Abstract

We present pulsed illumination spectral-domain optical coherence tomography (SD-OCT) for in vivo human retinal imaging. We analyze the signal-to-noise (SNR) for continuous wave (CW) and pulsed illumination SD-OCT. The lateral beam scan motion is responsible for a SNR drop due to lateral scanning induced interference fringe washout. Pulsed illumination can reduce the SNR drop by shorter sample illumination time during the integration time of a camera. First, we demonstrate the SNR benefit of pulsed illumination over CW as function of lateral scan speed for a paper sample. Finally, we show better SNR in retinal images of a normal subject with pulsed illumination SD-OCT over CW at high lateral scanning speed.

© 2006 Optical Society of America

Full Article  |  PDF Article

References

  • View by:
  • |
  • |
  • |

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
    [CrossRef] [PubMed]
  2. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
    [CrossRef] [PubMed]
  3. H. Ozdemir, S. A. Karacorlu, and M. Karacorlu, "Early Optical Coherence Tomography Changes After Photodynamic Therapy in Patients With Age-Related Macular Degeneration," Am. J. Ophthalmol. 141, 574-576, (2006)
    [CrossRef] [PubMed]
  4. A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
    [CrossRef] [PubMed]
  5. W. Goebel and R. Franke, "Retinal thickness in diabetic retinopathy - Comparison of optical coherence tomography, the retinal thickness analyzer, and fundus photography," Retina,  26, 49-57, (2006)
    [CrossRef] [PubMed]
  6. A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
    [CrossRef] [PubMed]
  7. A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
    [CrossRef]
  8. M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)
  9. C. L. Shields, M. A. Materin, and J. A. Shields, "Review of optical coherence tomography for intraocular tumors," Curr. Opin. Ophthalmol. 16, 141-154, (2005)
    [CrossRef] [PubMed]
  10. B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
    [CrossRef]
  11. G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
    [CrossRef] [PubMed]
  12. F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
    [CrossRef] [PubMed]
  13. J. M. J. Roodhooft, "Leading causes of blindness worldwide," Bull. Soc. belge. Ophtalmol. 283, 19-25, (2002)
    [PubMed]
  14. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
    [CrossRef]
  15. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22, 340-342, (1997)
    [CrossRef] [PubMed]
  16. S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963, (2003).
    [CrossRef] [PubMed]
  17. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894, (2003).
    [CrossRef] [PubMed]
  18. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069, (2003)
    [CrossRef] [PubMed]
  19. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189, (2003).
    [CrossRef] [PubMed]
  20. N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
    [CrossRef] [PubMed]
  21. W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
    [CrossRef]
  22. B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
    [CrossRef] [PubMed]
  23. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422, (2004).
    [CrossRef] [PubMed]
  24. T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
    [CrossRef] [PubMed]
  25. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
    [CrossRef] [PubMed]
  26. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
    [CrossRef] [PubMed]
  27. G. Moneron, A. C. Boccara, and A. Dubois, "Stroboscopic ultrahigh-resolution full-field optical coherence tomography," Opt. Lett. 30, 1351-1353, (2005)
    [CrossRef] [PubMed]
  28. N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
    [CrossRef] [PubMed]
  29. American National Standards Institute, American National Standard for Safe Use of Lasers Z136.1. 2000: Orlando.
  30. M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
    [CrossRef] [PubMed]
  31. S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452, (2005),
    [CrossRef] [PubMed]
  32. S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
    [CrossRef] [PubMed]
  33. I. Escudero-Sanz and R. Navarro, "Off-axis aberrations of a wide-angle schematic eye model," J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 16, 1881-1891, (1999)
    [CrossRef] [PubMed]
  34. D. A. Goss and R. W. West, Introduction to the Optics of the Eye, (Butterworth-Heinemann, 2002), Chap. 3.

