Abstract

Specific detection of proteins is demonstrated using planar photonic crystal waveguides. Using immobilized biotin as probe, streptavidin was captured, causing the waveguide mode cut-off to red-shift. The device was shown to detect a 2.5 nm streptavidin film with a 0.86 nm cut-off red-shift. An improved photonic crystal waveguide sensor design is also described and shown to have a 40% improved bulk refractive index response.

© 2008 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).
  2. J. H. Growdon, "Biomarkers of alzheimer disease," Arch. Neurol. 56, 281-283 (1999).
    [CrossRef] [PubMed]
  3. P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
    [PubMed]
  4. J. B. Jensen, P. E. Hoiby, G. Emiliyanov, O. Bang, L. Pedersen, and A. Bjarklev, "Selective detection of antibodies in microstructured polymer optical fibers," Opt. Express 13, 5883-5889 (2005).
    [CrossRef] [PubMed]
  5. L. Rindorf, J. B. Jensen, M. Dufva, L. Pedersen, P. Hoiby, and O. Bang, "Photonic crystal fiber long-period gratings for biochemical sensing," Opt. Express 14, 8224-8231 (2006).
    [CrossRef] [PubMed]
  6. L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
    [CrossRef]
  7. O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
    [CrossRef] [PubMed]
  8. M. Lee and P. M. Fauchet, "Two-dimensional silicon photonic crystal based biosensing platform for protein detection," Opt. Express 15, 4530-4535 (2007).
    [CrossRef] [PubMed]
  9. L. W. Mirkarimi, S. Zlatanovic, S. Sigalas, M. A. Bynum, K. Robotti, E. Chow, and A. Grot, "Toward single molecule detection with photonic crystal microcavity biosensors," Digest of the LEOS Summer Topical Meetings (IEEE 2006) pp. 29-30.
    [CrossRef]
  10. M. Lee and P. Fauchet, "Two-dimensional Si photonic crystal microcavity for single particle detection," Proceedings of the 4th IEEE International Conference Group IV Photonics (IEEE 2007) pp. 1-3.
    [PubMed]
  11. J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
    [CrossRef]
  12. R. Ferrini, J. Martz, L. Zuppiroli, B. Wild, V. Zabelin, L. Dunbar, R. Houdre, M. Mulot, and S. Anand, "Planar photonic crystals infiltrated with liquid crystals: optical characterization of molecule orientation," Opt. Lett. 31, 1238- 1240 (2006).
    [CrossRef] [PubMed]
  13. N. Skivesen, A. Ttu, M. Kristensen, J. Kjems, L. Frandsen, and P. Borel, "Photonic crystal waveguide biosensor," Opt. Express 15, 3169-3176 (2007).
    [CrossRef] [PubMed]
  14. Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
    [CrossRef]
  15. Y. Tanaka, T. Asano, R. Hatsuta, and S. Noda, "Analysis of a line-defect waveguide on a silicon-on-insulator two-dimensional photonic crystal slab," J. Lightwave Technol. 22, 2787-2792 (2004).
    [CrossRef]
  16. R. G. Heideman and P. V. Lambeck, "Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach-Zehnder interferometer system," Sens. Actuators. B 61, 100-127 (1999).
  17. M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
    [CrossRef]
  18. L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
    [CrossRef]

2007

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

M. Lee and P. M. Fauchet, "Two-dimensional silicon photonic crystal based biosensing platform for protein detection," Opt. Express 15, 4530-4535 (2007).
[CrossRef] [PubMed]

N. Skivesen, A. Ttu, M. Kristensen, J. Kjems, L. Frandsen, and P. Borel, "Photonic crystal waveguide biosensor," Opt. Express 15, 3169-3176 (2007).
[CrossRef] [PubMed]

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

2006

2005

2004

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Y. Tanaka, T. Asano, R. Hatsuta, and S. Noda, "Analysis of a line-defect waveguide on a silicon-on-insulator two-dimensional photonic crystal slab," J. Lightwave Technol. 22, 2787-2792 (2004).
[CrossRef]

2003

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
[CrossRef]

2002

P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
[PubMed]

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

1999

R. G. Heideman and P. V. Lambeck, "Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach-Zehnder interferometer system," Sens. Actuators. B 61, 100-127 (1999).

J. H. Growdon, "Biomarkers of alzheimer disease," Arch. Neurol. 56, 281-283 (1999).
[CrossRef] [PubMed]

Abdelghani, A.

