Abstract

We present a high speed full range spectral domain optical coherence tomography system. By inserting a phase modulator into the reference arm and recording of every other spectrum with a 90° phase shift (introduced by the phase modulator) we are able to distinguish between negative and positive optical path differences with respect to the reference mirror. A modified two-frame algorithm eliminates the problem of suppressing symmetric structure terms in the final image. To demonstrate the performance of our method we present images of the anterior chamber of the human eye in vivo recorded with an A-scan rate of 10000 depth profiles per second.

© 2005 Optical Society of America

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J. Biomed. Opt. (2)

G. Häusler and M. W. Lindner, "Coherence radar and spectral radar - new tools for dermatological diagnosis," J. Biomed. Opt. 3, 21-31 (1998)
[CrossRef]

M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002)
[CrossRef]

Opt Express (1)

S. H. Yun, G. J. Tearney, J. F. de Boer, and B. E. Bouma, "Motion artifacts in optical coherence tomography with frequency domain ranging," Opt Express 12, 2977- 2998 (2004), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-13-2977">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-13-2977</a>
[CrossRef]

Opt. Commun. (2)

A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El- Zaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995)
[CrossRef]

P. Targowski, M. Wojtkowski, A. Kowalczyk, T. Bajraszewski, M. Szkulmowski, and I. Gorczynska, "Complex spectral OCT in human eye imaging in vivo," Opt. Commun. 229, 79-84 (2004)
[CrossRef]

Opt. Express (6)

R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A.F Fercher, "Ultrahigh resolution Fourier domain optical coherence tomography," Opt. Express 12, 2156-2165 (2004), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-10-2156">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-10-2156</a>
[CrossRef]

M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultra high resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-11-2404">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-11-2404</a>
[CrossRef]

B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-11-2435">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-11-2435</a>
[CrossRef]

R. A. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier Domain vs. Time Domain optical coherence tomography," Opt. Express 11, 889-894 (2003), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-8-889">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-8-889</a>

N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-3-367">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-12-3-367</a>
[CrossRef]

M. A. Choma, M. V. Sarunic, C. Yang, and J. A. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-18-2183">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-18-2183</a>

Opt. Lett. (6)

Proc. SPIE. (1)

A. F. Fercher, R. Leitgeb, C. K. Hitzenberger, H. Sattmann, and M. Wojtkowski, "Complex spectral interferometry OCT," Proc. SPIE. 3564, 173-178 (1999)

Progress in Optics (1)

A. F. Fercher and C. K. Hitzenberger, "Optical coherence tomography," Progress in Optics 44, 215-302 (2002)

Rep. Prog. Physics (1)

A. F. Fercher, W. Drexler, C. K. Hitzenberger, and T. Lasser, "Optical coherence tomography-principles and applications," Rep. Prog. Physics 66, 239-303 (2003)

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254 , 1178-1181 (1991)
[CrossRef]

Other (2)

R. N. Bracewell, The Fourier transform and its applications, 3rd ed. (McGraw-Hill, New York, 2000)

American National Standards Institute: "American National Standard for Safe Use of Lasers," ANSI Z136.1- 2000. Orlando, Laser Institute of America, 35-49 (2000).

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