Abstract

Four very low birth weight, very premature infants were monitored during a 12° postural elevation using diffuse correlation spectroscopy (DCS) to measure microvascular cerebral blood flow (CBF) and transcranial Doppler ultrasound (TCD) to measure macrovascular blood flow velocity in the middle cerebral artery. DCS data correlated significantly with peak systolic, end diastolic, and mean velocities measured by TCD (pA=0.036, 0.036, 0.047). Moreover, population averaged TCD and DCS data yielded no significant hemodynamic response to this postural change (p>0.05). We thus demonstrate feasibility of DCS in this population, we show correlation between absolute measures of blood flow from DCS and blood flow velocity from TCD, and we do not detect significant changes in CBF associated with a small postural change (12°) in these patients.

© 2009 Optical Society of America

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  1. J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).
  2. M. C. Allen, “Neurodevelopmental outcomes of preterm infants,” Curr. Opin. Neurol. 21(2), 123–128 (2008).
    [CrossRef]
  3. J. M. Perlman, “White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome,” Early Hum. Dev. 53, 99–120 (1998).
    [CrossRef]
  4. A. J. du Plessis and J. J. Volpe, “Perinatal brain injury in the preterm and term newborn,” Curr. Opin. Neurol. 15, 151–7 (2002).
    [CrossRef] [PubMed]
  5. S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).
  6. G. Greisen, “Brain Monitoring in the Neonate-the Rationale,” Clin. Perinatol. 33(3) (2006).
  7. D. H. Evans and W. N. McDicken, Doppler Ultrasound: Physics, Instrumentation, and Signal Processing, 2nd ed. (John Wiley and Sons, Ltd, New York, NY, 2000).
  8. C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
    [CrossRef] [PubMed]
  9. N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
    [CrossRef]
  10. H. A. Kontos, “Validity of cerebral arterial blood flow calculations from velocity measurements,” Stroke 20(1), 1–3 (1989).
    [CrossRef]
  11. M. Drayton and R. Skidmore, “Vasoactivity of the major intracranial arteries in newborn infants,” Arch. Dis. Child 62(3), 236–240 (1987).
    [CrossRef]
  12. M. Y. Anthony, D. H. Evans, and M. I. Levene, “Neonatal cerebral blood flow velocity responses to changes in posture,” Arch. Dis. Child 69(3 Spec No), 304–308 (1993).
    [CrossRef]
  13. A. Yodh and B. Chance, “Spectroscopy and Imaging with Diffusing Light,” Phys. Todaypp. 34–40 (1995).
  14. A. J. Wolfberg and A. J. du Plessis, “Near-infrared spectroscopy in the fetus and neonate,” Clin. Perinatol. 33(3), 707–728 (2006).
    [CrossRef]
  15. A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
    [CrossRef]
  16. G. Maret and P. E. Wolf, “Multiple light scattering from disordered media. The effect of Brownian motion of scatterers,” Z. Naturforsch. B 65(4), 409–413 (1987).
  17. D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
    [CrossRef]
  18. D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
    [CrossRef]
  19. D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
    [CrossRef]
  20. M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
    [CrossRef]
  21. T. Durduran, “Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods.” Ph. D. Thesis, University of Pennsylvania (2004).
  22. C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
    [CrossRef] [PubMed]
  23. J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
    [CrossRef] [PubMed]
  24. T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
    [CrossRef] [PubMed]
  25. T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
    [CrossRef] [PubMed]
  26. G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
    [CrossRef] [PubMed]
  27. J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).
  28. C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
    [CrossRef] [PubMed]
  29. U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).
  30. C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).
  31. F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
    [CrossRef]
  32. G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
    [CrossRef] [PubMed]
  33. J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
    [CrossRef]
  34. T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
    [CrossRef]
  35. C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).
  36. J. P. Finley, R. Hamilton, and M. G. MacKenzie, “Heart rate response to tilting in newborns in quiet and active sleep,” Biol. Neonate 45(1), 1–10 (1984).
  37. H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
    [CrossRef] [PubMed]
  38. B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).
  39. H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
    [CrossRef]
  40. R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
    [CrossRef] [PubMed]
  41. J. Gronlund, J. Jalonen, and I. Valimaki, “Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt,” Early Hum. Dev. 47, 11–18 (1997).
    [CrossRef] [PubMed]
  42. G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
    [CrossRef]
  43. L. Schrod and J. Walter, “Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants,” Biol. Neonate 81(4), 255–259 (2002).
    [CrossRef]
  44. G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).
  45. W. Brown, ed., Dynamic Light Scattering: The Method and Some Applications (Oxford University Press, 1993).
  46. L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
    [CrossRef]
  47. J. Hebden and T. Austin, “Optical tomography of the neonatal brain,” European Radiology 17(11), 2926–2933 (2007).
    [CrossRef]
  48. J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
    [CrossRef]
  49. C. Spearman, “The proof and measurement of association between two things. By C. Spearman, 1904.” Am. J. Psychol. 100(3–4), 441–471 (1987).
    [CrossRef]
  50. F. Wilcoxon, “Individual Comparisons by Ranking Methods”, Biometrics Bulletin 1(6), 80–83 (1945).
    [CrossRef]
  51. R Development Core Team (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org.
  52. Y. Hochberg, “A sharper Bonferroni procedure for multiple tests of significance” Biometrika 75, 800–802 (1988).
    [CrossRef]
  53. S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
    [CrossRef]
  54. J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

