Abstract

Ultrahigh resolution two and three-dimensional optical coherence tomography (OCT) imaging was performed using a miniaturized, two-axis scanning catheter based upon microelectromechanical systems (MEMS) mirror technology. The catheter incorporated a custom-designed and fabricated, 1-mm diameter MEMS mirror driven by angular vertical comb (AVC) actuators on both an inner mirror axis and an outer, orthogonal gimbal axis. Using a differential drive scheme, a linearized position response over +/- 6 degrees mechanical angle was achieved. The flexible, fiber-optic catheter device measured < 5 mm in outer diameter with a rigid length of ∼ 2.5 cm at the distal end. In vivo and ex vivo images are presented with < 4 μm axial and ∼ 12 μm transverse resolution in tissue.

© 2007 Optical Society of America

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2006

R. Huber, M. Wojtkowski, and J. G. Fujimoto, "Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography," Opt. Express 14, 3225-3237 (2006),
[CrossRef] [PubMed]

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

2005

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
[CrossRef] [PubMed]

M. A. Choma, K. Hsu, and J. A. Izatt, "Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source," J. Biomed. Opt. 10, 44009 (2005).
[CrossRef] [PubMed]

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

R. Huber, M. Wojtkowski, J. G. Fujimoto, J. Y. Jiang, and A. E. Cable, "Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm," Opt. Express 13, 10523-10538 (2005),
[CrossRef] [PubMed]

2004

2003

S. Bourquin, A. D. Aguirre, I. Hartl, P. Hsiung, T. H. Ko, J. G. Fujimoto, T. A. Birks, W. J. Wadsworth, U. Bunting, and D. Kopf, "Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd : Glass laser and nonlinear fiber," Opt. Express 11, 3290-3297 (2003)
[CrossRef] [PubMed]

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
[CrossRef] [PubMed]

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

A. D. Aguirre, P. Hsiung, T. H. Ko, I. Hartl, and J. G. Fujimoto, "High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging," Opt. Lett. 28, 2064-2066 (2003).
[CrossRef] [PubMed]

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003).
[CrossRef] [PubMed]

M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003),
[CrossRef] [PubMed]

2002

E. J. Seibel and Q. Y. J. Smithwick, "Unique features of optical scanning, single fiber endoscopy," Lasers Surg. Med. 30, 177-183 (2002).
[CrossRef] [PubMed]

2001

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
[CrossRef] [PubMed]

Y. Pan, H. Xie, and G. K. Fedder, "Endoscopic optical coherence tomography based on a microelectromechanical mirror," Opt. Lett. 26, 1966-1968 (2001).
[CrossRef]

2000

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography," Gastrointest. Endosc. 51, 467-474 (2000).
[CrossRef] [PubMed]

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

1998

D. L. Dickensheets and G. S. Kino, "Silicon-micromachined scanning confocal optical microscope," J. Microelectromech. Syst. 7, 38-47 (1998).
[CrossRef]

1997

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
[CrossRef]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

1996

Aguirre, A. D.

Aoki, Y.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Asaoka, N.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Bajraszewski, T.

Birks, T. A.

Boppart, S. A.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
[CrossRef]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).
[CrossRef] [PubMed]

Bouma, B. E.

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004),
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003),
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
[CrossRef] [PubMed]

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography," Gastrointest. Endosc. 51, 467-474 (2000).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
[CrossRef]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).
[CrossRef] [PubMed]

Bourquin, S.

Brand, B.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Brand, S.

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

Brezinski, M. E.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
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S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
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G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
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G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).
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Cable, A. E.

Cense, B.

Chahwan, A.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
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Chak, A.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
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Chen, T. C.

Chen, Y.

Chen, Z. P.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
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W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
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Cho, J. Y.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
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Choma, M. A.

M. A. Choma, K. Hsu, and J. A. Izatt, "Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source," J. Biomed. Opt. 10, 44009 (2005).
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M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003).
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Compton, C. C.

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
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B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography," Gastrointest. Endosc. 51, 467-474 (2000).
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Delaney, P. M.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
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Denk, W.

F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
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Dickensheets, D. L.

D. L. Dickensheets and G. S. Kino, "Silicon-micromachined scanning confocal optical microscope," J. Microelectromech. Syst. 7, 38-47 (1998).
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Dickensheets, L. D.

