Abstract

A promising method to incorporate tissue structural information into the reconstruction of diffusion-based fluorescence imaging is introduced. The method regularizes the inversion problem with a Laplacian-type matrix, which inherently smoothes pre-defined tissue, but allows discontinuities between adjacent regions. The technique is most appropriately used when fluorescence tomography is combined with structural imaging systems. Phantom and simulation studies were used to illustrate significant improvements in quantitative imaging and linearity of response with the new algorithm. Images of an inclusion containing the fluorophore Lutetium Texaphyrin (Lutex) embedded in a cylindrical phantom are more accurate than in situations where no structural information is available, and edge artifacts which are normally prevalent were almost entirely suppressed. Most importantly, spatial priors provided a higher degree of sensitivity and accuracy to fluorophore concentration, though both techniques suffer from image bias caused by excitation signal leakage. The use of spatial priors becomes essential for accurate recovery of fluorophore distributions in complex tissue volumes. Simulation studies revealed an inability of the “no-priors” imaging algorithm to recover Lutex fluorescence yield in domains derived from T1 weighted images of a human breast. The same domains were reconstructed accurately to within 75% of the true values using prior knowledge of the internal tissue structure. This algorithmic approach will be implemented in an MR-coupled fluorescence spectroscopic tomography system, using the MR images for the structural template and the fluorescence data for region quantification.

© 2007 Optical Society of America

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  1. D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, "Imaging of fluorescent yeild and lifetime from multiply scattered light reemitted from random media," Appl. Opt. 36, 2260-2272 (1997).
  2. H. B. Jiang, "Frequency-domain fluorescent diffusion tomography: a finite- element-based algorithm and simulations," Appl. Opt. 37, 5337-5343 (1998).
  3. D. J. Hawrysz, and E. M. Sevick-Muraca, "Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents," Neoplasia 2, 388-417 (2000).
    [CrossRef]
  4. M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
    [CrossRef]
  5. A. B. Milstein, O. Seungseok, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, "Fluorescence optical diffusion tomograhy," Appl. Opt. 42, 3081-3094 (2003).
  6. V. Ntziachristos, and R. Weissleder, "Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation," Opt. Lett. 26, 893-895 (2001).
  7. V. Ntziachristos, and R. Weissleder, "Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media," Med. Phys. 29, 803-809 (2002).
    [CrossRef]
  8. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
    [CrossRef]
  9. A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
    [CrossRef]
  10. R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissue with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
    [CrossRef]
  11. S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
    [CrossRef]
  12. A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).
  13. B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
    [CrossRef]
  14. X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, "Diffuse Optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).</jrn>
  15. M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
    [CrossRef]
  16. P. K. Yalavarthy, H. Dehghani, B. W. Pogue, C. M. Carpenter, H. B. Jiang, and K. D. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," IEEE Trans. Med. Imaging In review (2006).</other>
  17. G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
    [CrossRef]
  18. K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).
  19. M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
    [CrossRef]
  20. A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
    [CrossRef]
  21. H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
    [CrossRef]
  22. S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
    [CrossRef]
  23. K. D. Paulsen, and JiangH. , "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
    [CrossRef]
  24. S. R. Arridge, and M. Schweiger, "Photon-measurement density functions. Part2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).
  25. A. Borsic, W. R. B. Lionheart, and C. N. McLeod, "Generation of anisotropic-smoothness regularization filters for EIT," IEEE Trans. Med. Imaging 21, 579-587 (2002).
    [CrossRef]
  26. B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).
  27. K. D. Paulsen, Jiang, H. , "Enhanced frequency-domain optical image reconstruction in tissues through total-variation minimization," Appl. Opt. 35, 3447-3458 (1996).
  28. K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
    [CrossRef]
  29. M. Schweiger, and S. R. Arridge, "Optical tomographic reconstruction in a complex head model using a priori boundary information," Phys. Med. Biol. 44, 2703-2722 (1999).
    [CrossRef]
  30. B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
    [CrossRef]
  31. S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
    [CrossRef]
  32. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging," Opt. Lett. 26, 822-824 (2001).
  33. B. W. Pogue, McBride, T. O. , Prewitt, J. , Osterberg, U. L. , Paulsen, K. D. , "Spatially variant regularization improves diffuse optical tomography," Appl. Opt. 38, 2950-2961 (1999).
  34. S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
    [CrossRef]
  35. B. Pogue, and M. Patterson, "Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry," J. Biomed. Opt. 11, 0411021-04110216 (2006).

2006 (3)

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Pogue, and M. Patterson, "Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry," J. Biomed. Opt. 11, 0411021-04110216 (2006).

2005 (3)

S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
[CrossRef]

A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).

