Abstract

The theory of photoacoustic tomography (PAT) imaging using a 4f acoustic lens imaging system has been investigated, and the theoretical results show that a 4f acoustic lens has the ability of imaging and guarantees axial and lateral unit magnification of image. A system, a 4f acoustic lens imaging system combining with time-resolved technique, is developed to acquire PAT images. The 4f acoustic lens is able to image initial photoacoustic (PA) pressure distribution, which exactly resembles the absorption distribution, onto an imaging plane. Combining with time-resolved technique, the linear transducer array is adopted to acquire the PA pressure distribution to reconstruct the PAT images. Experimental results demonstrate that the system is able to obtain PAT images and the images contrast sharply with their backgrounds.

© 2007 Optical Society of America

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  1. X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
    [CrossRef] [PubMed]
  2. R. J. Siphanto, K. K. Thumma, R. G. M. Kolkman, T. G. van Leeuwen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem and W. Steenbergen, "Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis," Opt. Express 13, 89-95 (2005).
    [CrossRef] [PubMed]
  3. R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
    [CrossRef] [PubMed]
  4. A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).
  5. C. G. A. Hoelen, F. F. M. de Mul, R. Pongers, and A. Dekker, "Three-dimensional photoacoustic imaging of blood vessels in tissue," Opt. Lett. 23, 648-650 (1998).
    [CrossRef]
  6. K. Geng, W. Xueding, X. Xueyi, S. George, and W. Lihong, "Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography," Appl. Opt.,  44, 770-775 (2005).
    [CrossRef]
  7. K. H. Song, G. Stoica, and L. H. V. Wang, "In vivo three-dimensional photoacoustic tomography of a whole mouse head," Opt. Lett. 31, 2453-2455 (2006).
    [CrossRef] [PubMed]
  8. X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
    [CrossRef]
  9. R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
    [CrossRef] [PubMed]
  10. M. H. Xu, and L. H. Wang, "Time-Domain Reconstruction for Thermoacoustic Tomography in a Spherical Geometry," IEEE Trans. Med. Imag. 21, 814-822 (2002).
    [CrossRef]
  11. K. P. Köstli, and P. C. Beard, "Two-dimensional photoacoustic imaging by use of Fourier-transform image reconstruction and a detector with an anisotropic response," Appl. Opt. 42, 1899-1908 (2003).
    [CrossRef] [PubMed]
  12. Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
    [CrossRef] [PubMed]
  13. B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
    [CrossRef] [PubMed]
  14. D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
    [CrossRef]
  15. J. J. Niederhauser, M. Jaeger, and M. Frenz, "Real-time three-dimensional optoacoustic imaging using an acoustic lens system," Appl. Phys. Lett. 85, 846-848 (2004).
    [CrossRef]
  16. Z. X. Chen, Z. L. tang, W. Wan, and Y. H. He, "Photoacoustic tomography imaging based on an acoustic lens imaging system," Acta.Phys. Sin. 55, 4365-4370 (2006).
  17. W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
    [CrossRef]

2007 (1)

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

2006 (3)

Z. X. Chen, Z. L. tang, W. Wan, and Y. H. He, "Photoacoustic tomography imaging based on an acoustic lens imaging system," Acta.Phys. Sin. 55, 4365-4370 (2006).

K. H. Song, G. Stoica, and L. H. V. Wang, "In vivo three-dimensional photoacoustic tomography of a whole mouse head," Opt. Lett. 31, 2453-2455 (2006).
[CrossRef] [PubMed]

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

2005 (3)

2004 (4)

J. J. Niederhauser, M. Jaeger, and M. Frenz, "Real-time three-dimensional optoacoustic imaging using an acoustic lens system," Appl. Phys. Lett. 85, 846-848 (2004).
[CrossRef]

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
[CrossRef] [PubMed]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

2003 (2)

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

K. P. Köstli, and P. C. Beard, "Two-dimensional photoacoustic imaging by use of Fourier-transform image reconstruction and a detector with an anisotropic response," Appl. Opt. 42, 1899-1908 (2003).
[CrossRef] [PubMed]

2002 (1)

M. H. Xu, and L. H. Wang, "Time-Domain Reconstruction for Thermoacoustic Tomography in a Spherical Geometry," IEEE Trans. Med. Imag. 21, 814-822 (2002).
[CrossRef]

2001 (1)

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

1998 (1)

1995 (1)

R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
[CrossRef] [PubMed]

Andreev, V. G.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Appledom, C. R.

R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
[CrossRef] [PubMed]

Beard, P. C.

Chen, Q.

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
[CrossRef] [PubMed]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Chen, Z. X.

