Abstract

We present a fast full-view photoacoustic imaging system for visualizing tissue structures using a linear transducer array with combined scan. In this system, a 128-element linear transducer array was used to detect photoacoustic signals by combined scanning of electronic scan and mechanical scan. An improved limited-field filtered back projection algorithm with directivity factors was applied to reconstruct the optical absorption distribution. The experiments on phantoms and in vivo blood vessels in a rat brain were performed with this system. And a clear view of the curve boundaries of objects and the network of blood vessels of rat’s brain were acquired. The experimental results demonstrate the multielement photoacoustic imaging system has the ability of imaging complicated structures of objects.

© 2007 Optical Society of America

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  1. R. O. Esenaliev, A. A. Karabutov and A. A Oraevsky, "Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors," IEEE J.Sel.Top.Quantum Electron. 5, 981-988 (1999).
    [CrossRef]
  2. A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
    [CrossRef]
  3. V. G. Andreev, A. A. Karabutov and A. A. Oraevsky, "Detection of ultrawide-band ultrasound pulses in optoacoustic tomography," IEEE Trans. Ultrason. Ferroelectr. Freq. control. 50, 1383-1390 (2003).
    [CrossRef] [PubMed]
  4. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
    [CrossRef] [PubMed]
  5. J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
    [CrossRef] [PubMed]
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    [CrossRef]
  7. E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
    [CrossRef]
  8. J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
    [CrossRef]
  9. E. V. Savateenva, A. A. Karabutov, S. V. Solomatin, and A. A. oraevsky, " Optical properties of blood at various level of oxygenation studied by time detection of laser-induced pressure profiles," Proc. SPIE 4618, 63-75 (2002).
    [CrossRef]
  10. R. O. Esenaliev, I. V. larina, K. V. Larin, D. J. Deyo, M. Motamedi and D. S. Prough, " Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study," Appl. Opt. 43, 3401 1-7 (2002).
  11. H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
    [PubMed]
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  16. R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
    [CrossRef]
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    [CrossRef]
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    [CrossRef]
  19. B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
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    [CrossRef]
  22. Y. Xu, L. V. Wang, "Reconstructions in limited-view thermoacoustic tomography," Med. Phys. 31, 724-733 (2004).
    [CrossRef] [PubMed]
  23. A. A. oraevsky, V. G. Andreev, A. A. Karabutov, and R. O. Esenaliev, " Two-dimensional opto-acoustic tomography transducer array and image reconstruction algorithm," Proc. SPIE 3601, 256-267 (1999).
    [CrossRef]
  24. M. H. Xu and L. V. Wang, "Time-domain reconstruction for thermoacoustic tomography in a spherical geometry," IEEE Trans. Med. Imaging. 21, 814-822 (2002).
    [CrossRef] [PubMed]

2007

2005

M. Kinnunen and R. Myllyla, "Effect of glucose on photoacoustic signals at wavelengths of 1064 and 532 nm in pig blood and Intralipid," J. Phys D: Appl. Phys. 38, 2654-2661 (2005).
[CrossRef]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

2004

Y. Xu, L. V. Wang, "Reconstructions in limited-view thermoacoustic tomography," Med. Phys. 31, 724-733 (2004).
[CrossRef] [PubMed]

R. I. Siphanto, K. K. Thumma, T. G. Van Leewen, F. F. M. de Mul, J. W. van Neck, L. N. A. van Adrichem and W. Steenbergen, "Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis," Opt. Express 13, 89-95 (2004).
[CrossRef]

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

2003

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

V. G. Andreev, A. A. Karabutov and A. A. Oraevsky, "Detection of ultrawide-band ultrasound pulses in optoacoustic tomography," IEEE Trans. Ultrason. Ferroelectr. Freq. control. 50, 1383-1390 (2003).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

2002

M. H. Xu and L. V. Wang, "Time-domain reconstruction for thermoacoustic tomography in a spherical geometry," IEEE Trans. Med. Imaging. 21, 814-822 (2002).
[CrossRef] [PubMed]