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
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Drexler, W.

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004),
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X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
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Duker, J. S.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
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Fedder, G. K.

A. Jain, A. Kopa, Y. T. Pan, G. K. Fedder, and H. K. Xie, "A two-axis electrothermal micromirror for endoscopic optical coherence tomography," IEEE J. Sel. Top. Quantum Electron 10, 636-642 (2004).
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Y. Pan, H. Xie, and G. K. Fedder, "Endoscopic optical coherence tomography based on a microelectromechanical mirror," Opt. Lett. 26, 1966-1968 (2001).
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Fee, M. S.

F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
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Feldchtein, F.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
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Fercher, A. F.

Freund, J.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
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Fritscher-Ravens, A.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
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Fujimori, O.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Fujimoto, J. G.

R. Huber, M. Wojtkowski, and J. G. Fujimoto, "Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography," Opt. Express 14, 3225-3237 (2006),
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R. Huber, M. Wojtkowski, J. G. Fujimoto, J. Y. Jiang, and A. E. Cable, "Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm," Opt. Express 13, 10523-10538 (2005),
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M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

A. D. Aguirre, P. Hsiung, T. H. Ko, I. Hartl, and J. G. Fujimoto, "High-resolution optical coherence microscopy for high-speed, in vivo cellular imaging," Opt. Lett. 28, 2064-2066 (2003).
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S. Bourquin, A. D. Aguirre, I. Hartl, P. Hsiung, T. H. Ko, J. G. Fujimoto, T. A. Birks, W. J. Wadsworth, U. Bunting, and D. Kopf, "Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd : Glass laser and nonlinear fiber," Opt. Express 11, 3290-3297 (2003)
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X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
[CrossRef]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).
[CrossRef] [PubMed]

Fukami, N.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Gelikonov, G.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Gelikonov, V.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Gladkova, N.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Goldenberg, A. A.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

Gordon, L. M.

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
[CrossRef]

Gordon, M. L.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

Hartl, I.

Helmchen, F.

F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
[CrossRef] [PubMed]

Hermann, B.

Hidaka, E.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Himmer, A. P.

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
[CrossRef]

Hitzenberger, C. K.

Hsiung, P.

Hsu, K.

M. A. Choma, K. Hsu, and J. A. Izatt, "Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source," J. Biomed. Opt. 10, 44009 (2005).
[CrossRef] [PubMed]

Huber, R.

Iftimia, N.

Imai, M.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Inoue, H.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Isenberg, G. A.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Isokawa, T.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Izatt, J. A.

M. A. Choma, K. Hsu, and J. A. Izatt, "Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source," J. Biomed. Opt. 10, 44009 (2005).
[CrossRef] [PubMed]

M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003).
[CrossRef] [PubMed]

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
[CrossRef] [PubMed]

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Jackle, S.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Jain, A.

A. Jain, A. Kopa, Y. T. Pan, G. K. Fedder, and H. K. Xie, "A two-axis electrothermal micromirror for endoscopic optical coherence tomography," IEEE J. Sel. Top. Quantum Electron 10, 636-642 (2004).
[CrossRef]

Jiang, J. Y.

Jung, W.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

Jung, W. G.

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

Kashida, H.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Katashiro, M.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Kiesslich, R.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
[CrossRef] [PubMed]

Kimmey, M. B.

Kino, G. S.

D. L. Dickensheets and G. S. Kino, "Silicon-micromachined scanning confocal optical microscope," J. Microelectromech. Syst. 7, 38-47 (1998).
[CrossRef]

Klein, M.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

Ko, T.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Ko, T. H.

Kobayashi, K.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Kopa, A.

A. Jain, A. Kopa, Y. T. Pan, G. K. Fedder, and H. K. Xie, "A two-axis electrothermal micromirror for endoscopic optical coherence tomography," IEEE J. Sel. Top. Quantum Electron 10, 636-642 (2004).
[CrossRef]

Kopf, D.

Kowalczyk, A.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Krinsky, M. L.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

Kudo, S.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Le, T.

Leitgeb, R.

Leitgeb, R. A.

Li, X.

Li, X. D.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

Liu, X.

