Abstract

We have designed a compact dual wavelength multi-channel time-resolved system for functional near infrared spectroscopy. The system enables 16 sources and up to 64 collection points, with a minimum acquisition time of 5 ms per channel. Performances of the system have been tested on tissue phantoms in terms of linearity, noise, stability and reproducibility. Preliminary measurements on volunteers have been performed to validate the instrument capability to acquire in vivo maps of the hemodynamic parameters in the muscle during arterial occlusion and in the adult head during a finger tapping experiment.

© 2006 Optical Society of America

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2006

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

2005

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 15, 409-411 (2005).
[CrossRef]

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
[CrossRef] [PubMed]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

F. Martelli, S. Del Bianco and G. Zaccanti, "Perturbation model for light propagation through diffusive layered media," Phys. Med. Biol. 50, 2159-2166 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

B. Montcel, R. Chabrier, and P. Poulet, "Detection of cortical activation with time-resolved diffuse optical methods," Appl Opt. 44, 1942-1947 (2005).
[CrossRef] [PubMed]

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
[CrossRef]

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

2004

C. Abrahamsson, T. Svensson, S. Svanberg, and S. Andersson-Engels,"Time and wavelength resolved spectroscopy of turbid media using light continuum generated in a crystal fiber," Opt. Express 12, 4103-4112 (2004).
[CrossRef] [PubMed]

D. A. Boas, A. M. Dale, and M. A. Franceschini, "Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy," Neuroimage 23, S275-S288 (2004).
[CrossRef] [PubMed]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

R. Esposito, S. De Nicola, M. Lepore, I. Delfino and P. L. Indovina, "A perturbation approach to characterize absorptive inclusions in diffusing media by time-resolved contrast measurements," J. Opt. A: Pure Appl. Opt. 6, 736-741 (2004).
[CrossRef]

2003

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
[CrossRef]

H. Obrig and A. Villringer, "Beyond the Visible—Imaging the Human Brain With Light," J. Cereb. Blood Flow Metab. 23, 1-18 (2003).
[CrossRef]

C. Zint, W. Uhring, M. Torregrossa, B. Cunin, and P. Poulet, "Streak Camera: A Multidetector for Diffuse Optical Tomography, " Appl. Opt. 42, 3313-3320 (2003).
[CrossRef] [PubMed]

2002

G. Strangman, D. A. Boas, and J. P. Sutton, "Non-invasive neuroimaging using near-infrared light," Biol. Psychiatry 52, 679-693 (2002).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli and G. Zaccanti "Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation," Phys. Med. Biol. 47, 4131-44 (2002).
[CrossRef] [PubMed]

2001

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer and H. Rinneberg, "Determining changes in NIR absorption using a layered model of the human head," Phys. Med. Biol. 46, 879-896 (2001).
[CrossRef] [PubMed]

1999

1997

Y. Nomura, O. Hazeki and M. Tamura, "Relationship between time-resolved and non-time-resolved Beer-Lambert law in turbid media," Phys. Med. Biol. 42, 1009-1023 (1997).
[CrossRef] [PubMed]

A. Villringer and B. Chance, "Noninvasive optical spectroscopy and imaging of human brain function," Trends in Neurosci. 20, 435-442 (1997).
[CrossRef]

1996

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Experimental test of theoretical models for time-resolved reflectance," Med. Phys. 23, 1625-1634 (1996).
[CrossRef] [PubMed]

1995

A. Yodh and B. Chance, "Spectroscopy and imaging with diffusing light", Phys. Today 48, 34-40 (1995).
[CrossRef]

1994

1993

Y. Hoshi and M. Tamura, "Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man," Neurosci. Lett. 150, 5-8 (1993).
[CrossRef] [PubMed]

1991

1989

Abrahamsson, C.

Andersson-Engels, S.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

C. Abrahamsson, T. Svensson, S. Svanberg, and S. Andersson-Engels,"Time and wavelength resolved spectroscopy of turbid media using light continuum generated in a crystal fiber," Opt. Express 12, 4103-4112 (2004).
[CrossRef] [PubMed]

Avrillier, S.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Bassi, A.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Berndt, K. W.

Biscotti, G.

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

Boas, D. A.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
[CrossRef] [PubMed]

D. A. Boas, A. M. Dale, and M. A. Franceschini, "Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy," Neuroimage 23, S275-S288 (2004).
[CrossRef] [PubMed]

G. Strangman, D. A. Boas, and J. P. Sutton, "Non-invasive neuroimaging using near-infrared light," Biol. Psychiatry 52, 679-693 (2002).
[CrossRef] [PubMed]

Chabrier, R.

