Abstract

Abstract

Ultra-high resolution optical coherence tomography (OCT) imaging is demonstrated simultaneously at 840 nm and 1230 nm central wavelength using an off-the-shelf turn-key supercontinuum light source. Spectral filtering of the light source emission results in a double peak spectrum with average powers exceeding 100 mW and bandwidths exceeding 200 nm for each wavelength band. A free-space OCT setup optimized to support both wavelengths in parallel is introduced. OCT imaging of biological tissue ex vivo and in vivo is demonstrated with axial resolutions measured to be <2 µm and <4 µm at 840 nm and 1230 nm, respectively. This measuring scheme is used to extract spectroscopic features with outstanding spatial resolution enabling enhanced image contrast.

© 2007 Optical Society of America

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2007 (1)

2006 (2)

T. Støren, A. Røyset, L. O. Svaasand, and T. Lindmo, "Measurement of dye diffusion in scattering tissue phantoms using dual-wavelength low-coherence interferometry," J. Biomed. Opt. 11, 014017 (2006).
[CrossRef] [PubMed]

A. D. Aguirre, N. Nishizawa, J. G. Fujimoto, W. Seitz, M. Lederer, and D. Kopf, "Continuum generation in a novel photonic crystal fiber for ultrahigh resolution optical coherence tomography at 800 nm and 1300 nm," Opt. Express 14, 1145-1160 (2006).
[CrossRef] [PubMed]

2005 (3)

2004 (6)

D. C. Adler, T. H. Ko, P. R. Herz, and J. G. Fujimoto, "Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation," Opt. Express 12, 5487-5501 (2004).
[CrossRef] [PubMed]

W. Drexler, "Ultrahigh-resolution optical coherence tomography," J. Biomed. Opt. 9, 47-74 (2004).
[CrossRef] [PubMed]

C. Vinegoni, J. S. Bredfeldt, D. L. Marks, and S. A. Boppart, "Nonlinear optical contrast enhancement for optical coherence tomography," Opt. Express 12, 331-341 (2004).
[CrossRef] [PubMed]

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

C. H. Yang, L. E. L. McGuckin, J. D. Simon, M. A. Choma, B. E. Applegate, and J. A. Izatt, "Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent," Opt. Lett. 29, 2016-2018 (2004).
[CrossRef] [PubMed]

V. M. Gelikonov, G. V. Gelikonov, and F. I. Feldchtein, "Two-wavelength optical coherence tomography," Radiophys. Quantum Electron. 47, 848-859 (2004).
[CrossRef]

2003 (5)

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography," Opt. Express 11, 2190-2197 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Speckle reduction in optical coherence tomography by frequency compounding," J. Biomed. Opt. 8, 565-569 (2003).
[CrossRef] [PubMed]

K. Bizheva, B. Povazay, B. Hermann, H. Sattmann, W. Drexler, M. Mei, R. Holzwarth, T. Hoelzenbein, V. Wacheck, and H. Pehamberger, "Compact, broad-bandwidth fiber laser for sub-2-microm axial resolution optical coherence tomography in the 1300-nm wavelength region," Opt. Lett. 28, 707-709 (2003).
[CrossRef] [PubMed]

J. G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nat. Biotechnol. 21, 1361-1367 (2003).
[CrossRef] [PubMed]

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

2002 (1)

2000 (1)

1998 (3)

1997 (3)

1996 (1)

1995 (1)

1994 (2)

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).
[CrossRef] [PubMed]

1993 (1)

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Aalders, M. C. G.

Adler, D. C.

Aguirre, A. D.

Ahnelt, P. K.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Apolonski, A.

Applegate, B. E.

Barton, J. K.

Bilinsky, I. P.

Bizheva, K.

Boppart, S. A.

Bouma, B.

Bouma, B. E.

Bredfeldt, J. S.

Brezinski, M. E.

Budka, H.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Burgholzer, P.

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

Carney, P. S.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Choma, M. A.

Cope, M.