Mashimo, H.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

Matsumoto, K.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

McCormick, D. T.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

McLaren, W. J.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
[CrossRef] [PubMed]

Miyajima, H.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Mutinga, M.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

Nassif, N. A.

Neurath, M. F.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
[CrossRef] [PubMed]

Nishioka, N. S.

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography," Gastrointest. Endosc. 51, 467-474 (2000).
[CrossRef] [PubMed]

Ogata, M.

H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Pan, Y.

Pan, Y. T.

A. Jain, A. Kopa, Y. T. Pan, G. K. Fedder, and H. K. Xie, "A two-axis electrothermal micromirror for endoscopic optical coherence tomography," IEEE J. Sel. Top. Quantum Electron 10, 636-642 (2004).
[CrossRef]

Park, B. H.

Pierce, M. C.

Pitris, C.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
[CrossRef]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

Polglase, A. L.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
[CrossRef] [PubMed]

Poneros, J. M.

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

Qi, B.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
[CrossRef]

Rao, K. D.

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
[CrossRef] [PubMed]

Rollins, A. M.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Sakashita, M.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Sarunic, M. V.

Satodate, H.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Schroder, S.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Schuman, J. S.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Seibel, E. J.

E. J. Seibel and Q. Y. J. Smithwick, "Unique features of optical scanning, single fiber endoscopy," Lasers Surg. Med. 30, 177-183 (2002).
[CrossRef] [PubMed]

Seitz, U.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Sergeev, A.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Shiokawa, A.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Sivak, M. V.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Skinner, S. A.

A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
[CrossRef] [PubMed]

Smith, S. W.

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
[CrossRef] [PubMed]

Smithwick, Q. Y. J.

E. J. Seibel and Q. Y. J. Smithwick, "Unique features of optical scanning, single fiber endoscopy," Lasers Surg. Med. 30, 177-183 (2002).
[CrossRef] [PubMed]

Soehendra, N.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Southern, J. F.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).
[CrossRef] [PubMed]

Srinivasan, V.

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Stingl, A.

Tamegai, Y.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Tanaka, J.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Tank, D. W.

F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
[CrossRef] [PubMed]

Tearney, G. J.

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004),
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003),
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
[CrossRef] [PubMed]

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography," Gastrointest. Endosc. 51, 467-474 (2000).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
[CrossRef] [PubMed]

S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, "Forward-imaging instruments for optical coherence tomography," Opt. Lett. 22, 1618-1620 (1997).
[CrossRef]

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21, 543-545 (1996).
[CrossRef] [PubMed]

Terentieva, A.

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

Tien, N. C.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

Ung-Runyawee, R.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Unterhuber, A.

Van Dam, J.

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

Vitkin, I. A.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
[CrossRef]

Wadsworth, W. J.

Wang, L.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

Weissman, N. J.

Wilder-Smith, P.

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

Willis, J.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Wilson, B. C.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

Wojtkowski, M.

Wong, R. C.

M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
[CrossRef] [PubMed]

Xie, H.

Xie, H. K.

A. Jain, A. Kopa, Y. T. Pan, G. K. Fedder, and H. K. Xie, "A two-axis electrothermal micromirror for endoscopic optical coherence tomography," IEEE J. Sel. Top. Quantum Electron 10, 636-642 (2004).
[CrossRef]

Yang, C. H.

Yang, V. X. D.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

Yang, X. D. V.

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
[CrossRef]

Yazdanfar, S.

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
[CrossRef] [PubMed]

Yeow, J. T. W.

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

Yoshida, T.

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Yun, S. H.

Zara, J. M.

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
[CrossRef] [PubMed]

Zhang, J.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

App. Phys. Lett.

W. Jung, D. T. McCormick, J. Zhang, L. Wang, N. C. Tien, and Z. P. Chen, "Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror," App. Phys. Lett. 88, 163910 (2006).
[CrossRef]

Endoscopy

S. Jackle, N. Gladkova, F. Feldchtein, A. Terentieva, B. Brand, G. Gelikonov, V. Gelikonov, A. Sergeev, A. Fritscher-Ravens, J. Freund, U. Seitz, S. Schroder, and N. Soehendra, "In vivo endoscopic optical coherence tomography of esophagitis, Barrett's esophagus, and adenocarcinoma of the esophagus," Endoscopy 32, 750-755 (2000).
[CrossRef] [PubMed]

