Abstract

A novel paired surface plasma wave biosensor (PSPWB) is described and setup. By integrating the features of a common-path optical heterodyne interferometer and the amplitude-ratio detection mode, the PSPWB not only produces a high detection sensitivity but also provides a large dynamic measurement range for effective refractive index ( Δneff) based on amplitude-sensitive detection method. Thus, the performance of PSPWB becomes equivalent to shot-noise limited of a conventional SPR biosensor. To our knowledge, this novel PSPWB shows the highest detection sensitivity on Δneff when compared with conventional SPR biosensors using either a non-interferometric or interferometric technique. The experimental results correctly verify the properties of a PSPWB that the detection sensitivity is an order of 10-7 refractive index unit (RIU) when measuring a 0.001% sucrose-water solution. This result confirms the detection sensitivity up to 10-9 RIU of the IgG/anti-IgG interaction in real time successfully. Furthermore, a dynamic range of 105 using PSPWB was also obtained.

© 2006 Optical Society of America

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  1. J. Homola, "present and feture of surface plasmon resonance biosensor," Anal. Bioanal. Chem.,  377,528-539 (2003).
    [CrossRef] [PubMed]
  2. C. Nylander, B. Liedberg, T. Lind, "Gas detection by means of surface plasmon resonance," Sensors and Actuators 3, 79-88 (1982).
    [CrossRef]
  3. S. Y. Wu, H. P. Ho, W. C. Law, C. Lin, "Highly sensitive differential phase-sensitive surface plasmon resonance biosensor based on the Mach-Zehnder configuration," Opt. Lett. 29, 2378-2380 (2004).
    [CrossRef] [PubMed]
  4. J. Homola, S. S. Yee, G. Gauglitz, "Surface plasmon resonance sensors: a review," Sensors and Actuators B 54, 3-15 (1999).
    [CrossRef]
  5. W. C. Kuo, C. Chou, H. T. Wu, "Optical heterodyne surface-plasmon resonance biosensor," Opt. Lett. 28, 1329-1331 (2003).
    [CrossRef] [PubMed]
  6. A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
    [CrossRef] [PubMed]
  7. A. A. Kruchinin, Yu. G. Vlasov, "Surface plasmon resonance monitoring by means of polarization state measurement in reflected light as the basis of a DNA-probe biosensor," Sensors and Actuators B 30, 77-80 (1996).
    [CrossRef]
  8. P. S. Vukusic, G. P. Bryan-Brown, J. R. Sambles, "Surface plasmon resonance on grating as novel means for gas sensing," Sensor and Actuators B 8, 155-160 (1992).
    [CrossRef]
  9. C. Chou, C.Y. Han, "Optical heterodyne phase-sensitive SPR biosensor," Patent #88101282, Taiwan, R.O.C. (1999).
  10. M. V. Tratnik, E. Sipe, "Polarization eigenstates of a Zeeman laser," J. Opt. Soc. Am. B 3, 1127-1137 (1986).
    [CrossRef]
  11. N. Yu, Dabnitshev, V. P. Koronkevich, V. S. Sobelev, A. A. Stolpovski, Yu. G. Vasilenko, E. N. Utkin, "Laser Doppler velocimeter as an optoelectronic data processing system," Appl. Opt. 14, 180-184 (1995).
  12. B. Renter. N. talukder, "A new differential laser microanemeter " in European conference on optical systems& applications, D. J. Kroon eds., Proc. SPIE 236, 226-230 (1980).
  13. F. Jenkins, H. White, Fundamentals of optics 4th edition (McGraw-Hill book co., New York, 1976) chapter 25.
  14. M. Salahi, B. Cabon, "Theoretical and experimental analysis of influence of phase to intensity noise conversion in interferometric systems," J. Lightwave Technol. 22, 1510-1518 (2004).
    [CrossRef]
  15. D. A. Skoog, F. J. Holler and D. M. West, Analytical Chemistry (Saunders College Publishing, 1990), Chap. 2.
  16. "Sugar Analysis-ICUMSA"edited by F. Schneider and published by the International Commission for Uniform Methods of Sugar Analysis (ICUMSA) (1979).
  17. S. Löfås and B. Johnsson, "A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands," J. Chem. Soc., Chem. Commun. 21, 1526-1528 (1990).
    [CrossRef]
  18. A. A. Kolomenskii, P. D. Gershon, and H. A. Schuessler, "Sensitivity and detection limit of concentration and adsorption measurements by laser-induced surface plasmon resonance," Appl. Opt. 36, 6539-6547 (1997).
    [CrossRef]
  19. A. Brandenburg, R. Krauter, C. Kunzel, M. Stefan, H. Schulte, "Interferometric sensor for detection of surface-bound bioreactions," Appl. Opt. 39, 6396-6404 (2000).
    [CrossRef]
  20. S.C. Cohan, "Heterodyne detection: phase front alignment, beam spot size and detector uniformity," Appl. Opt. 14, 1953-1958 (1975).
    [CrossRef]

2004 (2)

2003 (2)

