Abstract

Polarization sensitive optical coherence tomography (PS-OCT) provides a cross-sectional image of birefringence in biological samples that is complementary in many applications to the standard reflectance-based image. Recent ex vivo studies have demonstrated that birefringence mapping enables the characterization of collagen and smooth muscle concentration and distribution in vascular tissues. Instruments capable of applying these measurements percutaneously in vivo may provide new insights into coronary atherosclerosis and acute myocardial infarction. We have developed a polarization sensitive optical frequency domain imaging (PS-OFDI) system that enables high-speed intravascular birefringence imaging through a fiber-optic catheter. The novel design of this system utilizes frequency multiplexing to simultaneously measure reflectance of two incident polarization states, overcoming concerns regarding temporal variations of the catheter fiber birefringence and spatial variations in the birefringence of the sample. We demonstrate circular cross-sectional birefringence imaging of a human coronary artery ex vivo through a flexible fiber-optic catheter with an A-line rate of 62 kHz and a ranging depth of 6.2 mm.

© 2008 Optical Society of America

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  8. T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
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  11. D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
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  12. S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
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    [CrossRef]
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    [CrossRef] [PubMed]
  16. M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
    [CrossRef] [PubMed]
  17. B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
    [CrossRef] [PubMed]
  18. S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, and B.E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003).
    [CrossRef] [PubMed]
  19. S.A. Kingsley and D.E.N. Davies, "OFDR diagnostics or fibre and integrated-optic systems," Electron. Lett. 21, 434-435 (1985).
    [CrossRef]
  20. S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
    [CrossRef] [PubMed]
  21. J. Zhang, W. Jung, J.S. Nelson, and Z. Chen, "Full range polarization-sensitive Fourier domain optical coherence tomography," Opt. Express 12, 6033-6039 (2004).
    [CrossRef] [PubMed]
  22. S.H. Yun, G.J. Tearney, J.F. de Boer, and B.E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004).
    [CrossRef] [PubMed]
  23. S.H. Yun, C. Boudoux, G.J. Tearney, and B.E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Optics Letters 28, 1981-1983 (2003).
    [CrossRef] [PubMed]
  24. W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
    [CrossRef] [PubMed]
  25. W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
    [CrossRef]
  26. B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," J. Biomed. Opt. 12, 020501-020503 (2007).
    [CrossRef] [PubMed]
  27. I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
    [CrossRef] [PubMed]
  28. I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
    [CrossRef] [PubMed]
  29. H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
    [CrossRef] [PubMed]
  30. G.J. Tearney, I.K. Jang, and B.E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11(2), 021002 (2006).
    [CrossRef] [PubMed]
  31. R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
    [CrossRef]

2007 (2)

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," J. Biomed. Opt. 12, 020501-020503 (2007).
[CrossRef] [PubMed]

2006 (3)

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

G.J. Tearney, I.K. Jang, and B.E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

2005 (5)

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
[CrossRef] [PubMed]

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

2004 (6)

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, and B.E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004).
[CrossRef] [PubMed]

J. Zhang, W. Jung, J.S. Nelson, and Z. Chen, "Full range polarization-sensitive Fourier domain optical coherence tomography," Opt. Express 12, 6033-6039 (2004).
[CrossRef] [PubMed]

2003 (3)

2002 (5)

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).
[CrossRef]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

2001 (1)

B.H. Park, C. Saxer, S.M. Srinivas, J.S. Nelson, and J.F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001).
[CrossRef] [PubMed]

2000 (2)

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

C.E. Saxer, J.F. de Boer, B.H. Park, Y.H. Zhao, Z.P. Chen, and J.S. Nelson, "High-speed fiber-based polarization-sensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25, 1355-1357 (2000).
[CrossRef]

1998 (1)

1997 (1)

1992 (1)

1985 (1)

S.A. Kingsley and D.E.N. Davies, "OFDR diagnostics or fibre and integrated-optic systems," Electron. Lett. 21, 434-435 (1985).
[CrossRef]

Aretz, H.T.

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Boudoux, C.

S.H. Yun, C. Boudoux, G.J. Tearney, and B.E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Optics Letters 28, 1981-1983 (2003).
[CrossRef] [PubMed]

Bouma, B.E.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," J. Biomed. Opt. 12, 020501-020503 (2007).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

G.J. Tearney, I.K. Jang, and B.E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, and B.E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, and B.E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003).
[CrossRef] [PubMed]

S.H. Yun, C. Boudoux, G.J. Tearney, and B.E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Optics Letters 28, 1981-1983 (2003).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Breunig, T.M.

