Abstract

Motion of the sample arm fiber in optical coherence tomography (OCT) systems can dynamically alter the polarization state of light incident on tissue during imaging, with consequences for both conventional and polarization-sensitive (PS-)OCT. Endoscopic OCT is particularly susceptible to polarization-related effects, since in most cases, the transverse scanning mechanism involves motion of the sample arm optical fiber to create an image. We investigated the effects of a scanning sample arm fiber on the polarization state of light in an OCT system, and demonstrate that by referencing the state backscattered from within a sample to the measured state at the surface, changes in polarization state due to sample fiber motion can be isolated. The technique is demonstrated by high-speed PS-OCT imaging at 1 frame per second, with both linear and rotary scanning fiber-optic probes. Measurements were made on a calibrated wave plate, and endoscopic PS-OCT images of ex-vivo human tissues are also presented, allowing comparison with features in histologic sections.

© 2005 Optical Society of America

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Acad. Radiol. (1)

B. E. Bouma, G. J. Tearney, �??Clinical imaging with optical coherence tomography,�?? Acad. Radiol. 9, 942-953 (2002).
[CrossRef]

Appl. Opt. (1)

Invest. Ophthalmol. Vis. Sci. (1)

B. Cense, T. C. Chen, B. H. Park, M. C. Pierce, J. F. de Boer, �??Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomography,�?? Invest. Ophthalmol. Vis. Sci. 45, 2606-2612 (2004).
[CrossRef]

J. Biomed. Opt. (1)

J. Strasswimmer, M. C. Pierce, B. H. Park, V. Neel, J. F. de Boer, �??Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma,�?? J. Biomed. Opt. 9, 292-298 (2004).
[CrossRef]

J. Invest. Dermatol. (1)

M. C. Pierce, J. Strasswimmer, B. H. Park, B. Cense, J. F. de Boer, �??Advances in optical coherence tomography for dermatology,�?? J. Invest. Dermatol. 123, 458-463 (2004).
[CrossRef]

J. Opt. Soc. Am. A (1)

Opt. Express (5)

Opt. Lett. (16)

J. E. Roth, J. A. Kozak, S. Yazdanfar, A. M. Rollins, J. A. Izatt, �??Simplified method for polarization-sensitive optical coherence tomography,�?? Opt. Lett. 26, 1069-1071 (2001).

Y. Pan, H. Xie, G. K. Fedder, �??Endoscopic optical coherence tomography based on a microelectromechanical mirror," Opt. Lett. 26, 1966-1968 (2001).

J. F. de Boer, T. E. Milner, M. J. C. van Gemert, J. S. Nelson, �??Two-dimensional birefringence imaging in biological tissue by polarization-sensitive optical coherence tomography,�?? Opt. Lett. 22, 934-936 (1997).

M. J. Everett, K. Schoenenberger, B. W. Colston, Jr., L. B. Da Silva, �??Birefringence characterization of biological tissue by use of optical coherence tomography,�?? Opt. Lett. 23, 228-230 (1998).

J. F. de Boer, T. E. Milner, J. S. Nelson, �??Determination of the depth-resolved Stokes parameters of light backscattered from turbid media by use of polarization-sensitive optical coherence tomography,�?? Opt. Lett. 24, 300-302 (1999).

B. E. Bouma, G. J. Tearney, �??Power-efficient nonreciprocal interferometer and linear-scanning fiber-optic catheter for optical coherence tomography,�?? Opt. Lett. 24, 531-533 (1999).

G. Yao, L. V. Wang, �??Two-dimensional depth-resolved Mueller matrix characterization of biological tissue by optical coherence tomography,�?? Opt. Lett. 24, 537-539 (1999).

A. M. Rollins, R. Ung-arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., J. A. Izatt, �??Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design,�?? Opt. Lett. 24, 1358-1360 (1999).

G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, J. G. Fujimoto, �??Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography,�?? Opt. Lett. 21, 543-545 (1996).

C. E. Saxer, J. F. de Boer, B. H. Park, Y. Zhao, Z. Chen, J. S. Nelson, �??High-speed fiber-based polarization-sensitive optical coherence tomography of in vivo human skin,�?? Opt. Lett. 25, 1355-1357 (2000).

M. C. Pierce, B. H. Park, B. Cense, J. F. de Boer, "Simultaneous intensity, birefringence, and flow measurements with high-speed fiber-based optical coherence tomography," Opt. Lett. 27, 1534-1536 (2002).

S. L. Jiao, W. R. Yu, G. Stoica, L. H. V. Wang, �??Optical-fiber-based Mueller optical coherence tomography,�?? Opt. Lett. 28, 1206-1208 (2003).

D. P. Davé, T. Akkin, T. E. Milner, �??Polarization-maintaining fiber-based optical low-coherence reflectometer for characterization and ranging of birefringence,�?? Opt. Lett. 28, 1775-1777 (2003).

P. H. Tran, D. S. Mukai, M. Brenner, Z. Chen, �??In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe,�?? Opt. Lett. 29, 1236-1238 (2004).
[CrossRef]

S. Guo, J. Zhang, L. Wang, J. S. Nelson, Z. Chen, �??Depth-resolved birefringence and differential optical axis orientation measurements with fiber-based polarization-sensitive optical coherence tomography,�?? Opt. Lett. 29, 2025-2027 (2004).
[CrossRef]

P. R. Herz, Y. Chen, A. D. Aguirre, K. Schneider, P. Hsiung, J. G. Fujimoto, K. Madden, J. Schmitt, J. Goodnow, C. Petersen, �??Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography,�?? Opt. Lett. 29, 2261-2263 (2004).
[CrossRef]

Science (1)

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, J. G. Fujimoto, �??In vivo endoscopic optical biopsy with optical coherence tomography,�?? Science 276, 2037-2039 (1997).
[CrossRef]

Other (1)

P. R. Wheater, H. G. Burkitt, V. G. Daniels, Functional Histology, 2nd Ed., Ch. 8 (Churchill Livingstone, New York, 1987).

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