2009 (1)

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

2008 (3)

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

M. C. Allen, “Neurodevelopmental outcomes of preterm infants,” Curr. Opin. Neurol. 21(2), 123–128 (2008).
[CrossRef]

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

2007 (4)

J. Hebden and T. Austin, “Optical tomography of the neonatal brain,” European Radiology 17(11), 2926–2933 (2007).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
[CrossRef] [PubMed]

2006 (5)

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

G. Greisen, “Brain Monitoring in the Neonate-the Rationale,” Clin. Perinatol. 33(3) (2006).

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

A. J. Wolfberg and A. J. du Plessis, “Near-infrared spectroscopy in the fetus and neonate,” Clin. Perinatol. 33(3), 707–728 (2006).
[CrossRef]

2005 (4)

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
[CrossRef] [PubMed]

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

2004 (2)

G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[CrossRef] [PubMed]

2003 (1)

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

2002 (5)

N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
[CrossRef]

A. J. du Plessis and J. J. Volpe, “Perinatal brain injury in the preterm and term newborn,” Curr. Opin. Neurol. 15, 151–7 (2002).
[CrossRef] [PubMed]

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

L. Schrod and J. Walter, “Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants,” Biol. Neonate 81(4), 255–259 (2002).
[CrossRef]

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

2001 (2)

G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
[CrossRef]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

1998 (1)

J. M. Perlman, “White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome,” Early Hum. Dev. 53, 99–120 (1998).
[CrossRef]

1997 (3)

D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
[CrossRef]

M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
[CrossRef]

J. Gronlund, J. Jalonen, and I. Valimaki, “Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt,” Early Hum. Dev. 47, 11–18 (1997).
[CrossRef] [PubMed]

1995 (2)

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef]

1993 (1)

M. Y. Anthony, D. H. Evans, and M. I. Levene, “Neonatal cerebral blood flow velocity responses to changes in posture,” Arch. Dis. Child 69(3 Spec No), 304–308 (1993).
[CrossRef]

1991 (2)

B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).

H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
[CrossRef]

1990 (1)

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

1989 (1)

H. A. Kontos, “Validity of cerebral arterial blood flow calculations from velocity measurements,” Stroke 20(1), 1–3 (1989).
[CrossRef]

1988 (3)

D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
[CrossRef]

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Y. Hochberg, “A sharper Bonferroni procedure for multiple tests of significance” Biometrika 75, 800–802 (1988).
[CrossRef]

1987 (3)

C. Spearman, “The proof and measurement of association between two things. By C. Spearman, 1904.” Am. J. Psychol. 100(3–4), 441–471 (1987).
[CrossRef]

G. Maret and P. E. Wolf, “Multiple light scattering from disordered media. The effect of Brownian motion of scatterers,” Z. Naturforsch. B 65(4), 409–413 (1987).

