interactions, " Q. Rev. Biophys. 29, 91-117 (1996).
[CrossRef] [PubMed]

1995 (1)

B. Liedberg, C. Nylander, and I. Lundstrom, "Biosensing with surface plasmon resonance - how it all started, " Biosens. Bioelectron. 10, i-ix (1995).
[CrossRef] [PubMed]

1988 (1)

L.M. Zhang and D. Uttamchandani, "Optical chemical sensing employing surface plasmon resonance, " Electron. Lett. 23, 1469-1470 (1988).
[CrossRef]

1983 (1)

B. Liedberg, C. Nylander, and I. Lundstrum, "Surface plasmon resonance for gas detection and biosensing," Sens. Actuators B 4, 299-304 (1983).
[CrossRef]

Baev, A.

Bartlett, P. N.

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
[CrossRef]

Beloglazov, A. A.

A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
[CrossRef]

Chang, L. B.

C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
[CrossRef]

Chang, R.

Chiang, P.

Garland, P. B.

P. B. Garland, "Optical evanescent wave methods for the study of biomolecular interactions, " Q. Rev. Biophys. 29, 91-117 (1996).
[CrossRef] [PubMed]

Grigorenko, A. N.

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging," Appl. Phys. Lett. 75, 3917-3919 (1999).
[CrossRef]

Guo, J.

Harris, R. D.

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
[CrossRef]

Ho, H. P.

Jian, Z. C.

C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
[CrossRef]

Joe, S. F.

C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
[CrossRef]

Kabashin, A. V.

S. Patskovsky, M. Meunier, and A. V. Kabashin, "Surface plasmon resonance polarizator for biosensing and imaging," Optics Commun. 281,5492 (2008).
[CrossRef]

P. P. Markowicz, W. C. Law, A. Baev, P. Prasad, S. Patskovsky, and A. V. Kabashin, "Phase-sensitive time-modulated surface plasmon resonance polarimetry for wide dynamic range biosensing," Opt. Express 15, 1745 (2007).
[CrossRef] [PubMed]

A. V. Kabashin, V. E. Kochergin, and P. I. Nikitin, "Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast," Sens. Actuators B 54, 51-56 (1999).
[CrossRef]

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging," Appl. Phys. Lett. 75, 3917-3919 (1999).
[CrossRef]

A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
[CrossRef]

A. V. Kabashin and P. I. Nikitin, "Interferometer based on a surface-plasmon resonance for sensor applications, Quant. Electron. 27, 653-654 (1997).
[CrossRef]

Kabashin, A.V.

A.V. Kabashin and P. I. Nikitin, "Surface plasmon resonance interferometer for bio- and chemical-sensors," Opt. Commun. 150, 5-8 (1998).
[CrossRef]

Kajikawa, K.

R. Naraoka and K. Kajikawa, "Phase detection of surface plasmon resonance using rotating analyzer method," Sens. Actuators B 107, 952-956 (2005).
[CrossRef]

Kochergin, V. E.

A. V. Kabashin, V. E. Kochergin, and P. I. Nikitin, "Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast," Sens. Actuators B 54, 51-56 (1999).
[CrossRef]

A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
[CrossRef]

Kong, S. K.

Lam, W.W

H. P. Ho and W.W Lam, "Application of differential phase measurement technique to surface plasmon resonance sensors," Sens. Actuators B 96, 554-559 (2003).
[CrossRef]

Law, W. C.

Leung, P.T.

Liedberg, B.

B. Liedberg, C. Nylander, and I. Lundstrom, "Biosensing with surface plasmon resonance - how it all started, " Biosens. Bioelectron. 10, i-ix (1995).
[CrossRef] [PubMed]

B. Liedberg, C. Nylander, and I. Lundstrum, "Surface plasmon resonance for gas detection and biosensing," Sens. Actuators B 4, 299-304 (1983).
[CrossRef]

Lin, C.

Lin, J.

Lipson, S. G.

A. G. Notcovich, V. Zhuk, and S. G. Lipson, "Surface plasmon resonance phase imaging, Appl. Phys. Lett. 76, 1665-1667 (2000).
[CrossRef]

Liu, T.

Lundstrom, I.

B. Liedberg, C. Nylander, and I. Lundstrom, "Biosensing with surface plasmon resonance - how it all started, " Biosens. Bioelectron. 10, i-ix (1995).
[CrossRef] [PubMed]

Lundstrum, I.

