Abstract

We report on experimental demonstration of photoacoustic tomography for simultaneous recovery of the optical and acoustic properties of heterogeneous media. Photoacoustic images are reconstructed from a series of tissue-like phantom experiments using a finite element-based reconstruction algorithm coupled with a scanning photoacoustic imaging system. The results show that the images obtained are quantitative in terms of the shape, size, location and optical and acoustic properties of the heterogeneities examined.

© 2006 Optical Society of America

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  1. G. Paltauf, J. Viator, S. Prahl, S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544(2002).
    [CrossRef] [PubMed]
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    [CrossRef]
  3. A.A. Karabutov, E. Savateeva, A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," Proc. SPIE 3601, 284-295(1999).
    [CrossRef]
  4. R.A. Kruger, D. Reinecke, G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837(1999).
    [CrossRef] [PubMed]
  5. Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
    [CrossRef]
  6. R. I. Siphanto, K. K. Thumma, R.G.M. Kolkman, T.G. van Leeuwen, F.F.M. de mul, J.W. van Neck, L.N.A. van Adrichem, and W. Steenbergen, "Serial noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis," Opt. Express 13, 89-95 (2005).
    [CrossRef] [PubMed]
  7. B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
    [CrossRef] [PubMed]
  8. J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
    [CrossRef] [PubMed]
  9. X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
    [CrossRef]
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    [CrossRef] [PubMed]
  11. K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
    [CrossRef]
  12. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
    [CrossRef]
  13. JoelJ. Niederhauser, Michael Jaeger, Robot Lemor, Peter Weber, and Martin Frenz, "Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo," IEEE Trans. Biomed. Eng. 24, 436-440 (2005).
  14. C.G.A. Hoelen, F.F. de Mul, R. Pongers, A. Dekker, "Three-dimensional photoacoustic imaging of blood vessls in tissue," Opt. Lett. 23, 648-650 (1998).
    [CrossRef]
  15. H. Jiang, Z. Yuan, X. Gu, "Spatially varying optical and acoustic property reconstruction using finite element-based photoacoustic tomography," J. Opt. Soc. Am. A 23, 878-888 (2006).
    [CrossRef]
  16. Z. Yuan, C. Wu, H. Zhao, H. Jiang, "Imaging of small nanoparticle-containing objects by finite element-based photoacoustic tomography," Opt. Lett. 30, 3054-3056 (2005).
    [CrossRef] [PubMed]
  17. Z. Yuan, H. Zhao, C. Wu, Q. Zhang, H. Jiang, "Finite element-based photoacoustic tomography: phantom and chicken bone experiments," Appl. Opt. 45, 3177-3183 (2006).
    [CrossRef] [PubMed]
  18. Z. Yuan, H. Jiang, "Quantitative photoacoustic tomography: recovery of optical absorption coefficient maps of heterogeneous media," Appl. Phys. Lett. 88, 231101 (2006).
    [CrossRef]
  19. J.F. Greenleaf, R.C. Bahn, "Clinical imaging with transmissive ultrasound computerized tomography," IEEE Trans. Biomed. Eng. 28, 177-185 (1981).
    [CrossRef] [PubMed]
  20. S. Schreiman, J.J. Gisvold, J.F. Greenleaf, R.C. Bahn, "Ultrasound transmission computed tomography of the breast," Radiol. 150, 523-530 (1984).

2006 (3)

2005 (3)

2004 (2)

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

2003 (2)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

S.J. Norton, T. Vo-Dinh, "Optoacoustic diffraction tomography: analysis of algorihms," J. Opt. Soc. Am. A 20, 1859-1866(2003).
[CrossRef]

2002 (3)

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

G. Paltauf, J. Viator, S. Prahl, S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544(2002).
[CrossRef] [PubMed]

2001 (1)

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

1999 (2)

A.A. Karabutov, E. Savateeva, A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," Proc. SPIE 3601, 284-295(1999).
[CrossRef]

R.A. Kruger, D. Reinecke, G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837(1999).
[CrossRef] [PubMed]

1998 (2)

1984 (1)

S. Schreiman, J.J. Gisvold, J.F. Greenleaf, R.C. Bahn, "Ultrasound transmission computed tomography of the breast," Radiol. 150, 523-530 (1984).

1981 (1)

J.F. Greenleaf, R.C. Bahn, "Clinical imaging with transmissive ultrasound computerized tomography," IEEE Trans. Biomed. Eng. 28, 177-185 (1981).
[CrossRef] [PubMed]

Au, G.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

Bahn, R.C.

S. Schreiman, J.J. Gisvold, J.F. Greenleaf, R.C. Bahn, "Ultrasound transmission computed tomography of the breast," Radiol. 150, 523-530 (1984).