M. Drayton and R. Skidmore, “Vasoactivity of the major intracranial arteries in newborn infants,” Arch. Dis. Child 62(3), 236–240 (1987).
[CrossRef]

1984 (1)

J. P. Finley, R. Hamilton, and M. G. MacKenzie, “Heart rate response to tilting in newborns in quiet and active sleep,” Biol. Neonate 45(1), 1–10 (1984).

1945 (1)

F. Wilcoxon, “Individual Comparisons by Ranking Methods”, Biometrics Bulletin 1(6), 80–83 (1945).
[CrossRef]

Allen, M. C.

M. C. Allen, “Neurodevelopmental outcomes of preterm infants,” Curr. Opin. Neurol. 21(2), 123–128 (2008).
[CrossRef]

Anthony, M. Y.

M. Y. Anthony, D. H. Evans, and M. I. Levene, “Neonatal cerebral blood flow velocity responses to changes in posture,” Arch. Dis. Child 69(3 Spec No), 304–308 (1993).
[CrossRef]

Arridge, S. R.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Arvin, K. L.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Austin, T.

J. Hebden and T. Austin, “Optical tomography of the neonatal brain,” European Radiology 17(11), 2926–2933 (2007).
[CrossRef]

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Back, S. A.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Bherer, L.

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

Boas, D. A.

D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
[CrossRef]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef]

Brown, W.

W. Brown, ed., Dynamic Light Scattering: The Method and Some Applications (Oxford University Press, 1993).

Burnett, M. G.

Busch, T. M.

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Butler, J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Campbell, L. E.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef]

Cerussi, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Chaikin, P. M.

D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
[CrossRef]

Chance, B.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

A. Yodh and B. Chance, “Spectroscopy and Imaging with Diffusing Light,” Phys. Todaypp. 34–40 (1995).

Cheung, C.

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

Choe, R.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
[CrossRef] [PubMed]

Chricton, C. A.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Cope, M.

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Cucchiara, B. L.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

Culver, J. P.

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

Czerniecki, B. J.

Daisuke, F.

De Carolis, M.

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Dellagrammaticas, H. D.

H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
[CrossRef]

Delpy, D. T.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Desjardins, M.

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

Detre, J. A.

Dietsche, G.

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Ding, H. S.

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

Drayton, M.

M. Drayton and R. Skidmore, “Vasoactivity of the major intracranial arteries in newborn infants,” Arch. Dis. Child 62(3), 236–240 (1987).
[CrossRef]

Du, J.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

du Plessis, A. J.

A. J. Wolfberg and A. J. du Plessis, “Near-infrared spectroscopy in the fetus and neonate,” Clin. Perinatol. 33(3), 707–728 (2006).
[CrossRef]

A. J. du Plessis and J. J. Volpe, “Perinatal brain injury in the preterm and term newborn,” Curr. Opin. Neurol. 15, 151–7 (2002).
[CrossRef] [PubMed]

Durduran, T.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

T. Durduran, “Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods.” Ph. D. Thesis, University of Pennsylvania (2004).

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Durkin, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Edlow, B. L.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

Edwards, A. D.

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Edwards, D.

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

Elbert, T.

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Eucker, S.

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Evans, D.

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

Evans, D. H.

M. Y. Anthony, D. H. Evans, and M. I. Levene, “Neonatal cerebral blood flow velocity responses to changes in posture,” Arch. Dis. Child 69(3 Spec No), 304–308 (1993).
[CrossRef]

D. H. Evans and W. N. McDicken, Doppler Ultrasound: Physics, Instrumentation, and Signal Processing, 2nd ed. (John Wiley and Sons, Ltd, New York, NY, 2000).

Evans, N.

N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
[CrossRef]

Everdell, N.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Finley, J. P.

J. P. Finley, R. Hamilton, and M. G. MacKenzie, “Heart rate response to tilting in newborns in quiet and active sleep,” Biol. Neonate 45(1), 1–10 (1984).

Floyd, T. F.

Friess, S.

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Furuya, T.

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

Gagnon, L.

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

Gallini, F.

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Giannantonio, C.

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Gibson, A.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Gisler, T.

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Glatstein, E.