2006

H. Ozdemir, S. A. Karacorlu, and M. Karacorlu, "Early Optical Coherence Tomography Changes After Photodynamic Therapy in Patients With Age-Related Macular Degeneration," Am. J. Ophthalmol. 141, 574-576, (2006)
[CrossRef] [PubMed]

W. Goebel and R. Franke, "Retinal thickness in diabetic retinopathy - Comparison of optical coherence tomography, the retinal thickness analyzer, and fundus photography," Retina,  26, 49-57, (2006)
[CrossRef] [PubMed]

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

2005

S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452, (2005),
[CrossRef] [PubMed]

G. Moneron, A. C. Boccara, and A. Dubois, "Stroboscopic ultrahigh-resolution full-field optical coherence tomography," Opt. Lett. 30, 1351-1353, (2005)
[CrossRef] [PubMed]

M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
[CrossRef] [PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

C. L. Shields, M. A. Materin, and J. A. Shields, "Review of optical coherence tomography for intraocular tumors," Curr. Opin. Ophthalmol. 16, 141-154, (2005)
[CrossRef] [PubMed]

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

2004

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
[CrossRef]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422, (2004).
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
[CrossRef] [PubMed]

2003

2002

J. M. J. Roodhooft, "Leading causes of blindness worldwide," Bull. Soc. belge. Ophtalmol. 283, 19-25, (2002)
[PubMed]

1999

I. Escudero-Sanz and R. Navarro, "Off-axis aberrations of a wide-angle schematic eye model," J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 16, 1881-1891, (1999)
[CrossRef] [PubMed]

1997

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22, 340-342, (1997)
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

1995

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
[CrossRef]

1991

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Akkin, T.

Alvarez-Vidal, A.

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

Aydin, A.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Bandello, F.

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Baumal, C. R.

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

Boccara, A. C.

Boppart, S. A.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Bouma, B. E.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069, (2003)
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963, (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Bowd, C.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

Brezinski, M. E.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Cense, B.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
[CrossRef]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069, (2003)
[CrossRef] [PubMed]

Chan, R. C.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Chen, T. C.

M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
[CrossRef] [PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
[CrossRef]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

Chinn, S. R.

Choma, M. A.

de Boer, J. F.

M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
[CrossRef] [PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
[CrossRef]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069, (2003)
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963, (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
[CrossRef] [PubMed]

Del Borrello, M.

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Dubois, A.

Duker, J. S.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422, (2004).
[CrossRef] [PubMed]

Elzaiat, S. Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
[CrossRef]

Escudero-Sanz, I.

I. Escudero-Sanz and R. Navarro, "Off-axis aberrations of a wide-angle schematic eye model," J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 16, 1881-1891, (1999)
[CrossRef] [PubMed]

Fercher, A. F.

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894, (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
[CrossRef]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Franke, R.

W. Goebel and R. Franke, "Retinal thickness in diabetic retinopathy - Comparison of optical coherence tomography, the retinal thickness analyzer, and fundus photography," Retina,  26, 49-57, (2006)
[CrossRef] [PubMed]

Fujimoto, J. G.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422, (2004).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22, 340-342, (1997)
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Furlan, F.

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Garcia-Layana, A.

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

Goebel, W.

W. Goebel and R. Franke, "Retinal thickness in diabetic retinopathy - Comparison of optical coherence tomography, the retinal thickness analyzer, and fundus photography," Retina,  26, 49-57, (2006)
[CrossRef] [PubMed]

Gregori, G.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Hertzmark, E.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Hitzenberger, C. K.

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894, (2003).
[CrossRef] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
[CrossRef]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Huang, X. R.

Iftimia, N.

Ishikawa, H.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Isola, M.

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Izatt, J. A.

Jiao, S. L.

Joo, C.

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
[CrossRef]

Karacorlu, M.

H. Ozdemir, S. A. Karacorlu, and M. Karacorlu, "Early Optical Coherence Tomography Changes After Photodynamic Therapy in Patients With Age-Related Macular Degeneration," Am. J. Ophthalmol. 141, 574-576, (2006)
[CrossRef] [PubMed]

Karacorlu, S. A.

