Abstract

For the first time in vivo retinal imaging has been performed with a new compact, low noise Yb-based ASE source operating in the 1 µm range (NP Photonics, λc = 1040 nm, �?λ = 50 nm, Pout = 30 mW) at the dispersion minimum of water with ~7 µm axial resolution. OCT tomograms acquired at 800 nm are compared to those achieved at 1040 nm showing about 200 µm deeper penetration into the choroid below the retinal pigment epithelium. Retinal OCT at longer wavelengths significantly improves the visualization of the retinal pigment epithelium/choriocapillaris/choroids interface and superficial choroidal layers as well as reduces the scattering through turbid media and therefore might provide a better diagnosis tool for early stages of retinal pathologies such as age related macular degeneration which is accompanied by choroidal neovascularization, i.e., extensive growth of new blood vessels in the choroid and retina.

© 2005 Optical Society of America

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Appl. Opt. (1)

Arch. Ophthalmol (1)

W. Drexler, H. Sattmann, B. Hermann, T. H. Ko, M. Stur, A. Unterhuber, C. Scholda, O. Findl, M. Wirtitsch, J. G. Fujimoto, and A. F. Fercher, �??Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography,�?? Arch. Ophthalmol 121, 695-706 (2003).
[CrossRef]

Health Phy. (1)

International Comission of Non-Ionizing Radiation Protection, �??Revision of guidelines on limits of exposure to laser radiation of wavelengths between 400 nm and 1.4 µm,�?? Health Phy. 79, 432-440 (2000).

Invest. Ophthalmo. Vis. Sci. (1)

E. Ergun, B. Hermann, M. Wirtitsch, A. Unterhuber, T. H. Ko, H. Sattmann, C. Scholda, J. G. Fujimoto, M. Stur, and W. Drexler, �??Assessment of central visual function in Stargardt`s disease/Fundus flavimaculatus with ultrahigh-resolution optical coherence tomography,�?? Invest. Ophthalmo. Vis. Sci. 46, 310-316 (2005)

J. Biomed. Opt. (2)

A. F. Fercher, �??Optical coherence tomography,�?? J. Biomed. Opt. 1, 157-73 (1996)
[CrossRef]

W. Drexler, �??Ultrahigh resolution optical coherence tomography,�?? J. Biomed. Opt. 9 (1), 47-74 (2004).
[CrossRef]

Nature Medicine (2)

J. G. Fujimoto, M. E Brezinski., G. J. Tearney, S. A. Boppart, B. Bouma, M. R. Hee, J. F. Southern, and E. A. Swanson,�??Optical biopsy and imaging using optical coherence tomography,�?? Nature Medicine 1, 970-2 (1995).
[CrossRef]

W. Drexler, U. Morgner, R. K. Ghanta, J. S. Schuman, F. X. Kärtner, and J. G. Fujimoto, �??Ultrahigh-resolution ophthalmic optical coherence tomography,�?? Nature Medicine 7, 502-507 (2001).
[CrossRef]

Ophthalmology (2)

G. Wollstein, L. A. Paunescu, T. H. Ko, J. G. Fujimoto, A. Kowalevicz, I. Hartl, S. Beaton, H. Ishikawa, C. Mattox, O. Singh, J. Duker, W. Drexler , and J. S. Schuman, �??Ultrahigh-resolution optical coherence tomography in glaucoma,�?? Ophthalmology 112, 229-237 (2005).
[CrossRef]

T. H. Ko, J. G. Fujimoto, J. S. Duker, L. A. Paunescu, W. Drexler, C. R. Baumal, C. A. Puliafito, E. Reichel, A. H. Rogers, and J. S. Schuman, �??Comparison of ultrahigh- and standard- resolution optical coherence tomography for imaging macular hole pathology and repair,�?? Ophthalmology 111, 2033-2043 (2004).
[CrossRef]

Opt. Express (2)

Opt. Lett. (3)

Phys. Med. Biol. (1)

M. Hammer, A. Roggan, D. Schweitzer and G. Müller, �??Optical properties of ocular fundus tissues-an in vitro study using the double-integrating-sphere technique and inverse Monte Carlo simulation,�?? Phys. Med. Biol. 40, 963-978 (1995).
[CrossRef]

Science (1)

D. Huang, E.A. Swanson, C.P. Lin, J.S. Schuman, W.G. Stinson, W. Chang, M.R. Hee, T. Flotte, K. Gregory, C.A. Puliafito, and J. G. Fujimoto, �??Optical coherence tomography,�?? Science 254, 1178-81 (1991).
[CrossRef]

Other (2)

J.S. Schuman, C.A. Puliafito, and J. G. Fujimoto, �??Optical coherence tomography of ocular disease,�?? Slack Inc, Thorofare, New Jersey (2004).

American National Standards Institute, �??American National Standard for Safe Use of Lasers,�?? ANSI Z 136-1 (2000).

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