Abstract

Optical frequency domain imaging (OFDI) in the 800-nm biological imaging window is demonstrated by using a novel wavelength-swept laser source. The laser output is tuned continuously from 815 to 870 nm at a 43.2-kHz repetition rate with 7-mW average power. Axial resolution of 10-µm in biological tissue and peak sensitivity of 96 dB are achieved. In vivo imaging of Xenopus laevis is demonstrated with an acquisition speed of 84 frames per second (512 axial lines per frame). This new imaging technique may prove useful in comprehensive retinal screening for medical diagnosis and contrast-agent-based imaging for biological investigations.

©2006 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
High-speed imaging of human retina in vivo with swept-source optical coherence tomography

H. Lim, M. Mujat, C. Kerbage, E. C. W. Lee, Y. Chen, Teresa C. Chen, and J. F. de Boer
Opt. Express 14(26) 12902-12908 (2006)

In vivo optical frequency domain imaging of human retina and choroid

Edward C. W. Lee, Johannes F. de Boer, Mircea Mujat, Hyungsik Lim, and Seok H. Yun
Opt. Express 14(10) 4403-4411 (2006)

Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm

R. Huber, M. Wojtkowski, J. G. Fujimoto, J. Y. Jiang, and A. E. Cable
Opt. Express 13(26) 10523-10538 (2005)

More Recommended Articles

References

  • View by:
  • Article Order
  • |
  • Year
  • |
  • Author
  • |
  • Publication
  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
    [Crossref] [PubMed]
  2. W. SorinD. Derickson, Optical reflectometry for component characterization, in Fiber Optic Test and Measurement ed., (Prentice Hall PTR, 1998).
  3. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
    [Crossref]
  4. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22, 340–342 (1997).
    [Crossref] [PubMed]
  5. B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr/sup 4+/:forsterite laser,” Opt. Lett. 22, 1704–1706 (1997).
    [Crossref]
  6. S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11, 2953–2963 (2003).
    [Crossref] [PubMed]
  7. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express 11, 2183–2189 (2003).
    [Crossref] [PubMed]
  8. R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14, 3225–3237 (2006).
    [Crossref] [PubMed]
  9. R. Huber, M. Wojtkowski, K. Taira, J. G. Fujimoto, and K. Hsu, “Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles,” Opt. Express 13, 3513–3528 (2005).
    [Crossref] [PubMed]
  10. B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13, 5483–5493 (2005).
    [Crossref] [PubMed]
  11. Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, “Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments,” Opt. Express 13, 10652–10664 (2005).
    [Crossref] [PubMed]
  12. J. Zhang, W. G. Jung, J. S. Nelson, and Z. P. Chen, “Full range polarization-sensitive Fourier domain optical coherence tomography,” Opt. Express 12, 6033–6039 (2004).
    [Crossref] [PubMed]
  13. M. V. Sarunic, S. Weinberg, and J. A. Izatt, “Full-field swept-source phase microscopy,” Opt. Lett. 31, 1462–1646 (2006).
    [Crossref] [PubMed]
  14. W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
    [Crossref]
  15. E. C. W. Lee, J. F. de Boer, M. Mujat, H. Lim, and S. H. Yun, “In vivo optical frequency domain imaging of human retina and choroid,” Opt. Express 14, 4403–4411 (2006),
    [Crossref] [PubMed]
  16. M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
    [Crossref] [PubMed]
  17. W. Drexler, “Ultrahigh-resolution optical coherence tomography,” J. Biomed. Opt. 9, 47–74 (2004).
    [Crossref] [PubMed]
  18. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
    [Crossref] [PubMed]
  19. N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve,” Opt. Express 12, 367–376 (2004).
    [Crossref] [PubMed]
  20. S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10, 041208 (2005).
    [Crossref]
  21. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting,” Opt. Express 12, 4822–4828 (2004),
    [Crossref] [PubMed]
  22. S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12, 2977–2998 (2004).
    [Crossref] [PubMed]
  23. S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter,” Opt. Lett. 28, 1981–1983 (2003).
    [Crossref] [PubMed]
  24. M. Fukuda, Reliability and Degradation of Semiconductor Lasers and LEDs, (Artech House Publishers, 1991).
  25. B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
    [Crossref]
  26. B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13, 3931–3944 (2005).
    [Crossref] [PubMed]
  27. S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
    [Crossref] [PubMed]
  28. K. D. Rao, M. A. Choma, S. Yazdanfar, A. M. Rollins, and J. A. Izatt, “Molecular contrast in optical coherence tomography by use of a pump-probe technique,” Opt. Lett. 28, 340–342 (2003).
    [Crossref] [PubMed]
  29. C. H. Yang, L. E. L. McGuckin, J. D. Simon, M. A. Choma, B. E. Applegate, and J. A. Izatt, “Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent,” Opt. Lett. 29, 2016–2018 (2004).
    [Crossref] [PubMed]
  30. H. Cang, T. Sun, Z. Y. Li, J. Y. Chen, B. J. Wiley, Y. N. Xia, and X. D. Li, “Gold nanocages as contrast agents for spectroscopic optical coherence tomography,” Opt. Lett. 30, 3048–3050 (2005).
    [Crossref] [PubMed]