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

Z. X. Chen, Z. L. tang, W. Wan, and Y. H. He, "Photoacoustic tomography imaging based on an acoustic lens imaging system," Acta.Phys. Sin. 55, 4365-4370 (2006).

de Mul, F. F. M.

Dekker, A.

Fang, Y. C.

R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
[CrossRef] [PubMed]

Fleming, R. Y. D.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Frenz, M.

J. J. Niederhauser, M. Jaeger, and M. Frenz, "Real-time three-dimensional optoacoustic imaging using an acoustic lens system," Appl. Phys. Lett. 85, 846-848 (2004).
[CrossRef]

Gatalica, Z.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Geng, K.

George, S.

Gu, H. M.

D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

He, Y. H.

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

Hoelen, C. G. A.

Hondebrink, E.

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Hopman, J. C. W.

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, and M. Frenz, "Real-time three-dimensional optoacoustic imaging using an acoustic lens system," Appl. Phys. Lett. 85, 846-848 (2004).
[CrossRef]

Karabutov, A.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Klaessens, J. H. G. M.

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Kolkman, R. G. M.

R. J. Siphanto, K. K. Thumma, R. G. M. Kolkman, T. G. van Leeuwen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem and W. Steenbergen, "Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis," Opt. Express 13, 89-95 (2005).
[CrossRef] [PubMed]

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Köstli, K. P.

Kruger, R. A.

R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
[CrossRef] [PubMed]

Ku, G.

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Liang, R. S.

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

Lihong, W.

Liu, P. Y.

R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
[CrossRef] [PubMed]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, and M. Frenz, "Real-time three-dimensional optoacoustic imaging using an acoustic lens system," Appl. Phys. Lett. 85, 846-848 (2004).
[CrossRef]

Oraesky, A.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Pang, Y. J.

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Pongers, R.

Savateeva, E. V.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Singh, H.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Siphanto, R. J.

Solomatin, V. S.

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

Song, K. H.

Steenbergen, W.

R. J. Siphanto, K. K. Thumma, R. G. M. Kolkman, T. G. van Leeuwen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem and W. Steenbergen, "Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis," Opt. Express 13, 89-95 (2005).
[CrossRef] [PubMed]

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Stoica, G.

K. H. Song, G. Stoica, and L. H. V. Wang, "In vivo three-dimensional photoacoustic tomography of a whole mouse head," Opt. Lett. 31, 2453-2455 (2006).
[CrossRef] [PubMed]

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Tan, Y.

D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Tang, Z. L.

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

Thijssen, J. M.

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Thumma, K. K.

van Adrichem, L. N. A.

van Leeuwen, T. G.

R. J. Siphanto, K. K. Thumma, R. G. M. Kolkman, T. G. van Leeuwen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem and W. Steenbergen, "Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis," Opt. Express 13, 89-95 (2005).
[CrossRef] [PubMed]

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

van Neck, J. W.

Wan, W.

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

Wang, L. H.

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

M. H. Xu, and L. H. Wang, "Time-Domain Reconstruction for Thermoacoustic Tomography in a Spherical Geometry," IEEE Trans. Med. Imag. 21, 814-822 (2002).
[CrossRef]

Wang, L. H. V.

Wang, X. D.

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Wang, Y.

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
[CrossRef] [PubMed]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Xie, X. Y.

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Xing, D.

D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
[CrossRef] [PubMed]

Xu, M. H.

M. H. Xu, and L. H. Wang, "Time-Domain Reconstruction for Thermoacoustic Tomography in a Spherical Geometry," IEEE Trans. Med. Imag. 21, 814-822 (2002).
[CrossRef]

Xueding, W.

Xueyi, X.

Yang, D. W.

D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

Yin, B. Z.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Zeng, L. M.

D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

Zeng, Y. G.

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
[CrossRef] [PubMed]

Zhang, H. C.

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

Appl. Opt. (2)

Appl. Phys. Lett. (2)

D. W. Yang, D. Xing, H. M. Gu, Y. Tan, and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

J. J. Niederhauser, M. Jaeger, and M. Frenz, "Real-time three-dimensional optoacoustic imaging using an acoustic lens system," Appl. Phys. Lett. 85, 846-848 (2004).
[CrossRef]

IEEE Trans. Med. Imag. (1)

M. H. Xu, and L. H. Wang, "Time-Domain Reconstruction for Thermoacoustic Tomography in a Spherical Geometry," IEEE Trans. Med. Imag. 21, 814-822 (2002).
[CrossRef]