M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
[CrossRef]

2004 (4)

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissue with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
[CrossRef]

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

2003 (5)

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
[CrossRef]

B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).

S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
[CrossRef]

A. B. Milstein, O. Seungseok, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, "Fluorescence optical diffusion tomograhy," Appl. Opt. 42, 3081-3094 (2003).

2002 (3)

A. Borsic, W. R. B. Lionheart, and C. N. McLeod, "Generation of anisotropic-smoothness regularization filters for EIT," IEEE Trans. Med. Imaging 21, 579-587 (2002).
[CrossRef]

V. Ntziachristos, and R. Weissleder, "Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media," Med. Phys. 29, 803-809 (2002).
[CrossRef]

M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
[CrossRef]

2001 (2)

2000 (2)

D. J. Hawrysz, and E. M. Sevick-Muraca, "Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents," Neoplasia 2, 388-417 (2000).
[CrossRef]

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

1999 (2)

1998 (1)

1997 (3)

D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, "Imaging of fluorescent yeild and lifetime from multiply scattered light reemitted from random media," Appl. Opt. 36, 2260-2272 (1997).

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

1996 (1)

1995 (3)

S. R. Arridge, and M. Schweiger, "Photon-measurement density functions. Part2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).

K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
[CrossRef]

K. D. Paulsen, and JiangH. , "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
[CrossRef]

K. D. Paulsen, and JiangH. , "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
[CrossRef]

1993 (1)

S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
[CrossRef]

Achilefu, S.

S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
[CrossRef]

Arridge, S. R.

M. Schweiger, and S. R. Arridge, "Optical tomographic reconstruction in a complex head model using a priori boundary information," Phys. Med. Biol. 44, 2703-2722 (1999).
[CrossRef]

S. R. Arridge, and M. Schweiger, "Photon-measurement density functions. Part2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).

S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
[CrossRef]

Bloch, S. R.

S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
[CrossRef]

Boas, D. A.

Borsic, A.

A. Borsic, W. R. B. Lionheart, and C. N. McLeod, "Generation of anisotropic-smoothness regularization filters for EIT," IEEE Trans. Med. Imaging 21, 579-587 (2002).
[CrossRef]

Bouman, C. A.

Brooksby, B.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

Chance, B.

M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
[CrossRef]

Chen, A. U.

Culver, J. P.

S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
[CrossRef]

D, P. K.

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

Dehghani, H.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

Delpy, D. T.

S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
[CrossRef]

Doyley, M.

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

Ehrenberg, B.

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

Eppstein, M. J.

A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
[CrossRef]

Fan, Q.

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

Gibson, J. J.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

Godavarty, A.

A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
[CrossRef]

Graves, E.

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
[CrossRef]

Gurfinkel, M.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

Guven, M.

M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
[CrossRef]

Hawrysz, D. J.

M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
[CrossRef]

D. J. Hawrysz, and E. M. Sevick-Muraca, "Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents," Neoplasia 2, 388-417 (2000).
[CrossRef]

Hiraoka, M.

S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
[CrossRef]

Intes, X.

M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
[CrossRef]

Jiang, H. B.

Jiang, K. D.

K. D. Paulsen, Jiang, H. , "Enhanced frequency-domain optical image reconstruction in tissues through total-variation minimization," Appl. Opt. 35, 3447-3458 (1996).

K. D. Paulsen, and JiangH. , "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
[CrossRef]

Jiang, S.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging," Opt. Lett. 26, 822-824 (2001).

Kessel, D.

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

Kogel, C.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

Kostenich, G.

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

Kral, V.

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

Lionheart, W. R. B.

A. Borsic, W. R. B. Lionheart, and C. N. McLeod, "Generation of anisotropic-smoothness regularization filters for EIT," IEEE Trans. Med. Imaging 21, 579-587 (2002).
[CrossRef]

Luo, Y.

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

Malik, Z.

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

Matejka, P.

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

McBride, B. W.

McBride, T. O.

S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging," Opt. Lett. 26, 822-824 (2001).

McLeod, C. N.

A. Borsic, W. R. B. Lionheart, and C. N. McLeod, "Generation of anisotropic-smoothness regularization filters for EIT," IEEE Trans. Med. Imaging 21, 579-587 (2002).
[CrossRef]

Meaney, P.

K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
[CrossRef]

Miles, D. R.

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

Millane, R. P.

Milstein, A. B.

Monnier, P.

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

Moskowitz, M.

K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
[CrossRef]

Ntziachristos, V.

R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissue with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
[CrossRef]

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
[CrossRef]

V. Ntziachristos, and R. Weissleder, "Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media," Med. Phys. 29, 803-809 (2002).
[CrossRef]

V. Ntziachristos, and R. Weissleder, "Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation," Opt. Lett. 26, 893-895 (2001).