X. D. Li, S. A. Boppart, J. Van Dam, H. Mashimo, M. Mutinga, W. Drexler, M. Klein, C. Pitris, M. L. Krinsky, M. E. Brezinski, and J. G. Fujimoto, "Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus," Endoscopy 32, 921-930 (2000).
[CrossRef]

M. Sakashita, H. Inoue, H. Kashida, J. Tanaka, J. Y. Cho, H. Satodate, E. Hidaka, T. Yoshida, N. Fukami, Y. Tamegai, A. Shiokawa, and S. Kudo, "Virtual histology of colorectal lesions using laser-scanning confocal microscopy," Endoscopy 35, 1033-1038 (2003).
[CrossRef] [PubMed]

Gastroenterology

J. M. Poneros, S. Brand, B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "Diagnosis of specialized intestinal metaplasia by optical coherence tomography," Gastroenterology 120, 7-12 (2001).
[CrossRef] [PubMed]

Gastrointest. Endosc.

B. E. Bouma, G. J. Tearney, C. C. Compton, and N. S. Nishioka, "High-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography," Gastrointest. Endosc. 51, 467-474 (2000).
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M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A. Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51, 474-479 (2000).
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A. L. Polglase, W. J. McLaren, S. A. Skinner, R. Kiesslich, M. F. Neurath, and P. M. Delaney, "A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract," Gastrointest. Endosc. 62, 686-695 (2005).
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IEEE J. Sel. Top. Quantum Electron

A. Jain, A. Kopa, Y. T. Pan, G. K. Fedder, and H. K. Xie, "A two-axis electrothermal micromirror for endoscopic optical coherence tomography," IEEE J. Sel. Top. Quantum Electron 10, 636-642 (2004).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron.

W. G. Jung, J. Zhang, L. Wang, P. Wilder-Smith, Z. P. Chen, D. T. McCormick, and N. C. Tien, "Three-dimensional optical coherence tomography employing a 2-axis microelectromechanical scanning mirror," IEEE J. Sel. Top. Quantum Electron. 11, 806-810 (2005).
[CrossRef]

J. Biomed. Opt.

M. A. Choma, K. Hsu, and J. A. Izatt, "Swept source optical coherence tomography using an all-fiber 1300-nm ring laser source," J. Biomed. Opt. 10, 44009 (2005).
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J. Microelectromech. Syst.

D. L. Dickensheets and G. S. Kino, "Silicon-micromachined scanning confocal optical microscope," J. Microelectromech. Syst. 7, 38-47 (1998).
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H. Miyajima, N. Asaoka, T. Isokawa, M. Ogata, Y. Aoki, M. Imai, O. Fujimori, M. Katashiro, and K. Matsumoto, "A MEMS electromagnetic optical scanner for a commercial confocal laser scanning microscope," J. Microelectromech. Syst. 12, 243-251 (2003).
[CrossRef]

Lasers Surg. Med.

E. J. Seibel and Q. Y. J. Smithwick, "Unique features of optical scanning, single fiber endoscopy," Lasers Surg. Med. 30, 177-183 (2002).
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Neuron

F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, "A miniature head-mounted two-photon microscope: High-resolution brain imaging in freely moving animals," Neuron 31, 903-912 (2001).
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Ophthalmology

M. Wojtkowski, V. Srinivasan, J. G. Fujimoto, T. Ko, J. S. Schuman, A. Kowalczyk, and J. S. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology 112, 1734-1746 (2005).
[CrossRef] [PubMed]

Opt. Commun.

B. Qi, A. P. Himmer, L. M. Gordon, X. D. V. Yang, L. D. Dickensheets, and I. A. Vitkin, "Dynamic focus control in high-speed optical coherence tomography based on a microelectromechanical mirror," Opt. Commun. 232, 123-128 (2004).
[CrossRef]

Opt. Express

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963 (2003),
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S. Bourquin, A. D. Aguirre, I. Hartl, P. Hsiung, T. H. Ko, J. G. Fujimoto, T. A. Birks, W. J. Wadsworth, U. Bunting, and D. Kopf, "Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd : Glass laser and nonlinear fiber," Opt. Express 11, 3290-3297 (2003)
[CrossRef] [PubMed]