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Greenberg, J. H.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

Greisen, G.

G. Greisen, “Brain Monitoring in the Neonate-the Rationale,” Clin. Perinatol. 33(3) (2006).

Gronlund, J.

J. Gronlund, J. Jalonen, and I. Valimaki, “Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt,” Early Hum. Dev. 47, 11–18 (1997).
[CrossRef] [PubMed]

Hamilton, B. E.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Hamilton, R.

J. P. Finley, R. Hamilton, and M. G. MacKenzie, “Heart rate response to tilting in newborns in quiet and active sleep,” Biol. Neonate 45(1), 1–10 (1984).

Han, B. H.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Hebden, J.

J. Hebden and T. Austin, “Optical tomography of the neonatal brain,” European Radiology 17(11), 2926–2933 (2007).
[CrossRef]

Hebden, J. C.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Heckmeier, M.

M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
[CrossRef]

Hendersonsmart, D.

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

Herbolzheimer, E.

D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
[CrossRef]

Hertzberg, T.

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

Hillman, E. M. C.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Hochberg, Y.

Y. Hochberg, “A sharper Bonferroni procedure for multiple tests of significance” Biometrika 75, 800–802 (1988).
[CrossRef]

Holtzman, D. M.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Hou, X. L.

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

Hsiang, D.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Ichord, R.

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Iftime, D.

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Ijichi, S.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Imai, T.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Isobe, K.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Itoh, S.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Jaillon, F.

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

Jalonen, J.

J. Gronlund, J. Jalonen, and I. Valimaki, “Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt,” Early Hum. Dev. 47, 11–18 (1997).
[CrossRef] [PubMed]

Jeffery, H.

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

Jehanne-Lacasse, J.

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

Kapetanakis, J.

H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
[CrossRef]

Kasner, S. E.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

Kawada, K.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Kelsall, R.

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

Kilger, A.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

Kim, M. N.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

Kirmeyer, S.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Kissler, J.

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

Kluckow, M.

N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
[CrossRef]

Koban, L.

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

Kontos, H. A.

H. A. Kontos, “Validity of cerebral arterial blood flow calculations from velocity measurements,” Stroke 20(1), 1–3 (1989).
[CrossRef]

Kourakis, G.

H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
[CrossRef]

Kusaka, T.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Lagercrantz, H.

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

Lesage, F.

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

Levene, M. I.

M. Y. Anthony, D. H. Evans, and M. I. Levene, “Neonatal cerebral blood flow velocity responses to changes in posture,” Arch. Dis. Child 69(3 Spec No), 304–308 (1993).
[CrossRef]

Li, J.

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Loevner, L.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

Luo, N. L.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Lustig, R.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

MacKenzie, M. G.

J. P. Finley, R. Hamilton, and M. G. MacKenzie, “Heart rate response to tilting in newborns in quiet and active sleep,” Biol. Neonate 45(1), 1–10 (1984).

Maret, G.

M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
[CrossRef]

G. Maret and P. E. Wolf, “Multiple light scattering from disordered media. The effect of Brownian motion of scatterers,” Z. Naturforsch. B 65(4), 409–413 (1987).

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Margulies, S.

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Martin, J. A.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Maynard, R.

M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
[CrossRef]

McDicken, W. N.

D. H. Evans and W. N. McDicken, Doppler Ultrasound: Physics, Instrumentation, and Signal Processing, 2nd ed. (John Wiley and Sons, Ltd, New York, NY, 2000).

Md Yusof, R.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Meek, J. H.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

Mehta, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Menacker, F.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Muller, W.

B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).

Müller, W.

G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).

G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
[CrossRef]

Munson, M. L.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Namba, M.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Ninck, M.

J. Li, M. Ninck, L. Koban, T. Elbert, J. Kissler, and T. Gisler, “Transient functional blood flow change in the human brain measured noninvasively by diffusing-wave spectroscopy.” Opt. Lett. 33(19), 2233–2235 (2008).
[CrossRef]

Nioka, S.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

Nishida, T.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Okada, H.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Okubo, K.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Osborn, D.

N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
[CrossRef]

Panerai, R.

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

Papacci, P.

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Papadimitriou, M.