Cowey, A.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

deBoer, J. F.

Delpy, D. T.

Drexler, W.

Eckhaus, M. A.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).
[CrossRef] [PubMed]

Faber, D. J.

Farkas, D. L.

Y. Pan and D. L. Farkas, "Noninvasive imaging of living human skin with dual-wavelength optical coherence tomography in two and three dimensions," J. Biomed. Opt. 3, 446-455 (1998).
[CrossRef]

Feldchtein, F. I.

Fercher, A. F.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Fujimoto, J. G.

A. D. Aguirre, N. Nishizawa, J. G. Fujimoto, W. Seitz, M. Lederer, and D. Kopf, "Continuum generation in a novel photonic crystal fiber for ultrahigh resolution optical coherence tomography at 800 nm and 1300 nm," Opt. Express 14, 1145-1160 (2006).
[CrossRef] [PubMed]

D. C. Adler, T. H. Ko, P. R. Herz, and J. G. Fujimoto, "Optical coherence tomography contrast enhancement using spectroscopic analysis with spectral autocorrelation," Opt. Express 12, 5487-5501 (2004).
[CrossRef] [PubMed]

J. G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nat. Biotechnol. 21, 1361-1367 (2003).
[CrossRef] [PubMed]

U. Morgner, W. Drexler, F. X. Kartner, X. D. Li, C. Pitris, E. P. Ippen, and J. G. Fujimoto, "Spectroscopic optical coherence tomography," Opt. Lett. 25, 111-113 (2000).
[CrossRef]

B. E. Bouma, G. J. Tearney, I. P. Bilinsky, B. Golubovic, and J. G. Fujimoto, "Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography," Opt. Lett. 21, 1839-1841 (1996).
[CrossRef] [PubMed]

B. Bouma, G. J. Tearney, S. A. Boppart, M. R. Hee, M. E. Brezinski, and J. G. Fujimoto, "High-resolutiom optical coherence tomography imaging using a mode-locked TiAl2O3 laser source," Opt. Lett. 20, 1486-1488 (1995).
[CrossRef] [PubMed]

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Gelikonov, G. V.

Gelikonov, V. M.

Gladkova, N. D.

Golubovic, B.

Götzinger, E.

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography," Opt. Express 11, 2190-2197 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Speckle reduction in optical coherence tomography by frequency compounding," J. Biomed. Opt. 8, 565-569 (2003).
[CrossRef] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hee, M. R.

B. Bouma, G. J. Tearney, S. A. Boppart, M. R. Hee, M. E. Brezinski, and J. G. Fujimoto, "High-resolutiom optical coherence tomography imaging using a mode-locked TiAl2O3 laser source," Opt. Lett. 20, 1486-1488 (1995).
[CrossRef] [PubMed]

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Hermann, B.

Herz, P. R.

Hitzenberger, C. K.

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Speckle reduction in optical coherence tomography by frequency compounding," J. Biomed. Opt. 8, 565-569 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography," Opt. Express 11, 2190-2197 (2003).
[CrossRef] [PubMed]

Hoelzenbein, T.

Hoglinger, O.

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

Holzwarth, R.

Huang, D.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Iksanov, R. R.

Ippen, E. P.

Izatt, J. A.

Kartner, F. X.

Knight, J. C.

Knüttel, A.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).
[CrossRef] [PubMed]

Ko, T. H.

Kopf, D.

Kulkami, M. D.

Kuranov, R. V.

Le, T.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Lederer, M.

Leitgeb, R.

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Speckle reduction in optical coherence tomography by frequency compounding," J. Biomed. Opt. 8, 565-569 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography," Opt. Express 11, 2190-2197 (2003).
[CrossRef] [PubMed]

Li, X. D.

Lin, C. P.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Lindmo, T.

T. Støren, A. Røyset, L. O. Svaasand, and T. Lindmo, "Measurement of dye diffusion in scattering tissue phantoms using dual-wavelength low-coherence interferometry," J. Biomed. Opt. 11, 014017 (2006).
[CrossRef] [PubMed]

Marks, D. L.