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Akahane, Y.

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

Anand, S.

Asano, T.

Y. Tanaka, T. Asano, R. Hatsuta, and S. Noda, "Analysis of a line-defect waveguide on a silicon-on-insulator two-dimensional photonic crystal slab," J. Lightwave Technol. 22, 2787-2792 (2004).
[CrossRef]

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

Bang, O.

Bhattacharya, P.

J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
[CrossRef]

Bjarklev, A.

Borel, P.

Chen, R. T.

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

Chen, X. N.

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

D???Auria, S.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Dufva, M.

Dunbar, L.

Emiliyanov, G.

Fan, S. H.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Fauchet, P. M.

Ferrini, R.

Frandsen, L.

Growdon, J. H.

J. H. Growdon, "Biomarkers of alzheimer disease," Arch. Neurol. 56, 281-283 (1999).
[CrossRef] [PubMed]

Gu, L. L.

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

Hatsuta, R.

Heideman, R. G.

R. G. Heideman and P. V. Lambeck, "Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach-Zehnder interferometer system," Sens. Actuators. B 61, 100-127 (1999).

Hoiby, P.

Hoiby, P. E.

Hortobagyi, G.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Houdre, R.

Ibanescu, M.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Ippen, E.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Jaffrezic-Renault, N.

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Jensen, J. B.

Jiang, W.

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

Joannopoulos, J. D.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Johnson, S. G.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Kashala, O.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Kjems, J.

Kristensen, M.

Lambeck, P. V.

R. G. Heideman and P. V. Lambeck, "Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach-Zehnder interferometer system," Sens. Actuators. B 61, 100-127 (1999).

Lee, M.

Linette, G. P.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Martelet, C.

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Martz, J.

Meskini, O.

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Mgaieth, R.

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Moretti, L.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Mulot, M.

Noda, S.

Y. Tanaka, T. Asano, R. Hatsuta, and S. Noda, "Analysis of a line-defect waveguide on a silicon-on-insulator two-dimensional photonic crystal slab," J. Lightwave Technol. 22, 2787-2792 (2004).
[CrossRef]

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

Pedersen, L.

Pusztai, L.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Rendina, I.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Rindorf, L.

Ross, J. S.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Rossi, M.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Rotiroti, L.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Sabarinathan, J.

J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
[CrossRef]

Schenkein, D. P.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Scognamiglio, V.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Skivesen, N.

Soljacic, M.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Song, B.

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

Srinivas, P. R.

P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
[PubMed]

Srivastava, S.

P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
[PubMed]

Stec, J.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Stefano, L.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Symmans, W. F.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Tanaka, Y.

Y. Tanaka, T. Asano, R. Hatsuta, and S. Noda, "Analysis of a line-defect waveguide on a silicon-on-insulator two-dimensional photonic crystal slab," J. Lightwave Technol. 22, 2787-2792 (2004).
[CrossRef]

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

Tlili, A.

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Topolancik, J.

J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
[CrossRef]

Ttu, A.

Verma, M.

P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
[PubMed]

Wang, L.

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

Wild, B.

Yu, P. C.

J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
[CrossRef]

Zabelin, V.

Zhao, Y. M.

P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
[PubMed]

Zuppiroli, L.

Adv. Anat. Pathol.

J. S. Ross, D. P. Schenkein, O. Kashala, G. P. Linette, J. Stec, W. F. Symmans, L. Pusztai, and G. Hortobagyi, "Pharmacogenomics," Adv. Anat. Pathol. 11, 211-220 (2004).

Appl. Phys. Lett.

J. Topolancik, P. Bhattacharya, J. Sabarinathan, and P. C. Yu, "Fluid detection with photonic crystal-based multichannel waveguides," Appl. Phys. Lett. 82, 1143-1145 (2003).
[CrossRef]

Y. Tanaka, T. Asano, Y. Akahane, B. Song, and S. Noda, "Theoretical investigation of a two-dimensional photonic crystal slab with truncated cone air holes," Appl. Phys. Lett. 82, 1661-1663 (2003).
[CrossRef]

L. L. Gu, W. Jiang, X. N. Chen, L. Wang, and R. T. Chen, "High speed silicon photonic crystal waveguide modulator for low voltage operation," Appl. Phys. Lett. 90, 071105 (2007).
[CrossRef]

Arch. Neurol.