H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
[CrossRef]

Perlman, J. M.

J. M. Perlman, “White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome,” Early Hum. Dev. 53, 99–120 (1998).
[CrossRef]

Pichler, G.

G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).

G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
[CrossRef]

Pine, D. J.

D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
[CrossRef]

Putt, M. E.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Quon, H.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

Reiterer, F.

B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).

Rennie, J.

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

Reynolds, E. O. R.

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Richardson, C.

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Ritschl, E.

B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).

Rockstroh, B.

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Romagnoli, C.

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Saunders, H. M.

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Schmölzer, G.

G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).

Schrod, L.

L. Schrod and J. Walter, “Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants,” Biol. Neonate 81(4), 255–259 (2002).
[CrossRef]

Sehgal, C. M.

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Shah, N.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Shah, Q.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

Simmons, M.

N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
[CrossRef]

Skidmore, R.

M. Drayton and R. Skidmore, “Vasoactivity of the major intracranial arteries in newborn infants,” Arch. Dis. Child 62(3), 236–240 (1987).
[CrossRef]

Skipetrov, S. E.

M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
[CrossRef]

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

Spearman, C.

C. Spearman, “The proof and measurement of association between two things. By C. Spearman, 1904.” Am. J. Psychol. 100(3–4), 441–471 (1987).
[CrossRef]

Sunar, U.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

Sutton, P. D.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Takahashi, K.

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

Tam, J.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Tchou, J. C.

Tromberg, B. J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

Urlesberger, B.

G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).

G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
[CrossRef]

B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).

Valimaki, I.

J. Gronlund, J. Jalonen, and I. Valimaki, “Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt,” Early Hum. Dev. 47, 11–18 (1997).
[CrossRef] [PubMed]

van Boetzelar, M. C.

G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
[CrossRef]

Ventura, S. J.

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

Volpe, J. J.

A. J. du Plessis and J. J. Volpe, “Perinatal brain injury in the preterm and term newborn,” Curr. Opin. Neurol. 15, 151–7 (2002).
[CrossRef] [PubMed]

Walter, J.

L. Schrod and J. Walter, “Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants,” Biol. Neonate 81(4), 255–259 (2002).
[CrossRef]

Wang, H.

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Wang, J.

Weitz, D. A.

D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
[CrossRef]

Wilcoxon, F.

F. Wilcoxon, “Individual Comparisons by Ranking Methods”, Biometrics Bulletin 1(6), 80–83 (1945).
[CrossRef]

Wilfred, A.

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

Wolf, P. E.

G. Maret and P. E. Wolf, “Multiple light scattering from disordered media. The effect of Brownian motion of scatterers,” Z. Naturforsch. B 65(4), 409–413 (1987).

Wolfberg, A. J.

A. J. Wolfberg and A. J. du Plessis, “Near-infrared spectroscopy in the fetus and neonate,” Clin. Perinatol. 33(3), 707–728 (2006).
[CrossRef]

Wyatt, J. S.

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Xanthoudakis, S.

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

Yodh, A.

A. Yodh and B. Chance, “Spectroscopy and Imaging with Diffusing Light,” Phys. Todaypp. 34–40 (1995).

Yodh, A. G.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[CrossRef] [PubMed]

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
[CrossRef]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef]

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Yu, G.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
[CrossRef] [PubMed]

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[CrossRef] [PubMed]

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Yu, G. Q.

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Zecca, E.

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Zhang, J.

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

Zhao, J.

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

Zhou, C.

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
[CrossRef] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

T. Durduran, R. Choe, G. Yu, C. Zhou, J. C. Tchou, B. J. Czerniecki, and A. G. Yodh, “Diffuse optical measurement of blood flow in breast tumors,” Opt. Lett. 30, 2915–2917 (2005).
[CrossRef] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[CrossRef] [PubMed]

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

Zhou, C. L.

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

Acta Paediatr. (1)

G. Pichler, B. Urlesberger, G. Schmölzer, and W. Müller, “Effect of tilting on cerebral haemodynamics in preterm infants with periventricular leucencephalomalacia,” Acta Paediatr. 93(1), 70–75 (2004).