Matcher, S. J.

McGuckin, L. E. L.

Mei, M.

Menzel, R.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Mik, E. G.

Milner, T. E.

Morgan, J. E.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Morgner, U.

Nelson, J. S.

Nishizawa, N.

Ourutina, M. N.

Pan, Y.

Y. Pan and D. L. Farkas, "Noninvasive imaging of living human skin with dual-wavelength optical coherence tomography in two and three dimensions," J. Biomed. Opt. 3, 446-455 (1998).
[CrossRef]

Pehamberger, H.

Pircher, M.

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Measurement and imaging of water concentration in human cornea with differential absorption optical coherence tomography," Opt. Express 11, 2190-2197 (2003).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Speckle reduction in optical coherence tomography by frequency compounding," J. Biomed. Opt. 8, 565-569 (2003).
[CrossRef] [PubMed]

Pitris, C.

Povazay, B.

Preusser, M.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Puliafito, C. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Reitsamer, H.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Reitze, D. H.

Rollins, A. M.

Røyset, A.

T. Støren, A. Røyset, L. O. Svaasand, and T. Lindmo, "Measurement of dye diffusion in scattering tissue phantoms using dual-wavelength low-coherence interferometry," J. Biomed. Opt. 11, 014017 (2006).
[CrossRef] [PubMed]

Russell, P. S. J.

Sattmann, H.

Scherzer, E.

Schmitt, J. M.

J. M. Schmitt, S. H. Xiang, and K. M. Yung, "Differential absorption imaging with optical coherence tomography," J. Opt. Soc. Am. A 15, 2288-2296 (1998).
[CrossRef]

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).
[CrossRef] [PubMed]

Schubert, C.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Schuman, J. S.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Schumann, J. S.

Seefeld, M.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Seitz, W.

Sergeev, A. M.

Simon, J. D.

Stifter, D.

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

Stingl, A.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Støren, T.

T. Støren, A. Røyset, L. O. Svaasand, and T. Lindmo, "Measurement of dye diffusion in scattering tissue phantoms using dual-wavelength low-coherence interferometry," J. Biomed. Opt. 11, 014017 (2006).
[CrossRef] [PubMed]

Svaasand, L. O.

T. Støren, A. Røyset, L. O. Svaasand, and T. Lindmo, "Measurement of dye diffusion in scattering tissue phantoms using dual-wavelength low-coherence interferometry," J. Biomed. Opt. 11, 014017 (2006).
[CrossRef] [PubMed]

Swanson, E. A.

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

Tearney, G. J.

Unterhuber, A.

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

B. Povazay, K. Bizheva, A. Unterhuber, B. Hermann, H. Sattmann, A. F. Fercher, W. Drexler, A. Apolonski, W. J. Wadsworth, J. C. Knight, P. S. J. Russell, M. Vetterlein, and E. Scherzer, "Submicrometer axial resolution optical coherence tomography," Opt. Lett. 27, 1800-1802 (2002).
[CrossRef]

van Leeuwen, T. G.

vanGemert, M. J. C.

Vetterlein, M.

Vinegoni, C.

Wacheck, V.

Wadsworth, W. J.

Wang, H.

Warren, J. A.

Welch, A. J.

Xiang, S. H.

Xu, C. Y.

Yadlowsky, M.

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).
[CrossRef] [PubMed]

Yang, C.

C. Yang, "Molecular contrast optical coherence tomography: a review," Photochem. Photobiol. 81, 215-237 (2005).
[CrossRef]

Yang, C. H.

Yazdanfar, S.

Yung, K. M.

