Abstract

The spectral absorption features of methamphetamine (MA), one of the most widely consumed illicit drugs in the world, are studied experimentally by Terahertz (THz) time-domain spectroscopy (THz-TDS), and the characteristic absorption spectra are obtained in the range of 0.2 to 2.6 THz. The vibrational frequencies are calculated using the density functional theory (DFT). Theoretical results show significant agreement with experimental results, and identification of vibrational modes are given. The calculated results further confirm that the characteristic frequencies come from the collective vibrational modes. The results suggest that use of the THz-TDS technique can be an effective way to inspect for illicit drugs.

© 2005 Optical Society of America

PDF Article

References

  • View by:
  • |

  1. K. Kawase, Y. Ogawa, Y. Watanable, and H. Inoue, �??Non-destructive terahertz imaging of illicit drugs using spectral fingerprints,�?? Opt. Express 11, 2549-2554 (2003), <a href ="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-20-2549."> http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-20-2549.</a>
  2. B. M. Fischer, M. Walther, and P. U. Jepsen, �??Far-infrared vibrational modes of DNA components studied by terahertz time-domain spectroscopy,�?? Phys. Med. Biol. 47, 3807-3814 (2002).
  3. S. P. Mickan, A. Menikh, H. Liu, C. A. Mannella, R. MacColl, D. Abbott, J. Munch, and X.-C. Zhang, �??Label-free bioaffinity detection using terahertz technology,�?? Phys. Med. Biol. 47, 3789-3795 (2002).
    [CrossRef]
  4. P. H. Bolivar, M. Brucherseifer, M. Nagel, H. Kurz, A. Bosserhoff, and R. Buttner, �??Label-free probing of genes by time-domain terahertz sensing,�?? Phys. Med. Biol. 47, 3815-3821 (2002).
    [CrossRef]
  5. M. Brucherseifer, M. Nagel, P. H. Bolivar, and H. Kurz, �??Label-free probing of the binding state of DNA by time-domain terahertz sensing,�?? Appl. Phys. Lett. 77, 4049-4051 (2000).
    [CrossRef]
  6. A. Markelz, S. Whitmire, J. Hillebrecht, and R. Birge, �??THz time domain spectroscopy of biomolecular conformational modes,�?? Phys. Med. Biol. 47, 3797-3805 (2002).
    [CrossRef]
  7. M. Walther, P. Plochocka, B. Fischer, H. Helm, and P. U. Jepsen, �??Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy,�?? Biopolymers 67, 310-313 (2002).
    [CrossRef]
  8. K. Kawase, �??Terahertz imaging for drug detection and large-scale integrated circuit inspection,�?? Opt. Photon. News 15 (10), 34-39 (2004).
  9. M. J. Frisch, et al., GAUSSIAN03, Gaussian Inc., Pittsburgh, Pa., 2003.
  10. A. D. Becke, �??Density-functional thermochemistry. III. The role of exact exchange,�?? J. Chem. Phys. 98, 5648-5652 (1993).
    [CrossRef]
  11. C. Lee, W. Yang, and R. G. Parr, �??Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density,�?? Phys. Rev. B 37, 785-789 (1988).
    [CrossRef]

Appl. Phys. Lett.

M. Brucherseifer, M. Nagel, P. H. Bolivar, and H. Kurz, �??Label-free probing of the binding state of DNA by time-domain terahertz sensing,�?? Appl. Phys. Lett. 77, 4049-4051 (2000).
[CrossRef]

Biopolymers

M. Walther, P. Plochocka, B. Fischer, H. Helm, and P. U. Jepsen, �??Collective vibrational modes in biological molecules investigated by terahertz time-domain spectroscopy,�?? Biopolymers 67, 310-313 (2002).
[CrossRef]

J. Chem. Phys.

A. D. Becke, �??Density-functional thermochemistry. III. The role of exact exchange,�?? J. Chem. Phys. 98, 5648-5652 (1993).
[CrossRef]

Opt. Express

Opt. Photon. News

K. Kawase, �??Terahertz imaging for drug detection and large-scale integrated circuit inspection,�?? Opt. Photon. News 15 (10), 34-39 (2004).

Phys. Med. Biol.

A. Markelz, S. Whitmire, J. Hillebrecht, and R. Birge, �??THz time domain spectroscopy of biomolecular conformational modes,�?? Phys. Med. Biol. 47, 3797-3805 (2002).
[CrossRef]

B. M. Fischer, M. Walther, and P. U. Jepsen, �??Far-infrared vibrational modes of DNA components studied by terahertz time-domain spectroscopy,�?? Phys. Med. Biol. 47, 3807-3814 (2002).

S. P. Mickan, A. Menikh, H. Liu, C. A. Mannella, R. MacColl, D. Abbott, J. Munch, and X.-C. Zhang, �??Label-free bioaffinity detection using terahertz technology,�?? Phys. Med. Biol. 47, 3789-3795 (2002).
[CrossRef]

P. H. Bolivar, M. Brucherseifer, M. Nagel, H. Kurz, A. Bosserhoff, and R. Buttner, �??Label-free probing of genes by time-domain terahertz sensing,�?? Phys. Med. Biol. 47, 3815-3821 (2002).
[CrossRef]

Phys. Rev. B

C. Lee, W. Yang, and R. G. Parr, �??Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density,�?? Phys. Rev. B 37, 785-789 (1988).
[CrossRef]

Other

M. J. Frisch, et al., GAUSSIAN03, Gaussian Inc., Pittsburgh, Pa., 2003.

Cited By

OSA participates in CrossRef's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Metrics