J. H. Growdon, "Biomarkers of alzheimer disease," Arch. Neurol. 56, 281-283 (1999).
[CrossRef] [PubMed]

Biosens. Bioelectron.

L. Stefano, L. Rotiroti, I. Rendina, L. Moretti, V. Scognamiglio, M. Rossi, and S. D???Auria, "Porous silicon-based optical microsensor for the detection of l-glutamine," Biosens. Bioelectron. 21, 1664-1667 (2006).
[CrossRef]

Clin. Chem.

P. R. Srinivas, M. Verma, Y. M. Zhao, and S. Srivastava, "Proteomics for cancer biomarker discovery," Clin. Chem. 48, 1160-1169 (2002).
[PubMed]

J. Lightwave Technol.

J. Opt. Soc. Am.

M. Soljacic, S. G. Johnson, S. H. Fan, M. Ibanescu, E. Ippen, and J. D. Joannopoulos, "Photonic crystal enhancement of nonlinear phase sensitivity," J. Opt. Soc. Am. 19, 2052-2059 (2002).
[CrossRef]

Opt. Express

Opt. Lett.

Sens. Actuators. B

R. G. Heideman and P. V. Lambeck, "Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach-Zehnder interferometer system," Sens. Actuators. B 61, 100-127 (1999).

Talanta

O. Meskini, A. Abdelghani, A. Tlili, R. Mgaieth, N. Jaffrezic-Renault, and C. Martelet, "Porous silicon as functionalized material for immunosensor application," Talanta 71, 1430-1433 (2007).
[CrossRef] [PubMed]

Other

L. W. Mirkarimi, S. Zlatanovic, S. Sigalas, M. A. Bynum, K. Robotti, E. Chow, and A. Grot, "Toward single molecule detection with photonic crystal microcavity biosensors," Digest of the LEOS Summer Topical Meetings (IEEE 2006) pp. 29-30.
[CrossRef]

M. Lee and P. Fauchet, "Two-dimensional Si photonic crystal microcavity for single particle detection," Proceedings of the 4th IEEE International Conference Group IV Photonics (IEEE 2007) pp. 1-3.
[PubMed]

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (10)

Fig. 1.
Fig. 1.

Band diagram for a two-dimensional hexagonal lattice silicon W1 photonic crystal waveguide projected in the propagation direction, simulated by the plane-wave expansion technique. Two waveguide modes are visible. As indicated by the lightly-shaded region, at lower frequency the waveguide is effectively single-moded before reaching a cut-off.

Fig. 2.
Fig. 2.

A single sensing element composed of a 24Λ long W1 photonic crystal waveguide coupled to strip waveguides which have been tapered to 450 nm at the interface.

Fig. 3.
Fig. 3.

Optical coupling apparatus for measurement of waveguide transmission spectra.

Fig. 4.
Fig. 4.

Tapered & lensed fiber coupling to 2 µm strip waveguide at the chip edge (left). The strip waveguide continues to the PCW, narrowing to a terminal width of 450 nm at the interface (right).

Fig. 5.
Fig. 5.

Transmission response of a 2D silicon photonic crystal waveguide for air (solid) and water (dashed) infiltrated holes, simulated by FDTD. There is a significant red-shift associated with the infiltration of a higher refractive index material.

Fig. 6.
Fig. 6.

The surface of a silicon PCW sensor. A bioreceptor, biotin, is bound to the silicon surface with an MPTMS layer. If present streptavidin proteins will bind to the biotin immobilized on the sensor surface.

Fig. 7.
Fig. 7.

Observed mode cut-off under ambient air condition (dashed) and under a homogenous de-ionized water layer (solid). The mode cut-off red-shifts in the presence of a high refractive index cover layer. Point A is chosen as a reference.

Fig. 8.
Fig. 8.

Photonic crystal waveguide mode cut-off following biotin attachment (dashed) and following streptavidin capture (solid). The mode cut-off red-shifts by 0.86 nm.

Fig. 9.
Fig. 9.

Modified photonic crystal waveguide sensor for increased sensitivity. In this case, a line defect is created by shrinking a row of holes rather than removing them.

Fig. 10.
Fig. 10.

Response of a modified photonic crystal waveguide as in seen in Fig. 9. Observed mode cut-off under ambient air condition (dashed) and under a homogenous de-ionized water layer (solid). As before, the mode cut-off red-shifts in the presence of a high refractive index cover layer.

Metrics