B. Montcel, R. Chabrier, and P. Poulet, "Detection of cortical activation with time-resolved diffuse optical methods," Appl Opt. 44, 1942-1947 (2005).
[CrossRef] [PubMed]

Chance, B.

A. Villringer and B. Chance, "Noninvasive optical spectroscopy and imaging of human brain function," Trends in Neurosci. 20, 435-442 (1997).
[CrossRef]

A. Yodh and B. Chance, "Spectroscopy and imaging with diffusing light", Phys. Today 48, 34-40 (1995).
[CrossRef]

M. S. Patterson, B. Chance, and B. C. Wilson, "Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties," Appl. Opt. 28, 2331-2336 (1989).
[CrossRef] [PubMed]

Comelli, D.

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
[CrossRef]

Contini, D.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

Cubeddu, R.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance", Appl. Opt. 38, 3670-3680 (1999).
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R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Experimental test of theoretical models for time-resolved reflectance," Med. Phys. 23, 1625-1634 (1996).
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Cunin, B.

Dale, A. M.

D. A. Boas, A. M. Dale, and M. A. Franceschini, "Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy," Neuroimage 23, S275-S288 (2004).
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D'Andrea, C.

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
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De Nicola, S.

R. Esposito, S. De Nicola, M. Lepore, I. Delfino and P. L. Indovina, "A perturbation approach to characterize absorptive inclusions in diffusing media by time-resolved contrast measurements," J. Opt. A: Pure Appl. Opt. 6, 736-741 (2004).
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Del Bianco, S.

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
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F. Martelli, S. Del Bianco and G. Zaccanti, "Perturbation model for light propagation through diffusive layered media," Phys. Med. Biol. 50, 2159-2166 (2005).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli and G. Zaccanti "Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation," Phys. Med. Biol. 47, 4131-44 (2002).
[CrossRef] [PubMed]

Delfino, I.

R. Esposito, S. De Nicola, M. Lepore, I. Delfino and P. L. Indovina, "A perturbation approach to characterize absorptive inclusions in diffusing media by time-resolved contrast measurements," J. Opt. A: Pure Appl. Opt. 6, 736-741 (2004).
[CrossRef]

Esposito, R.

R. Esposito, S. De Nicola, M. Lepore, I. Delfino and P. L. Indovina, "A perturbation approach to characterize absorptive inclusions in diffusing media by time-resolved contrast measurements," J. Opt. A: Pure Appl. Opt. 6, 736-741 (2004).
[CrossRef]

Feng, T. C.

Ferrari, M.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

Franceschini, M. A.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
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D. A. Boas, A. M. Dale, and M. A. Franceschini, "Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy," Neuroimage 23, S275-S288 (2004).
[CrossRef] [PubMed]

Grosenick, D.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Haskell, R. C.

Hazeki, O.

Y. Nomura, O. Hazeki and M. Tamura, "Relationship between time-resolved and non-time-resolved Beer-Lambert law in turbid media," Phys. Med. Biol. 42, 1009-1023 (1997).
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Y. Hoshi and M. Tamura, "Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man," Neurosci. Lett. 150, 5-8 (1993).
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S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

Imai, T.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

Indovina, P. L.

R. Esposito, S. De Nicola, M. Lepore, I. Delfino and P. L. Indovina, "A perturbation approach to characterize absorptive inclusions in diffusing media by time-resolved contrast measurements," J. Opt. A: Pure Appl. Opt. 6, 736-741 (2004).
[CrossRef]

Islam, F.

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

Isobe, K.

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

Itoh, S.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

Kawada, K.

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

Kusaka, T.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

Lakowicz, J. R.

Lepore, M.

R. Esposito, S. De Nicola, M. Lepore, I. Delfino and P. L. Indovina, "A perturbation approach to characterize absorptive inclusions in diffusing media by time-resolved contrast measurements," J. Opt. A: Pure Appl. Opt. 6, 736-741 (2004).
[CrossRef]

Liebert, A.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

Macdonald, R.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

Martelli, F.

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

F. Martelli, S. Del Bianco and G. Zaccanti, "Perturbation model for light propagation through diffusive layered media," Phys. Med. Biol. 50, 2159-2166 (2005).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli and G. Zaccanti "Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation," Phys. Med. Biol. 47, 4131-44 (2002).
[CrossRef] [PubMed]

McAdams, M. S.

Moller, M.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

Möller, M.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Montcel, B.