Acta Paediatr. Scand. (1)

H. Lagercrantz, D. Edwards, D. Hendersonsmart, T. Hertzberg, and H. Jeffery, “Autonomic reflexes in preterm infants,” Acta Paediatr. Scand. 79, 721–728 (1990).
[CrossRef] [PubMed]

Am. J. Psychol. (1)

C. Spearman, “The proof and measurement of association between two things. By C. Spearman, 1904.” Am. J. Psychol. 100(3–4), 441–471 (1987).
[CrossRef]

Arch. Dis. Child (2)

M. Drayton and R. Skidmore, “Vasoactivity of the major intracranial arteries in newborn infants,” Arch. Dis. Child 62(3), 236–240 (1987).
[CrossRef]

M. Y. Anthony, D. H. Evans, and M. I. Levene, “Neonatal cerebral blood flow velocity responses to changes in posture,” Arch. Dis. Child 69(3 Spec No), 304–308 (1993).
[CrossRef]

Arch. Dis. Child Fetal Neonatal Ed. (1)

N. Evans, M. Kluckow, M. Simmons, and D. Osborn, “Which to measure, systemic or organ blood flow? Middle cerebral artery and superior vena cava flow in very preterm infants,” Arch. Dis. Child Fetal Neonatal Ed. 87(3), F181–184 (2002).
[CrossRef]

Arch. Dis. Child. (1)

H. D. Dellagrammaticas, J. Kapetanakis, M. Papadimitriou, and G. Kourakis, “Effect of body tilting on physiological functions in stable very low birthweight neonates,” Arch. Dis. Child. 66(4), 429–432 (1991).
[CrossRef]

Biol. Neonate (3)

J. P. Finley, R. Hamilton, and M. G. MacKenzie, “Heart rate response to tilting in newborns in quiet and active sleep,” Biol. Neonate 45(1), 1–10 (1984).

G. Pichler, M. C. van Boetzelar, W. Müller, and B. Urlesberger“Effect of tilting on cerebral hemodynamics in preterm and term infants,” Biol. Neonate 80(3), 179–185 (2001).
[CrossRef]

L. Schrod and J. Walter, “Effect of head-up body tilt position on autonomic function and cerebral oxygenation in preterm infants,” Biol. Neonate 81(4), 255–259 (2002).
[CrossRef]

Biometrics Bulletin (1)

F. Wilcoxon, “Individual Comparisons by Ranking Methods”, Biometrics Bulletin 1(6), 80–83 (1945).
[CrossRef]

Biometrika (1)

Y. Hochberg, “A sharper Bonferroni procedure for multiple tests of significance” Biometrika 75, 800–802 (1988).
[CrossRef]

Childs Nervous System (1)

B. Urlesberger, W. Muller, E. Ritschl, and F. Reiterer, “The influence of head position on the intracranial-pressure in preterm infants with posthemorrhagic hydrocephalus,” Childs Nervous System 7(2), 85–87 (1991).

Clin. Cancer Res. (1)

G. Q. Yu, T. Durduran, C. Zhou, H. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11, 3543–3552 (2005).
[CrossRef] [PubMed]

Clin. Perinatol. (2)

A. J. Wolfberg and A. J. du Plessis, “Near-infrared spectroscopy in the fetus and neonate,” Clin. Perinatol. 33(3), 707–728 (2006).
[CrossRef]

G. Greisen, “Brain Monitoring in the Neonate-the Rationale,” Clin. Perinatol. 33(3) (2006).

Curr. Opin. Neurol. (2)

M. C. Allen, “Neurodevelopmental outcomes of preterm infants,” Curr. Opin. Neurol. 21(2), 123–128 (2008).
[CrossRef]

A. J. du Plessis and J. J. Volpe, “Perinatal brain injury in the preterm and term newborn,” Curr. Opin. Neurol. 15, 151–7 (2002).
[CrossRef] [PubMed]

Early Hum. Dev. (2)

J. M. Perlman, “White matter injury in the preterm infant: an important determination of abnormal neurodevelopment outcome,” Early Hum. Dev. 53, 99–120 (1998).
[CrossRef]

J. Gronlund, J. Jalonen, and I. Valimaki, “Transcephalic electrical impedance provides a means for quantifying pulsatile cerebral blood volume changes following head-up tilt,” Early Hum. Dev. 47, 11–18 (1997).
[CrossRef] [PubMed]

European Radiology (1)

J. Hebden and T. Austin, “Optical tomography of the neonatal brain,” European Radiology 17(11), 2926–2933 (2007).
[CrossRef]

J. Biomed. Opt. (3)

J. Zhao, H. S. Ding, X. L. Hou, C. L. Zhou, and B. Chance, “In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy,” J. Biomed. Opt. 10(2), 024028-1–024028-7 (2005).