H. Ozdemir, S. A. Karacorlu, and M. Karacorlu, "Early Optical Coherence Tomography Changes After Photodynamic Therapy in Patients With Age-Related Macular Degeneration," Am. J. Ophthalmol. 141, 574-576, (2006)
[CrossRef] [PubMed]

Knighton, R.

Ko, T. H.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422, (2004).
[CrossRef] [PubMed]

Kowalczyk, A.

Lai, E.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Leitgeb, R.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Maldonado, M. J.

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

Materin, M. A.

C. L. Shields, M. A. Materin, and J. A. Shields, "Review of optical coherence tomography for intraocular tumors," Curr. Opin. Ophthalmol. 16, 141-154, (2005)
[CrossRef] [PubMed]

Mattox, C.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Medeiros, F. A.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

Moneron, G.

Mujat, M.

Nassif, N.

Navarro, R.

I. Escudero-Sanz and R. Navarro, "Off-axis aberrations of a wide-angle schematic eye model," J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 16, 1881-1891, (1999)
[CrossRef] [PubMed]

Oh, W. Y.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

Ozdemir, H.

H. Ozdemir, S. A. Karacorlu, and M. Karacorlu, "Early Optical Coherence Tomography Changes After Photodynamic Therapy in Patients With Age-Related Macular Degeneration," Am. J. Ophthalmol. 141, 574-576, (2006)
[CrossRef] [PubMed]

Park, B. H.

M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
[CrossRef] [PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
[CrossRef]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069, (2003)
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
[CrossRef] [PubMed]

Paunescu, L. A.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Pierce, M. C.

Pitris, C.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Polini, G.

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Polito, A.

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Price, L. L.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Puliafito, C. A.

S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452, (2005),
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Reichel, E.

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

Rogers, A. H.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

Roodhooft, J. M. J.

J. M. J. Roodhooft, "Leading causes of blindness worldwide," Bull. Soc. belge. Ophtalmol. 283, 19-25, (2002)
[PubMed]

Sainz-Gomez, C.

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

Salinas-Alaman, A.

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

Sarunic, M. V.

Schuman, J. S.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Shields, C. L.

C. L. Shields, M. A. Materin, and J. A. Shields, "Review of optical coherence tomography for intraocular tumors," Curr. Opin. Ophthalmol. 16, 141-154, (2005)
[CrossRef] [PubMed]

Shields, J. A.

C. L. Shields, M. A. Materin, and J. A. Shields, "Review of optical coherence tomography for intraocular tumors," Curr. Opin. Ophthalmol. 16, 141-154, (2005)
[CrossRef] [PubMed]

Southern, J. F.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Srinivasan, V. J.

Stark, P. C.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Subramanian, M. L.

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

Susanna, R.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

Swanson, E. A.

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, "Optical coherence tomography using a frequency-tunable optical source," Opt. Lett. 22, 340-342, (1997)
[CrossRef] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

Tearney, G. J.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069, (2003)
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963, (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Truong, S. N.

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

Vakoc, B. J.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

Vessani, R. M.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

Weinreb, R. N.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

White, B. R.

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

Witkin, A. J.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

Wojtkowski, M.

Wollstein, G.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

Yang, C. H.

Yun, S. H.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482, (2004)
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963, (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
[CrossRef] [PubMed]

Zangwill, L. M.

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

Am. J. Ophthalmol.

H. Ozdemir, S. A. Karacorlu, and M. Karacorlu, "Early Optical Coherence Tomography Changes After Photodynamic Therapy in Patients With Age-Related Macular Degeneration," Am. J. Ophthalmol. 141, 574-576, (2006)
[CrossRef] [PubMed]

A. Salinas-Alaman, A. Garcia-Layana, M. J. Maldonado, C. Sainz-Gomez, and A. Alvarez-Vidal, "Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration," Am. J. Ophthalmol. 140, 23-28, (2005)
[CrossRef] [PubMed]

F. A. Medeiros, L. M. Zangwill, C. Bowd, R. M. Vessani, R. Susanna, and R. N. Weinreb, "Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography," Am. J. Ophthalmol. 139, 44-55, (2005)
[CrossRef] [PubMed]

Appl. Phys. Lett.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, "Ultrahigh-speed optical frequency domain imaging and application to laser ablation monitoring," Appl. Phys. Lett. 88, (2006)
[CrossRef]

Arch. Ophthalmol.