Appl. Opt. (2)

Appl. Phys. A (1)

D. Stifter, P. Burgholzer, O. Hoglinger, E. Götzinger, and C. K. Hitzenberger, "Polarisation-sensitive optical coherence tomography for material characterisation and strain-field mapping," Appl. Phys. A 76, 947-951 (2003).
[CrossRef]

Arch. Ophthalmol. (1)

J. A. Izatt, M. R. Hee, E. A. Swanson, C. P. Lin, D. Huang, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, "Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography," Arch. Ophthalmol. 112, 1584-1589 (1994).
[CrossRef] [PubMed]

J. Biomed. Opt. (4)

W. Drexler, "Ultrahigh-resolution optical coherence tomography," J. Biomed. Opt. 9, 47-74 (2004).
[CrossRef] [PubMed]

T. Støren, A. Røyset, L. O. Svaasand, and T. Lindmo, "Measurement of dye diffusion in scattering tissue phantoms using dual-wavelength low-coherence interferometry," J. Biomed. Opt. 11, 014017 (2006).
[CrossRef] [PubMed]

M. Pircher, E. Götzinger, R. Leitgeb, A. F. Fercher, and C. K. Hitzenberger, "Speckle reduction in optical coherence tomography by frequency compounding," J. Biomed. Opt. 8, 565-569 (2003).
[CrossRef] [PubMed]

Y. Pan and D. L. Farkas, "Noninvasive imaging of living human skin with dual-wavelength optical coherence tomography in two and three dimensions," J. Biomed. Opt. 3, 446-455 (1998).
[CrossRef]

J. Opt. Soc. Am. A (1)

Nat. Biotechnol. (1)

J. G. Fujimoto, "Optical coherence tomography for ultrahigh resolution in vivo imaging," Nat. Biotechnol. 21, 1361-1367 (2003).
[CrossRef] [PubMed]

Opt. Express (6)

Opt. Lett. (10)

D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, "Toward assessment of blood oxygen saturation by spectroscopic optical coherence tomography," Opt. Lett. 30, 1015-1017 (2005).
[CrossRef] [PubMed]

K. Bizheva, B. Povazay, B. Hermann, H. Sattmann, W. Drexler, M. Mei, R. Holzwarth, T. Hoelzenbein, V. Wacheck, and H. Pehamberger, "Compact, broad-bandwidth fiber laser for sub-2-microm axial resolution optical coherence tomography in the 1300-nm wavelength region," Opt. Lett. 28, 707-709 (2003).
[CrossRef] [PubMed]

C. H. Yang, L. E. L. McGuckin, J. D. Simon, M. A. Choma, B. E. Applegate, and J. A. Izatt, "Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent," Opt. Lett. 29, 2016-2018 (2004).
[CrossRef] [PubMed]

U. Morgner, W. Drexler, F. X. Kartner, X. D. Li, C. Pitris, E. P. Ippen, and J. G. Fujimoto, "Spectroscopic optical coherence tomography," Opt. Lett. 25, 111-113 (2000).
[CrossRef]

J. A. Izatt, M. D. Kulkami, S. Yazdanfar, J. K. Barton, and A. J. Welch, "In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomograghy," Opt. Lett. 22, 1439-1441 (1997).
[CrossRef]

J. F. deBoer, T. E. Milner, M. J. C. vanGemert, and J. S. Nelson, "Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography," Opt. Lett. 22, 934-936 (1997).
[CrossRef]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schumann, C. A. Puliafito, and J. G. Fujimoto, "In vivo retinal imaging by optical coherence tomography," Opt. Lett. 18, 1864-1866 (1993).
[CrossRef] [PubMed]

B. Bouma, G. J. Tearney, S. A. Boppart, M. R. Hee, M. E. Brezinski, and J. G. Fujimoto, "High-resolutiom optical coherence tomography imaging using a mode-locked TiAl2O3 laser source," Opt. Lett. 20, 1486-1488 (1995).
[CrossRef] [PubMed]

B. E. Bouma, G. J. Tearney, I. P. Bilinsky, B. Golubovic, and J. G. Fujimoto, "Self-phase-modulated Kerr-lens mode-locked Cr:forsterite laser source for optical coherence tomography," Opt. Lett. 21, 1839-1841 (1996).
[CrossRef] [PubMed]