Orenstein, A.

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

Osterberg, J.

Osterberg, U. L.

Paithankar, D. Y.

Patterson, M.

B. Pogue, and M. Patterson, "Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry," J. Biomed. Opt. 11, 0411021-04110216 (2006).

Patterson, M. S.

Patwardhan, S. V.

S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
[CrossRef]

Paulsen, K. D.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
[CrossRef]

B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging," Opt. Lett. 26, 822-824 (2001).

K. D. Paulsen, Jiang, H. , "Enhanced frequency-domain optical image reconstruction in tissues through total-variation minimization," Appl. Opt. 35, 3447-3458 (1996).

K. D. Paulsen, and JiangH. , "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
[CrossRef]

K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
[CrossRef]

Paulsen, U. L.

Pogue, B.

B. Pogue, and M. Patterson, "Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry," J. Biomed. Opt. 11, 0411021-04110216 (2006).

Pogue, B. W.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
[CrossRef]

B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging," Opt. Lett. 26, 822-824 (2001).

B. W. Pogue, McBride, T. O. , Prewitt, J. , Osterberg, U. L. , Paulsen, K. D. , "Spatially variant regularization improves diffuse optical tomography," Appl. Opt. 38, 2950-2961 (1999).

D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, "Imaging of fluorescent yeild and lifetime from multiply scattered light reemitted from random media," Appl. Opt. 36, 2260-2272 (1997).

Poplack, S. P.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, K. D. Paulsen, and S. P. Poplack, "Initial studies of in vivo absorbing and scattering heterogeneity in near-infrared tomographic breast imaging," Opt. Lett. 26, 822-824 (2001).

Pouckova, P.

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

Prewitt, T. O.

Radu, A.

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

Ripoll, J.

R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissue with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
[CrossRef]

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
[CrossRef]

Roitman, L.

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

Roy, R.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

Schulz, R. B.

R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissue with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
[CrossRef]

Schweiger, M.

M. Schweiger, and S. R. Arridge, "Optical tomographic reconstruction in a complex head model using a priori boundary information," Phys. Med. Biol. 44, 2703-2722 (1999).
[CrossRef]

S. R. Arridge, and M. Schweiger, "Photon-measurement density functions. Part2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).

S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
[CrossRef]

Sessler, J. L.

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

Seungseok, O.

Sevick-Muraca, E. M.

A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
[CrossRef]

D. J. Hawrysz, and E. M. Sevick-Muraca, "Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents," Neoplasia 2, 388-417 (2000).
[CrossRef]

D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, "Imaging of fluorescent yeild and lifetime from multiply scattered light reemitted from random media," Appl. Opt. 36, 2260-2272 (1997).

Soho, S.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

Srinivasan, S.

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

Sullican, J.

K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
[CrossRef]

Synytsya, A.

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

Thompson, A. B.

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

Tosteson, T. D.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

van den Bergh, H.

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

Vishwanath, K.

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

Volka, K.

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

Wagnieres, G.

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

Weaver, J.

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

Weaver, J. B.

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

Webb, K. J.

Weissleder, R.

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
[CrossRef]

V. Ntziachristos, and R. Weissleder, "Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media," Med. Phys. 29, 803-809 (2002).
[CrossRef]

V. Ntziachristos, and R. Weissleder, "Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation," Opt. Lett. 26, 893-895 (2001).

Woodburn, K. W.

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

Yazici, B.

M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
[CrossRef]

Young, S. W.

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

Zellweger, M.

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

Zhang, C.

A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

Zhang, Q.

Acad. Radiol. (1)

S. Srinivasan, B. W. Pogue, S. Jiang, H. Dehghani, C. Kogel, S. Soho, J. J. Gibson, T. D. Tosteson, S. P. Poplack, and K. D. Paulsen, "In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction," Acad. Radiol. 13, 195-202 (2006).
[CrossRef]

Appl. Opt. (6)

IEEE J. STQE (1)

B. Brooksby, H. Dehghani, B. W. Pogue, and K. D. Paulsen, "Near infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities," IEEE J. STQE 9, 199-209 (2003).

IEEE Trans. Med. Imaging (3)

A. Borsic, W. R. B. Lionheart, and C. N. McLeod, "Generation of anisotropic-smoothness regularization filters for EIT," IEEE Trans. Med. Imaging 21, 579-587 (2002).
[CrossRef]

K. D. Paulsen, P. Meaney, M. Moskowitz, and J. Sullican, Jr., "A dual mesh for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
[CrossRef]

R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissue with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
[CrossRef]

J. Biomed. Opt. (3)

S. Jiang, B. W. Pogue, T. O. McBride, and K. D. Paulsen, "Quantitative analysis of near-infrared tomography: sensitivity to the tissue-simulating precalibration phantom," J. Biomed. Opt. 8, 308-315 (2003).
[CrossRef]

B. Pogue, and M. Patterson, "Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry," J. Biomed. Opt. 11, 0411021-04110216 (2006).