U. Sunar, H. Quon, T. Durduran, J. Zhang, J. Du, C. Zhou, G. Yu, R. Choe, A. Kilger, R. Lustig, L. Loevner, S. Nioka, B. Chance, and A. G. Yodh, “Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study,” J. Biomed. Opt. 11(6), 064,021-1-064,021-13 (2006).

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051,903 (2007).

J. Cereb. Blood Flow Metab. (1)

J. P. Culver, T. Durduran, T. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).
[CrossRef] [PubMed]

J. Neurosci. (1)

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman, “Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia,” J. Neurosci. 22(2), 455–463 (2002).

J. Opt. Soc. Am. A (2)

D. A. Boas and A. G. Yodh, “Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation,” J. Opt. Soc. Am. A 14(1), 192–215 (1997).
[CrossRef]

M. Heckmeier, S. E. Skipetrov, G. Maret, and R. Maynard, “Imaging of dynamic heterogeneities in multiple-scattering media,” J. Opt. Soc. Am. A 14(1), 185–191 (1997).
[CrossRef]

Opt. Express (5)

C. Zhou, G. Yu, F. Daisuke, J. H. Greenberg, A. G. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14, 1125–1144 (2006).
[CrossRef] [PubMed]

F. Jaillon, J. Li, G. Dietsche, T. Elbert, and T. Gisler, “Activity of the human visual cortex measured noninvasively by diffusing-wave spectroscopy,” Opt. Express 15(11), 6643–6650 (2007).
[CrossRef]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15, 1064–1075 (2007).
[CrossRef] [PubMed]

T. Durduran, C. Zhou, B. L. Edlow, G. Yu, R. Choe, M. N. Kim, B. L. Cucchiara, M. E. Putt, Q. Shah, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients,” Opt. Express 17(5), 3884–3902 (2009).
[CrossRef]

L. Gagnon, M. Desjardins, J. Jehanne-Lacasse, L. Bherer, and F. Lesage, “Investigation of diffuse correlation spectroscopy in multi-layered media including the human head,” Opt. Express 16(20), 15514–15530 (2008).
[CrossRef]

Opt. Lett. (3)

Pediatr. Res. (1)

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, “Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy,” Pediatr. Res. 58(3), 568–573 (2005).
[CrossRef]

Phys. Med. Biol. (2)

J. C. Hebden, A. Gibson, R. Md Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, “Three-dimensional optical tomography of the premature infant brain,” Phys. Med. Biol. 47(23), 4155–4166 (2002).
[CrossRef]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[CrossRef] [PubMed]

Phys. Rev. Lett. (2)

D. J. Pine, D. A. Weitz, P. M. Chaikin, and E. Herbolzheimer, “Diffusing wave spectroscopy,” Phys. Rev. Lett. 60(12), 1134–1137 (1988).
[CrossRef]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[CrossRef]

Stroke (2)

H. A. Kontos, “Validity of cerebral arterial blood flow calculations from velocity measurements,” Stroke 20(1), 1–3 (1989).
[CrossRef]

R. Panerai, A. Wilfred, R. Kelsall, J. Rennie, and D. Evans, “Cerebral autoregulation dynamics in premature Newborns,” Stroke 26, 74–80 (1995).
[CrossRef] [PubMed]

The Lancet (1)

A. D. Edwards, C. Richardson, M. Cope, J. S. Wyatt, D. T. Delpy, and E. O. R. Reynolds, “Cotside measurement of cerebral blood-flow in ill newborn infants by near-infrared spectroscopy,” The Lancet 2(8614), 770–771 (1988).
[CrossRef]

