Abstract

The authors of the work: ‘Chromosomal analysis and identification based on optical tweezers and raman spectroscopy’ [Opt. Express 14, 5385 (2006], claim that they have been able to identify and differentiate between three human chromosomes with an optical-tweezer - Raman Spectroscopic experimental (LTRS) set-up. The results and conclusions as they are presented in the paper are questionable, however, when the spectral data and data analysis are studied in greater detail.

© 2007 Optical Society of America

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References

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  1. J. F. Ojeda, C. Xie, Y-Q. Li, F. E. Bertrand, J. Wiley, and T. J. McConell, "Chromosomal analysis and identification based on optical tweezers and raman spectroscopy," Opt. Express 14, 5385 (2006).
    [CrossRef] [PubMed]
  2. G. Baudat and F. Anouar, "Generalized discriminant analysis using a kernel approach," Neural Compt. 12, 2385-2404 (2000).
    [CrossRef]
  3. N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
    [CrossRef] [PubMed]
  4. S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
    [CrossRef]

2006

2005

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

2004

N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
[CrossRef] [PubMed]

2000

G. Baudat and F. Anouar, "Generalized discriminant analysis using a kernel approach," Neural Compt. 12, 2385-2404 (2000).
[CrossRef]

Anouar, F.

G. Baudat and F. Anouar, "Generalized discriminant analysis using a kernel approach," Neural Compt. 12, 2385-2404 (2000).
[CrossRef]

Axelson, D. E.

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

Baudat, G.

G. Baudat and F. Anouar, "Generalized discriminant analysis using a kernel approach," Neural Compt. 12, 2385-2404 (2000).
[CrossRef]

Bertrand, F. E.

De Moor, B.

N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
[CrossRef] [PubMed]

De Smet, F.

N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
[CrossRef] [PubMed]

Guillou, C.

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

Heberger, K.

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

Li, Y-Q.

Mariani, C.

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

McConell, T. J.

Ojeda, J. F.

Pochet, N.

N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
[CrossRef] [PubMed]

Reiero, F.

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

Rezzi, S.

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

Suykens, J.

N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
[CrossRef] [PubMed]

Wiley, J.

Xie, C.

Anal. Chim. Acta

S. Rezzi, D. E. Axelson, K. Heberger, F. Reiero, C. Mariani, and C. Guillou, "Classification of olive oils using high throughput flow [1]H NMR fingerprinting with principal component analysis, linear discriminant analysis and probabilistic neural networks," Anal. Chim. Acta 552, 13-24 (2005).
[CrossRef]

Bioinformatics

N. Pochet, F. De Smet, J. Suykens, and B. De Moor, "Systematic benchmarking of micro array data classification: assessing the role of nonlinearity and dimensionality reduction," Bioinformatics 20, 3185-3195 (2004).
[CrossRef] [PubMed]

Neural Compt.

G. Baudat and F. Anouar, "Generalized discriminant analysis using a kernel approach," Neural Compt. 12, 2385-2404 (2000).
[CrossRef]

Opt. Express

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