Abstract

Silica particles were partially coated with silver, and a suitable chromophore, such that they could be trapped within an optical tweezers system and simultaneously be excited to emit a surface–enhanced resonance Raman scattering (SERRS) spectrum. A standard 1064 nm TEM00 mode laser was used to trap the bead whilst a frequency doubling crystal inserted into the beam gave several microwatts of 532 nm co-linear light to excite the SERRS emission. The configuration has clear applications in providing apparatus that can manipulate a particle whilst simultaneously obtaining surface sensitive sensory information.

© 2005 Optical Society of America

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References

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Anal. Chem. (1)

K. Faulds, W. E. Smith and D. Graham, �??Evaluation of surface-enhanced resonance Raman scattering for quantitative DNA analysis,�?? Anal. Chem. 76, 412�??417 (2004).
[CrossRef] [PubMed]

Angew. Chem. Int. Ed. (1)

G. McNay, F. T. Docherty, D. Graham, W. Ewen Smith, P. Jordan, M. Padgett, J. Leach, G. Sinclair, P. B. Monaghan and J. M. Cooper, �??Visual observation of SERRS from single silver coated silica microparticles within optical tweezers,�?? Angew. Chem. Int. Ed. 43, 19, 2512�??2514 (2004).
[CrossRef]

Annu. Rev. Biophys. Biomol. Struct. (1)

K. Svoboda and S. M. Block, �??Biological applications of optical forces,�?? Annu. Rev. Biophys. Biomol. Struct. 23, 247�??285 (1994).
[CrossRef] [PubMed]

App. Spectrosc. (1)

K. Kneipp, Y. Wang, R. R. Dasari and M. S. Feld, �??An approach to single molecule detection using surface-enhanced resonance Raman scattering (SERRS): a study using rhodamine 6G on colloidal silver,�?? App. Spectrosc. 49, 780�??784 (1995).
[CrossRef]

Appl. Phys. Lett. (1)

K. Sasaki, M. Koshioka, H. Misawa and N. Kitamura, �??Optical trapping of a metal particle and a water droplet by a scanning laser beam,�?? Appl. Phys. Lett. 60, 7, 807�??809 (1992).
[CrossRef]

J. Biomed. Opt. (1)

K. Ramser, K. Logg, M. Goks¨or, J. Enger, M. K¨all and D. Hanstorp, �??Resonance Raman spectroscopy of optically trapped functional erythrocytes,�?? J. Biomed. Opt. 9, 593-600 (2004).
[CrossRef] [PubMed]

J. Chem. Phys. (2)

J. Gersten and A. Nitzan, �??Spectroscopic properties of molecules interacting with small dielectric particles,�?? J. Chem. Phys. 75, 3, 1139�??1152 (1981).
[CrossRef]

R. Ruppin, �??Decay of an excited molecule near a small metal sphere,�?? J. Chem. Phys. 76, 1681�??1684 (1982).
[CrossRef]

Langmuir (1)

Y. Saito, J. J. Wang, D. A. Smith and D. N. Batchelder, �??A simple chemical method for the preparation of silver surfaces for efficient SERS,�?? Langmuir 18, 2959�??2961 (2002).
[CrossRef]

Opt. Lett. (6)

Rev. Sci. Instrum. (1)

K. C. Neuman and S. M. Block, �??Optical trapping,�?? Rev. Sci. Instrum. 75, 2787�??2809 (2004).
[CrossRef]

Science (1)

S. Nie and S. R. Emory, �??Probing single molecules and single nanoparticles by surface enhanced Raman scattering,�?? Science 275, 1102�??1106 (1997).
[CrossRef] [PubMed]

Other (1)

M. J. Pelletier, �??Analytical applications in Raman spectroscopy,�?? Blackwell Science Ltd, (1999).

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Figures (4)

Fig. 1.
Fig. 1.

Schematic diagram of experimental set-up.

Fig. 2.
Fig. 2.

Photo-degradation of several different individually trapped, silver and dye-coated particles using 436 mW of 1064 nm laser light which, after transmission through the frequency doubling crystal, introduced 10.9 µW of 532 nm excitation light in the trapping plane.

Fig. 3.
Fig. 3.

Comparison of the spectra recorded from the silver and dye coated micro-particle in the optical tweezers to the same dye adsorbed onto a silver colloid and recorded using a dedicated Raman system.

Fig. 4.
Fig. 4.

The spectra of a SERRS active bead being trapped, released and re-trapped. The particle is only active when trapped; when it is not trapped the intensity falls down to noise levels.

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