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

Burke, A.P.

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

Cense, B.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004).
[CrossRef] [PubMed]

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, J.F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11, 782-793 (2003).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).
[CrossRef]

Chan, R.C.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

Chen, T.C.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

Chen, Z.

Chen, Z.P.

Choi, K.B.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Colston, B.W.

Da Silva, L.B.

Davies, D.E.N.

S.A. Kingsley and D.E.N. Davies, "OFDR diagnostics or fibre and integrated-optic systems," Electron. Lett. 21, 434-435 (1985).
[CrossRef]

de Boer, J.F.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, and B.E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, and B.E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, J.F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11, 782-793 (2003).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).
[CrossRef]

B.H. Park, C. Saxer, S.M. Srinivas, J.S. Nelson, and J.F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001).
[CrossRef] [PubMed]

C.E. Saxer, J.F. de Boer, B.H. Park, Y.H. Zhao, Z.P. Chen, and J.S. Nelson, "High-speed fiber-based polarization-sensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25, 1355-1357 (2000).
[CrossRef]

J.F. de Boer, T. E. Milner, M.J.C. van Gemert, and J.S. Nelson, "Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography," Opt. Lett. 22, 934-936 (1997).
[CrossRef] [PubMed]

Desjardins, A.E.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

Evans, J.A.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

Everett, M.J.

Farb, A.

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

Featherstone, J.D.B.

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

Fried, D.

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

Fujimoto, J.G.

Halpern, E.F.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Hee, M.R.

Houser, S.

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

Houser, S.L.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Huang, D.

Iftimia, N.

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, and B.E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003).
[CrossRef] [PubMed]

Jang, I.K.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

G.J. Tearney, I.K. Jang, and B.E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Jung, W.

Kang, D.H.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Kauffman, C.R.

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Kingsley, S.A.

S.A. Kingsley and D.E.N. Davies, "OFDR diagnostics or fibre and integrated-optic systems," Electron. Lett. 21, 434-435 (1985).
[CrossRef]

Kolodgie, F.D.

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

Le, C.

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

MacNeill, B.

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

Milner, T. E.

Moselewski, F.

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

Mujat, M.

Nadkarni, S.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

Nassif, N.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

Nassif, N.A.

Neel, V.

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

Nelson, J.S.

Nishioka, N.S.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

Oh, W.Y.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
[CrossRef] [PubMed]

Park, B.H.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, J.F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11, 782-793 (2003).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).
[CrossRef]

B.H. Park, C. Saxer, S.M. Srinivas, J.S. Nelson, and J.F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001).
[CrossRef] [PubMed]

C.E. Saxer, J.F. de Boer, B.H. Park, Y.H. Zhao, Z.P. Chen, and J.S. Nelson, "High-speed fiber-based polarization-sensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25, 1355-1357 (2000).
[CrossRef]

Park, S.J.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Park, S.W.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Pierce, M.C.

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, J.F. de Boer, "Real-time multi-functional optical coherence tomography," Opt. Express 11, 782-793 (2003).
[CrossRef] [PubMed]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).
[CrossRef]

Pomerantsev, E.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Saxer, C.

B.H. Park, C. Saxer, S.M. Srinivas, J.S. Nelson, and J.F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001).
[CrossRef] [PubMed]

Saxer, C.E.

Schlendorf, K.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Schlendorf, K.H.

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Schoenenberger, K.

Schwartz, S.M.

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

Seung, K.B.

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Shafi, S.

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

Sheridan, R.L.

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

Shishkov, M.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

Srinivas, S.M.

B.H. Park, C. Saxer, S.M. Srinivas, J.S. Nelson, and J.F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001).
[CrossRef] [PubMed]

Strasswimmer, J.

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

Suter, M J.

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

Swanson, E.A.

Takano, M.

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

Tearney, G.J.

B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," J. Biomed. Opt. 12, 020501-020503 (2007).
[CrossRef] [PubMed]

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

G.J. Tearney, I.K. Jang, and B.E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

M.C. Pierce, M. Shishkov, B.H. Park, N.A. Nassif, B.E. Bouma, G.J. Tearney, and J.F. de Boer, "Effects of sample arm motion in endoscopic polarization-sensitive optical coherence tomography," Opt. Express 13, 5739-5749 (2005).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, and B.E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, and B.E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003).
[CrossRef] [PubMed]

S.H. Yun, C. Boudoux, G.J. Tearney, and B.E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Optics Letters 28, 1981-1983 (2003).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Vakoc, B.J.