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004),
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M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003).
[CrossRef] [PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004),
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R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003).
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R. Huber, M. Wojtkowski, J. G. Fujimoto, J. Y. Jiang, and A. E. Cable, "Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm," Opt. Express 13, 10523-10538 (2005),
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R. Huber, M. Wojtkowski, and J. G. Fujimoto, "Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography," Opt. Express 14, 3225-3237 (2006),
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Opt. Lett

J. M. Zara, S. Yazdanfar, K. D. Rao, J. A. Izatt, and S. W. Smith, "Electrostatic micromachine scanning mirror for optical coherence tomography," Opt. Lett 28, 628-630 (2003).
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Opt. Lett.

Science

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039 (1997).
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Sens. Actuators A

J. T. W. Yeow, V. X. D. Yang, A. Chahwan, M. L. Gordon, B. Qi, I. A. Vitkin, B. C. Wilson, and A. A. Goldenberg, "Micromachined 2-D scanner for 3-D optical coherence tomography," Sens. Actuators A 117, 331-340 (2005).
[CrossRef]

Other

W. Piyawattanametha, L. Fan, S. Hsu, M. Fujino, M. C. Wu, P. R. Herz, A. D. Aguirre, Y. Chen, and J. G. Fujimoto, "Two-dimensional endoscopic MEMS scanner for high resolution optical coherence tomography," presented at Conference on Lasers and Electro-Optics (CLEO), San Francisco, CA, USA, 2004.

P. R. Patterson, D. Hah, H. Nguyen, H. Toshiyoshi, R.-m. Chao, and M. C. Wu, "A scanning micromirror with angular comb drive actuation," presented at Fifteenth IEEE International Conference on Micro Electro Mechanical Systems, 20-24 Jan. 2002, Las Vegas, NV, USA, 2002.

W. Piyawattanametha, P. R. Patterson, G. D. J. Su, H. Toshiyoshi, and M. C. Wu, "A MEMS non-interferometric differential confocal scanning optical microscope," presented at Proceedings of 11th International Conference on Solid State Sensors and Actuators Transducers '01/Eurosensors XV, Munich, Germany, 2001.

W. Piyawattanametha, J. T. C. Liu, M. J. Mandella, H. Ra, L. K. Wong, P. Hsiung, T. D. Wang, G. S. Kino, and O. Solgaard, "MEMS Based Dual-axes Confocal Reflectance Handheld Microscope for In Vivo Imaging," presented at IEEE/LEOS International Conference on Optical MEMS, 2006.

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Figures (6)

Fig. 1.
Fig. 1.

Scanning electron micrograph (A) and electrical schematic (B) of the MEMS two-axis optical scanner. The scanner has a larger 1 mm diameter mirror and uses angled vertical comb (AVC) actuators to produce a large angle scan for high resolution imaging.

Fig. 2.
Fig. 2.

MEMS catheter design and performance characteristics. (A) Optical schematic. (B) Mechanical drawing. (C) Non-resonant drive characteristics for the MEMS optical scanner after packaging in the catheter endoscope. SMF, single mode fiber. FC, fiber collimator. AL, aluminum.

Fig. 3.
Fig. 3.

Resonance characteristics of the MEMS scanner. The mirror resonance was at 463 Hz and the gimbal axis resonance was 140 Hz.

Fig. 4.
Fig. 4.

Drive control scheme for the MEMS optical scanner. (A) Response to a linear drive waveform. (B) Linearized response to a differential, square-root drive function.

Fig. 5.
Fig. 5.

OCT system schematic for imaging with the MEMS endoscope. PC, polarization control. AGC, air-gap coupling. Det, detector. Amp, amplifier. D/A, digital to analog converter.

Fig. 6.
Fig. 6.

OCT images acquired with the MEMS scanning catheter. (A,B) In vivo cross-sectional images of human skin. sc, stratum corneum; e, epidermis; d, dermis. (C) Cross-sectional image of lime pulp. (D) Serial cross-sections and en face plane extracted from a three-dimensional OCT volume of hamster cheek pouch acquired in vitro. (E) Three-dimensional rendering of OCT volume data set from the hamster cheek pouch. (F) OCT intensity projection of the 3D volume. Scale bar, 500 μm.

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