B. Montcel, R. Chabrier, and P. Poulet, "Detection of cortical activation with time-resolved diffuse optical methods," Appl Opt. 44, 1942-1947 (2005).
[CrossRef] [PubMed]

Moulton, J. D.

Namba, M.

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

Nghiem, H. L.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Nishida, T.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

Nomura, Y.

Y. Nomura, O. Hazeki and M. Tamura, "Relationship between time-resolved and non-time-resolved Beer-Lambert law in turbid media," Phys. Med. Biol. 42, 1009-1023 (1997).
[CrossRef] [PubMed]

Ntziachristos, V.

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 15, 409-411 (2005).
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Obrig, H.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

H. Obrig and A. Villringer, "Beyond the Visible—Imaging the Human Brain With Light," J. Cereb. Blood Flow Metab. 23, 1-18 (2003).
[CrossRef]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer and H. Rinneberg, "Determining changes in NIR absorption using a layered model of the human head," Phys. Med. Biol. 46, 879-896 (2001).
[CrossRef] [PubMed]

Oda, M.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
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Ohmae, E.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
[CrossRef]

Okada, H.

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

Okubo, K.

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

S. Ijichi, T. Kusaka, K. Isobe, K. Okubo, K. Kawada, M. Namba, H. Okada, T. Nishida, T. Imai, and S. Itoh, "Developmental Changes of Optical Properties in Neonates Determined by Near-Infrared Time-Resolved Spectroscopy," Ped. Res. 58, 568-573 (2005).
[CrossRef]

Patterson, M. S.

Pifferi, A.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance", Appl. Opt. 38, 3670-3680 (1999).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Experimental test of theoretical models for time-resolved reflectance," Med. Phys. 23, 1625-1634 (1996).
[CrossRef] [PubMed]

Poulet, P.

B. Montcel, R. Chabrier, and P. Poulet, "Detection of cortical activation with time-resolved diffuse optical methods," Appl Opt. 44, 1942-1947 (2005).
[CrossRef] [PubMed]

C. Zint, W. Uhring, M. Torregrossa, B. Cunin, and P. Poulet, "Streak Camera: A Multidetector for Diffuse Optical Tomography, " Appl. Opt. 42, 3313-3320 (2003).
[CrossRef] [PubMed]

Quaresima, V.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

Rinneberg, H.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer and H. Rinneberg, "Determining changes in NIR absorption using a layered model of the human head," Phys. Med. Biol. 46, 879-896 (2001).
[CrossRef] [PubMed]

Ripoll, J.

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 15, 409-411 (2005).
[CrossRef]

Selb, J.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
[CrossRef] [PubMed]

Sorensen, A. G.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
[CrossRef] [PubMed]

Soubret, A.

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 15, 409-411 (2005).
[CrossRef]

Spinelli, L.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

Stamm, H.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Steinbrink, J.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer and H. Rinneberg, "Determining changes in NIR absorption using a layered model of the human head," Phys. Med. Biol. 46, 879-896 (2001).
[CrossRef] [PubMed]

Sterenborg, H. J. C. M.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Stott, J. J.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
[CrossRef] [PubMed]

Strangman, G.

G. Strangman, D. A. Boas, and J. P. Sutton, "Non-invasive neuroimaging using near-infrared light," Biol. Psychiatry 52, 679-693 (2002).
[CrossRef] [PubMed]

Sutton, J. P.

G. Strangman, D. A. Boas, and J. P. Sutton, "Non-invasive neuroimaging using near-infrared light," Biol. Psychiatry 52, 679-693 (2002).
[CrossRef] [PubMed]

Suzuki, T.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
[CrossRef]

Svaasand, L. O.

Svanberg, S.

Svensson, T.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

C. Abrahamsson, T. Svensson, S. Svanberg, and S. Andersson-Engels,"Time and wavelength resolved spectroscopy of turbid media using light continuum generated in a crystal fiber," Opt. Express 12, 4103-4112 (2004).
[CrossRef] [PubMed]

Swartling, J.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
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Tamura, M.

Y. Nomura, O. Hazeki and M. Tamura, "Relationship between time-resolved and non-time-resolved Beer-Lambert law in turbid media," Phys. Med. Biol. 42, 1009-1023 (1997).
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Y. Hoshi and M. Tamura, "Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man," Neurosci. Lett. 150, 5-8 (1993).
[CrossRef] [PubMed]

Taroni, P.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance", Appl. Opt. 38, 3670-3680 (1999).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Experimental test of theoretical models for time-resolved reflectance," Med. Phys. 23, 1625-1634 (1996).
[CrossRef] [PubMed]

Tinet, E.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Torregrossa, M.