B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," J. Biomed. Opt. 12, 020501-020503 (2007).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

van Gemert, M.J.C.

Virmani, R.

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

White, B.R.

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

Xie, J.

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

Yabushita, H.

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Yun, S.H.

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, S.H. Yun, M. Mujat, G.J. Tearney, B.E. Bouma, and J.F. de Boer, "Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 μm," Opt. Express 13, 3931-3944 (2005).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, and B.E. Bouma, "Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting," Opt. Express 12, 4822-4828 (2004).
[CrossRef] [PubMed]

S.H. Yun, G.J. Tearney, J.F. de Boer, N. Iftimia, and B.E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003).
[CrossRef] [PubMed]

S.H. Yun, C. Boudoux, G.J. Tearney, and B.E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Optics Letters 28, 1981-1983 (2003).
[CrossRef] [PubMed]

Zhang, J.

Zhao, Y.H.

Appl. Phys. Lett. (1)

W.Y. Oh, S.H. Yun, B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, 103902-103904 (2006).
[CrossRef]

Archives of Ophthalmology (1)

T.C. Chen, B. Cense, M.C. Pierce, N. Nassif, B.H. Park, S.H. Yun, B.R. White, B.E. Bouma, G.J. Tearney, J.F. de Boer, "Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging," Archives of Ophthalmology,"  123, 1715-1720 (2005).
[CrossRef] [PubMed]

Arterioscler. Thromb. Vasc. Biol. (1)

R. Virmani, F.D. Kolodgie, A.P. Burke, A. Farb, and S.M. Schwartz, "Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions," Arterioscler. Thromb. Vasc. Biol. 2000;20, 1262-1275 (2000).
[CrossRef]

Burns (1)

M.C. Pierce, R.L. Sheridan, B.H. Park, B. Cense, and J.F. de Boer, "Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography," Burns 30, 511-517, (2004).
[CrossRef] [PubMed]

Circulation (2)

I.K. Jang, G.J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftimia, M. Shishkov, S. Houser, H.T. Aretz, E.F. Halpern, and B.E. Bouma, "In vivo characterization of coronary atherosclerotic plaque by use of optical coherence tomography," Circulation 111, 1551-1555 (2005).
[CrossRef] [PubMed]

H. Yabushita, B.E. Bouma, S.L. Houser, H.T. Aretz, I.K. Jang, K.H. Schlendorf, C.R. Kauffman, M. Shishkov, D.H. Kang, E.F. Halpern, G.J. Tearney, "Characterization of human atherosclerosis by optical coherence tomography," Circulation 106, 1640-1645 (2002).
[CrossRef] [PubMed]

Electron. Lett. (1)

S.A. Kingsley and D.E.N. Davies, "OFDR diagnostics or fibre and integrated-optic systems," Electron. Lett. 21, 434-435 (1985).
[CrossRef]

Invest. Ophthalmol. Vis. Sci. (1)

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography," Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef] [PubMed]

J. Am. Coll. Cardiol. (2)

S. Nadkarni, M.C. Pierce, B.H. Park, J.F. de Boer, E.F. Halpern, S.L. Houser, B.E. Bouma, G.J. Tearney, "Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography," J. Am. Coll. Cardiol. 49, 1474-1481 (2007).
[CrossRef] [PubMed]

I.K. Jang, B.E. Bouma, D.H. Kang, S.J. Park, S.W. Park, K.B. Seung, K.B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S.L. Houser, H.T. Aretz, and G.J. Tearney, "Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound," J. Am. Coll. Cardiol. 39, 604-609 (2002).
[CrossRef] [PubMed]

J. Biomed. Opt. (5)

G.J. Tearney, I.K. Jang, and B.E. Bouma, "Optical coherence tomography for imaging the vulnerable plaque," J. Biomed. Opt. 11(2), 021002 (2006).
[CrossRef] [PubMed]

B.H. Park, C. Saxer, S.M. Srinivas, J.S. Nelson, and J.F. de Boer, "In vivo burn depth determination by high-speed fiber-based polarization sensitive optical coherence tomography," J. Biomed. Opt. 6, 474-479 (2001).
[CrossRef] [PubMed]

B.J. Vakoc, G.J. Tearney, and B.E. Bouma, "Real-time microscopic visualization of tissue response to laser thermal therapy," J. Biomed. Opt. 12, 020501-020503 (2007).
[CrossRef] [PubMed]

J. Strasswimmer, M.C. Pierce, B.H. Park, V. Neel, and J.F. de Boer, "Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma," J. Biomed. Opt. 9,292-298 (2004).
[CrossRef] [PubMed]