G. Wollstein, J. S. Schuman, L. L. Price, A. Aydin, P. C. Stark, E. Hertzmark, E. Lai, H. Ishikawa, C. Mattox, J. G. Fujimoto, and L. A. Paunescu, "Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma," Arch. Ophthalmol. 123, 464-470, (2005)
[CrossRef] [PubMed]

T. C. Chen, B. Cense, M. C. Pierce, N. Nassif, B. H. Park, S. H. Yun, B. R. White, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging," Arch. Ophthalmol. 123, 1715-1720, (2005)
[CrossRef] [PubMed]

Bull. Soc. belge. Ophtalmol.

J. M. J. Roodhooft, "Leading causes of blindness worldwide," Bull. Soc. belge. Ophtalmol. 283, 19-25, (2002)
[PubMed]

Curr. Opin. Ophthalmol.

C. L. Shields, M. A. Materin, and J. A. Shields, "Review of optical coherence tomography for intraocular tumors," Curr. Opin. Ophthalmol. 16, 141-154, (2005)
[CrossRef] [PubMed]

Invest. Ophthalmol. Visual Sci.

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, and J. F. de Boer, "Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization sensitive optical coherence tomography," Invest. Ophthalmol. Visual Sci. 45, 2606-2612, (2004)
[CrossRef]

J. Opt. Soc. Am. A-Opt. Image Sci. Vis.

I. Escudero-Sanz and R. Navarro, "Off-axis aberrations of a wide-angle schematic eye model," J. Opt. Soc. Am. A-Opt. Image Sci. Vis. 16, 1881-1891, (1999)
[CrossRef] [PubMed]

Ophthalmic Surg. Lasers

M. L. Subramanian, S. N. Truong, A. H. Rogers, J. S. Duker, E. Reichel, and C. R. Baumal, "Vitrectomy for stage 1 macular holes identified by optical coherence tomography," Ophthalmic Surg. Lasers 37, 42-46, (2006)

Ophthalmol.

A. J. Witkin, T. H. Ko, J. G. Fujimoto, J. S. Schuman, C. R. Baumal, A. H. Rogers, E. Reichel, and J. S. Duker, "Redefining lamellar holes and the vitreomacular interface: An ultrahigh-resolution optical coherence tomography study," Ophthalmol. 113, 388-397, (2006)
[CrossRef]

Opt. Commun.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, "Measurement of Intraocular Distances by Backscattering Spectral Interferometry," Opt. Commun. 117, 43-48, (1995)
[CrossRef]

Opt. Express

R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894, (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, "High-speed optical frequency-domain imaging," Opt. Express 11, 2953-2963, (2003).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, B. E. Bouma, B. H. Park, and J. F. de Boer, "High-speed spectral-domain optical coherence tomography at 1.3 mu m wavelength," Opt. Express 11, 3598-3604, (2003).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express,  12367-376, (2004).
[CrossRef] [PubMed]

M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189, (2003).
[CrossRef] [PubMed]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422, (2004).
[CrossRef] [PubMed]

B. Cense, N. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-Resolution High-Speed Retinal Imaging Using Spectral-Domain Optical Coherence Tomography," Opt. Express 12, 2435-2447, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998, (2004).
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Pulsed-source and swept-source spectral-domain optical coherence tomography with reduced motion artifacts," Opt. Express 12, 5614-5624, (2004).
[CrossRef] [PubMed]

S. L. Jiao, R. Knighton, X. R. Huang, G. Gregori, and C. A. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13, 444-452, (2005),
[CrossRef] [PubMed]

M. Mujat, R. C. Chan, B. Cense, B. H. Park, C. Joo, T. Akkin, T. C. Chen, and J. F. de Boer, "Retinal nerve fiber layer thickness map determined from optical coherence tomography images," Opt. Express 13, 9480-9491, (2005).
[CrossRef] [PubMed]

Opt. Lett.