2006 (3)

2005 (6)

2004 (6)

2003 (4)

2002 (1)

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
[Crossref] [PubMed]

2000 (1)

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

1997 (3)

1995 (2)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
[Crossref]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Akiba, M.

Applegate, B. E.

Bajraszewski, T.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
[Crossref] [PubMed]

Boppart, S. A.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10, 041208 (2005).
[Crossref]

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

Boudoux, C.

Bouma, B.

Bouma, B. E.

B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13, 3931–3944 (2005).
[Crossref] [PubMed]

B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13, 5483–5493 (2005).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12, 2977–2998 (2004).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting,” Opt. Express 12, 4822–4828 (2004),
[Crossref] [PubMed]

S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter,” Opt. Lett. 28, 1981–1983 (2003).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11, 2953–2963 (2003).
[Crossref] [PubMed]

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr/sup 4+/:forsterite laser,” Opt. Lett. 22, 1704–1706 (1997).
[Crossref]

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
[Crossref]

Brezinski, M. E.

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

Cang, H.

Cense, B.

Chan, K. P.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Chen, J. Y.

Chen, T.

Chen, Z. P.

Chinn, S. R.

Choma, M. A.

Chong, C.

Chu, K. K.

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

Chumbes, E. M.

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

de Boer, J.

de Boer, J. F.

Drexler, W.

W. Drexler, “Ultrahigh-resolution optical coherence tomography,” J. Biomed. Opt. 9, 47–74 (2004).
[Crossref] [PubMed]

Eastman, L. F.

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

Elzaiat, S. Y.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
[Crossref]

Fercher, A. F.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
[Crossref] [PubMed]

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
[Crossref]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Fujimoto, J. G.

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14, 3225–3237 (2006).
[Crossref] [PubMed]

R. Huber, M. Wojtkowski, K. Taira, J. G. Fujimoto, and K. Hsu, “Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles,” Opt. Express 13, 3513–3528 (2005).
[Crossref] [PubMed]

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr/sup 4+/:forsterite laser,” Opt. Lett. 22, 1704–1706 (1997).
[Crossref]

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22, 340–342 (1997).
[Crossref] [PubMed]

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Fukuda, M.

M. Fukuda, Reliability and Degradation of Semiconductor Lasers and LEDs, (Artech House Publishers, 1991).

Golubovic, B.

Green, B. M.

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Hee, M. R.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Hitzenberger, C. K.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
[Crossref]

Hsu, K.

Huang, D.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Huber, R.

Iftimia, N.

Itoh, M.

Izatt, J. A.

Jung, W. G.

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
[Crossref]

Kowalczyk, A.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
[Crossref] [PubMed]

Lee, E. C. W.

Leitgeb, R.

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
[Crossref] [PubMed]

Li, X. D.

Li, Z. Y.

Lim, H.

Lin, C. P.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Madjarova, V. D.

Makita, S.

Mark, D. L.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10, 041208 (2005).
[Crossref]

McGuckin, L. E. L.

Morosawa, A.

Mujat, M.

Nassif, N.

Nelson, J. S.

Oh, W. Y.

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
[Crossref]

Oldenburg, A. L.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10, 041208 (2005).
[Crossref]

Park, B.

Park, B. H.

Pierce, M.

Pierce, M. C.

Puliafito, C. A.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Rao, K. D.

Rollins, A. M.

Sakai, T.

Sarunic, M. V.

Schuman, J. S.

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Shealy, J. R.

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

Simon, J. D.