J. Homola, "present and feture of surface plasmon resonance biosensor," Anal. Bioanal. Chem.,  377,528-539 (2003).
[CrossRef] [PubMed]

W. C. Kuo, C. Chou, H. T. Wu, "Optical heterodyne surface-plasmon resonance biosensor," Opt. Lett. 28, 1329-1331 (2003).
[CrossRef] [PubMed]

2002 (1)

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

2000 (1)

1999 (1)

J. Homola, S. S. Yee, G. Gauglitz, "Surface plasmon resonance sensors: a review," Sensors and Actuators B 54, 3-15 (1999).
[CrossRef]

1997 (1)

1996 (1)

A. A. Kruchinin, Yu. G. Vlasov, "Surface plasmon resonance monitoring by means of polarization state measurement in reflected light as the basis of a DNA-probe biosensor," Sensors and Actuators B 30, 77-80 (1996).
[CrossRef]

1995 (1)

1992 (1)

P. S. Vukusic, G. P. Bryan-Brown, J. R. Sambles, "Surface plasmon resonance on grating as novel means for gas sensing," Sensor and Actuators B 8, 155-160 (1992).
[CrossRef]

1990 (1)

S. Löfås and B. Johnsson, "A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands," J. Chem. Soc., Chem. Commun. 21, 1526-1528 (1990).
[CrossRef]

1986 (1)

1982 (1)

C. Nylander, B. Liedberg, T. Lind, "Gas detection by means of surface plasmon resonance," Sensors and Actuators 3, 79-88 (1982).
[CrossRef]

1980 (1)

B. Renter. N. talukder, "A new differential laser microanemeter " in European conference on optical systems& applications, D. J. Kroon eds., Proc. SPIE 236, 226-230 (1980).

1975 (1)

Bartholomew, D.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Brandenburg, A.

Bryan-Brown, G. P.

P. S. Vukusic, G. P. Bryan-Brown, J. R. Sambles, "Surface plasmon resonance on grating as novel means for gas sensing," Sensor and Actuators B 8, 155-160 (1992).
[CrossRef]

Cabon, B.

Chou, C.

Cohan, S.C.

Dabnitshev, N.

Dunlap, L.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Elkind, J.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Furlong, C. E.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Gauglitz, G.

J. Homola, S. S. Yee, G. Gauglitz, "Surface plasmon resonance sensors: a review," Sensors and Actuators B 54, 3-15 (1999).
[CrossRef]

Gershon, P. D.

Ho, H. P.

Homola, J.

J. Homola, "present and feture of surface plasmon resonance biosensor," Anal. Bioanal. Chem.,  377,528-539 (2003).
[CrossRef] [PubMed]

J. Homola, S. S. Yee, G. Gauglitz, "Surface plasmon resonance sensors: a review," Sensors and Actuators B 54, 3-15 (1999).
[CrossRef]

Johnsson, B.

S. Löfås and B. Johnsson, "A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands," J. Chem. Soc., Chem. Commun. 21, 1526-1528 (1990).
[CrossRef]

Kolomenskii, A. A.

Krauter, R.

Kruchinin, A. A.

A. A. Kruchinin, Yu. G. Vlasov, "Surface plasmon resonance monitoring by means of polarization state measurement in reflected light as the basis of a DNA-probe biosensor," Sensors and Actuators B 30, 77-80 (1996).
[CrossRef]

Kunzel, C.

Kuo, W. C.

Law, W. C.

Liedberg, B.

C. Nylander, B. Liedberg, T. Lind, "Gas detection by means of surface plasmon resonance," Sensors and Actuators 3, 79-88 (1982).
[CrossRef]

Lin, C.

Lind, T.

C. Nylander, B. Liedberg, T. Lind, "Gas detection by means of surface plasmon resonance," Sensors and Actuators 3, 79-88 (1982).
[CrossRef]

Löfås, S.

S. Löfås and B. Johnsson, "A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands," J. Chem. Soc., Chem. Commun. 21, 1526-1528 (1990).
[CrossRef]

Melendez, J.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Naimushin, A. N.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Nguyen, D. K.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Nylander, C.

C. Nylander, B. Liedberg, T. Lind, "Gas detection by means of surface plasmon resonance," Sensors and Actuators 3, 79-88 (1982).
[CrossRef]

Renter, B.

B. Renter. N. talukder, "A new differential laser microanemeter " in European conference on optical systems& applications, D. J. Kroon eds., Proc. SPIE 236, 226-230 (1980).

Salahi, M.

Sambles, J. R.

P. S. Vukusic, G. P. Bryan-Brown, J. R. Sambles, "Surface plasmon resonance on grating as novel means for gas sensing," Sensor and Actuators B 8, 155-160 (1992).
[CrossRef]

Schuessler, H. A.

Schulte, H.

Sipe, E.

Soelberg, S. D.

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

Stefan, M.

Tratnik, M. V.

Vlasov, Yu. G.

A. A. Kruchinin, Yu. G. Vlasov, "Surface plasmon resonance monitoring by means of polarization state measurement in reflected light as the basis of a DNA-probe biosensor," Sensors and Actuators B 30, 77-80 (1996).
[CrossRef]

Vukusic, P. S.