J.F. Greenleaf, R.C. Bahn, "Clinical imaging with transmissive ultrasound computerized tomography," IEEE Trans. Biomed. Eng. 28, 177-185 (1981).
[CrossRef] [PubMed]

Chen, Q.

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Chen, Z.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

de Mul, F.F.

de Mul, Frits F M

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Dekker, A.

Frauchiger, D.

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

Frenz, M.

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

Fry, E.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Gisvold, J.J.

S. Schreiman, J.J. Gisvold, J.F. Greenleaf, R.C. Bahn, "Ultrasound transmission computed tomography of the breast," Radiol. 150, 523-530 (1984).

Greenleaf, J.F.

S. Schreiman, J.J. Gisvold, J.F. Greenleaf, R.C. Bahn, "Ultrasound transmission computed tomography of the breast," Radiol. 150, 523-530 (1984).

J.F. Greenleaf, R.C. Bahn, "Clinical imaging with transmissive ultrasound computerized tomography," IEEE Trans. Biomed. Eng. 28, 177-185 (1981).
[CrossRef] [PubMed]

Gu, X.

Hoelen, C.G.A.

Hondebrink, Erwin

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Hopman, Jeroen CW

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Jacques, S.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

G. Paltauf, J. Viator, S. Prahl, S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544(2002).
[CrossRef] [PubMed]

Jiang, H.

Joel,

JoelJ. Niederhauser, Michael Jaeger, Robot Lemor, Peter Weber, and Martin Frenz, "Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo," IEEE Trans. Biomed. Eng. 24, 436-440 (2005).

Karabutov, A.A.

A.A. Karabutov, E. Savateeva, A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," Proc. SPIE 3601, 284-295(1999).
[CrossRef]

Klaessens, John H.G.M.

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Kolkman, R.G.M.

Kollkman, Roy. G.M

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Kostli, K.P.

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

Kruger, G.

R.A. Kruger, D. Reinecke, G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837(1999).
[CrossRef] [PubMed]

Kruger, R.A.

R.A. Kruger, D. Reinecke, G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837(1999).
[CrossRef] [PubMed]

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

Liu, P.

P. Liu, "The P-transform and photoacoustic image reconstruction," Phys. Med. Biol. 43, 667-674 (1998).
[CrossRef] [PubMed]

Nelson, J.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

Niederhauser, J.

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

Norton, S.J.

Oraevsky, A.

A.A. Karabutov, E. Savateeva, A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," Proc. SPIE 3601, 284-295(1999).
[CrossRef]

Paltauf, G.

G. Paltauf, J. Viator, S. Prahl, S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544(2002).
[CrossRef] [PubMed]

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

Pongers, R.

Prahl, S.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

G. Paltauf, J. Viator, S. Prahl, S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544(2002).
[CrossRef] [PubMed]

Reinecke, D.

R.A. Kruger, D. Reinecke, G. Kruger, "Thermoacoustic computed tomography-technical considerations," Med. Phys. 26, 1832-1837(1999).
[CrossRef] [PubMed]

Ren, H.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

Savateeva, E.

A.A. Karabutov, E. Savateeva, A. Oraevsky, "Imaging of layered structures in biological tissues with opto-acoustic front surface transducer," Proc. SPIE 3601, 284-295(1999).
[CrossRef]

Schreiman, S.

S. Schreiman, J.J. Gisvold, J.F. Greenleaf, R.C. Bahn, "Ultrasound transmission computed tomography of the breast," Radiol. 150, 523-530 (1984).

Siphanto, R. I.

Steenbergen, Wiendelt

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Stoica, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

Tan, Y.

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Thijssen, Johan M

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Thumma, K. K.

van Leeuwen, T.G.

van Leeuwen, Ton G

Roy. G.M . Kollkman, John H.G.M. Klaessens, Erwin Hondebrink, Jeroen CW Hopman, Frits F M de Mul, Wiendelt Steenbergen, Johan M Thijssen and Ton G van Leeuwen, "Photoacoustic determination of blood vessel diameter," Phys. Med. Biol. 49, 4745-4756(2004).
[CrossRef]

Viator, J.

G. Paltauf, J. Viator, S. Prahl, S. Jacques, "Iterative reconstruction algorithm for optoacoustic imaging," J. Acoust. Soc. Am. 112, 1536-1544(2002).
[CrossRef] [PubMed]

Viator, J.A.

J.A. Viator, G. Au, G. Paltauf, S. Jacques, S. Prahl, H. Ren, Z. Chen, J. Nelson, "Clinical testing of a photoacoustic probe for port wine stain depth determination," Lasers Surg. Med. 30, 141-148(2002).
[CrossRef] [PubMed]

Vo-Dinh, T.