B. Povazay, K. Bizheva, A. Unterhuber, B. Hermann, H. Sattmann, A. F. Fercher, W. Drexler, A. Apolonski, W. J. Wadsworth, J. C. Knight, P. S. J. Russell, M. Vetterlein, and E. Scherzer, "Submicrometer axial resolution optical coherence tomography," Opt. Lett. 27, 1800-1802 (2002).
[CrossRef]

Photochem. Photobiol. (1)

C. Yang, "Molecular contrast optical coherence tomography: a review," Photochem. Photobiol. 81, 215-237 (2005).
[CrossRef]

Phys. Med. Biol. (2)

A. Unterhuber, B. Povazay, K. Bizheva, B. Hermann, H. Sattmann, A. Stingl, T. Le, M. Seefeld, R. Menzel, M. Preusser, H. Budka, C. Schubert, H. Reitsamer, P. K. Ahnelt, J. E. Morgan, A. Cowey, and W. Drexler, "Advances in broad bandwidth light sources for ultrahigh resolution optical coherence tomogram phy," Phys. Med. Biol. 49, 1235-1246 (2004).
[CrossRef] [PubMed]

J. M. Schmitt, A. Knüttel, M. Yadlowsky, and M. A. Eckhaus, "Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering," Phys. Med. Biol. 39, 1705-1720 (1994).
[CrossRef] [PubMed]

Radiophys. Quantum Electron. (1)

V. M. Gelikonov, G. V. Gelikonov, and F. I. Feldchtein, "Two-wavelength optical coherence tomography," Radiophys. Quantum Electron. 47, 848-859 (2004).
[CrossRef]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991).
[CrossRef] [PubMed]

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Figures (5)

Fig. 1.
Fig. 1.

Experimental measurements of the unfiltered (black) and filtered (gray) supercontinuum spectra on a linear (a) and a logarithmic (b) scale. Both spectra were normalized to the maximum of the filtered spectra.

Fig. 2.
Fig. 2.

Schematic of the prism sequence used for spectral filtering of the light source (a) and of the time-domain free space OCT setup (b) used for simultaneous dual-band UHROCT. M-metallic mirror, SP-short pass filter, T-telescope beam expander and spatial filter, BS-beamsplitter, DC-dispersion compensating glass plates, GM-galvanometer mirror, L-achromatic lens, DM-dichroic mirror, BP-balanced photoreceiver.

Fig. 3.
Fig. 3.

Experimental measurements of the spectral bands of the light source used for OCT imaging at 840 nm (a) and 1230 nm (b) central wavelength (gray curves). The black curves correspond to the interference bandwidths calculated by Fourier transform of the linear scaled point spread functions (PSFs) at 830 nm (c) and 1230 nm (d) measured simultaneously by the introduced OCT setup using a single reflection of a glass substrate. The corresponding demodulated logarithmic PSFs are displayed in (e) and (f).

Fig. 4.
Fig. 4.

In vivo dual-band UHR-OCT imaging of a human nail fold. (a) and (b) are the intensity based images at 840 nm and 1230 nm, respectively. (c) was derived by frequency compounding and (d) is the differential color image. Image dimensions are 2.5 mm×1.5 mm. S-stratum corneum; E-epidermis; BM-basement membrane; D-dermis; BV-blood vessel; N-nail plate.

Fig. 5.
Fig. 5.

Dual-band UHR-OCT imaging of the transitional zone between the stroma and the sclera of a rabbit eye in vitro. (a) was imaged at 840 nm, (b) was imaged at 1230 nm, (c) was derived by frequency compounding and (d) is the differential color image. Image dimensions are 3.5 mm×1.5 mm. Ep-epithelium; St-Stroma; En-endothelium; DM- Descement’s membrane; BV-blood vessels; CA-chamber angle; Ir-iris; Co-conjunctiva; Sc-sclera; CM-ciliary muscle.

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