P. S. Vukusic, G. P. Bryan-Brown, J. R. Sambles, "Surface plasmon resonance on grating as novel means for gas sensing," Sensor and Actuators B 8, 155-160 (1992).
[CrossRef]

Wu, H. T.

Wu, S. Y.

Yee, S. S.

J. Homola, S. S. Yee, G. Gauglitz, "Surface plasmon resonance sensors: a review," Sensors and Actuators B 54, 3-15 (1999).
[CrossRef]

Yu, N.

Anal. Bioanal. Chem. (1)

J. Homola, "present and feture of surface plasmon resonance biosensor," Anal. Bioanal. Chem.,  377,528-539 (2003).
[CrossRef] [PubMed]

Appl. Opt. (4)

Biosens. Bioelectron. (1)

A. N. Naimushin, S. D. Soelberg, D. K. Nguyen, L. Dunlap, D. Bartholomew, J. Elkind, J. Melendez, C. E. Furlong, "Detection of Staphylococcus aureus enterotoxin B at femtomolar levels with a miniature integrated two-channel surface plasmon resonance (SPR) biosensor," Biosens. Bioelectron. 17, 573-584 (2002).
[CrossRef] [PubMed]

J. Chem. Soc., Chem. Commun. (1)

S. Löfås and B. Johnsson, "A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors for fast and efficient covalent immobilization of ligands," J. Chem. Soc., Chem. Commun. 21, 1526-1528 (1990).
[CrossRef]

J. Lightwave Technol. (1)

J. Opt. Soc. Am. B (1)

Opt. Lett. (2)

Proc. SPIE (1)

B. Renter. N. talukder, "A new differential laser microanemeter " in European conference on optical systems& applications, D. J. Kroon eds., Proc. SPIE 236, 226-230 (1980).

Sensor and Actuators B (1)

P. S. Vukusic, G. P. Bryan-Brown, J. R. Sambles, "Surface plasmon resonance on grating as novel means for gas sensing," Sensor and Actuators B 8, 155-160 (1992).
[CrossRef]

Sensors and Actuators (1)

C. Nylander, B. Liedberg, T. Lind, "Gas detection by means of surface plasmon resonance," Sensors and Actuators 3, 79-88 (1982).
[CrossRef]

Sensors and Actuators B (2)

J. Homola, S. S. Yee, G. Gauglitz, "Surface plasmon resonance sensors: a review," Sensors and Actuators B 54, 3-15 (1999).
[CrossRef]

A. A. Kruchinin, Yu. G. Vlasov, "Surface plasmon resonance monitoring by means of polarization state measurement in reflected light as the basis of a DNA-probe biosensor," Sensors and Actuators B 30, 77-80 (1996).
[CrossRef]

Other (4)

C. Chou, C.Y. Han, "Optical heterodyne phase-sensitive SPR biosensor," Patent #88101282, Taiwan, R.O.C. (1999).

F. Jenkins, H. White, Fundamentals of optics 4th edition (McGraw-Hill book co., New York, 1976) chapter 25.

D. A. Skoog, F. J. Holler and D. M. West, Analytical Chemistry (Saunders College Publishing, 1990), Chap. 2.

"Sugar Analysis-ICUMSA"edited by F. Schneider and published by the International Commission for Uniform Methods of Sugar Analysis (ICUMSA) (1979).

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Figures (6)

Fig. 1.
Fig. 1.

Schematic of the amplitude-sensitive PSPWB: λ/2 : a half-wave plate; AO1, AO2: acoustic-optic modulators; D1, D2: drivers; PBS: a polarized beam splitter; BS1, BS2: beam splitters; M1, M2: mirrors; He-Ne: He-Ne laser; RC: reaction chamber; Dp and Ds: photo detectors; BF1 and BF2: band pass filters; LIA: lock-in amplifier.

Fig. 2.
Fig. 2.

Detected amplitude obtained from the PSPWB at different wt% of sucrose-water solution. (a) concentrations in a range of 1–10%, (b) concentrations in a range of 0.1–1.0%, (c) concentration in a range of 0.001–0.005 %.

Fig. 3.
Fig. 3.

The time response of glycerin-water solutions with various percentages by weight concentration. Glycerin-water concentration in the range of (a)1.0–10% and (b) 0.01–0.5%

Fig. 4.
Fig. 4.

Sensogram of the immobilization of rabbit anti-mouse IgG by use of the amine coupling method on CM5 sensor chip.

Fig. 5.
Fig. 5.

Time response of 10pg/ml mouse IgG interacting with immobilized rabbit anti-mouse IgG on CM5 biochip

Fig. 6.
Fig. 6.

A 50ng/ml mouse IgG interacting with immobilized protein-G in PBS buffer solution. (SNR=120)

Equations (2)

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I P 1 + P 2 ( Δ ω t ) = A P 1 A P 2 cos ( Δ ω t + Δ ϕ P )
I S 1 + S 2 ( Δ ω t ) = A S 1 A S 2 cos ( Δ ω t + Δ ϕ S )

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