Smart, J. A.

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

Sorin, W.

W. SorinD. Derickson, Optical reflectometry for component characterization, in Fiber Optic Test and Measurement ed., (Prentice Hall PTR, 1998).

Southern, J. F.

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Sun, T.

Swanson, E. A.

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22, 340–342 (1997).
[Crossref] [PubMed]

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Taira, K.

Tearney, G.

Tearney, G. J.

B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13, 3931–3944 (2005).
[Crossref] [PubMed]

B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13, 5483–5493 (2005).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting,” Opt. Express 12, 4822–4828 (2004),
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12, 2977–2998 (2004).
[Crossref] [PubMed]

S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter,” Opt. Lett. 28, 1981–1983 (2003).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11, 2953–2963 (2003).
[Crossref] [PubMed]

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr/sup 4+/:forsterite laser,” Opt. Lett. 22, 1704–1706 (1997).
[Crossref]

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
[Crossref]

Vakoc, B. J.

B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13, 5483–5493 (2005).
[Crossref] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
[Crossref]

Weinberg, S.

Wiley, B. J.

Wojtkowski, M.

Xia, Y. N.

Xu, C.

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10, 041208 (2005).
[Crossref]

Yang, C. H.

Yasuno, Y.

Yatagai, T.

Yazdanfar, S.

Yun, S.

Yun, S. H.

E. C. W. Lee, J. F. de Boer, M. Mujat, H. Lim, and S. H. Yun, “In vivo optical frequency domain imaging of human retina and choroid,” Opt. Express 14, 4403–4411 (2006),
[Crossref] [PubMed]

B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13, 3931–3944 (2005).
[Crossref] [PubMed]

B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13, 5483–5493 (2005).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12, 2977–2998 (2004).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting,” Opt. Express 12, 4822–4828 (2004),
[Crossref] [PubMed]

S. H. Yun, C. Boudoux, G. J. Tearney, and B. E. Bouma, “High-speed wavelength-swept semiconductor laser with a polygon-scanner-based wavelength filter,” Opt. Lett. 28, 1981–1983 (2003).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11, 2953–2963 (2003).
[Crossref] [PubMed]

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
[Crossref]

Zhang, J.

Arch. Ophthalmol. (1)

M. R. Hee, J. A. Izatt, E. A. Swanson, D. Huang, J. S. Schuman, C. P. Lin, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography of the human retina,” Arch. Ophthalmol. 113, 325–32 (1995).
[Crossref] [PubMed]

IEEE Electron. Dev. Lett. (1)

B. M. Green, K. K. Chu, E. M. Chumbes, J. A. Smart, J. R. Shealy, and L. F. Eastman, “The effect of surface passivation on the microwave characteristicsof undoped AlGaN/GaN HEMTs,” IEEE Electron. Dev. Lett. 21, 268–270 (2000).
[Crossref]

J. Biomed. Opt. (3)

W. Drexler, “Ultrahigh-resolution optical coherence tomography,” J. Biomed. Opt. 9, 47–74 (2004).
[Crossref] [PubMed]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, “In vivo human retinal imaging by fourier domain optical coherence tomography,” J. Biomed. Opt. 7, 457–463 (2002).
[Crossref] [PubMed]

S. A. Boppart, A. L. Oldenburg, C. Xu, and D. L. Mark, “Optical probes and techniques for molecular contrast enhancement in coherence imaging,” J. Biomed. Opt. 10, 041208 (2005).
[Crossref]

Opt. Commun. (1)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. Elzaiat, “Measurement of intraocular distances by backscattering spectral interferometry,” Opt. Commun. 117, 43–48 (1995).
[Crossref]

Opt. Express (12)

E. C. W. Lee, J. F. de Boer, M. Mujat, H. Lim, and S. H. Yun, “In vivo optical frequency domain imaging of human retina and choroid,” Opt. Express 14, 4403–4411 (2006),
[Crossref] [PubMed]

Y. Yasuno, V. D. Madjarova, S. Makita, M. Akiba, A. Morosawa, C. Chong, T. Sakai, K. P. Chan, M. Itoh, and T. Yatagai, “Three-dimensional and high-speed swept-source optical coherence tomography for in vivo investigation of human anterior eye segments,” Opt. Express 13, 10652–10664 (2005).
[Crossref] [PubMed]