Torricelli, A.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

A. Torricelli, V. Quaresima, A. Pifferi, G. Biscotti, L. Spinelli, P. Taroni, M. Ferrari and R. Cubeddu, "Mapping of calf muscle oxygenation and haemoglobin content during dynamic plantar flexion exercise by multi-channel time-resolved near infrared spectroscopy", Phys. Med. Biol. 49, 685-699, (2004).
[CrossRef] [PubMed]

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance", Appl. Opt. 38, 3670-3680 (1999).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Experimental test of theoretical models for time-resolved reflectance," Med. Phys. 23, 1625-1634 (1996).
[CrossRef] [PubMed]

Tromberg, B. J.

Tsay, T. T.

Tualle, J. M.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Turner, G. M.

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 15, 409-411 (2005).
[CrossRef]

Ueda, Y.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
[CrossRef]

Uhring, W.

Valentini, G.

C. D'Andrea, D. Comelli, A. Pifferi, A. Torricelli, G. Valentini and R. Cubeddu, "Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera," J. Phys. D: Appl. Phys. 36, 1675-1681 (2003).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Compact tissue oximeter based on dual-wavelength multichannel time-resolved reflectance", Appl. Opt. 38, 3670-3680 (1999).
[CrossRef]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli and G. Valentini, "Experimental test of theoretical models for time-resolved reflectance," Med. Phys. 23, 1625-1634 (1996).
[CrossRef] [PubMed]

van Veen, R. L. P.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Villringer, A.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

H. Obrig and A. Villringer, "Beyond the Visible—Imaging the Human Brain With Light," J. Cereb. Blood Flow Metab. 23, 1-18 (2003).
[CrossRef]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer and H. Rinneberg, "Determining changes in NIR absorption using a layered model of the human head," Phys. Med. Biol. 46, 879-896 (2001).
[CrossRef] [PubMed]

A. Villringer and B. Chance, "Noninvasive optical spectroscopy and imaging of human brain function," Trends in Neurosci. 20, 435-442 (1997).
[CrossRef]

Wabnitz, H.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Moller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, "Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance," Neuroimage 24, 426-435 (2005).
[CrossRef] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
[CrossRef] [PubMed]

J. Steinbrink, H. Wabnitz, H. Obrig, A. Villringer and H. Rinneberg, "Determining changes in NIR absorption using a layered model of the human head," Phys. Med. Biol. 46, 879-896 (2001).
[CrossRef] [PubMed]

Whelan, M.

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J. M. Tualle, H. L. Nghiem, E. Tinet, S. Avrillier, M. Whelan, and H. Stamm, "Performance assessment of photon migration instruments: the Medphot protocol," Appl. Opt. 11, 2104-2114 (2005).
[CrossRef]

Wilson, B. C.

Yamanaka, T.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
[CrossRef]

Yamashita, D.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
[CrossRef]

Yamashita, Y.

Y. Ueda, T. Yamanaka, D. Yamashita, T. Suzuki, E. Ohmae, M. Oda, and Y. Yamashita, "Reflectance diffuse optical tomography:its application to hunam brain mapping," Jap. J. Appl. Phys. 44, L1203-L1206 (2005).
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Yodh, A.

A. Yodh and B. Chance, "Spectroscopy and imaging with diffusing light", Phys. Today 48, 34-40 (1995).
[CrossRef]

Zaccanti, G.

A. Torricelli, A. Pifferi, L. Spinelli, R. Cubeddu, F. Martelli, S. Del Bianco and G. Zaccanti, "Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging," Phys. Rev. Lett. 95, 078101 (2005).
[CrossRef] [PubMed]

F. Martelli, S. Del Bianco and G. Zaccanti, "Perturbation model for light propagation through diffusive layered media," Phys. Med. Biol. 50, 2159-2166 (2005).
[CrossRef] [PubMed]

S. Del Bianco, F. Martelli and G. Zaccanti "Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation," Phys. Med. Biol. 47, 4131-44 (2002).
[CrossRef] [PubMed]

Zacharakis, G.

G. M. Turner, G. Zacharakis, A. Soubret, J. Ripoll, and V. Ntziachristos, "Complete-angle projection diffuse optical tomography by use of early photons," Opt. Lett. 15, 409-411 (2005).
[CrossRef]

Zint, C.

Appl Opt.

A. Liebert, H. Wabnitz, J. Steinbrink, H. Obrig, M. Moller, R. Macdonald, A. Villringer, and H. Rinneberg, "Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons," Appl Opt. 43, 3037-47 (2004).
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B. Montcel, R. Chabrier, and P. Poulet, "Detection of cortical activation with time-resolved diffuse optical methods," Appl Opt. 44, 1942-1947 (2005).
[CrossRef] [PubMed]

Appl. Opt.