A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
[CrossRef]

Med. Phys. (4)

V. Ntziachristos, and R. Weissleder, "Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media," Med. Phys. 29, 803-809 (2002).
[CrossRef]

E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
[CrossRef]

S. R. Arridge, M. Schweiger, M. Hiraoka and D. T. Delpy, "A finite element approach for modeling photon transport in tissue," Med. Phys. 20, 299-309 (1993).
[CrossRef]

K. D. Paulsen, and JiangH. , "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
[CrossRef]

Neoplasia (1)

D. J. Hawrysz, and E. M. Sevick-Muraca, "Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents," Neoplasia 2, 388-417 (2000).
[CrossRef]

Opt. Exp. (1)

S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distribution in mice," Opt. Exp. 13, 2564-2577 (2005).
[CrossRef]

Opt. Lett. (2)

Photochem. & Photobiol. (3)

G. Kostenich, A. Orenstein, L. Roitman, Z. Malik, and B. Ehrenberg, "In vivo photodynamic therapy with the new near-IR absorbing water soluble photosensitizer lutetium texaphyrin and a high intensity pulsed light delivery system," Photochem. & Photobiol. 39, 36-42 (1997).
[CrossRef]

K. W. Woodburn, Q. Fan, D. R. Miles, D. Kessel, Y. Luo, and S. W. Young, "Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model," Photochem. & Photobiol. 65, 410-415 (1997).

A. Synytsya, V. Kral, P. Matejka, P. Pouckova, K. Volka, and J. L. Sessler, "Biodistribution assessment of a lutetium(III) texaphyrin analogue in tumor-bearing mice using NIR Fourier-transform Raman spectroscopy," Photochem. & Photobiol. 79, 453-460 (2004).
[CrossRef]

Photochem. & Photobiol. B (1)

M. Zellweger, A. Radu, P. Monnier, H. van den Bergh, and G. Wagnieres, "Fluorescence pharmacokinetics of Lutetium Texaphyrin (PCI-0123, Lu-Tex) in the skin and in healthy and tumoral hamster cheek-pouch mucosa," Photochem. & Photobiol. B 55, 56-62 (2000).
[CrossRef]

Phys. Med. Biol. (3)

H. Dehghani, B. Brooksby, K. Vishwanath, B. W. Pogue, and P. K. D., "The effects of internal refractive index variation in near infrared optical tomography: A finite element modeling approach," Phys. Med. Biol. 48, 2713-2727 (2003).
[CrossRef]

M. Guven, B. Yazici, X. Intes, and B. Chance, "Diffuse optical tomography with a priori anatomical information," Phys. Med. Biol. 50, 2837-2858 (2005).
[CrossRef]

M. Schweiger, and S. R. Arridge, "Optical tomographic reconstruction in a complex head model using a priori boundary information," Phys. Med. Biol. 44, 2703-2722 (1999).
[CrossRef]

Proc. Natl. Acad. Sci. USA (2)

B. Brooksby, B. W. Pogue, S. Jiang, H. Dehghani, S. Srinivasan, C. Kogel, T. D. Tosteson, J. Weaver, S. P. Poplack, and K. D. Paulsen, "Imaging breast adipose and fibroglandular tissue molecular signatures using hybrid MRI-guided near-infrared spectral tomography," Proc. Natl. Acad. Sci. USA 103, 8828-8833 (2006).
[CrossRef]

M. J. Eppstein, D. J. Hawrysz, A. Godavarty, and E. M. Sevick-Muraca, "Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomography," Proc. Natl. Acad. Sci. USA 99, 9619-9624 (2002).
[CrossRef]

Radiol. (1)

A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiol. 235, 148-154 (2005).

Rev. Sci. Instrum. (1)

B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. B. Weaver, S. P. Poplack, B. W. Pogue, and K. D. Paulsen, "Magnetic resonance-guided near-infrared tomography of the breast," Rev. Sci. Instrum. 75, 5262-5270 (2004).
[CrossRef]

Other (2)

X. Intes, C. Maloux, M. Guven, B. Yazici, and B. Chance, "Diffuse Optical tomography with physiological and spatial a priori constraints," Phys. Med. Biol. 49, N155-N163 (2004).</jrn>

P. K. Yalavarthy, H. Dehghani, B. W. Pogue, C. M. Carpenter, H. B. Jiang, and K. D. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," IEEE Trans. Med. Imaging In review (2006).</other>

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