Abstract

A parallel Frequency Domain Optical Coherence Tomography (FD-OCT) system and - to the best of our knowledge- first in vivo tomograms obtained with such system are presented. A full tomogram of 256(x)×512(z) pixels covering a sample region of 8 mm×3,8 mm is recorded in only 1 ms. Since the transverse as well as the depth information is obtained in parallel, the structure is free of any motion artifacts. In order to study cross talk issues for parallel illumination the transversal resolution for a thermal light source is compared to that with an SLD.

© 2005 Optical Society of America

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    [CrossRef]
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    [CrossRef]
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    [CrossRef] [PubMed]

Opt. Commun. (2)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995).
[CrossRef]

A. F. Fercher, C. K. Hitzenberger, M. Sticker, R. Leitgeb, E. Barriouso "A thermal light source technique for optical coherence tomography," Opt. Commun. 185, 57-64 (2000).
[CrossRef]

Opt. Express (6)

R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003) <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-23-3116">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-23-3116</a>.
[CrossRef] [PubMed]

V. Westphal, A. M. Rollins, S. Radhakrishnan, J. A. Izatt, "Correction of geometric and refractive image distorsions in optical coherence tomography applying Fermat’s principle," Opt. Express 10, 397-404 (2002) <a href="http://www.opticsinfobase.org/abstract.cfm?id=68842">http://www.opticsinfobase.org/abstract.cfm?id=68842</a>.
[PubMed]

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, A. F. Fercher "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004) <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-10-2156">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-10-2156</a>.
[CrossRef] [PubMed]

R. A. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003) <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-8-889">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-8-889</a>.
[CrossRef] [PubMed]

S. H. Yun, G. J. Tearney, J. F. de Boer, B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency-domain ranging," Opt. Express 12, 2977-2998 (2004) <a href="http://www.opticsinfobase.org/abstract.cfm?id=80320">http://www.opticsinfobase.org/abstract.cfm?id=80320</a>.
[CrossRef] [PubMed]

M. Laubscher, M. Ducros, B. Karamata, T. Lasser, R., Salathe "Video-rate three-dimensional optical coherence tomography," Opt. Express 10, 429-435 (2002) <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-9-429">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-10-9-429</a>.
[PubMed]

Opt. Lett. (8)

E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, H. Saint-Jalmes, "Full-field optical coherence microscopy," Opt. Lett. 23, 244-246 (1998).
[CrossRef]

A. F. Zuluaga, R. Richards-Kortum, "Spatially resolved spectral interferometry for determination of subsurface structure," Opt. Lett. 24, 519-521 (1999).
[CrossRef]

J. F. de Boer, B. Cense, B. Hyle Park, M. C. Pierce, G. J. Tearney, B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003).
[CrossRef] [PubMed]

M. Wojtkowski, T. Bajraszewski, P. Targowski, A. Kowalczyk, "Real-time in vivo imaging by high-speed spectral optical coherence tomography," Opt. Lett. 28, 1745-1747 (2003).
[CrossRef] [PubMed]

N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Letters 29, 480-482 (2004) <a href="http://ol.osa.org/abstract.cfm?id=78865">http://ol.osa.org/abstract.cfm?id=78865</a>.

B. Karamata, P. Lambelet, M. Laubscher, R. P. Salathé, T. Lasser, "Spatially incoherent illumination as a mechanism for cross-talk suppression in wide-field optical coherence tomography," Opt. Lett. 29, 736-738 (2004).
[CrossRef] [PubMed]

M. Wojtkowski, A. Kowalczyk, R. Leitgeb, A. F. Fercher, "Full range complex spectral optical coherence tomography technique in eye imaging," Opt. Lett. 27, 1415-1417 (2002).
[CrossRef]

R. A. Leitgeb, C. K. Hitzenberger, T. Bajraszewski, A. F. Fercher, "Phase Shifting Algorithm to achieve high speed long depth range probing by Fourier Domain Optical Coherence Tomography," Opt. Lett. 28, 2201-2203 (2003).
[CrossRef] [PubMed]

Proc. SPIE (1)

A. F. Fercher, R. Leitgeb, C. K. Hitzenberger, H. Sattmann, M. Wojtkowski, "Complex Spectral Interferometry OCT," Proc. SPIE 3564, 173-178 (1998).
[CrossRef]

SPIE Proc. (1)

R. J Zawadzki, C. Leisser, R. Leitgeb, M. Pircher, A. F Fercher, "Three-dimensional ophthalmic optical coherence tomography with a refraction correction algorithm," SPIE Proc. 5140, 20-27 (2003).
[CrossRef]

Other (2)

R. Henderson, K. Schulmeister, Laser Safety (Institute of Physics Publishing, London 2004).
[CrossRef]

American National Standards Institute, Safe Use of Lasers, ANSI Z136.1-2000, (Laser Institute of America, 2000).

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Figures (6)

Fig. 1.
Fig. 1.

(a) The schematic of the Parallel FD OCT system. SLD - light source; L1 – collimator; CL-cylindrical lens, f=100 mm; L1–L5 - achromatic lens f=100 mm; NPBS - non-polarizing beam splitter 50:50; L6, L7 - achromatic lens f=310 mm; DG – diffraction grating; (b) Demonstration of line illumination (millimeter scale)

Fig. 2.
Fig. 2.

(a) Spectrum of the interferometer output after subtraction of the reference arm light: SLD (Red), Halogen Lamp (Blue), (b) Normalized coherence envelope after FFT of (a): SLD (Red), Halogen Lamp (Blue).

Fig. 3.
Fig. 3.

Diagrams of optical paths for two orthogonal planes of the anamorphic optical system. The abbreviations are the same as in Fig. 1.

Fig. 4.
Fig. 4.

(a) OCT tomogram of RTT- Group 1 – with SLD; (b) OCT tomogram of RTT- Group 2 with Halogen Lamp; (c) Cross section along the RTT surface for SLD, and in (d) for the Halogen Lamp.

Fig. 5.
Fig. 5.

Calculation of MPE for the eye

Fig. 6.
Fig. 6.

Human eye in vivo - Anterior chamber angle (a) without and (b) with correction. (c) Cornea and iris at a position close to iris rim; the scale bars correspond to 1mm vertically and 0.5mm horizontally.

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