E. V. Savateenva, A. A. Karabutov, S. V. Solomatin, and A. A. oraevsky, " Optical properties of blood at various level of oxygenation studied by time detection of laser-induced pressure profiles," Proc. SPIE 4618, 63-75 (2002).
[CrossRef]

2001

Z. Zhao and R. Myllyla, "Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode," Proc. SPIE 4256, 77-83 (2001).
[CrossRef]

D. Feng, Y. Xu, G. Ku, and L. V. Wang, "Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture," Med. Phys. 28, 2427-2431 (2001).
[CrossRef]

2000

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

1999

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

R. O. Esenaliev, A. A. Karabutov and A. A Oraevsky, "Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors," IEEE J.Sel.Top.Quantum Electron. 5, 981-988 (1999).
[CrossRef]

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

A. A. oraevsky, V. G. Andreev, A. A. Karabutov, and R. O. Esenaliev, " Two-dimensional opto-acoustic tomography transducer array and image reconstruction algorithm," Proc. SPIE 3601, 256-267 (1999).
[CrossRef]

Aguilar, G.

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

Andreev, V. A.

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Andreev, V. G.

V. G. Andreev, A. A. Karabutov and A. A. Oraevsky, "Detection of ultrawide-band ultrasound pulses in optoacoustic tomography," IEEE Trans. Ultrason. Ferroelectr. Freq. control. 50, 1383-1390 (2003).
[CrossRef] [PubMed]

Ashton, H. S.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Bell, B.

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

Bitton, R.

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

Chen, Q.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Chen, W. R.

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

Chen, Zh. X.

Choi, B.

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

de Mul, F. F. M.

Esenaliev, R. O.

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

R. O. Esenaliev, A. A. Karabutov and A. A Oraevsky, "Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors," IEEE J.Sel.Top.Quantum Electron. 5, 981-988 (1999).
[CrossRef]

R. O. Esenaliev, I. V. larina, K. V. Larin, D. J. Deyo, M. Motamedi and D. S. Prough, " Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study," Appl. Opt. 43, 3401 1-7 (2002).

Feng, D.

D. Feng, Y. Xu, G. Ku, and L. V. Wang, "Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture," Med. Phys. 28, 2427-2431 (2001).
[CrossRef]

Fleming, R. D.

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Freeborn, S. S.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Frenz, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

Gatalica, Z.

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Gu, H. M

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

Gu, H. M.

D. W. Yang, D. Xing, Y. Tan, H. M. Gu and S. H. Yang, "Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head," Appl. Phys. Lett. 88, 174101 1-3 (2006).
[CrossRef]

D. W. Yang, D. Xing, H. M. Gu, Y. Tan and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

Hannigan, J.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

Johnigan, R.

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

Karabutov, A. A.

V. G. Andreev, A. A. Karabutov and A. A. Oraevsky, "Detection of ultrawide-band ultrasound pulses in optoacoustic tomography," IEEE Trans. Ultrason. Ferroelectr. Freq. control. 50, 1383-1390 (2003).
[CrossRef] [PubMed]

E. V. Savateenva, A. A. Karabutov, S. V. Solomatin, and A. A. oraevsky, " Optical properties of blood at various level of oxygenation studied by time detection of laser-induced pressure profiles," Proc. SPIE 4618, 63-75 (2002).
[CrossRef]

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

R. O. Esenaliev, A. A. Karabutov and A. A Oraevsky, "Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors," IEEE J.Sel.Top.Quantum Electron. 5, 981-988 (1999).
[CrossRef]

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Kinnunen, M.

M. Kinnunen and R. Myllyla, "Effect of glucose on photoacoustic signals at wavelengths of 1064 and 532 nm in pig blood and Intralipid," J. Phys D: Appl. Phys. 38, 2654-2661 (2005).
[CrossRef]

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

D. Feng, Y. Xu, G. Ku, and L. V. Wang, "Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture," Med. Phys. 28, 2427-2431 (2001).
[CrossRef]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

Li, M. L.

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

Lindberg, J.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Mackenzie, H. A

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Montamedi, M.

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

Myllyla, R.