B. Liedberg, C. Nylander, and I. Lundstrum, "Surface plasmon resonance for gas detection and biosensing," Sens. Actuators B 4, 299-304 (1983).
[CrossRef]

Markowicz, P. P.

Meunier, M.

S. Patskovsky, M. Meunier, and A. V. Kabashin, "Surface plasmon resonance polarizator for biosensing and imaging," Optics Commun. 281,5492 (2008).
[CrossRef]

Naraoka, R.

R. Naraoka and K. Kajikawa, "Phase detection of surface plasmon resonance using rotating analyzer method," Sens. Actuators B 107, 952-956 (2005).
[CrossRef]

Nikitin, P. I.

A. V. Kabashin, V. E. Kochergin, and P. I. Nikitin, "Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast," Sens. Actuators B 54, 51-56 (1999).
[CrossRef]

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging," Appl. Phys. Lett. 75, 3917-3919 (1999).
[CrossRef]

A.V. Kabashin and P. I. Nikitin, "Surface plasmon resonance interferometer for bio- and chemical-sensors," Opt. Commun. 150, 5-8 (1998).
[CrossRef]

A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
[CrossRef]

A. V. Kabashin and P. I. Nikitin, "Interferometer based on a surface-plasmon resonance for sensor applications, Quant. Electron. 27, 653-654 (1997).
[CrossRef]

Notcovich, A. G.

A. G. Notcovich, V. Zhuk, and S. G. Lipson, "Surface plasmon resonance phase imaging, Appl. Phys. Lett. 76, 1665-1667 (2000).
[CrossRef]

Nylander, C.

B. Liedberg, C. Nylander, and I. Lundstrom, "Biosensing with surface plasmon resonance - how it all started, " Biosens. Bioelectron. 10, i-ix (1995).
[CrossRef] [PubMed]

B. Liedberg, C. Nylander, and I. Lundstrum, "Surface plasmon resonance for gas detection and biosensing," Sens. Actuators B 4, 299-304 (1983).
[CrossRef]

Patskovsky, S.

Prasad, P.

Schuck, P.

P. Schuck, "Use of surface plasmon resonance to probe the equilibrium and dynamic aspects of interactions between biological macromolecules, " Annu. Rev. Biophys. Biomol. Struct. 26, 541-566 (1997).
[CrossRef] [PubMed]

Shen, S.

Sheridan, A. K.

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
[CrossRef]

Su, S.

Uttamchandani, D.

L.M. Zhang and D. Uttamchandani, "Optical chemical sensing employing surface plasmon resonance, " Electron. Lett. 23, 1469-1470 (1988).
[CrossRef]

Wilkinson, J. S.

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
[CrossRef]

Wu, C. M.

C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
[CrossRef]

Wu, S. Y.

Zhang, L.M.

L.M. Zhang and D. Uttamchandani, "Optical chemical sensing employing surface plasmon resonance, " Electron. Lett. 23, 1469-1470 (1988).
[CrossRef]

Zhuk, V.

A. G. Notcovich, V. Zhuk, and S. G. Lipson, "Surface plasmon resonance phase imaging, Appl. Phys. Lett. 76, 1665-1667 (2000).
[CrossRef]

Annu. Rev. Biophys. Biomol. Struct. (1)

P. Schuck, "Use of surface plasmon resonance to probe the equilibrium and dynamic aspects of interactions between biological macromolecules, " Annu. Rev. Biophys. Biomol. Struct. 26, 541-566 (1997).
[CrossRef] [PubMed]

Appl. Opt. (1)

Appl. Phys. Lett. (2)

A. N. Grigorenko, P. I. Nikitin, and A. V. Kabashin, "Phase Jumps and Interferometric Surface Plasmon Resonance Imaging," Appl. Phys. Lett. 75, 3917-3919 (1999).
[CrossRef]

A. G. Notcovich, V. Zhuk, and S. G. Lipson, "Surface plasmon resonance phase imaging, Appl. Phys. Lett. 76, 1665-1667 (2000).
[CrossRef]

Biosens. Bioelectron. (2)

B. Liedberg, C. Nylander, and I. Lundstrom, "Biosensing with surface plasmon resonance - how it all started, " Biosens. Bioelectron. 10, i-ix (1995).
[CrossRef] [PubMed]

A. V. Kabashin, V. E. Kochergin, A. A. Beloglazov, and P. I. Nikitin, "Phase-polarization contrast for SPR biosensors," Biosens. Bioelectron. 13, 1263-1269 (1998).
[CrossRef]

Electron. Lett. (1)