Retina

W. Goebel and R. Franke, "Retinal thickness in diabetic retinopathy - Comparison of optical coherence tomography, the retinal thickness analyzer, and fundus photography," Retina,  26, 49-57, (2006)
[CrossRef] [PubMed]

A. Polito, M. Del Borrello, G. Polini, F. Furlan, M. Isola, and F. Bandello, "Diurnal variation in clinically significant diabetic macular edema measured by the stratus OCT," Retina,  26, 14-20, (2006)
[CrossRef] [PubMed]

Science

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical Coherence Tomography," Science 254, 1178-1181, (1991)
[CrossRef] [PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, "In vivo endoscopic optical biopsy with optical coherence tomography," Science 276, 2037-2039, (1997)
[CrossRef] [PubMed]

Other

American National Standards Institute, American National Standard for Safe Use of Lasers Z136.1. 2000: Orlando.

D. A. Goss and R. W. West, Introduction to the Optics of the Eye, (Butterworth-Heinemann, 2002), Chap. 3.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (7)

Fig. 1.
Fig. 1.

Theoretical SNR decrease due to lateral motion for a CW source and for pulsed illumination with different duty cycles.

Fig. 2.
Fig. 2.

Slit lamp integrated with a biconvex lens and a paper sample

Fig. 3.
Fig. 3.

SNR decrease for the flat paper sample parallel to the focal plane (left) and with 4.1° tilt (right) for CW and pulsed illumination compared with theory. 1000 and 500 A-lines are equivalent to 2.3 and 4.3 normalized displacements, respectively.

Fig. 4.
Fig. 4.

Maximum permissible exposure expressed as average power into the eye, according to the ANSI standards for CW and pulsed illumination. Red line: CW power limitation. Black line: Pulsed source power limitation calculated from Eq. (3) as a function of pulse repetition frequency. The smaller MPE of CW and pulsed illumination at specific frequency determines the power limitation to the retina.

Fig. 5.
Fig. 5.

Integrated reflectance images of in-vivo human retina centered on the optic nerve head for two kinds of illumination (CW and pulsed) at two different lateral scanning speeds. (a) CW, 1000 A-lines (b) pulsed, 1000 A-lines (c) CW, 500 A-lines (d) pulsed, 500 A-lines. Four regions of interest are indicated (zones A to D), where the SNR was analyzed in each image. Some discontinuities in (a) and (b) were caused by eye motion during the two times longer measurement time as compared to (c) and (d). The lateral scan angle of 30° in the experiment results in 8.6 mm lateral scan range. Vertical scan range is 5.2 mm on the retina.

Fig. 6.
Fig. 6.

ONH images from zone C in Fig 4(a) ~ 4(d) at the same location, gray scale coded over the same dynamic range. The ONH is in axially different locations. SNR was compared after correcting for the depth dependent sensitivity decrease. The horizontal dimension is 8.6 mm and vertical dimension is 1.7 mm.

Fig. 7.
Fig. 7.

Relative SNR fitted with w o and offset as parameters. The theoretical fit for CW illumination (continuous line) starts 1.9 dB above the theoretical fit for pulsed illumination (dotted line) because of the higher average CW power. Despite the lower average power for pulsed illumination, the SNR is better for normalized displacements larger than 2.

Tables (1)

Tables Icon

Table 1. SNR calculated in each zone of the in-vivo human retina data shown in Fig. 6 after correcting for the depth dependent sensitivity decrease.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

SNR decrease 5 log 10 ( 1 + 0.5 Δ x 2 w o 2 ) ,
MP E sp = 5.0 C a 10 7 [ J cm 2 ]
MPE = ( n 0.25 ) MP E sp f rep 0.385 cm 2
= MP E sp 10 0.25 f rep 0.75 0.385 cm 2 [ μW ]
σ 2 noise = σ 2 r + d + η e 2 J p E v + ( ηe J p E v τ i ) 2 τ i τ coh [ e 2 ]

Metrics