M. Kinnunen and R. Myllyla, "Effect of glucose on photoacoustic signals at wavelengths of 1064 and 532 nm in pig blood and Intralipid," J. Phys D: Appl. Phys. 38, 2654-2661 (2005).
[CrossRef]

Z. Zhao and R. Myllyla, "Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode," Proc. SPIE 4256, 77-83 (2001).
[CrossRef]

Nelson, J. S.

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

Oraevsky, A. A

R. O. Esenaliev, A. A. Karabutov and A. A Oraevsky, "Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors," IEEE J.Sel.Top.Quantum Electron. 5, 981-988 (1999).
[CrossRef]

Oraevsky, A. A.

V. G. Andreev, A. A. Karabutov and A. A. Oraevsky, "Detection of ultrawide-band ultrasound pulses in optoacoustic tomography," IEEE Trans. Ultrason. Ferroelectr. Freq. control. 50, 1383-1390 (2003).
[CrossRef] [PubMed]

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Rare, P.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Savateenva, E. V.

E. V. Savateenva, A. A. Karabutov, S. V. Solomatin, and A. A. oraevsky, " Optical properties of blood at various level of oxygenation studied by time detection of laser-induced pressure profiles," Proc. SPIE 4618, 63-75 (2002).
[CrossRef]

Savateeva, E. V.

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

Shen, Y.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Shung, K. K.

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

Singh, H.

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Siphanto, R. I.

Solomatin, S. V.

E. V. Savateenva, A. A. Karabutov, S. V. Solomatin, and A. A. oraevsky, " Optical properties of blood at various level of oxygenation studied by time detection of laser-induced pressure profiles," Proc. SPIE 4618, 63-75 (2002).
[CrossRef]

Spiers, S.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

Steenbergen, W.

Stoca, G.

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

Stoica, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Svaasand, L. O.

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

Tan, Y.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

D. W. Yang, D. Xing, H. M. Gu, Y. Tan and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

D. W. Yang, D. Xing, Y. Tan, H. M. Gu and S. H. Yang, "Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head," Appl. Phys. Lett. 88, 174101 1-3 (2006).
[CrossRef]

Tang, Zh. L.

Thumma, K. K.

van Adrichem, L. N. A.

Van Leewen, T. G.

van Neck, J. W.

Viator, J. A.

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

Wan, W.

Wang, L. V.

Y. Xu, L. V. Wang, "Reconstructions in limited-view thermoacoustic tomography," Med. Phys. 31, 724-733 (2004).
[CrossRef] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

M. H. Xu and L. V. Wang, "Time-domain reconstruction for thermoacoustic tomography in a spherical geometry," IEEE Trans. Med. Imaging. 21, 814-822 (2002).
[CrossRef] [PubMed]

D. Feng, Y. Xu, G. Ku, and L. V. Wang, "Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture," Med. Phys. 28, 2427-2431 (2001).
[CrossRef]

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

Wang, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Wang, Y.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

Xiang, L.Zh.

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Xing, D.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

D. W. Yang, D. Xing, H. M. Gu, Y. Tan and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

D. W. Yang, D. Xing, Y. Tan, H. M. Gu and S. H. Yang, "Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head," Appl. Phys. Lett. 88, 174101 1-3 (2006).
[CrossRef]

Xu, M. H.

M. H. Xu and L. V. Wang, "Time-domain reconstruction for thermoacoustic tomography in a spherical geometry," IEEE Trans. Med. Imaging. 21, 814-822 (2002).
[CrossRef] [PubMed]

Xu, Y.

Y. Xu, L. V. Wang, "Reconstructions in limited-view thermoacoustic tomography," Med. Phys. 31, 724-733 (2004).
[CrossRef] [PubMed]

D. Feng, Y. Xu, G. Ku, and L. V. Wang, "Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture," Med. Phys. 28, 2427-2431 (2001).
[CrossRef]

Yang, D. W.

D. W. Yang, D. Xing, H. M. Gu, Y. Tan and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

D. W. Yang, D. Xing, Y. Tan, H. M. Gu and S. H. Yang, "Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head," Appl. Phys. Lett. 88, 174101 1-3 (2006).
[CrossRef]

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

Yang, S. H.