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14, 3225–3237 (2006).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Removing the depth-degeneracy in optical frequency domain imaging with frequency shifting,” Opt. Express 12, 4822–4828 (2004),
[Crossref] [PubMed]

J. Zhang, W. G. Jung, J. S. Nelson, and Z. P. Chen, “Full range polarization-sensitive Fourier domain optical coherence tomography,” Opt. Express 12, 6033–6039 (2004).
[Crossref] [PubMed]

R. Huber, M. Wojtkowski, K. Taira, J. G. Fujimoto, and K. Hsu, “Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles,” Opt. Express 13, 3513–3528 (2005).
[Crossref] [PubMed]

B. H. Park, M. C. Pierce, B. Cense, S. H. Yun, M. Mujat, G. J. Tearney, B. E. Bouma, and J. F. de Boer, “Real-time fiber-based multi-functional spectral-domain optical coherence tomography at 1.3 µm,” Opt. Express 13, 3931–3944 (2005).
[Crossref] [PubMed]

B. J. Vakoc, S. H. Yun, J. F. de Boer, G. J. Tearney, and B. E. Bouma, “Phase-resolved optical frequency domain imaging,” Opt. Express 13, 5483–5493 (2005).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, N. Iftimia, and B. E. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11, 2953–2963 (2003).
[Crossref] [PubMed]

N. Nassif, B. Cense, B. Park, M. Pierce, S. Yun, B. Bouma, G. Tearney, T. Chen, and J. de Boer, “In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve,” Opt. Express 12, 367–376 (2004).
[Crossref] [PubMed]

M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express 11, 2183–2189 (2003).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, “Motion artifacts in optical coherence tomography with frequency-domain ranging,” Opt. Express 12, 2977–2998 (2004).
[Crossref] [PubMed]

Opt. Lett. (7)

Proc. Natl. Acad. Sci. U.S.A. (1)

S. A. Boppart, G. J. Tearney, B. E. Bouma, J. F. Southern, M. E. Brezinski, and J. G. Fujimoto, “Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography,” Proc. Natl. Acad. Sci. U.S.A. 94, 4256–4261 (1997).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science 254, 1178–1181 (1991).
[Crossref] [PubMed]

Other (3)

W. SorinD. Derickson, Optical reflectometry for component characterization, in Fiber Optic Test and Measurement ed., (Prentice Hall PTR, 1998).

M. Fukuda, Reliability and Degradation of Semiconductor Lasers and LEDs, (Artech House Publishers, 1991).

W. Y. Oh, S. H. Yun, B. J. Vakoc, G. J. Tearney, and B. E. Bouma, “Ultrahigh-speed optical frequency domain imaging and application to ablation monitoring,” Appl. Phys. Lett.103902 (2006).
[Crossref]

Supplementary Material (2)

» Media 1: AVI (2557 KB)     
» Media 2: AVI (4983 KB)     

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1.
Fig. 1. Schematic of the wavelength-swept laser source. SOA; semiconductor optical amplifier. (Inset) the intracavity wavelength scanning filter.

Download Full Size | PPT Slide | PDF

Fig. 2.
Fig. 2. Output characteristics of the wavelength-swept laser. (a) Peak-hold output spectrum on logarithmic (dashed) and linear (solid) scales. (b) Time-domain trace at a 43.2 kHz sweep rate and 7 mW average power.

Download Full Size | PPT Slide | PDF

Fig. 3.
Fig. 3. Schematic of the optical frequency domain imaging system.

Download Full Size | PPT Slide | PDF

Fig. 4.
Fig. 4. Sensitivity of the OFDI system as a function of the reference power (a) and depth (b), measured with an attenuated mirror with a -50 dB reflectivity. The dashed lines are theoretical fits.

Download Full Size | PPT Slide | PDF

Fig. 5.
Fig. 5. (2.5 MB) A sequence of OFDI images of Xenopus laevis tadpole in vivo placed in a Petri dish filled with saline. A cross section of ventricle (yellow arrow) shows trabeculae within the chamber. Blood in the heart produces strong light scattering, resulting in a shadow region denoted by red asterisk. The saline surface produces relatively strong back reflection (green arrows), and the sample top surface is somewhat flattened due to surface tension of saline. Although the movie was acquired at 84 frames per second, it is displayed at 30 frames per second. Scale bar, 200 µm. [Media 2]

Download Full Size | PPT Slide | PDF

Metrics