Wang, L.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Wang, L.V.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

Wang, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Wang, Y.

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Weber, H.

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

Wu, C.

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L.V. Wang, "Non-invasive laser-induced photoacoustic tomography for structural and functional imaging of the brain in vivo," Nat. Biotech. 21, 803-806(2003).
[CrossRef]

Xing, D.

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Xu, M.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Xu, Y.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Yin, B.

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Yokoo, S.

X. Wang, Y. Xu, M. Xu, S. Yokoo, E. Fry, L. Wang, "Photoacoustic tomography of biological tissues with high cross-section resolution: Reconstruction and experiment," Med. Phys. 29, 2799-2805 (2002).
[CrossRef]

Yuan, Z.

Zeng, Y.

B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, "Fast photoacoustic imaging system based on 320-element linear transducer array," Phys. Med. Biol. 49, 1339-1346 (2004).
[CrossRef] [PubMed]

Zhang, Q.

Zhao, H.

Appl. Opt. (1)

Appl. Phys. Lett. (1)

Z. Yuan, H. Jiang, "Quantitative photoacoustic tomography: recovery of optical absorption coefficient maps of heterogeneous media," Appl. Phys. Lett. 88, 231101 (2006).
[CrossRef]

IEEE J. Sel. Top. Quantum Electron (1)

K.P. Kostli, D. Frauchiger, J. Niederhauser, G. Paltauf, H. Weber, M. Frenz, "Optoacoustic imaging using a three-dimensional reconstruction algorithm," IEEE J. Sel. Top. Quantum Electron 7, 918-923(2001).
[CrossRef]

IEEE Trans. Biomed. Eng. (2)

JoelJ. Niederhauser, Michael Jaeger, Robot Lemor, Peter Weber, and Martin Frenz, "Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo," IEEE Trans. Biomed. Eng. 24, 436-440 (2005).

J.F. Greenleaf, R.C. Bahn, "Clinical imaging with transmissive ultrasound computerized tomography," IEEE Trans. Biomed. Eng. 28, 177-185 (1981).
[CrossRef] [PubMed]

J. Acoust. Soc. Am. (1)

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Figures (7)

Fig. 1.
Fig. 1.

Experiment geometry for (a) phantoms 1 and 2, (b) phantom 3 and (c) phantom 4. The dimension units are millimeters

Fig. 2.
Fig. 2.

Reconstructed acoustic speed (left column) and absorbed optical energy density (right column) images with different acoustic contrast levels with respect to the background. (a) and (b) for experiment 1. (c) and (d) for experiment 2. The axes (left and bottom) illustrate the spatial scale, in millimeters, whereas the color scale (right) records the acoustic speed, in mm/s, or absorbed optical energy density, in a relative unit.

Fig. 3.
Fig. 3.

Recovered acoustic speed profiles plotted along x=0mm (a), y=0mm (b) from the images shown in Figs. 2(a) and 2(c), respectively.

Fig. 4.
Fig. 4.

Reconstructed acoustic speed (left) and absorbed optical energy density (right) images for experiment 3. The axes (left and bottom) illustrate the spatial scale, in millimeters, whereas the color scale (right) records the acoustic speed, in mm/s, or absorbed optical energy density, in a relative unit.

Fig. 5.
Fig. 5.

Recovered acoustic speed profiles plotted along y=0mm (a), y=-8mm (b) from the image shown in Fig. 4(a).

Fig. 6.
Fig. 6.

Reconstructed acoustic speed (left) and absorbed optical energy density (right) images for experiment 4. The axes (left and bottom) illustrate the spatial scale, in millimeters, whereas the color scale (right) records the acoustic speed, in mm/s, or absorbed optical energy density, in a relative unit.

Fig. 7.
Fig. 7.

Recovered acoustic speed profile plotted along x=0mm from the image shown in Fig. 6(a).

Equations (7)

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2 p r ω + k 0 2 ( 1 + O ) P r ω = ik 0 c 0 βΦ ( r ) C p
O = c o 2 c 2 1 + i k 0 αc 0 c 2
Ap =
A ij = ψ j ψ i k 0 2 ψ j ψ i k 0 2 k O R , k ψ k ψ j ψ i ik 0 2 l O I , l ψ l ψ j ψ i ( η ψ i + γ 2 ψ j φ 2 ) ψ i ds ,
B i = ik 0 c 0 β C p k Φ R , k ψ k ψ i + k 0 c 0 β C p l Φ I , l ψ l ψ i
ψ n n ̂ = ηψ n + γ 2 ψ n 2 θ
( T + λ I ) Δχ = T ( p o p c )

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