L.M. Zhang and D. Uttamchandani, "Optical chemical sensing employing surface plasmon resonance, " Electron. Lett. 23, 1469-1470 (1988).
[CrossRef]

Opt. Commun. (1)

A.V. Kabashin and P. I. Nikitin, "Surface plasmon resonance interferometer for bio- and chemical-sensors," Opt. Commun. 150, 5-8 (1998).
[CrossRef]

Opt. Express (1)

Opt. Lett. (2)

Optics Commun. (1)

S. Patskovsky, M. Meunier, and A. V. Kabashin, "Surface plasmon resonance polarizator for biosensing and imaging," Optics Commun. 281,5492 (2008).
[CrossRef]

Q. Rev. Biophys. (1)

P. B. Garland, "Optical evanescent wave methods for the study of biomolecular interactions, " Q. Rev. Biophys. 29, 91-117 (1996).
[CrossRef] [PubMed]

Quant. Electron. (1)

A. V. Kabashin and P. I. Nikitin, "Interferometer based on a surface-plasmon resonance for sensor applications, Quant. Electron. 27, 653-654 (1997).
[CrossRef]

Sens. Actuators B (6)

A. V. Kabashin, V. E. Kochergin, and P. I. Nikitin, "Surface plasmon resonance bio- and chemical sensors with phase-polarisation contrast," Sens. Actuators B 54, 51-56 (1999).
[CrossRef]

B. Liedberg, C. Nylander, and I. Lundstrum, "Surface plasmon resonance for gas detection and biosensing," Sens. Actuators B 4, 299-304 (1983).
[CrossRef]

H. P. Ho and W.W Lam, "Application of differential phase measurement technique to surface plasmon resonance sensors," Sens. Actuators B 96, 554-559 (2003).
[CrossRef]

C. M. Wu, Z. C. Jian, S. F. Joe, and L. B. Chang, "High-sensitivity sensor based on surface Plasmon resonance and heterodyne interferometry," Sens. Actuators B 92, 133-136 (2003).
[CrossRef]

A. K. Sheridan, R. D. Harris, P. N. Bartlett, and J. S. Wilkinson, "Phase interrogation of an integrated optical SPR sensor, " Sens. Actuators B 97, 114-121 (2004).
[CrossRef]

R. Naraoka and K. Kajikawa, "Phase detection of surface plasmon resonance using rotating analyzer method," Sens. Actuators B 107, 952-956 (2005).
[CrossRef]

Other (2)

P. N. Prasad, Introduction to Biophotonics (Wiley-Interscience, New Jersey, 2003).
[CrossRef]

V. M. Agranovich and D. L. Mills (Eds) Surface polaritons (North Holland, Amsterdam, 1982).

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Figures (8)

Fig. 1.
Fig. 1.

Angular phase (solid curves) and intensity (dashed curves) curves for different gold layer thicknesses. The data are given for air ambient medium

Fig. 2.
Fig. 2.

Angular and intensity dependence for the minimum of SPR intensity curves (resonance point) on the SPR-supporting film thickness. Solid and dashed curves correspond to air and water ambiences, respectively

Fig. 3.
Fig. 3.

Typical SPR intensity (dashed curves) and phase (solid curves) curves for 25nm and 45nm gold film layer (A) Step-like RI change; (B) Wavelength change

Fig. 4.
Fig. 4.

Schematics of an SPR polarimetry setup for the determination of the zero calibration point

Fig. 5.
Fig. 5.

(A) Typical phase and intensity SPR angular curves; (b) Calculated intensity fringes for several angular positions: (I) before; (II) inside; and (III) after the plasmon resonance.

Fig. 6.
Fig. 6.

Typical images of interference patterns produced in imaging (A) and biosensing (B) geometries

Fig. 7.
Fig. 7.

Typical geometries of variable thickness experiment and corresponding distribution of interference fringes over different areas. The angle of light incidence does not match the phase intersection point to clearly show the phase jump between areas of different thicknesses

Fig. 8.
Fig. 8.

Experimental SPR intensity (dashed) and phase (solid) curves

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

M BW = [ exp ( ) 0 0 1 ] with δ = δ e δ o = 2 π λ L [ n e n 0 ]
M SPR = [ P 0 0 S ] with P = A p exp ( i ϕ p + α ) and S = A s exp ( i ϕ s )
M p = [ cos ( θ ) 2 sin ( θ ) cos ( θ ) sin ( θ ) cos ( θ ) sin ( θ ) 2 ]
I CCD = E ̄ CCD · E CCD where E CCD = M P M SPR M BW E INI

Metrics