Ultrasound Med. Biol. (1)

C. Romagnoli, C. Giannantonio, M. De Carolis, F. Gallini, E. Zecca, and P. Papacci, “Neonatal color Doppler US study: Normal values of cerebral blood flow velocities in preterm infants in the first month of life,” Ultrasound Med. Biol. 32, 321–331 (2006).
[CrossRef] [PubMed]

Z. Naturforsch. B (1)

G. Maret and P. E. Wolf, “Multiple light scattering from disordered media. The effect of Brownian motion of scatterers,” Z. Naturforsch. B 65(4), 409–413 (1987).

Other (8)

A. Yodh and B. Chance, “Spectroscopy and Imaging with Diffusing Light,” Phys. Todaypp. 34–40 (1995).

J. A. Martin, B. E. Hamilton, P. D. Sutton, S. J. Ventura, F. Menacker, S. Kirmeyer, and M. L. Munson, “Births: Final Data for 2005,” Tech. Rep. 6, National Center for Health Statistics (2007).

D. H. Evans and W. N. McDicken, Doppler Ultrasound: Physics, Instrumentation, and Signal Processing, 2nd ed. (John Wiley and Sons, Ltd, New York, NY, 2000).

J. Li, G. Dietsche, D. Iftime, S. E. Skipetrov, G. Maret, T. Elbert, B. Rockstroh, and T. Gisler, “Noninvasive detection of functional brain activity with near-infrared diffusing-wave spectroscopy,” J. Biomed. Opt.10(4) (2005).

T. Durduran, “Non-invasive measurements of tissue hemodynamics with hybrid diffuse optical methods.” Ph. D. Thesis, University of Pennsylvania (2004).

C. Zhou, S. Eucker, T. Durduran, G. Yu, S. Friess, R. Ichord, S. Margulies, and A. G. Yodh. “Diffuse optical monitoring of hemodynamics in piglet brain with head trauma injury”. J. Biomed. Opt. (to be published).

W. Brown, ed., Dynamic Light Scattering: The Method and Some Applications (Oxford University Press, 1993).

R Development Core Team (2008). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org.

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Figures (4)

Fig. 1.
Fig. 1.

The fibers used to deliver and detect light are secured to the infant’s forehead using a soft black pad. The pad is held in place with a mask that wraps around the head.

Fig. 2.
Fig. 2.

Diagram of the protocol used for DCS (top) and TCD (bottom) measurements. DCS and TCD measurements were NOT taken at the same time. For DCS, data was taken continuously (8 data points per minute) for 5 minutes at each head of bed angle adjustment. The head of bed 0° to 12° elevation was repeated 3 times, making the total study time 35 minutes. By comparison, for TCD only 3 data points were taken at each HOB angle before the bed was repositioned, and the HOB angle was only elevated twice.

Fig. 3.
Fig. 3.

(Left) Typical normalized intensity autocorrelation curve derived directly from the correlator board as a function of time, τ (data measured on the forehead of a preterm infant). (Right) The corresponding normalized electric field autocorrelation curve, g 1(r,τ), calculated using the Siegert relation with a fitted value for β. The solid line shows the raw data. The dotted line is the best fit curve to a Brownian motion model, which we use to derive the blood flow index (BFI).

Fig. 4.
Fig. 4.

(Left) Correlation between population averaged mean TCD PSV taken at the initial (PSV¯) and population averaged mean DCS BFI also taken at the initial (BFI¯) . (Center) Correlation between population averaged mean TCD MV taken at the initial (MV¯) and DCS BFI¯ . (Right) Correlation between population averaged mean TCD EDV taken at first HOB=0° event (EDV¯) and DCS BFI¯ . The solid line in each plot shows the best linear fit between the two variables. Both Pearson’s and Spearman’s correlation coefficients (R 2 and rs, respectively) were calculated. The R 2 Pearson values are displayed for each plot.

Tables (1)

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Table 1. Median and range of average daily hemodynamic response to postural elevation (*pA =0.48, pA =0.91).

Equations (1)

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G1(r,τ)=3μsS04π(eκ(τ)r1r1eκ(τ)r2r2) .

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