Biol. Psychiatry

G. Strangman, D. A. Boas, and J. P. Sutton, "Non-invasive neuroimaging using near-infrared light," Biol. Psychiatry 52, 679-693 (2002).
[CrossRef] [PubMed]

IEEE Trans. Instrum. Meas.

D. Contini, A. Torricelli, A. Pifferi, L. Spinelli, P. Taroni, V. Quaresima, M. Ferrari and R. Cubeddu, "Multi-channel time-resolved tissue oximeter for functional imaging of the brain," IEEE Trans. Instrum. Meas. 55, 85-90 (2006).
[CrossRef]

J. Biomed Opt.

J. Selb, J. J. Stott, M. A. Franceschini, A. G. Sorensen, and D. A. Boas, "Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation," J. Biomed Opt. 10, 11013 (2005).
[CrossRef] [PubMed]

J. Biomed. Opt.

S. Ijichi, T. Kusaka, K. Isobe, F. Islam, K. Okubo, H. Okada, M. Namba, K. Kawada, T. Imai, and S. Itoh, "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10, 024026 (2005).
[CrossRef] [PubMed]

V. Quaresima, M. Ferrari, A. Torricelli, L. Spinelli, A. Pifferi, and R. Cubeddu, "Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study," J. Biomed. Opt. 10, 011012 (2005).
[CrossRef]

J. Cereb. Blood Flow Metab.

H. Obrig and A. Villringer, "Beyond the Visible—Imaging the Human Brain With Light," J. Cereb. Blood Flow Metab. 23, 1-18 (2003).
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Figures (12)

Fig. 1.
Fig. 1.

Scheme of the system set-up (ND: neutral density attenuator; S1–S16: source fibers; R1–R4, reference fibers; F1–F16: collection bundles; PMT: photomultiplier; amp: amplifier; TCSPC: time-correlated single photon counting; sync: synchronization signal; µCHIP: microcontroller unit).

Fig. 2.
Fig. 2.

Example of instrument response function (IRF) and time-resolved reflectance curve (TRS) at 690 nm and 820 nm.

Fig. 3.
Fig. 3.

Example of fiber bundles displacement for two hexagonal probes, with 4 sources and 16 fiber bundles each (top). Strategy for avoiding cross talk among bundles for probe 1 (bottom). A similar scheme can be applied in parallel to PMT-3 and PMT4 for probe 2.

Fig. 4.
Fig. 4.

Linearity on absorption coefficient (top) and scattering coefficient (bottom) at 690 nm. Details on experimental set-up are shown in the inset in panel (a).

Fig. 5.
Fig. 5.

(a) Coefficient of variation (CV) for the measured absorption and reduced scattering coefficient at 690 nm. The line in the log-log plot is a best fit to the data (excluding the last three points) to a square law: CV ÷ Nn. (b) Stability test: plot of the error with respect to the mean value over the last 30 min for the measured absorption coefficient at 690 nm. The green (red) lines correspond to ±3% (±10%).

Fig. 6.
Fig. 6.

Muscle experiment: geometry of the position of sources and detectors (panel (a)) and photo during measurements (panel(b))

Fig. 7.
Fig. 7.

Time course of hemodynamic parameters in one channel of the left (thin line) and right (thick line) forearm muscle.

Fig. 8.
Fig. 8.

Spatial maps of hemodynamic changes during baseline (top), task (middle) and recovery (bottom) in the right (left column) and left (right column) forearm.

Fig. 9.
Fig. 9.

Brain experiment: geometry of the position of sources and detectors (panel (a)) and photo during measurements (panel(b))

Fig. 10.
Fig. 10.

Time course of hemodynamic changes in one channel of the left (thin line) and right (thick line) hemisphere.

Fig. 11.
Fig. 11.

Spatial maps of hemodynamic changes in the brain during baseline (top), task (middle) and recovery (bottom) for the contralateral (left column) and ipsilateral (right column) hemisphere.

Fig. 12.
Fig. 12.

Plot of the contrast for different time-gate values in the 0–2500 ps range in steps of 250 ps at 690 nm and 820 nm.

Equations (2)

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Δ μ a ( λ ) = 1 v t ln ( R ( ρ , t ; λ ) R 0 ( ρ , t ; λ ) )
μ a ( λ ) = μ a 0 ( λ ) + Δ μ a ( λ )

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