D. Fried, J. Xie, S. Shafi, J.D.B. Featherstone, T.M. Breunig, and C. Le, "Imaging caries lesions and lesion progression with polarization sensitive optical coherence tomography," J. Biomed. Opt. 7, 618-627 (2002).
[CrossRef] [PubMed]

J. Opt. Soc. Am. B (1)

Nat. Med. (1)

S.H. Yun, G.J. Tearney, B.J. Vakoc, M. Shishkov, W.Y. Oh, A.E. Desjardins, M J. Suter, R.C. Chan, J.A. Evans, I.K. Jang, N.S. Nishioka, J.F. de Boer, and B.E. Bouma, "Comprehensive volumetric optical microscopy in-vivo," Nat. Med. 12, 1429-1433 (2006).
[CrossRef] [PubMed]

Opt. Express (6)

Opt. Lett. (7)

W.Y. Oh, S.H. Yun, G.J. Tearney, and B.E. Bouma, "115 kHz tuning repetition rate ultrahigh-speed wavelength-swept semiconductor laser," Opt. Lett. 30, 3159-3161 (2005).
[CrossRef] [PubMed]

B.H. Park, M.C. Pierce, B. Cense, and J.F. de Boer, "Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic components," Opt. Lett. 29, 2512-2514 (2004).
[CrossRef] [PubMed]

J.F. de Boer, T. E. Milner, M.J.C. van Gemert, and J.S. Nelson, "Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography," Opt. Lett. 22, 934-936 (1997).
[CrossRef] [PubMed]

M.J. Everett, K. Schoenenberger, B.W. Colston, Jr., and L.B. Da Silva, "Birefringence characterization of biological tissue by use of optical coherence tomography," Opt. Lett. 23, 228-230 (1998).
[CrossRef]

C.E. Saxer, J.F. de Boer, B.H. Park, Y.H. Zhao, Z.P. Chen, and J.S. Nelson, "High-speed fiber-based polarization-sensitive optical coherence tomography of in vivo human skin," Opt. Lett. 25, 1355-1357 (2000).
[CrossRef]

M.C. Pierce, B.H. Park, B. Cense, and J.F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).
[CrossRef]

B. Cense, T.C. Chen, B.H. Park, M.C. Pierce, and J.F. de Boer, "In vivo depth-resolved birefringence measurements of the human retinal nerve fiber layer by polarization-sensitive optical coherence tomography," Opt. Lett. 27, 1610-1612 (2002).
[CrossRef]

Optics Letters (1)

S.H. Yun, C. Boudoux, G.J. Tearney, and B.E. Bouma, "High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter," Optics Letters 28, 1981-1983 (2003).
[CrossRef] [PubMed]

Supplementary Material (2)

» Media 1: MOV (1444 KB)     
» Media 2: MOV (1964 KB)     

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Figures (5)

Fig. 1.
Fig. 1.

Different schemes for PS-OFDI. (a) Conventional scheme, and (b) PS-OFDI with frequency multiplexing scheme. WSL, wavelength-swept laser; Pol.M, polarization modulator; RM, reference mirror; PDD, polarization diverse detection; PBS, polarization beam splitter; FS, frequency shifter; DC, directional coupler.

Fig. 2.
Fig. 2.

Schematic diagram of PS-OFDI system. FBG, fiber Bragg grating; PC, polarization controller; RFS, reference arm frequency shifter; SFS1, sample arm frequency shifter; SFS2, AMTIR glass block for dispersion matching; PBS, polarization beam splitter; Pol, polarizer; BS, beam splitter.

Fig. 3.
Fig. 3.

Intensity and phase retardation images of (a) and (b) chicken muscle ex vivo, and (c) human finger in vivo. A-line rate: 50 kHz, imaging speed: 99 fps, image size: 2 cm (transverse)×7 mm (axial), scale bar: 2mm.

Fig. 4.
Fig. 4.

Movie of a series of cross-sectional intensity and phase retardation images of chicken muscle tissue during laser ablation (below vaporization threshold). A-line rate: 50 kHz, imaging speed: 139 fps, presented at 20 fps, image size: 2.8 mm (transverse)×7 mm (axial), scale bar: 1mm. [Media 1]

Fig. 5.
Fig. 5.

Movie of a human coronary artery ex vivo acquired during a pull-back of 8 mm. Arrow: lipid-rich plaque. A-line rate: 62 kHz, imaging speed: 123 fps, presented at 6 fps. [Media 2]

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