J. Appl. Phys. (1)

W. Wan, R. S. Liang, Z. L. Tang, Z. X. Chen, H. C. Zhang, and Y. H. He, "The imaging property of photoacoustic Fourier imaging and tomography using an acoustic lens imaging system," J. Appl. Phys. 101, 063103 1-7 (2007).
[CrossRef]

J. Biomed. Opt. (1)

X. D. Wang, X. Y. Xie, G. Ku, and L. H. Wang, G. Stoica, "Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography," J. Biomed. Opt. 11, 024015 1-9 (2006).
[CrossRef]

Med. Phys. (1)

R. A. Kruger, P. Y. Liu, Y. C. Fang, and C. R. Appledom, "Photoacoustic ultrasound (PAUS)-Reconstruction tomography," Med. Phys. 22, 1605-1609 (1995).
[CrossRef] [PubMed]

Nat. Biotechnol. (1)

X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. H. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat. Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Opt. Express (1)

Opt. Lett. (2)

Phys. Med. Biol (1)

B. Z. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol.  49, 1339-1346 (2004).
[CrossRef] [PubMed]

Phys. Med. Biol. (2)

Y. Wang, D. Xing, Y. G. Zeng, and Q. Chen, "Photoacoustic imaging with deconvolution algorithm," Phys. Med. Biol. 49, 3117-3124 (2004).
[CrossRef] [PubMed]

R. G. M. Kolkman, J. H. G. M. Klaessens, E. Hondebrink, J. C. W. Hopman, F. F. M. de Mul, W. Steenbergen, J. M. Thijssen and T. G. van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 47454756 (2004).
[CrossRef] [PubMed]

Phys. Sin. (1)

Z. X. Chen, Z. L. tang, W. Wan, and Y. H. He, "Photoacoustic tomography imaging based on an acoustic lens imaging system," Acta.Phys. Sin. 55, 4365-4370 (2006).

Proc. SPIE (1)

A. Oraesky, A. Karabutov, V. S. Solomatin, E. V. Savateeva, V. G. Andreev, Z. Gatalica, H. Singh, and R. Y. D. Fleming, "Laser optoacoustic imaging of breast cancer in vivo," Proc. SPIE 4256, 12-22 (2001).

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Figures (11)

Fig. 1.
Fig. 1.

The 4f acoustic lens imaging system.

Fig. 2.
Fig. 2.

The principle of coherent imaging system.

Fig. 3.
Fig. 3.

The principle of the acoustic lens has the property of long focal depth.

Fig. 4.
Fig. 4.

Experiment setup of PAT imaging based on 4f acoustic lens.

Fig. 5.
Fig. 5.

The sample of three black adhesive tape points adhered to a piece of polymethylmethacrylate hidden inside scattering media (a) and the corresponding PA image (b).

Fig. 6.
Fig. 6.

The sample made of black adhesive tape is the patterns ‘V’ adhered to a piece of polymethylmethacrylate hidden inside scattering media (a) and the corresponding PA image (b).

Fig.7.
Fig.7.

The sample made of black adhesive tape is the patterns ‘C’ adhered to a piece of polymethylmethacrylate hidden inside scattering media (a) and the corresponding PA image (b).

Fig. 8.
Fig. 8.

The sample of a black adhesive tape point. It acted as a point acoustic source heating by the pulse laser (a) and the impulse response curve (b).

Fig. 9.
Fig. 9.

The PA images that two points are 3mm distance.

Fig. 10.
Fig. 10.

The photos of the sample that the two different patterns are adhere to the front as well as at the back of a piece of polymethylmethacrylate.

Fig.11.
Fig.11.

The PA signals of two image planes that are from two respective object planes

Equations (12)

Equations on this page are rendered with MathJax. Learn more.

P T u v = F 1 { P O x y } ,
P I x′ y′ = F 2 { P T u v } .
P T u v P O ( x , y ) exp [ ik f ( xu + yv ) ] dxdy
P I x′ y′ P T ( u , v ) exp [ ik f ( ux′ + vy′ ) ] dudv
P I x′ y′ + P O x y exp { ik f [ u ( x + x′ ) + v ( y + y′ ) ] } dudvdxdy
= + P O x y { + exp [ ik ( x + x′ ) f u ] du } × { + exp [ ik ( y + y′ ) f v ] dv } dxdy + P O x y δ ( x + x′ ) δ ( y + y′ ) dxdy
= P O x′ y′ o
α = β 2 f′ f = n′ n β 2
α = β 2
h ( 0 , Δ z ) = λf 2 a 2 Δ z exp ( j 2 π ( f + Δ z ) λ ) [ 1 exp ( jπa 2 Δ z λf ( f + Δ z ) ) ]
D = v · Δ t
DR = τv

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