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

D. W. Yang, D. Xing, Y. Tan, H. M. Gu and S. H. Yang, "Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head," Appl. Phys. Lett. 88, 174101 1-3 (2006).
[CrossRef]

Yin, B. Zh.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Zemp, R. J.

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

Zeng, L. M.

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

D. W. Yang, D. Xing, H. M. Gu, Y. Tan and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

Zeng, Y. G.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Zhao, Z.

Z. Zhao and R. Myllyla, "Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode," Proc. SPIE 4256, 77-83 (2001).
[CrossRef]

Clin. Chem.

H. A Mackenzie, H. S. Ashton, S. Spiers, Y. Shen, S. S. Freeborn, J. Hannigan, J. Lindberg and P. Rare, "Advance in photoacoustic noninvasive glucose testing," Clin. Chem. 45, 1587-1595 (1999).
[PubMed]

IEEE J. Sel. Top. Quantum Electron.

R. O. Esenaliev, A. A. Karabutov and A. A Oraevsky, "Sensitivity of laser opto-acoustic imaging in detection of small deeply embedded tumors," IEEE J.Sel.Top.Quantum Electron. 5, 981-988 (1999).
[CrossRef]

IEEE Trans. Med. Imaging

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, "Combined ultrasound and optoacoustic system for real-time high contrast vascular imaging in vivo," IEEE Trans. Med. Imaging 24, 436-440 (2005).
[CrossRef] [PubMed]

IEEE Trans. Med. Imaging.

M. H. Xu and L. V. Wang, "Time-domain reconstruction for thermoacoustic tomography in a spherical geometry," IEEE Trans. Med. Imaging. 21, 814-822 (2002).
[CrossRef] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. control.

V. G. Andreev, A. A. Karabutov and A. A. Oraevsky, "Detection of ultrawide-band ultrasound pulses in optoacoustic tomography," IEEE Trans. Ultrason. Ferroelectr. Freq. control. 50, 1383-1390 (2003).
[CrossRef] [PubMed]

J. Phys D: Appl. Phys.

M. Kinnunen and R. Myllyla, "Effect of glucose on photoacoustic signals at wavelengths of 1064 and 532 nm in pig blood and Intralipid," J. Phys D: Appl. Phys. 38, 2654-2661 (2005).
[CrossRef]

Med. Phys.

D. Feng, Y. Xu, G. Ku, and L. V. Wang, "Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture," Med. Phys. 28, 2427-2431 (2001).
[CrossRef]

Y. Xu, L. V. Wang, "Reconstructions in limited-view thermoacoustic tomography," Med. Phys. 31, 724-733 (2004).
[CrossRef] [PubMed]

Nat.Biotechnol.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, "Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain," Nat.Biotechnol. 21, 803-806 (2003).
[CrossRef] [PubMed]

Opt. Express

Phys. Med. Biol.

B. Zh. Yin, D. Xing, Y. Wang, Y. G. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on a 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Proc. SPIE

A. A. oraevsky, V. G. Andreev, A. A. Karabutov, and R. O. Esenaliev, " Two-dimensional opto-acoustic tomography transducer array and image reconstruction algorithm," Proc. SPIE 3601, 256-267 (1999).
[CrossRef]

Z. Zhao and R. Myllyla, "Photoacoustic determination of glucose concentration in whole blood by a near-infrared laser diode," Proc. SPIE 4256, 77-83 (2001).
[CrossRef]

E. V. Savateeva, A. A. Karabutov, B. Bell, R. Johnigan, M. Montamedi, and A. A. Oraevsky, "Noninvasive detection and staging of oral cancer in vivo with confocal optoacoustic tomography," Proc. SPIE 3597, 55-67 (2000).
[CrossRef]

J. A. Viator, L. O. Svaasand, G. Aguilar, B. Choi, and J. S. Nelson, "Photoacoustic measurement of epidermal melanin," Proc. SPIE 4960, 14-21 (2003).
[CrossRef]

E. V. Savateenva, A. A. Karabutov, S. V. Solomatin, and A. A. oraevsky, " Optical properties of blood at various level of oxygenation studied by time detection of laser-induced pressure profiles," Proc. SPIE 4618, 63-75 (2002).
[CrossRef]

Proc.SPIE

A. A. Oraevsky, V. A. Andreev, A. A. Karabutov, R. D. Fleming, Z. Gatalica, H. Singh and R. O. Esenaliev,"Laser optoacoustic imaging of breast: detection of cancer angiogenesis," Proc. SPIE 3597, 352-363 (1999).
[CrossRef]

Other

R. O. Esenaliev, I. V. larina, K. V. Larin, D. J. Deyo, M. Motamedi and D. S. Prough, " Optoacoustic technique for noninvasive monitoring of blood oxygenation: a feasibility study," Appl. Opt. 43, 3401 1-7 (2002).

L.Zh. Xiang, D. Xing, H. M Gu, D. W. Yang, S. H. Yang, L. M. Zeng and W. R. Chen, "Real-time optoacoustic monitoring of vascular damage during photodynamic therapy treatment of tumor," J. Biomed Opt. 12, 014001 1-8 (2007).
[CrossRef]

S. A. Ermilov, A. Coniusteau, K. Mehta, R. Lacewell, P. M. Henrichs and A. A. Oraevsky, "128-channel laser optoacoustic imaging system for breast cancer diagnostics," Proc. SPIE. 6086, 608609 1-12 (2006).

R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoca and L. V. Wang, "Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer," J. Biomed Opt. Lett. 12, 010501 1-3 (2007).
[CrossRef]

D. W. Yang, D. Xing, H. M. Gu, Y. Tan and L. M. Zeng, "Fast multielement phase-controlled photoacoustic imaging based on limited-field-filtered back-projection algorithm," Appl. Phys. Lett. 87, 194101 1-3 (2005).
[CrossRef]

D. W. Yang, D. Xing, Y. Tan, H. M. Gu and S. H. Yang, "Integrative prototype B-scan photoacoustic tomography system based on a novel hybridized scanning head," Appl. Phys. Lett. 88, 174101 1-3 (2006).
[CrossRef]

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Figures (7)

Fig. 1.
Fig. 1.

Directionality pattern of the ultrasound detection with a linear transducer array.

Fig. 2.
Fig. 2.

The experimental setup of the photoacoustic computed tomography system.

Fig. 3.
Fig. 3.

(a) Reconstructed image of the phantom with the LFBP algorithm. (b) Reconstructed image of the phantom with the improved LFBP algorithm. (c) The line normal to object axis profile of the reconstructed image shown in Fig. 3 (a) with y=30mm. (d) The line normal to object axis profile of the reconstructed image shown in Fig. 3 (b) with y=30mm.

Fig. 4.
Fig. 4.

(a) The schematic of measuring the slice width profile of the linear transducer array. (b) The amplitude slice-width profile of the linear transducer array to a point source placed at the position of 35mm in front of the linear transducer array.

Fig. 5.
Fig. 5.

Reconstructed image of the two elliptical absorbers embedded in phantom (inset: cross section of the phantom). (a) is the reconstructed photoacoustic image using the improved LFBP algorithm with the directivity pattern functions of individual transducer and the total transducer array. (b) is the reconstructed image using the improved LFBP algorithm with the directivity pattern function of individual transducer.

Fig. 6.
Fig. 6.

Reconstructed image of the network of simulated blood vessels (inset: cross section of the phantom).

Fig. 7.
Fig. 7.

Photoacoustic imaging of the rat brain in vivo. (a) Open-skull photograph of rat brain surface acquired after experiment. (b) Photoacoustic imaging of the superficial layer of a rat brain acquired with the skin and skull intact.

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

d ( θ ) = sin ( πa λ sin ( θ ) ) πa λ sin ( θ ) ,
D ( θ ) = sin ( πL λ sin ( θ ) ) sin ( πd λ sin ( θ ) ,
S f = m = 1 K n = 1 N d mn f D m f S mn ( t + τ mn f ) n = 1 N d mn f D m f .

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